2275-PUB: Relationship between the Effect of SGLT2 Inhibitors and Dietary Intake in Japanese Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2275-PUB
Author(s):  
HIDEYUKI KABASAWA ◽  
MICHIHIRO HOSOJIMA ◽  
TOSHIKO MURAYAMA ◽  
TAKAHIRO TANAKA ◽  
SHOJI KUWAHARA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intake ◽  
Japanese Patients ◽  
Sglt2 Inhibitors

scholarly journals Dietary intake in Japanese patients with type 2 diabetes: Analysis from Japan Diabetes Complications Study

2013 ◽  
Vol 5 (2) ◽  
pp. 176-187 ◽  
Author(s):  
Chika Horikawa ◽  
Yukio Yoshimura ◽  
Chiemi Kamada ◽  
Shiro Tanaka ◽  
Sachiko Tanaka ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intake ◽  
Diabetes Complications ◽  
Japanese Patients

767-P: Family Support for Medical Nutritional Therapy and Dietary Intake among Japanese Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 767-P
Author(s):  
CHIKA HORIKAWA ◽  
YASUNAGA TAKEDA ◽  
MARIKO HATTA ◽  
DAI ISHII ◽  
SAKIKO Y. MORIKAWA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intake ◽  
Family Support ◽  
Japanese Patients ◽  
Nutritional Therapy

Higher Dietary Intake of Vitamin D Is Associated with Lower Incidence of Diabetic Nephropathy in Japanese Patients with Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1561-P ◽  
Author(s):  
CHIKA HORIKAWA ◽  
REI AIDA ◽  
SHIRO TANAKA ◽  
SACHIKO TANAKA ◽  
CHIEMI KAMADA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Diabetic Nephropathy ◽  
Dietary Intake ◽  
Lower Incidence ◽  
Japanese Patients

scholarly journals Secular Trends in Dietary Intake over a 20-Year Period in People with Type 2 Diabetes in Japan: A Comparative Study of Two Nationwide Registries; Japan Diabetes Complications Study (JDCS) and Japan Diabetes Clinical Data Management Study (JDDM)

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3428
Author(s):  
Mizuki Takeuchi ◽  
Chika Horikawa ◽  
Mariko Hatta ◽  
Yasunaga Takeda ◽  
Rina Nedachi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intake ◽  
Data Management ◽  
Clinical Data ◽  
Diabetes Complications ◽  
Japanese Patients ◽  
Food Groups ◽  
Management Study ◽  
Vegetables And Fruits

Background: In order to provide effective dietary guidance, it is necessary to consider dietary intake, which can change over time. This study analyzed changes in the diet of Japanese patients with type 2 diabetes over a 20-year period. Methods: We compared the results of two dietary surveys that used the food frequency questionnaire format. The first was conducted in 1996 by the Japan Diabetes Complications Study (JDCS) (n = 1509; males 53.3%), and the second in 2014–2018 by the Japan Diabetes Clinical Data Management Study (JDDM) (n = 1145; males 65.6%). Both are nationwide representative registries of outpatients with type 2 diabetes in Japan. Results: Over a 20-year period, both men and women with type 2 diabetes had a significant increase in body mass index (BMI). Nonetheless, there was only a small change in energy intake. Conversely, there was a significant increase in fat intake and thus in the fat-to-energy ratio. With regard to food groups, there was a significant increase in meat intake and a decrease in the intake of fish, soybeans/soy products, vegetables, and fruits, with a particularly significant decrease in vegetables. Conclusions: Even in Japan, an industrialized country with a stable socioeconomic environment, there were many significant changes in the dietary intake of patients with type 2 diabetes over the 20-year period.

scholarly journals Habitual Dietary Intake Affects the Altered Pattern of Gut Microbiome by Acarbose in Patients with Type 2 Diabetes

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2107
Author(s):  
Fumie Takewaki ◽  
Hanako Nakajima ◽  
Daiki Takewaki ◽  
Yoshitaka Hashimoto ◽  
Saori Majima ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gut Microbiota ◽  
Dietary Intake ◽  
Hierarchical Clustering ◽  
Gut Microbiome ◽  
Japanese Patients ◽  
Carbohydrate Intake ◽  
Fat Intake ◽  
Lower Abundance

