Association of Exposure to Chinese Famine in Early Life with the Risk of Metabolic Syndrome in Adulthood

2020 ◽  
Vol 76 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Yue Peng ◽  
Miaomiao Hai ◽  
Pengcheng Li ◽  
Yongjie Chen
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Early Childhood ◽  
Early Life ◽  
Lower Risk ◽  
Late Childhood ◽  
Fetal Life ◽  
Childhood Exposure ◽  
Study Results ◽  
Famine Exposure

Objective: To explore the association of famine exposure in early life with the risk of metabolic syndrome (MS) in the ­Chinese adults. Methods: Data were obtained from the wave 2009 of the China Health and Nutrition Survey. MS was identified when 3 or more of the following components happened: (1) waist circumference >90 cm in males or >85 cm in females; (2) fasting glucose ≥6.1 mmol/L; (3) systolic blood pressure ≥130 mm Hg/diabolic blood pressure ≥85 mm Hg; (4) fasting triglyceride ≥1.70 mmol/L; and (5) high-density lipids cholesterol <1.04 mmol/L. All participants were divided into 5 groups: no exposure, born after 1961; fetal life exposure, between 1959 and 1961; early childhood exposure, between 1956 and 1958; mid-childhood exposure, between 1953 and 1955; and late childhood exposure, between 1949 and 1952. A total of 2,080 subjects were included in this study. Results: In rural, famine exposure in fetal life and early childhood was associated with the lower risk of MS (p = 0.0491 and 0.0245; OR 0.583 and 0.703; and OR, 95% CI 0.341–0.998 and 0.517–0.956, respectively). But famine exposure in late childhood was associated with the higher risk of MS (p = 0.0140; OR 3.096; and OR, 95% CI 1.257–7.625). Famine exposure in early childhood was associated with the lower risk of MS (p = 0.0120; OR 0.633; and OR, 95% CI 0.443–0.904) in males. Conclusions: Famine exposure in mid- and late-childhood was associated with the higher risk of MS, especially in rural, males, and severe famine areas.

Exposure to Chinese Famine in the Early Life, Adulthood Obesity Patterns, and the Incidence of Hypertension: A 22-Year Cohort Study

2021 ◽  
pp. 1-7
Author(s):  
Yu Wang ◽  
Jibin Jin ◽  
Yue Peng ◽  
Yongjie Chen
Keyword(s):  
Blood Pressure ◽  
Abdominal Obesity ◽  
Current Treatment ◽  
Late Childhood ◽  
Fetal Life ◽  
General Obesity ◽  
Antihypertensive Medications ◽  
Childhood Exposure ◽  
Famine Exposure ◽  
Obesity Hypertension

<b><i>Introduction:</i></b> Little is known regarding the joint associations of famine exposure and obesity patterns with the incidence of hypertension. <b><i>Methods:</i></b> We defined famine exposure cohorts as follows: nonexposure (born between 1962 and 1965), fetal life exposure (born between 1959 and 1961), early childhood exposure (born between 1956 and 1958), midchildhood exposure (born between 1953 and 1955), and late childhood exposure (born between 1949 and 1952). Obesity patterns were defined as follows: G−/A−: subjects without neither general obesity nor abdominal obesity; G+/A− or G−/A+: subjects with either general obesity or abdominal obesity; G+/A+: subjects with both general obesity and abdominal obesity. Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg or current treatment with antihypertensive medications. <b><i>Results:</i></b> There were 5,235 individuals participating in this study. In the subjects with general or abdominal obesity, famine exposure was associated with a lower risk of hypertension. In males with G−/A−, famine exposures in the midchildhood (<i>p</i> = 0.048; HR: 0.700; HR 95% CI: 0.491–0.998) and late childhood (<i>p</i> = 0.002; HR: 0.560; HR 95% CI: 0.374–0.840) were associated with a lower incidence of hypertension. <b><i>Conclusion:</i></b> The coexistence of famine exposure and obesity patterns was associated with the incidence of hypertension.

