scholarly journals Early Life Famine Exposure, Ideal Cardiovascular Health Metrics, and Risk of Incident Diabetes: Findings From the 4C Study

Diabetes Care ◽  
2020 ◽  
Vol 43 (8) ◽  
pp. 1902-1909 ◽  
Author(s):  
Jieli Lu ◽  
Mian Li ◽  
Yu Xu ◽  
Yufang Bi ◽  
Yingfen Qin ◽  
...  
Keyword(s):  
Early Life ◽  
Cardiovascular Health ◽  
Incident Diabetes ◽  
Ideal Cardiovascular Health ◽  
Famine Exposure

Early Life Famine Exposure, Ideal Cardiovascular Health Metrics and Risk of Incident Diabetes: Findings from the 4C Study

2020 ◽  
Author(s):  
Jieli Lu ◽  
Mian Li ◽  
Yu Xu ◽  
Yufang Bi ◽  
Yingfen Qin ◽  
...  
Keyword(s):  
Cardiovascular Health ◽  
Dietary Habits ◽  
Ideal Cardiovascular Health ◽  
Adjusted Risk ◽  
Increased Risk ◽  
Famine Exposure ◽  
Design And Methods ◽  
The Impact ◽  
Risk Ratios

<b>OBJECTIVE</b> <p>We aim to investigate the impact of ideal cardiovascular heath metrics (ICVHMs) on the association between famine exposure and adulthood diabetes risk. </p> <p><b>RESEARCH DESIGN AND METHODS</b></p> <p>This study included 77 925 participants from the China Cardiometabolic Disease and Cancer Cohort (4C) Study, who were born around the time of the Chinese Great Famine and free of diabetes at baseline. They were divided into 3 famine exposure groups according to the birth year, including non-exposed (1963-1974), fetal-exposed (1959-1962) and childhood exposed (1949-1958). Relative risk regression was used to examine the associations between famine exposure and ICVHMs on diabetes.</p> <p><b>RESULTS</b></p> <p>During a mean follow-up of 3.6 years, the cumulative incidence of diabetes was 4.2%, 6.0% and 7.5% in non-exposed, fetal-exposed and childhood-exposed participants, respectively. Compared with non-exposed participants, fetal-exposed but not childhood-exposed participants had increased risks of diabetes with multivariable-adjusted risk ratios (RRs) (95% confidence intervals) (CIs) of 1.17 (1.05-1.31) and 1.12 (0.96-1.30), respectively. Increased diabetes risks were observed in fetal-exposed individuals with non-ideal dietary habits, non-ideal physical activity, BMI ≥24.0 kg/m<sup>2</sup>, or blood pressure ≥120/80 mmHg, whereas significant interaction was detected only in BMI strata (P for interaction=0.0018). Significant interactions have been detected between number of ICVHMs and famine exposure on the risk of diabetes (P for interaction=0.0005). The increased risk was observed in fetal-exposed participants with 1 or less ICVHMs (RR, 1.59; 95% CI, 1.24-2.04), but not in those with 2 or more ICVHMs. </p> <p><b>CONCLUSIONS</b></p> <p>The increased risk of diabetes associated with famine exposure appears to be modified by the presence of ICVHMs. </p>

scholarly journals Ideal Cardiovascular Health Metrics Modify the Association Between Exposure to Chinese Famine in Fetal and Cardiovascular Disease: A Prospective Cohort Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiong Ding ◽  
Jinfeng Li ◽  
Ying Wu ◽  
Peng Yang ◽  
Dandan Zhao ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Study ◽  
Prospective Cohort ◽  
Cardiovascular Health ◽  
Cox Regression ◽  
Cvd Risk ◽  
Fetal Period ◽  
Ideal Cardiovascular Health ◽  
Famine Exposure

Background: No study has explored the modification effect of ideal cardiovascular health metrics (ICVHMs) on the association between famine exposure and risk of cardiovascular disease (CVD) so far. We aim to examine the effect of ICVHMs on the association between exposure to famine early in life and the risk of CVD in adulthood.Methods: A total of 61,527 participants free of CVD were included in this study from the Kailuan Study. All participants were divided into three groups, included nonexposed, fetal-exposed, and childhood-exposed groups. Cox regression was used to estimate the effect of famine exposure and ICVHMs on CVD risk.Results: After a median of 13.0 (12.7–13.2) years follow-up, 4,814 incident CVD cases were identified. Compared with nonexposed participants, the CVD risk increased in participants with fetal famine exposure (hazard ratio [HR]: 1.21; 95% CI: 1.07–1.37), but not in childhood famine-exposed participants. After stratifying by the number of ICVHMs, the increased CVD risk associated with fetal famine exposure was only observed in participants with less ICVHMs ( ≤ 2) (HR: 1.30; 95% CI: 1.11–1.52, P for interaction=0.008), but disappeared in those with three or more ICVHMs. The modified effect of ICVHMs was sex specific (P for sex interaction = 0.031).Conclusions: Exposing to famine in the fetal period could increase the risk of CVD in late life; however, ICVHMs might modify the effect of famine exposure on CVD risk, especially in men.

