2347-PUB: Relationship between Aging and Effects of SGLT2 Inhibitors on Glucose and Lipid Metabolisms and Hepatic Function in Japanese Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2347-PUB
Author(s):  
MASATAKA KUSUNOKI ◽  
YUKIE NATSUME ◽  
YOSHIHARU OSHIDA ◽  
TETSURO MIYATA
Keyword(s):  
Type 2 Diabetes ◽  
Japanese Patients ◽  
Hepatic Function ◽  
Sglt2 Inhibitors

scholarly journals Ezetimibe improves glucose metabolism by ameliorating hepatic function in Japanese patients with type 2 diabetes

2011 ◽  
Vol 3 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Shinji Ichimori ◽  
Seiya Shimoda ◽  
Rieko Goto ◽  
Yasuto Matsuo ◽  
Takako Maeda ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Metabolism ◽  
Japanese Patients ◽  
Hepatic Function

scholarly journals Real-world risk of hypoglycemia-related hospitalization in Japanese patients with type 2 diabetes using SGLT2 inhibitors: a nationwide cohort study

2020 ◽  
Vol 8 (2) ◽  
pp. e001856
Author(s):  
Takeshi Horii ◽  
Yoichi Oikawa ◽  
Narumi Kunisada ◽  
Akira Shimada ◽  
Koichiro Atsuda
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Real World ◽  
Sglt2 Inhibitor ◽  
Japanese Patients ◽  
Sglt2 Inhibitors ◽  
Clinical Factors ◽  
Glucose Levels ◽  
Increased Risk

IntroductionSodium-glucose cotransporter 2 (SGLT2) inhibitors are believed to lower glucose levels and inhibit cardiovascular events related to type 2 diabetes (T2D). To maximize their benefits, the risk of resultant hypoglycemia has to be minimized; however, the magnitude of this risk remains unclear. Here, we aimed to identify clinical factors linked to an increased risk of hypoglycemia among Japanese patients with T2D and treated with SGLT2 inhibitors.Research design and methodsThis was a real-world retrospective cohort study conducted using the Japanese Medical Data Vision database. We identified patients with T2D and treated with SGLT2 inhibitors who were enrolled in the database from April 2014 to October 2019. Cox multivariate regression analyses were performed to determine demographical and clinical factors linked to SGLT2 inhibitor-associated hypoglycemia-related hospitalization.ResultsOf 171 622 patients prescribed SGLT2 inhibitors, hypoglycemia-related hospitalization occurred in 216 (0.13%), with 0.60 incidences per 100 person-years. The risk of SGLT2 inhibitor-associated hypoglycemia was higher with each 10-year increase in age (HR 1.49; 95% CI 1.32 to 1.68) and high in patients with body mass index <25 kg/m2 (HR 1.98; 95% CI 1.50 to 2.61), insulin use (HR 3.26; 95% CI 2.43 to 4.38), and sulfonylurea use (HR 1.44; 95% CI 1.02 to 2.03). The risk was lower in women than in men (HR 0.73; 95% CI 0.54 to 0.98) and low in concomitant metformin users (HR 0.52; 95% CI 0.37 to 0.74).ConclusionsThese findings may help minimize the risk of hypoglycemia-related hospitalization due to T2D treatment with SGLT2 inhibitors. We revealed that the risk of hypoglycemia may be higher when combining SGLT2 inhibitors with sulfonylureas and/or insulin. Furthermore, we discovered a high risk of hypoglycemia in older and non-obese patients. These findings may assist in maximizing the benefits of SGLT2 inhibitors for the treatment of T2D.

2275-PUB: Relationship between the Effect of SGLT2 Inhibitors and Dietary Intake in Japanese Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2275-PUB
Author(s):  
HIDEYUKI KABASAWA ◽  
MICHIHIRO HOSOJIMA ◽  
TOSHIKO MURAYAMA ◽  
TAKAHIRO TANAKA ◽  
SHOJI KUWAHARA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intake ◽  
Japanese Patients ◽  
Sglt2 Inhibitors

2343-PUB: Reduction of HbA1c after SGLT2 Inhibitors Correlate with Change in Plasma Osmolarity but Not with Elevation of Hematocrit in Japanese Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2343-PUB ◽  
Author(s):  
YOSHIHARU WADA ◽  
YOSHIYUKI HAMAMOTO ◽  
YOSHIHISA NAKATANI ◽  
JUN FUJIKAWA ◽  
YORIHIRO IWASAKI ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Japanese Patients ◽  
Sglt2 Inhibitors ◽  
Plasma Osmolarity

148-OR: IDegLira Improves Glycemic Control in Japanese Patients with Type 2 Diabetes (T2D) Uncontrolled on Premixed Insulin Therapy

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 148-OR ◽  
Author(s):  
HIROTAKA WATADA ◽  
BUE F. AGNER ◽  
ANKUR DOSHI ◽  
RANDI GRØN ◽  
MATTIS F. RANTHE ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Insulin Therapy ◽  
Japanese Patients ◽  
Premixed Insulin

Large-Scale Cross-Sectional Study of the Problem Areas in Diabetes Survey among Japanese Patients with Type 2 Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2393-PUB
Author(s):  
KENICHIRO TAKAHASHI ◽  
MINORI SHINODA ◽  
RIKA SAKAMOTO ◽  
JUN SUZUKI ◽  
TADASHI YAMAKAWA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Large Scale ◽  
Japanese Patients ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diabetes Survey

774-P: Not Carbohydrate but Sucrose Intake Is Associated with Gut Dysbiosis in Japanese Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 774-P
Author(s):  
YOSHITAKA HASHIMOTO ◽  
MASAHIDE HAMAGUCHI ◽  
AYUMI KAJI ◽  
RYOSUKE SAKAI ◽  
RYO INOUE ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Japanese Patients ◽  
Sucrose Intake ◽  
Gut Dysbiosis
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