Association between Patients with Metabolic Syndrome and Other Various Factors Defining Metabolic Syndrome: A Cross-Sectional Study

2021 ◽  
Vol 8 (4) ◽  
pp. 12-17
Author(s):  
Basavaraj PG ◽  
Ashok P Yenkanchi ◽  
Chidanand Galagali
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Cardiovascular Diseases ◽  
Abdominal Obesity ◽  
Positive History ◽  
The Metabolic Syndrome ◽  
Study Results ◽  
History Of ◽  
The Mean

Background: Risk factors can lead to clinical conditions, like metabolic syndrome, that predisposes the development of cardiovascular diseases. Objective: The goal of this population-based, prospective and non-randomised cohort study was to study the association between patients with metabolic syndrome and other various factors defining metabolic syndrome. Methods: All the patients referred to the department of Medicine, Al-Ameen Medical college hospital and District Hospital, Vijayapur, Karnataka, India over a period of twenty-two months extending from December 2013 to September 2015 were considered in this study. Results: In the current study, out of 100 patients, 62.9% patients had metabolic syndrome with positive family history of hypertension, diabetes mellitus. 70.8% patients had metabolic syndrome with positive history of smoking. 64.3% patients had metabolic syndrome with positive history of alcohol .73.9% patients had metabolic syndrome with positive history of IHD. 87% of the patients with metabolic syndrome had SBP> 130 mmHg, and 78.85% patients had DBP>85 mmHg. And metabolic syndrome was observed in 71.8% patients on anti hypertensive drugs. The mean level of total cholesterol, LDL cholesterol, triglyceride is increased whereas the mean level of anti-atherogenic HDL cholesterol is low in subjects with MS. At least one lipid abnormality was present in > 95 % of cases. Around 81% subjects with BMI <25 (out of 38) had metabolic syndrome and 58% subjects with BMI>25(out of 62) had metabolic syndrome. Conclusion: All the components defining the metabolic syndrome correlated positively with the abdominal obesity. Systolic blood pressure values were significantly higher than diastolic blood pressure in subjects with abdominal obesity. Metabolic syndrome has multiple risk factors determined by various aspects like the race, the life style, geographical factors larger study is needed to understand the correlation between various components defining it. A healthy lifestyle, that includes avoiding tobacco exposure and proper weight control, must be encouraged in this high-risk population. Keywords: Cardiovascular diseases; Overweight; Risk factors; Smoking.

scholarly journals Prevalence of Metabolically Obese, Normal-Weight Individuals and Its Dietary Patterns Characteristics: A Cross-Sectional Study in Thai Adults

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1464-1464
Author(s):  
Hung Nguyen Ngoc ◽  
Wantanee Kriengsinyos ◽  
Nipa Rojroongwasinkul ◽  
Wichai Aekplakorn
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Abdominal Obesity ◽  
Dietary Patterns ◽  
Lower Risk ◽  
Normal Weight ◽  
Normal Body Mass Index ◽  
Health Examination ◽  
Cross Sectional ◽  
Metabolically Obese Normal Weight

Abstract Objectives Metabolically obese normal weight (MONW) individuals are subjects who have a normal body mass index (BMI), but manifest obesity-related metabolic syndrome (MetS). Nevertheless, the prevalence and correlation between MONW and dietary patterns have not been fully explored in Thais. This study aimed to investigate the national prevalence of MONW, determine which dietary patterns are consumed in Thai normal-weight adults and to identify whether those patterns were associated with the risk of MetS and its features. Methods Total 6899 Thais ≥18 years with normal BMI (18.5–22.9 kg/m2) were obtained from the Thai National Health Examination Survey IV. Sociodemographic, eating-habits, anthropometric, blood pressure and biochemical parameters were measured. MONW was diagnosed by the National Cholesterol Education Program/Adult Treatment Panel III within normal BMI. Dietary patterns were determined by means of factor analysis, and were evaluated by multiple logistic regressions for its association with MONW. Results Overall, the weighted prevalence of MONW was 9.9% (95% CI: 9.1–10.6%), particularly, the MONW prevalence was 7.2% (95% CI: 6.5–8.0%) and 13.1% (95% CI: 11.6–14.7%) in male and female respectively. Three major dietary patterns were distinguished: “westernized”, “healthy” and “carbohydrate” patterns. After controlling for potential confounders, compared with the lowest quartile, individuals in the highest quartile of the westernized and carbohydrate pattern were connected with the greater risk of MONW (adjusted odds ratio [OR]: 1.64, 95% CI: 1.25–2.17, P &lt; 0.001) and (OR: 1.57, 95% CI: 1.19–2.08, P &lt; 0.05) respectively, whereas subjects in the fourth quartile of healthy pattern reduce the risk of MONW and its components, except for elevated blood pressure and hyperglycemia (OR: 0.68, 95% CI: 0.50–0.92 for MONW, P &lt; 0.05; OR: 0.43, 95% CI: 0.28–0.68 for abdominal obesity, P &lt; 0.001; OR: 0.63, 95% CI: 0.49–0.81 for hypertriglyceridemia, P &lt; 0.001; OR: 0.67, 95% CI: 0.54–0.82 for low high-density lipoprotein cholesterol [HDL-C], P &lt; 0.01). Conclusions In Thai normal-weight adults, high consumption of whole grains, fruits, beans, juices, and dairy products is connected with a lower risk of metabolic syndrome and its features, i.e., lower risk of abdominal obesity, hypertriglyceridemia, and low HDL-C. Funding Sources This research received no funding.

