Higher Dietary Intake of Vitamin D Is Associated with Lower Incidence of Diabetic Nephropathy in Japanese Patients with Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1561-P ◽  
Author(s):  
CHIKA HORIKAWA ◽  
REI AIDA ◽  
SHIRO TANAKA ◽  
SACHIKO TANAKA ◽  
CHIEMI KAMADA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Diabetic Nephropathy ◽  
Dietary Intake ◽  
Lower Incidence ◽  
Japanese Patients

1579-P: Higher Calcium Intake Is Associated with Lower Incidence of Diabetic Nephropathy in Japanese Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1579-P
Author(s):  
CHIKA HORIKAWA ◽  
REI AIDA ◽  
SHIRO TANAKA ◽  
SACHIKO TANAKA ◽  
CHIEMI KAMADA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Calcium Intake ◽  
Lower Incidence ◽  
Japanese Patients

Serum lipoprotein(a) levels and diabetic nephropathy among Japanese patients with type 2 diabetes mellitus

2016 ◽  
Vol 30 (5) ◽  
pp. 923-927 ◽  
Author(s):  
Hidenori Senba ◽  
Shinya Furukawa ◽  
Takenori Sakai ◽  
Tetsuji Niiya ◽  
Teruki Miyake ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Japanese Patients ◽  
Serum Lipoprotein ◽  
Lipoprotein A

scholarly journals Evaluation of the Effect of Vitamin D Supplementation on Anthropometric Indicators and Dietary Intake of Patients with Type 2 Diabetes

2021 ◽  
Vol 9 (4) ◽  
pp. 490-497
Author(s):  
Mahnaz Zarei ◽  
Mohammad Hassan Javanbakht ◽  
Hanieh Jafary ◽  
Mahmoud Djalali ◽  
◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Dietary Intake ◽  
Vitamin D Supplementation ◽  
Anthropometric Indicators

scholarly journals Dietary intake in Japanese patients with type 2 diabetes: Analysis from Japan Diabetes Complications Study

2013 ◽  
Vol 5 (2) ◽  
pp. 176-187 ◽  
Author(s):  
Chika Horikawa ◽  
Yukio Yoshimura ◽  
Chiemi Kamada ◽  
Shiro Tanaka ◽  
Sachiko Tanaka ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intake ◽  
Diabetes Complications ◽  
Japanese Patients

scholarly journals Asosiasi antara Status Vitamin D 25(Oh)D dengan Albuminuria pada Pasien Diabetes Melitus Tipe 2

2017 ◽  
Vol 4 (1) ◽  
pp. 16
Author(s):  
Tities Anggraeni Indra ◽  
Aida Lydia ◽  
Dyah Purnamasari ◽  
Siti Setiati
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Vitamin D Deficiency ◽  
Blood Glucose Control ◽  
Chi Square ◽  
Diabetes Melitus