The aim of this research was to reveal the characteristics of gut microbiome altered by acarbose intervention in Japanese patients with type 2 diabetes (T2D) and its possible association with habitual dietary intake. Eighteen patients with T2D were administered acarbose for four weeks. The abundances of two major phyla, namely Actinobacteria and Bacteroidetes, were reciprocally changed accompanied by the acarbose intervention. There were also significant changes in the abundances of ten genera, including the greater abundance of Bifidobacterium, Eubacterium, and Lactobacillus and the lower abundance of Bacteroides in the group after the intervention than that before the intervention. Hierarchical clustering of habitual dietary intake was performed based on the pattern of changes in the gut microbiota and were classified into distinct three clusters. Cluster I consisted of sucrose, cluster II mainly included fat intake, and cluster III mainly included carbohydrate intake. Moreover, the amount of change in Faecalibacterium was positively correlated with the intake of rice, but negatively correlated with the intake of bread. The intake of potato was negatively correlated with the amount of change in Akkermansia and Subdoligranulum. Acarbose altered the composition of gut microbiome in Japanese patients with T2D, which might be linked to the habitual dietary intake.

scholarly journals Real-world risk of hypoglycemia-related hospitalization in Japanese patients with type 2 diabetes using SGLT2 inhibitors: a nationwide cohort study

2020 ◽  
Vol 8 (2) ◽  
pp. e001856
Author(s):  
Takeshi Horii ◽  
Yoichi Oikawa ◽  
Narumi Kunisada ◽  
Akira Shimada ◽  
Koichiro Atsuda
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Real World ◽  
Sglt2 Inhibitor ◽  
Japanese Patients ◽  
Sglt2 Inhibitors ◽  
Clinical Factors ◽  
Glucose Levels ◽  
Increased Risk

IntroductionSodium-glucose cotransporter 2 (SGLT2) inhibitors are believed to lower glucose levels and inhibit cardiovascular events related to type 2 diabetes (T2D). To maximize their benefits, the risk of resultant hypoglycemia has to be minimized; however, the magnitude of this risk remains unclear. Here, we aimed to identify clinical factors linked to an increased risk of hypoglycemia among Japanese patients with T2D and treated with SGLT2 inhibitors.Research design and methodsThis was a real-world retrospective cohort study conducted using the Japanese Medical Data Vision database. We identified patients with T2D and treated with SGLT2 inhibitors who were enrolled in the database from April 2014 to October 2019. Cox multivariate regression analyses were performed to determine demographical and clinical factors linked to SGLT2 inhibitor-associated hypoglycemia-related hospitalization.ResultsOf 171 622 patients prescribed SGLT2 inhibitors, hypoglycemia-related hospitalization occurred in 216 (0.13%), with 0.60 incidences per 100 person-years. The risk of SGLT2 inhibitor-associated hypoglycemia was higher with each 10-year increase in age (HR 1.49; 95% CI 1.32 to 1.68) and high in patients with body mass index <25 kg/m2 (HR 1.98; 95% CI 1.50 to 2.61), insulin use (HR 3.26; 95% CI 2.43 to 4.38), and sulfonylurea use (HR 1.44; 95% CI 1.02 to 2.03). The risk was lower in women than in men (HR 0.73; 95% CI 0.54 to 0.98) and low in concomitant metformin users (HR 0.52; 95% CI 0.37 to 0.74).ConclusionsThese findings may help minimize the risk of hypoglycemia-related hospitalization due to T2D treatment with SGLT2 inhibitors. We revealed that the risk of hypoglycemia may be higher when combining SGLT2 inhibitors with sulfonylureas and/or insulin. Furthermore, we discovered a high risk of hypoglycemia in older and non-obese patients. These findings may assist in maximizing the benefits of SGLT2 inhibitors for the treatment of T2D.

2347-PUB: Relationship between Aging and Effects of SGLT2 Inhibitors on Glucose and Lipid Metabolisms and Hepatic Function in Japanese Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2347-PUB
Author(s):  
MASATAKA KUSUNOKI ◽  
YUKIE NATSUME ◽  
YOSHIHARU OSHIDA ◽  
TETSURO MIYATA
Keyword(s):  
Type 2 Diabetes ◽  
Japanese Patients ◽  
Hepatic Function ◽  
Sglt2 Inhibitors

2078-P: Association of Dietary Intake of Phosphorus with Obesity in Japanese Patients with Type 2 Diabetes Mellitus (T2DM)

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2078-P
Author(s):  
MARIKO HATTA ◽  
KAZUYA FUJIHARA ◽  
YASUHIRO MATSUBAYASHI ◽  
YASUNAGA TAKEDA ◽  
RINA NEDACHI ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Dietary Intake ◽  
Japanese Patients

scholarly journals Dietary intake habits and the prevalence of nocturia in Japanese patients with type 2 diabetes mellitus

2017 ◽  
Vol 9 (2) ◽  
pp. 279-285 ◽  
Author(s):  
Shinya Furukawa ◽  
Takenori Sakai ◽  
Tetsuji Niiya ◽  
Hiroaki Miyaoka ◽  
Teruki Miyake ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Dietary Intake ◽  
Japanese Patients
Sign in / Sign up

Export Citation Format

Share Document