scholarly journals Exposure to Famine During Early Life and Abdominal Obesity in Adulthood: Findings from the Great Chinese Famine During 1959–1961

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 903 ◽  
Author(s):  
Dan Liu ◽  
Dong-mei Yu ◽  
Li-yun Zhao ◽  
Hong-yun Fang ◽  
Jian Zhang ◽  
...  
Keyword(s):  
Abdominal Obesity ◽  
Urban Areas ◽  
Early Life ◽  
Healthy Lifestyle ◽  
Positive Association ◽  
Fetal Life ◽  
Cross Sectional ◽  
Famine Exposure ◽  
Nationally Representative ◽  
The Relationship

Undernutrition during early life may lead to obesity in adulthood. This study was conducted to examine the relationship between famine exposure during early life and the risk of abdominal obesity in adulthood. A total of 18,984 and 16,594 adults were surveyed in 2002 and 2010–2012 in two nationally representative cross-sectional surveys, namely China Nutrition and Health Survey, respectively. The risk of abdominal obesity was evaluated for participants born during 1956–1961 and compared with that of participants born during 1962–1964. The overall prevalence of abdominal obesity in adulthood showed a positive association with famine exposure during early life. The odds ratios of famine exposure were 1.31 (1.19–1.44) and 1.28 (1.17–1.40) in 2002 during fetal life and infancy and 1.09 (1.00–1.19) in 2012 during fetal life, respectively. The relationships between famine exposure and abdominal obesity across the famine exposure groups were distinct among females and those who lived in urban areas and were physical inactive (p < 0.05). Exposure to famine during early life was associated with increased risks of abdominal obesity in adulthood, which was partially alleviated by healthy lifestyle factors (e.g., physical activity).

scholarly journals Risk of metabolic syndrome in adults exposed to the great Chinese famine during the fetal life and early childhood

2011 ◽  
Vol 66 (2) ◽  
pp. 231-236 ◽  
Author(s):  
X Zheng ◽  
Y Wang ◽  
W Ren ◽  
R Luo ◽  
S Zhang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Early Childhood ◽  
Fetal Life

scholarly journals Effect of Exposure to Famine during Early Life on Risk of Metabolic Syndrome in Adulthood: A Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Lu-Lu Qin ◽  
Bang-An Luo ◽  
Fan Gao ◽  
Xiang-Lin Feng ◽  
Jia-He Liu
Keyword(s):  
Metabolic Syndrome ◽  
Early Life ◽  
Web Of Science ◽  
Meta Analysis ◽  
Random Effects Model ◽  
The Metabolic Syndrome ◽  
Knowledge Infrastructure ◽  
Famine Exposure ◽  
Study Designs ◽  
Chinese National Knowledge Infrastructure

Background. Emerging studies have explored the association between the famine exposure during early life and the risk of the metabolic syndrome, and the results remain controversial. This meta-analysis was performed to summarize the famine effects on the prevalence of metabolic syndrome (MetS) in adulthood. Materials and Methods. We searched the PubMed, Web of Science, Embase, ScienceDirect, and Chinese National Knowledge Infrastructure for relevant studies up to December 2019. Pooled odd ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the effect exposure to famine on MetS using a random-effects model, and the I2 was used to evaluate the heterogeneity. Results. The analyses included 39 studies from 10 articles with a total of 81504 participants. Fourteen studies from 10 articles for fetal famine exposure, 20 studies from 7 articles for childhood famine exposure, and 5 studies from 3 articles for adolescence/adult famine exposure were included in this meta-analysis. Compared with a nonexposed group, famine exposure significantly increased the risk of MetS for early life famine exposure (OR=1.27, 95% CI: 1.18-1.38), fetal famine exposure (OR=1.27, 95% CI: 1.14-1.43), and childhood famine exposure (OR=1.29, 95% CI: 1.16-1.44). Subgroup analyses showed that the result was consistent regardless of the study designs, definitions of MetS, and causes of famine, with or without adjustment for age, smoking, drinking, and physical activity. Conclusions. This meta-analysis suggests that exposure to famine during early life may increase the risk of MetS in adulthood.

scholarly journals Exposure to Chinese famine in early life and the risk of sensory impairment in adulthood