scholarly journals Early Life Famine Exposure, Ideal Cardiovascular Health Metrics and Risk of Incident Diabetes: Findings from the 4C Study

2020 ◽  
Author(s):  
Jieli Lu ◽  
Mian Li ◽  
Yu Xu ◽  
Yufang Bi ◽  
Yingfen Qin ◽  
...  
Keyword(s):  
Cardiovascular Health ◽  
Dietary Habits ◽  
Ideal Cardiovascular Health ◽  
Adjusted Risk ◽  
Increased Risk ◽  
Famine Exposure ◽  
Design And Methods ◽  
The Impact ◽  
Risk Ratios

<b>OBJECTIVE</b> <p>We aim to investigate the impact of ideal cardiovascular heath metrics (ICVHMs) on the association between famine exposure and adulthood diabetes risk. </p> <p><b>RESEARCH DESIGN AND METHODS</b></p> <p>This study included 77 925 participants from the China Cardiometabolic Disease and Cancer Cohort (4C) Study, who were born around the time of the Chinese Great Famine and free of diabetes at baseline. They were divided into 3 famine exposure groups according to the birth year, including non-exposed (1963-1974), fetal-exposed (1959-1962) and childhood exposed (1949-1958). Relative risk regression was used to examine the associations between famine exposure and ICVHMs on diabetes.</p> <p><b>RESULTS</b></p> <p>During a mean follow-up of 3.6 years, the cumulative incidence of diabetes was 4.2%, 6.0% and 7.5% in non-exposed, fetal-exposed and childhood-exposed participants, respectively. Compared with non-exposed participants, fetal-exposed but not childhood-exposed participants had increased risks of diabetes with multivariable-adjusted risk ratios (RRs) (95% confidence intervals) (CIs) of 1.17 (1.05-1.31) and 1.12 (0.96-1.30), respectively. Increased diabetes risks were observed in fetal-exposed individuals with non-ideal dietary habits, non-ideal physical activity, BMI ≥24.0 kg/m<sup>2</sup>, or blood pressure ≥120/80 mmHg, whereas significant interaction was detected only in BMI strata (P for interaction=0.0018). Significant interactions have been detected between number of ICVHMs and famine exposure on the risk of diabetes (P for interaction=0.0005). The increased risk was observed in fetal-exposed participants with 1 or less ICVHMs (RR, 1.59; 95% CI, 1.24-2.04), but not in those with 2 or more ICVHMs. </p> <p><b>CONCLUSIONS</b></p> <p>The increased risk of diabetes associated with famine exposure appears to be modified by the presence of ICVHMs. </p>

220-LB: Early-Life Famine Exposure and Hyperuricemia in Adulthood

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 220-LB
Author(s):  
YUYING WANG ◽  
WEN ZHANG ◽  
HENG WAN ◽  
CHI CHEN ◽  
YI CHEN ◽  
...  
Keyword(s):  
Early Life ◽  
Famine Exposure

scholarly journals Cardiovascular Health, Functional Disability, and Leisure Activities Profiles in Relation to Mental Aging

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 663-663
Author(s):  
Dorina Cadar ◽  
Celine De Looze ◽  
Christine McGarrigle
Keyword(s):  
Longitudinal Study ◽  
Cognitive Aging ◽  
Representative Sample ◽  
Cardiovascular Health ◽  
Functional Disability ◽  
Physiological Stress ◽  
Leisure Activities ◽  
Functional Decline ◽  
Functional Impairments ◽  
Ideal Cardiovascular Health

