The Emerging Role of SOX Transcription Factors in Pancreatic Endocrine Cell Development and Function

2009 ◽  
Vol 18 (10) ◽  
pp. 1379-1388 ◽  
Author(s):  
Erin McDonald ◽  
Mansa Krishnamurthy ◽  
Cynthia G. Goodyer ◽  
Rennian Wang
Keyword(s):  
Transcription Factors ◽  
Endocrine Cell ◽  
Cell Development ◽  
Pancreatic Endocrine Cell ◽  
And Function

The role of Tec family kinases in T cell development and function

2003 ◽  
Vol 191 (1) ◽  
pp. 119-138 ◽  
Author(s):  
Julie A. Lucas ◽  
Andrew T. Miller ◽  
Luana O. Atherly ◽  
Leslie J. Berg
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function

scholarly journals Non-Coding RNA in Pancreas and β-Cell Development

2018 ◽  
Vol 4 (4) ◽  
pp. 41 ◽  
Author(s):  
Wilson K. M. Wong ◽  
Anja E. Sørensen ◽  
Mugdha V. Joglekar ◽  
Anand A. Hardikar ◽  
Louise T. Dalgaard
Keyword(s):  
Cell Function ◽  
Islet Cells ◽  
Current Knowledge ◽  
Cell Development ◽  
Pancreas Development ◽  
Β Cell ◽  
Neighboring Gene ◽  
Non Coding Rnas ◽  
And Function

In this review, we provide an overview of the current knowledge on the role of different classes of non-coding RNAs for islet and β-cell development, maturation and function. MicroRNAs (miRNAs), a prominent class of small RNAs, have been investigated for more than two decades and patterns of the roles of different miRNAs in pancreatic fetal development, islet and β-cell maturation and function are now emerging. Specific miRNAs are dynamically regulated throughout the period of pancreas development, during islet and β-cell differentiation as well as in the perinatal period, where a burst of β-cell replication takes place. The role of long non-coding RNAs (lncRNA) in islet and β-cells is less investigated than for miRNAs, but knowledge is increasing rapidly. The advent of ultra-deep RNA sequencing has enabled the identification of highly islet- or β-cell-selective lncRNA transcripts expressed at low levels. Their roles in islet cells are currently only characterized for a few of these lncRNAs, and these are often associated with β-cell super-enhancers and regulate neighboring gene activity. Moreover, ncRNAs present in imprinted regions are involved in pancreas development and β-cell function. Altogether, these observations support significant and important actions of ncRNAs in β-cell development and function.

scholarly journals Dynamics of chromatin marks and the role of JMJD3 during pancreatic endocrine cell fate commitment

Development ◽  
2018 ◽  
Vol 145 (6) ◽  
pp. dev163162 ◽  
Author(s):  
Xin-Xin Yu ◽  
Wei-Lin Qiu ◽  
Liu Yang ◽  
Lin-Chen Li ◽  
Yu-Wei Zhang ◽  
...  
Keyword(s):  
Cell Fate ◽  
Endocrine Cell ◽  
Pancreatic Endocrine Cell

Role of Shc in T-cell development and function

2003 ◽  
Vol 191 (1) ◽  
pp. 183-195 ◽  
Author(s):  
Li Zhang ◽  
Ulrike Lorenz ◽  
Kodi S. Ravichandran
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function

scholarly journals Foxo Transcription Factors Control Regulatory T Cell Development and Function

Immunity ◽  
2011 ◽  
Vol 34 (1) ◽  
pp. 135
Author(s):  
Yann M. Kerdiles ◽  
Erica L. Stone ◽  
Daniel R. Beisner ◽  
Maureen A. McGargill ◽  
Irene L. Ch'en ◽  
...  
Keyword(s):  
Transcription Factors ◽  
T Cell ◽  
Regulatory T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Foxo Transcription Factors ◽  
And Function

Regulation of White Cell Development.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. SCI-9-SCI-9
Author(s):  
Peter E. Newburger ◽  
Sherman M. Weissman
Keyword(s):  
Transcription Factors ◽  
Base Pair ◽  
Conflicts Of Interest ◽  
Cell Development ◽  
White Cell ◽  
Hoxa Cluster ◽  
Interacting Protein ◽  
Myeloid Development ◽  
Eosinophil Granule ◽  
And Function

Abstract Abstract SCI-9 During hematopoiesis, determination of lineage and maturation to functional leukocytes depend upon cytokine-mediated changes in the transcriptional programs of progenitor and precursor cells. The classic binary branching tree of hematopoiesis now appears to be a more subtle series of gradual changes in differentiation probabilities, with competitive promotion and inhibition of lineage pathways by regulatory transcription factors such as (among others) PU.1, C/EBPα, GFI-1, EGR1/2, and NAB2 for the myeloid lineages and RUNX1, Notch-1, E2A, GATA-3, EBF, and PAX5 for lymphoid cell development. In addition, the recent discovery of regulatory non-coding RNAs (ncRNAs) has revealed another, important layer of control of hematopoiesis. The best studied members of this diverse group are the microRNAs, which often down-regulate multiple target transcripts. miRNAs involved in the regulation of myeloid development and function include miR-155, miR-223, and miR-17-19 cluster members. In addition, miR-9, miR-146a, miR-155, and miR-181a regulate the responses of immunocytes of the innate and acquired immune systems. Most recently, increasing numbers of long ncRNAs have been identified and found to regulate expression of other genes, both in cis and in trans. EGO (eosinophil granule ontogeny), a 500 base pair spliced, polyadenylated transcript regulates eosinophil granule protein gene expression. HOTAIRM1 (Hox antisense intergenic RNA, myeloid-1), a ∼500 base pair spliced polyadenylated ncRNA, affects neutrophil expression of both contiguous and distant HoxA cluster genes, as well as transcripts for CD18 integrin. Thus the control of white cell development depends not simply on a small number of key transcription factors, but rather on a complex network of interacting protein and ncRNA regulators of the transcriptional and translational programs of cell differentiation and function. Disclosures No relevant conflicts of interest to declare.

Role of Itk in γδ T cell development and function

2008 ◽  
Vol 22 (S2) ◽  
pp. 410-410
Author(s):  
Catherine Chih‐tzu Yin ◽  
Martin Felices ◽  
Yoko Kosaka ◽  
Joonsoo Kang
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Γδ T Cell ◽  
And Function
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