2020 ◽  
pp. jech-2020-213775
Author(s):  
Hongguo Rong ◽  
Xiaozhen Lai ◽  
Elham Mahmoudi ◽  
Hai Fang
Keyword(s):  
Early Life ◽  
Late Childhood ◽  
Sensory Impairment ◽  
Fetal Period ◽  
Unexposed Group ◽  
Multi Stage ◽  
Sensory Impairments ◽  
Negative Effect ◽  
Famine Exposure ◽  
The Relationship

BackgroundStudies have shown that malnutrition in early life has a negative effect on midlife cognitive functions. Little is known, however, about the relationship between early-life malnutrition and visual, hearing or dual sensory impairments in adulthood. This study aims to investigate the association between exposure to the 1959–1961 Chinese famine in early life and sensory impairments in adulthood.MethodsA total of 6347 adults born between 1952 and 1964 surveyed in the 2015 China Health and Retirement Longitudinal Study were included in this study. The presence of sensory impairments was identified by self-reported assessment of visual and hearing functions. The associations between multi-stage early-life famine exposure and sensory functions were estimated using the multiple generalised linear model.ResultsCompared with the unexposed group, respondents exposed to famine in the fetal period and late childhood had a significantly higher risk of hearing impairment (OR 1.54, 95% CI 1.06 to 2.24; OR 1.75, 95% CI 1.23 to 2.50) and dual sensory impairments (OR 1.45, 95% CI 1.00 to 2.11; OR 1.55, 95% CI 1.09 to 2.21), respectively. Furthermore, in severely famine-affected areas, the early, mid and late childhood-exposed groups were more likely to have hearing and dual sensory impairments than the unexposed group. Those associations were not observed in less famine-affected areas. However, no significant association was found between famine exposure and visual impairment in early-life famine-exposed group.ConclusionExposure to Chinese famine in the fetal period and late childhood was linked to hearing and dual sensory impairments in adulthood.

scholarly journals Early life cognitive function and health behaviours in late childhood: testing the neuroselection hypothesis

2017 ◽  
Vol 72 (1) ◽  
pp. 41-46 ◽  
Author(s):  
Daniel Aggio ◽  
Lee Smith ◽  
Mark Hamer
Keyword(s):  
Early Childhood ◽  
Cognitive Function ◽  
Alcohol Consumption ◽  
Early Life ◽  
Verbal Ability ◽  
Health Behaviours ◽  
Late Childhood ◽  
Computer Gaming ◽  
Sedentary Behaviours ◽  
Selection Of

BackgroundHigher cognitive function in childhood is associated with healthier behaviours and a reduced risk of chronic disease in adulthood, but it is unclear whether this selection of healthier behaviours occurs in childhood or later in life. The present study investigated how cognitive function at age 3–7 years was associated with health behaviours at age 11.MethodsVerbal, non-verbal and spatial abilities were assessed using the British Ability Scales at ages 3–7. At age 11, children reported how often they engaged in sport/physical activity, sedentary behaviours (eg, reading and games console usage), cigarette smoking and alcohol consumption. Logistic regression was used to estimate odds of engaging in health behaviours at age 11 according to early life cognition.ResultsA 1 SD increase in early childhood verbal ability was associated with reduced odds of attempting smoking in boys and girls (OR 0.69 (95% CI 0.57 to 0.84)) and reduced odds of computer gaming in girls (OR 0.79 (95% CI 0.72 to 0.86)) by age 11. Early childhood verbal ability was also associated with reduced odds of regular participation in sport/active games (boys: OR 0.91 (95% CI 0.84 to 0.99); girls: OR 0.81 (95% CI 0.74 to 0.88)) and increased odds of reading for enjoyment (boys: OR 1.47 (95% CI 1.35 to 1.60); girls: OR 1.48 (95% CI 1.36 to 1.62)) at age 11. Early childhood non-verbal ability was associated with reduced odds of alcohol consumption in boys and girls (OR 0.92 (95% CI 0.85 to 0.99)) and reduced odds of online messaging in boys (OR 0.89 (95% CI 0.81 to 0.98)) at age 11. Early childhood spatial ability was associated with reduced odds of participating in sport/active games in boys at age 11 (OR 0.88 (95% CI 0.82 to 0.95).ConclusionNeuroselection may occur during early childhood resulting in some, but not all, healthier behaviours by age 11.

scholarly journals The relationship between famine exposure in early life and ascending aorta dilatation in adulthood

