220-LB: Early-Life Famine Exposure and Hyperuricemia in Adulthood

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 220-LB
Author(s):  
YUYING WANG ◽  
WEN ZHANG ◽  
HENG WAN ◽  
CHI CHEN ◽  
YI CHEN ◽  
...  
Keyword(s):  
Early Life ◽  
Famine Exposure

scholarly journals Early-Life Exposure to the Chinese Great Famine and Later Cardiovascular Diseases

2021 ◽  
Vol 66 ◽  
Author(s):  
Zhenghe Wang ◽  
Yanhui Dong ◽  
Rongbin Xu ◽  
Xijie Wang ◽  
Yanhui Li ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Early Life ◽  
Matched Control ◽  
Longitudinal Survey ◽  
Control Group ◽  
Unexposed Group ◽  
Great Famine ◽  
Early Life Exposure ◽  
Exposed Infant ◽  
Famine Exposure

Objectives: This study aimed to examine the association between early life famine exposure and adulthood cardiovascular diseases (CVDs) risk.Methods: A total of 5,504 subjects were selected using their birthdate from national baseline data of the China Health and Retirement Longitudinal Survey to analyze the association between famine exposure in early life and CVDs risk in adulthood. CVDs was defined based on the self-reported doctor’s diagnosis.Results: The prevalence of CVDs in the unexposed group, fetal-exposed, infant-exposed, and preschool-exposed groups was 15.0%, 18.0%, 21.0%, and 18.3%, respectively. Compared with the unexposed group, fetal-exposed, infant-exposed and preschool-exposed groups had higher CVDs risk in adulthood (p < 0.05). Compared with the age-matched control group, infancy exposed to famine had a significantly higher adulthood CVDs risk (OR = 1.52, 95% CI: 1.15, 2.01; p = 0.006). The association seems to be stronger among population with higher education level (Pinteraction = 0.043). Sensitivity analysis revealed consistent association between early-life famine exposure and adult CVDs risk.Conclusion: Early life exposed to the China great famine may elevate the risk of CVDs in adulthood.

scholarly journals Early-Life Exposure to the Chinese Famine and Risk of Cognitive Decline

2019 ◽  
Vol 8 (4) ◽  
pp. 484 ◽  
Author(s):  
Hongguo Rong ◽  
Xiaozhen Lai ◽  
Elham Mahmoudi ◽  
Hai Fang
Keyword(s):  
Cognitive Decline ◽  
Cognitive Performance ◽  
Early Life ◽  
Late Life ◽  
Cognitive Status ◽  
Word Recall ◽  
Long Term Effects ◽  
Negative Effects ◽  
Multi Stage ◽  
Famine Exposure

Previous studies on the Chinese famine suggested long-term effects of early-life famine exposure on health conditions. This study aims to investigate the association between exposure to the Chinese famine of 1959–1961 at different early-life stages and the risk of cognitive decline in adulthood. A total of 6417 adults born between 1952 and 1964 in the 2015 survey data of China Health and Retirement Longitudinal Study were included in this study. Cognitive performance was estimated through a series of comprehensive neuropsychological tests, including the Telephone Interview of Cognitive Status (TICS-10), word recall, and pentagon drawing. Multiple generalized linear model (GLM) was employed to detect the association between multi-stage early-life famine exposure and late-life cognitive performance. Compared with the unexposed group, respondents exposed to famine in the fetal period performed worse in the TICS (difference −0.52, 95% confidence interval (CI): −0.93 to −0.10), word recall (difference −0.46, 95% CI: −0.74 to −0.19), and general cognition (difference −1.05, 95% CI: −1.64 to −0.47). Furthermore, we also found negative effects of famine exposure on performance of word recall and pentagon drawing in the early (word recall difference −0.56, 95% CI: −1.00 to −0.11; pentagon drawing difference −0.76, 95% CI: −1.40 to −0.12), mid (word recall difference −0.46, 95% CI: −0.81 to −0.11; pentagon drawing difference −0.66, 95% CI: −1.16 to −0.16), and late (word recall difference −0.30, 95% CI: −0.55 to −0.04; pentagon drawing difference −0.75, 95% CI: −1.13 to −0.37) childhood-exposed groups. Early-life famine exposure in different stages is positively associated with late-life cognitive decline. Fetal famine exposure might affect the overall cognitive status in adulthood, and childhood famine exposure has potential adverse effects on visuospatial episodic memory.

