scholarly journals Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy

Diabetes ◽  
2011 ◽  
Vol 60 (9) ◽  
pp. 2386-2396 ◽  
Author(s):  
F. Barutta ◽  
F. Piscitelli ◽  
S. Pinach ◽  
G. Bruno ◽  
R. Gambino ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Mouse Model ◽  
Cannabinoid Receptor ◽  
Protective Role ◽  
Receptor Type ◽  
Cannabinoid Receptor Type 2

scholarly journals Cannabinoid Receptor Type 2: A Possible Target in SARS-CoV-2 (CoV-19) Infection?

2020 ◽  
Vol 21 (11) ◽  
pp. 3809 ◽  
Author(s):  
Francesca Rossi ◽  
Chiara Tortora ◽  
Maura Argenziano ◽  
Alessandra Di Paola ◽  
Francesca Punzo
Keyword(s):  
Cannabinoid Receptor ◽  
Protective Role ◽  
Receptor Type ◽  
Macrophage Phenotype ◽  
Small Vessels ◽  
Global Pandemic ◽  
Cannabinoid Receptor Type 2 ◽  
Novel Coronavirus

In late December 2019, a novel coronavirus (SARS-CoV-2 or CoV-19) appeared in Wuhan, China, causing a global pandemic. SARS-CoV-2 causes mild to severe respiratory tract inflammation, often developing into lung fibrosis with thrombosis in pulmonary small vessels and causing even death. COronaVIrus Disease (COVID-19) patients manifest exacerbated inflammatory and immune responses, cytokine storm, prevalence of pro-inflammatory M1 macrophages and increased levels of resident and circulating immune cells. Men show higher susceptibility to SARS-CoV-2 infection than women, likely due to estrogens production. The protective role of estrogens, as well as an immune-suppressive activity that limits the excessive inflammation, can be mediated by cannabinoid receptor type 2 (CB2). The role of this receptor in modulating inflammation and immune response is well documented in fact in several settings. The stimulation of CB2 receptors is known to limit the release of pro-inflammatory cytokines, shift the macrophage phenotype towards the anti-inflammatory M2 type and enhance the immune-modulating properties of mesenchymal stromal cells. For these reasons, we hypothesize that CB2 receptor can be a therapeutic target in COVID-19 pandemic emergency.

Therapy with a Selective Cannabinoid Receptor Type 2 Agonist Limits Albuminuria and Renal Injury in Mice with Type 2 Diabetic Nephropathy

Nephron ◽  
2015 ◽  
Vol 132 (1) ◽  
pp. 59-69 ◽  
Author(s):  
Carlamaria Zoja ◽  
Monica Locatelli ◽  
Daniela Corna ◽  
Sebastian Villa ◽  
Daniela Rottoli ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Injury ◽  
Cannabinoid Receptor ◽  
Receptor Type ◽  
Cannabinoid Receptor Type 2 ◽  
Type 2 Diabetic

scholarly journals Cannabinoids affect the mouse visual acuity via the cannabinoid receptor type 2

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Bruno Cécyre ◽  
Ismaël Bachand ◽  
François Papineau ◽  
Chloé Brochu ◽  
Christian Casanova ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Cannabinoid Receptor ◽  
Amacrine Cells ◽  
Oscillatory Potentials ◽  
Receptor Type ◽  
Mouse Retina ◽  
Cannabinoid Receptor Type 2 ◽  
And Function

Abstract Recently, there have been increasing indications that the endocannabinoid (eCB) system is involved in vision. Multiple research teams studied the cannabinoid receptor type 2 (CB2R) expression and function in the mouse retina. Here, we examined the consequence of CB2R modulation on visual acuity using genetic and pharmacologic tools. We found that Cnr2 knockout mice show an enhanced visual acuity, CB2R activation decreased visual acuity while CB2R blockade with the inverse agonist AM630 increased it. The inhibition of 2-arachidonylglycerol (2-AG) synthesis and degradation also greatly increased and decreased visual acuity, respectively. No differences were seen when the cannabinoid receptor type 1 (CB1R) was deleted, blocked or activated implying that CB2R exclusively mediates cannabinoid modulation of the visual acuity. We also investigated the role of cannabinoids in retinal function using electroretinography (ERG). We found that modulating 2-AG levels affected many ERG components, such as the a-wave and oscillatory potentials (OPs), suggesting an impact on cones and amacrine cells. Taken together, these results reveal that CB2R modulates visual acuity and that eCBs such as 2-AG can modulate both visual acuity and retinal sensitivity. Finally, these findings establish that CB2R is present in visual areas and regulates vision-related functions.

The Role of Cannabinoid Receptor Type 2 in the Bone Loss Associated with pediatric Celiac Disease

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Chiara Tortora ◽  
Francesca Punzo ◽  
Maura Argenziano ◽  
Alessandra Di Paola ◽  
Carlo Tolone ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Bone Loss ◽  
Cannabinoid Receptor ◽  
Receptor Type ◽  
Cannabinoid Receptor Type 2

scholarly journals Endocannabinoidome and its role in neurological disorders-A comprehensive update of existing literature

2021 ◽  
Vol 5 (1) ◽  
pp. 034-047
Author(s):  
Rajib Dutta
Keyword(s):  
Neurological Disorders ◽  
Cannabinoid Receptor ◽  
Endocannabinoid System ◽  
Receptor Type ◽  
Cannabinoid Receptor Type 2 ◽  
Medical Benefits ◽  
Related Compounds

Medical benefits of cannabis and related compounds is widely known. Discovery of psychotropic plant cannabinoid Δ9-tetrahydrocannabinol have urged researchers to study more about the cannabinoid system and related therapeutics in the field of neurology and medicine. Where activation of cannabinoid receptor type 1 (CB1R) yielded in unwanted and serious side effects, discovery of cannabinoid receptor type 2 (CB2R) and its ligands gave a new hope. Till now there is limited success in this field because of complex expanded endocannabinoid system comprising of receptors, ligands and enzymes. In this review we will update about the role of endocannabinoidome relevant to neurological disorders.

scholarly journals Cannabinoid receptor type 2 gene is associated with human osteoporosis

2005 ◽  
Vol 14 (22) ◽  
pp. 3389-3396 ◽  
Author(s):  
Meliha Karsak ◽  
Martine Cohen-Solal ◽  
Jan Freudenberg ◽  
Agnes Ostertag ◽  
Caroline Morieux ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Receptor Type ◽  
Cannabinoid Receptor Type 2

scholarly journals Cannabinoid Receptor Type 2 (CB2) Dependent and Independent Effects of WIN55,212-2 on Atherosclerosis in Ldlr-null Mice

2015 ◽  
Vol 3 (2) ◽  
pp. 53-63 ◽  
Author(s):  
Douglas Thewke ◽  
◽  
Courtney Netherland-Van Dyke ◽  
Ward Rodgers ◽  
Makenzie Fulmer ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Receptor Type ◽  
Cannabinoid Receptor Type 2 ◽  
Independent Effects
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