Pendahuluan. Angka kejadian nefropati diabetik di Indonesia dilaporkan meningkat. Defisiensi vitamin D juga cukup tinggi. Berbagai faktor telah diidentifikasi turut memperberat kejadian nefropati diabetik salah satunya status vitamin D 25(OH)D. Namun demikian, bekum ada studi yang mengidentifikasi hubungan keduanya di Indonesia. Penelitian ini bertujuan untuk mengetahui asosiasi antara status vitamin D 25(OH)D dengan albuminuria pada pasien diabetes melitus tipe 2 di Indonesia.Metode. Dilakukan studi potong lintang pada 96 pasien diabetes melitus (DM) tipe 2 yang berobat ke poliklinik MetabolikEndokrin Fakultas Kedokteran Universitas Indonesia/Rumah Sakit dr. Cipto Mangunkusumo (FKUI/RSCM), Jakarta pada November-Desember 2012. Pemeriksaan kadar vitamin D 25(OH)D diilakukan dengan menggunakan kit Diasorin dengan metode CLIA, sedangkan albuminuria dinilai berdasarkan kadar albumin pada sampel urin sewaktu. Uji statistik yang digunakan meliputi uji chi square pada analisis bivariat dan regresi logistik pada analisis multivariat.Hasil. Prevalensi defisiensi vitamin D 25(OH)D pada pasien diabetes melitus tipe 2 sebesar 49% dengan nilai median kadar vitamin D 25(OH)D adalah 16,35 (4,2-41,4) ng/mL. Tidak didapatkan adanya hubungan yang bermakna secara statistik antara defisiensi vitamin D dengan albuminuria, baik pada analisis bivariat maupun multivariat (OR 0,887; IK95% 0,3352,296). Faktor perancu yang memengaruhi hubungan antara defisiensi vitamin D dengan kejadian albuminuria pada pasien DM tipe 2 adalah kontrol gula darah yang buruk dan berat badan lebih.Simpulan. Studi ini belum dapat menyimpulkan adanya hubungan antara defisiensi vitamin D 25(OH)D dengan albuminuria pada pasien DM tipe 2 di Indonesia.Kata Kunci: albuminuria, defisiensi vitamin D 25(OH)D, DM tipe 2  The Association between Vitamin D 25(OH)D Level and Albuminuria in Type 2 Diabetes MellitusIntroduction. Vitamin D 25(OH)D deficiency was reported as a possible risk factor for the development of diabetic nephropathy in several epidemiologic studies. Whether vitamin D 25(OH)D deficiency plays a role in the development of diabetic nephropathy in Indonesia is unknown. This study aims to determinate the association between vitamin D 25(OH)D level with albuminuria in patients with type 2 diabetes mellitus in Indonesia. Methods. A cross-sectional study was conducted in 96 patients with type 2 diabetes mellitus at outpatient clinic of MetabolicEndocrine Cipto Mangunkusumo Hospital. Serum vitamin D level was assessed using Diasorin kit with CLIA method, while albuminuria was assessed using random urine sample. Statistical analysis was conducted using chi square for bivariate analysis and regression logistic method for multivariate analysis. Results.The prevalence of vitamin D 25(OH)D deficiency in patients with type 2 diabetes mellitus was 49% with a median value 16,35 (4,2-41,4) ng/mL. There was no significant correlation between vitamin D deficiency with the severity of albuminuria (OR 0,887; 95% CI 0,335 to 2,296). Confounding factors such as poor blood glucose control and overweight strongly influenced the association between vitamin D deficiency with the incidence of albuminuria in patients with type 2 diabetes mellitus. Conclusion. The results of this study showed that there was no association between vitamin D deficiency with the severity of albuminuria in patients with type 2 diabetes mellitus in Indonesia. 

The role of vitamin D deficiency and elevated inflammatory biomarkers as risk factors for the progression of diabetic nephropathy in patients with type 2 diabetes mellitus

2021 ◽  
Vol 19 (1) ◽  
pp. 1183-1192
Author(s):  
Ahmad El Askary ◽  
Amal F. Gharib ◽  
Mazen Almehmadi ◽  
Maha Mahfouz Bakhuraysah ◽  
Abdulaziz Ali Al Hajjiahmed ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Vitamin D Deficiency ◽  
Diabetic Patients ◽  
Tnf Α

Abstract Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. Albuminuria is the most sensitive marker for the early recognition of DN. Therefore, we aimed to study the risk factors of albuminuria as a marker of DN among diabetic patients. The study included 41 patients with type 2 diabetes mellitus (T2DM), 50 type 2 diabetic nephropathy (T2DN) patients with macroalbuminuria, 43 T2DN patients with microalbuminuria and 38 healthy controls. Logistic regression was used to detect the most significant risk factors for albuminuria. A high statistically significant difference was found between the groups regarding age, sex, body mass index (BMI), diabetes mellitus (DM) duration, glucose, glycated haemoglobin (HbA1c), creatinine, glomerular filtration rate (GFR), lipid profile, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), the albumin–creatinine ratio (ACR), vitamin D, total parathyroid hormone (PTH), urea, total calcium and chemerin (p < 0.001). It was found that the duration of DM, BMI, glucose, GFR, total cholesterol (TC), low-density lipoprotein (LDL), TNF-α, IL-6, CRP, ACR, vitamin D, PTH and chemerin are significant albuminuria risk factors in DN. Vitamin D deficiency and associated inflammatory mediators such as chemerin, TNF-α, IL-6 and CRP are the most essential risk factors for albuminuria in T2DM patients.

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