scholarly journals Exposure to Famine During Early Life and Abdominal Obesity in Adulthood: Findings from the Great Chinese Famine During 1959–1961

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 903 ◽  
Author(s):  
Dan Liu ◽  
Dong-mei Yu ◽  
Li-yun Zhao ◽  
Hong-yun Fang ◽  
Jian Zhang ◽  
...  
Keyword(s):  
Abdominal Obesity ◽  
Urban Areas ◽  
Early Life ◽  
Healthy Lifestyle ◽  
Positive Association ◽  
Fetal Life ◽  
Cross Sectional ◽  
Famine Exposure ◽  
Nationally Representative ◽  
The Relationship

Undernutrition during early life may lead to obesity in adulthood. This study was conducted to examine the relationship between famine exposure during early life and the risk of abdominal obesity in adulthood. A total of 18,984 and 16,594 adults were surveyed in 2002 and 2010–2012 in two nationally representative cross-sectional surveys, namely China Nutrition and Health Survey, respectively. The risk of abdominal obesity was evaluated for participants born during 1956–1961 and compared with that of participants born during 1962–1964. The overall prevalence of abdominal obesity in adulthood showed a positive association with famine exposure during early life. The odds ratios of famine exposure were 1.31 (1.19–1.44) and 1.28 (1.17–1.40) in 2002 during fetal life and infancy and 1.09 (1.00–1.19) in 2012 during fetal life, respectively. The relationships between famine exposure and abdominal obesity across the famine exposure groups were distinct among females and those who lived in urban areas and were physical inactive (p < 0.05). Exposure to famine during early life was associated with increased risks of abdominal obesity in adulthood, which was partially alleviated by healthy lifestyle factors (e.g., physical activity).

scholarly journals Early Life Famine Exposure, Ideal Cardiovascular Health Metrics, and Risk of Incident Diabetes: Findings From the 4C Study

Diabetes Care ◽  
2020 ◽  
Vol 43 (8) ◽  
pp. 1902-1909 ◽  
Author(s):  
Jieli Lu ◽  
Mian Li ◽  
Yu Xu ◽  
Yufang Bi ◽  
Yingfen Qin ◽  
...  
Keyword(s):  
Early Life ◽  
Cardiovascular Health ◽  
Incident Diabetes ◽  
Ideal Cardiovascular Health ◽  
Famine Exposure

Association of Exposure to Chinese Famine in Early Life with the Risk of Metabolic Syndrome in Adulthood

2020 ◽  
Vol 76 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Yue Peng ◽  
Miaomiao Hai ◽  
Pengcheng Li ◽  
Yongjie Chen
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Early Childhood ◽  
Early Life ◽  
Lower Risk ◽  
Late Childhood ◽  
Fetal Life ◽  
Childhood Exposure ◽  
Study Results ◽  
Famine Exposure

Objective: To explore the association of famine exposure in early life with the risk of metabolic syndrome (MS) in the ­Chinese adults. Methods: Data were obtained from the wave 2009 of the China Health and Nutrition Survey. MS was identified when 3 or more of the following components happened: (1) waist circumference >90 cm in males or >85 cm in females; (2) fasting glucose ≥6.1 mmol/L; (3) systolic blood pressure ≥130 mm Hg/diabolic blood pressure ≥85 mm Hg; (4) fasting triglyceride ≥1.70 mmol/L; and (5) high-density lipids cholesterol <1.04 mmol/L. All participants were divided into 5 groups: no exposure, born after 1961; fetal life exposure, between 1959 and 1961; early childhood exposure, between 1956 and 1958; mid-childhood exposure, between 1953 and 1955; and late childhood exposure, between 1949 and 1952. A total of 2,080 subjects were included in this study. Results: In rural, famine exposure in fetal life and early childhood was associated with the lower risk of MS (p = 0.0491 and 0.0245; OR 0.583 and 0.703; and OR, 95% CI 0.341–0.998 and 0.517–0.956, respectively). But famine exposure in late childhood was associated with the higher risk of MS (p = 0.0140; OR 3.096; and OR, 95% CI 1.257–7.625). Famine exposure in early childhood was associated with the lower risk of MS (p = 0.0120; OR 0.633; and OR, 95% CI 0.443–0.904) in males. Conclusions: Famine exposure in mid- and late-childhood was associated with the higher risk of MS, especially in rural, males, and severe famine areas.

Sign in / Sign up

Export Citation Format

Share Document