2020 ◽  
Author(s):  
Yu-qing HUANG ◽  
Lin LIU ◽  
Kenneth Lo ◽  
Yu-ling YU ◽  
Chao-lei CHEN ◽  
...  
Keyword(s):  
Early Life ◽  
Ascending Aorta ◽  
Exposed Group ◽  
Late Childhood ◽  
Cardiac Ultrasound ◽  
Multivariate Logistic Regression ◽  
Famine Exposure ◽  
Aorta Dilatation ◽  
Stratified Analysis ◽  
The Relationship

Abstract BackgroundThe relationship between malnutrition and ascending aorta dilatation (AAD) is still unclear. Therefore, the aim of this study was to examine the association of exposure to the Chinese famine during early life with AAD in adulthood.MethodsWe investigated data of 2598 adults born between 1952 and 1964 from Guangdong, China. All enrolled subjects were divided into five groups: no exposed, fetal exposed, early, mid and late childhood exposed. AAD was assessed by cardiac ultrasound. Multivariate logistic regression and interaction tests were used to estimate the odds ratio (OR) and confidence interval (CI) between famine exposure and AAD.ResultsThere were 2598 (943 male, mean age 59.1 ± 3.65 years) participants were enrolled, among them consist of 270 (10.4%) subjects with AAD. Compared with no exposed group, the adjusted ORs for AAD widening from fetal-exposed, early, mid to late childhood exposed were 1.374 (95% CI: 0.794, 2.364, P = 0.251), 1.976 (95% CI: 1.243, 3.181, P = 0.004), 1.929 (95% CI: 1.237, 3.058, P = 0.004) and 2.227 (95% CI: 1.433, 3.524, P < 0.001), respectively. Stratified analysis showed that the effect of famine exposure on AAD was more pronounced in female, smokers, BMI ≥ 24 kg/m2 and hypertensive patients.ConclusionsWe observed that exposure to famine during early life was an independent risk factor for AAD in adulthood; this effect was not modified by gender, BMI, smoking, hypertension and diabetes.Yu-qing HUANG and Lin LIU are equally to this paper.

scholarly journals Famine Exposure in Early Life and Risk of Metabolic Syndrome in Adulthood: Comparisons of Different Metabolic Syndrome Definitions

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Feng Ning ◽  
Jie Ren ◽  
Xin Song ◽  
Dong Zhang ◽  
Li Liu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Early Life ◽  
International Diabetes Federation ◽  
Later Life ◽  
Childhood And Adolescence ◽  
Marginal Effect ◽  
Odds Ratios ◽  
Increased Risk ◽  
Famine Exposure ◽  
Adult Exposure

This study examined the association between famine exposure in early life and the risk of metabolic syndrome (MetS) in adulthood during the 1959–1961 Chinese Famine. Two cross-sectional surveys involving randomly selected Chinese adults aged 35–74 years in the Qingdao area were conducted. A total of 9,588 individuals were grouped into four birth cohorts of unexposed (born between January 1, 1962, and December 31, 1975), fetal-exposed (born between January 1, 1959, and December 31, 1961), childhood-exposed (born between January 1, 1949, and December 31, 1958), and adolescence/adult-exposed cohorts (born between January 1, 1931, and December 31, 1948). We assessed the prevalence rate of MetS in relation to famine exposure according to three definitions of MetS by the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III), International Diabetes Federation (IDF), and China Diabetes Society (CDS). According to the CDS criterion, the prevalence rates of MetS were 17.8%, 25.7%, 31.1%, and 45.3% in the unexposed, fetal-, childhood-, and adolescence/adult-exposed cohorts, respectively (P<0.001). For the CDS criteria, compared with individuals without famine exposure, odds ratios (95% confidence interval) for MetS were 1.36 (1.02–1.81), 1.36 (1.06–1.75), and 1.60 (1.06–2.41) in women and 1.10 (0.79–1.53), 1.07 (0.79–1.42), and 1.21 (0.74–1.99) in men who were exposed in the fetal, childhood, and adolescence/adult periods, respectively, after adjustment for age, study cohorts, residential areas, education levels, income levels, current smoking, and current drinking. The same trend was observed in fetal and childhood exposure for the NCEP-ATP III and IDF definitions, except for a marginal effect in adolescence/adult exposure. Sensitivity analysis revealed that the odds ratios for MetS prevalence for the CDS definition were 1.37 (1.03–1.82), 1.40 (1.09–1.79), and 1.58 (1.04–2.40) among fetal, childhood, and adolescence/adult exposure in rural areas, respectively. The CDS definition is superior to the other definitions for determining the association between famine exposure and MetS with respect to early life. Famine exposure in early life is associated with an increased risk of MetS in later life, especially in women. Early-life malnutrition and later life overnutrition were critical in determining adulthood metabolic disorders.

Sign in / Sign up

Export Citation Format

Share Document