Abstract We investigated cardiovascular health, functional disability and leisure activities profiles independently and in relation to cognitive decline and dementia in high and low-medium income countries using data from the English Longitudinal Study of Ageing, Irish Longitudinal Study on Ageing and Brazilian Bambui Cohort Study of Aging. Functional loss among older Brazilians has shown a hierarchical sequence over the 15-year follow-up, with the highest incidence in functional disability reported for dressing, followed by getting out of bed, bathing/showering, walking across a room, using the toilet and eating (de Oliveira). Using the Life’s Simple 7, an ideal cardiovascular health scoring system evaluating the muscular strength, mobility and physiological stress, we showed a reliable prediction of cognitive trajectories in a representative sample of Irish individuals (De Looze). Within the same cohort, we report discrepancies between men and women in functional decline driven by domestic tasks, rather than determining differential cognitive trajectories (McGarrigle). In an English representative sample, we found that participants with an increasing number of functional impairments over almost a decade were more likely to be classified with subsequent dementia compared with those with no impairments and this may imply a more comprehensive ascertainment during the prodromal stage of dementia (Cadar). In contrast, a reduced risk of dementia was found for individuals with higher levels of engagement in cognitively stimulating activities, that may preserve cognitive reserve until later in life (Almeida). Identifying factors that influence cognitive aging and dementia risk in a multifactorial perspective is critical toward developing adequate intervention and treatment.

scholarly journals Ideal Cardiovascular Health in Racially and Ethnically Diverse People with Serious Mental Illness

2020 ◽  
Vol 31 (4) ◽  
pp. 1669-1692
Author(s):  
Mark R. Hawes ◽  
Kimberly B. Roth ◽  
Xiaoyan Wang ◽  
Ana Stefancic ◽  
Christopher Weatherly ◽  
...  
Keyword(s):  
Mental Illness ◽  
Serious Mental Illness ◽  
Cardiovascular Health ◽  
Ethnically Diverse ◽  
Ideal Cardiovascular Health

scholarly journals Data from Digital Health Devices Informs Ideal Cardiovascular Health

2021 ◽  
Vol 11 (3) ◽  
pp. 189
Author(s):  
Jane A. Leopold ◽  
Roger B. Davis ◽  
Elliott M. Antman
Keyword(s):  
Cardiovascular Health ◽  
Digital Health ◽  
Vigorous Exercise ◽  
Activity Data ◽  
Health Score ◽  
Ideal Cardiovascular Health ◽  
Digital Devices ◽  
Significant Difference ◽  
Life’S Simple 7 ◽  
Life's Simple 7

Ideal cardiovascular health is associated with a decrease in adverse cardiovascular events. The My Research Legacy study examined ideal cardiovascular health using the Life’s Simple 7 survey and data from digital health devices. We hypothesized that digital devices provide a more objective view of overall cardiovascular health status than self-reported measures. Therefore, we analyzed weight and activity data recorded by digital devices to recalculate the Life’s Simple 7 Health Score. All study participants (n = 1561) answered the survey, while a subgroup (n = 390) provided data from digital devices. Individuals with digital devices had a lower body mass index (BMI) and higher weekly minutes of vigorous exercise than participants without digital devices (p < 0.01). Baseline Health Scores were higher in individuals with digital devices compared to those without (7.0 ± 1.6 vs. 6.6 ± 1.6, p < 0.01). Data from digital devices reveal both increases and decreases in measured vs. self-reported BMI (p < 0.04) and weekly minutes of moderate and vigorous exercise activity (p < 0.01). Using these data, a significant difference was found between the recalculated and the self-reported Life’s Simple 7 Health Score (p < 0.05). These findings suggest that incorporation of digital health devices should be considered as part of a precision medicinal approach to assessing ideal cardiovascular health.

Ideal cardiovascular health is associated with self-rated health status. The Polish Norwegian Study (PONS)

2017 ◽  
Vol 230 ◽  
pp. 549-555 ◽  
Author(s):  
Marta Manczuk ◽  
Georgeta Vaidean ◽  
Mahshid Dehghan ◽  
Rajesh Vedanthan ◽  
Paolo Boffetta ◽  
...  
Keyword(s):  
Health Status ◽  
Cardiovascular Health ◽  
Ideal Cardiovascular Health ◽  
Self Rated Health

scholarly journals Prevalence and determinants of ideal cardiovascular health in a latin women cohort: a cross-sectional study

2021 ◽  
Vol 4 ◽  
pp. 100071
Author(s):  
Mónica Acevedo ◽  
Paola Varleta ◽  
Carolina Casas-Cordero ◽  
Amalia Berríos ◽  
Carlos Navarrete ◽  
...  
Keyword(s):  
Cardiovascular Health ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ideal Cardiovascular Health
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