scholarly journals Dynamic Changes in Pancreatic Endocrine Cell Abundance, Distribution, and Function in Antigen-Induced and Spontaneous Autoimmune Diabetes

Diabetes ◽  
2009 ◽  
Vol 58 (5) ◽  
pp. 1175-1184 ◽  
Author(s):  
K. Pechhold ◽  
X. Zhu ◽  
V. S. Harrison ◽  
J. Lee ◽  
S. Chakrabarty ◽  
...  
Keyword(s):  
Endocrine Cell ◽  
Autoimmune Diabetes ◽  
Abundance Distribution ◽  
Dynamic Changes ◽  
Cell Abundance ◽  
Pancreatic Endocrine Cell ◽  
And Function

The Emerging Role of SOX Transcription Factors in Pancreatic Endocrine Cell Development and Function

2009 ◽  
Vol 18 (10) ◽  
pp. 1379-1388 ◽  
Author(s):  
Erin McDonald ◽  
Mansa Krishnamurthy ◽  
Cynthia G. Goodyer ◽  
Rennian Wang
Keyword(s):  
Transcription Factors ◽  
Endocrine Cell ◽  
Cell Development ◽  
Pancreatic Endocrine Cell ◽  
And Function

scholarly journals Characterization of the dynamic changes in left ventricular morphology and function induced by exercise training and detraining

2019 ◽  
Vol 277 ◽  
pp. 178-185 ◽  
Author(s):  
Attila Oláh ◽  
Attila Kovács ◽  
Árpád Lux ◽  
Márton Tokodi ◽  
Szilveszter Braun ◽  
...  
Keyword(s):  
Exercise Training ◽  
Left Ventricular ◽  
Dynamic Changes ◽  
And Function ◽  
Left Ventricular Morphology ◽  
Training And Detraining

scholarly journals Analysis of polysomal mRNA populations of mouse oocytes and zygotes: Dynamic changes in maternal mRNA utilization and function

2006 ◽  
Vol 298 (1) ◽  
pp. 155-166 ◽  
Author(s):  
Santhi Potireddy ◽  
Rita Vassena ◽  
Bela G. Patel ◽  
Keith E. Latham
Keyword(s):  
Dynamic Changes ◽  
Mouse Oocytes ◽  
Maternal Mrna ◽  
Polysomal Mrna ◽  
And Function

scholarly journals Dynamics of chromatin marks and the role of JMJD3 during pancreatic endocrine cell fate commitment

Development ◽  
2018 ◽  
Vol 145 (6) ◽  
pp. dev163162 ◽  
Author(s):  
Xin-Xin Yu ◽  
Wei-Lin Qiu ◽  
Liu Yang ◽  
Lin-Chen Li ◽  
Yu-Wei Zhang ◽  
...  
Keyword(s):  
Cell Fate ◽  
Endocrine Cell ◽  
Pancreatic Endocrine Cell

scholarly journals Lack of Sprouty 1 and 2 enhances survival of effector CD8+ T cells and yields more protective memory cells

2018 ◽  
Vol 115 (38) ◽  
pp. E8939-E8947 ◽  
Author(s):  
Hesham M. Shehata ◽  
Shahzada Khan ◽  
Elise Chen ◽  
Patrick E. Fields ◽  
Richard A. Flavell ◽  
...  
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
Therapeutic Potential ◽  
Autoimmune Diabetes ◽  
Memory Cells ◽  
Double Knockout ◽  
And Function ◽  
I Cells ◽  
Better Than

Identifying novel pathways that promote robust function and longevity of cytotoxic T cells has promising potential for immunotherapeutic strategies to combat cancer and chronic infections. We show that sprouty 1 and 2 (Spry1/2) molecules regulate the survival and function of memory CD8+ T cells. Spry1/2 double-knockout (DKO) ovalbumin (OVA)-specific CD8+ T cells (OT-I cells) mounted more vigorous autoimmune diabetes than WT OT-I cells when transferred to mice expressing OVA in their pancreatic β-islets. To determine the consequence of Spry1/2 deletion on effector and memory CD8+ T cell development and function, we used systemic infection with lymphocytic choriomeningitis virus (LCMV) Armstrong. Spry1/2 DKO LCMV gp33-specific P14 CD8+ T cells survive contraction better than WT cells and generate significantly more polyfunctional memory T cells. The larger number of Spry1/2 DKO memory T cells displayed enhanced infiltration into infected tissue, demonstrating that absence of Spry1/2 can result in increased recall capacity. Upon adoptive transfer into naive hosts, Spry1/2 DKO memory T cells controlled Listeria monocytogenes infection better than WT cells. The enhanced formation of more functional Spry1/2 DKO memory T cells was associated with significantly reduced mTORC1 activity and glucose uptake. Reduced p-AKT, p-FoxO1/3a, and T-bet expression was also consistent with enhanced survival and memory accrual. Collectively, loss of Spry1/2 enhances the survival of effector CD8+ T cells and results in the formation of more protective memory cells. Deleting Spry1/2 in antigen-specific CD8+ T cells may have therapeutic potential for enhancing the survival and functionality of effector and memory CD8+ T cells in vivo.

Frequency and function of circulating invariant NKT cells in autoimmune diabetes mellitus and thyroid diseases in Colombian patients

2009 ◽  
Vol 70 (4) ◽  
pp. 262-268 ◽  
Author(s):  
Alejandro Roman-Gonzalez ◽  
Maria Eugenia Moreno ◽  
Juan Manuel Alfaro ◽  
Federico Uribe ◽  
Guillermo Latorre-Sierra ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Autoimmune Diabetes ◽  
Nkt Cells ◽  
Thyroid Diseases ◽  
Invariant Nkt Cells ◽  
And Function ◽  
Autoimmune Diabetes Mellitus

scholarly journals Specifying pancreatic endocrine cell fates

2006 ◽  
Vol 123 (7) ◽  
pp. 501-512 ◽  
Author(s):  
Patrick Collombat ◽  
Jacob Hecksher-Sørensen ◽  
Palle Serup ◽  
Ahmed Mansouri
Keyword(s):  
Endocrine Cell ◽  
Cell Fates ◽  
Pancreatic Endocrine Cell
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