scholarly journals A Genome-Wide Linkage Scan for Diabetic Retinopathy Susceptibility Genes in Mexican Americans With Type 2 Diabetes From Starr County, Texas

Diabetes ◽  
2007 ◽  
Vol 56 (4) ◽  
pp. 1167-1173 ◽  
Author(s):  
D. M. Hallman ◽  
E. Boerwinkle ◽  
V. H. Gonzalez ◽  
B. E. K. Klein ◽  
R. Klein ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Mexican Americans ◽  
Susceptibility Genes ◽  
Genome Wide ◽  
A Genome ◽  
Starr County

A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in an Extended Arab Family

2013 ◽  
Vol 77 (6) ◽  
pp. 488-503 ◽  
Author(s):  
Habiba S. Al Safar ◽  
Heather J. Cordell ◽  
Osman Jafer ◽  
Denise Anderson ◽  
Sarra E. Jamieson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Susceptibility Genes ◽  
Diabetes Susceptibility ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Search

scholarly journals A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in West Africans: The Africa America Diabetes Mellitus (AADM) Study

Diabetes ◽  
2004 ◽  
Vol 53 (3) ◽  
pp. 838-841 ◽  
Author(s):  
C. N. Rotimi ◽  
G. Chen ◽  
A. A. Adeyemo ◽  
P. Furbert-Harris ◽  
D. Guass ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Susceptibility Genes ◽  
Diabetes Susceptibility ◽  
Genome Wide ◽  
A Genome ◽  
West Africans ◽  
Genome Wide Search

A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians

Diabetes ◽  
1999 ◽  
Vol 48 (5) ◽  
pp. 1175-1182 ◽  
Author(s):  
S. C. Elbein ◽  
M. D. Hoffman ◽  
K. Teng ◽  
M. F. Leppert ◽  
S. J. Hasstedt
Keyword(s):  
Type 2 Diabetes ◽  
Susceptibility Genes ◽  
Diabetes Susceptibility ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Search

Genome-Wide Association Studies Identify Two Novel Loci Conferring Susceptibility to Diabetic Retinopathy in Japanese Patients with Type 2 Diabetes

2021 ◽  
Author(s):  
Minako Imamura ◽  
Atsushi Takahashi ◽  
Masatoshi Matsunami ◽  
Momoko Horikoshi ◽  
Minoru Iwata ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Association Studies ◽  
Meta Analysis ◽  
Japanese Patients ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Stage 1

Abstract Several reports have suggested that genetic susceptibility contributes to the development and progression of diabetic retinopathy. We aimed to identify genetic loci that confer susceptibility to diabetic retinopathy in Japanese patients with type 2 diabetes. We analysed 5 790 508 single nucleotide polymorphisms (SNPs) in 8880 Japanese patients with type 2 diabetes, 4839 retinopathy cases and 4041 controls, as well as 2217 independent Japanese patients with type 2 diabetes, 693 retinopathy cases, and 1524 controls. The results of these two genome-wide association studies (GWAS) were combined with an inverse variance meta-analysis (Stage-1), followed by de novo genotyping for the candidate SNP loci (p < 1.0 × 10−4) in an independent case–control study (Stage-2, 2260 cases and 723 controls). After combining the association data (Stage-1 and -2) using meta-analysis, the associations of two loci reached a genome-wide significance level: rs12630354 near STT3B on chromosome 3, p = 1.62 × 10−9, odds ratio (OR) = 1.17, 95% confidence interval (CI) 1.11–1.23, and rs140508424 within PALM2 on chromosome 9, p = 4.19 × 10−8, OR = 1.61, 95% CI 1.36–1.91. However, the association of these two loci were not replicated in Korean, European, or African American populations. Gene-based analysis using Stage-1 GWAS data identified a gene-level association of EHD3 with susceptibility to diabetic retinopathy (p = 2.17 × 10−6). In conclusion, we identified two novel SNP loci, STT3B and PALM2, and a novel gene, EHD3, that confers susceptibility to diabetic retinopathy; however, further replication studies are required to validate these associations.

A genome wide quantitative trait linkage analysis for serum lipids in type 2 diabetes in an African population

2005 ◽  
Vol 181 (2) ◽  
pp. 389-397 ◽  
Author(s):  
Adebowale A. Adeyemo ◽  
Thomas Johnson ◽  
Joseph Acheampong ◽  
Johnnie Oli ◽  
Godfrey Okafor ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Linkage Analysis ◽  
Quantitative Trait ◽  
Serum Lipids ◽  
African Population ◽  
Quantitative Trait Linkage Analysis ◽  
Genome Wide ◽  
A Genome ◽  
Quantitative Trait Linkage

scholarly journals A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

Science ◽  
2007 ◽  
Vol 316 (5829) ◽  
pp. 1341-1345 ◽  
Author(s):  
L. J. Scott ◽  
K. L. Mohlke ◽  
L. L. Bonnycastle ◽  
C. J. Willer ◽  
Y. Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Mapping of Diabetes Susceptibility Loci in a Domestic Cat Breed with an Unusually High Incidence of Diabetes Mellitus

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1369 ◽  
Author(s):  
Lois Balmer ◽  
Caroline Ann O’Leary ◽  
Marilyn Menotti-Raymond ◽  
Victor David ◽  
Stephen O’Brien ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Candidate Genes ◽  
The United States ◽  
Domestic Cat ◽  
Nucleotide Polymorphisms ◽  
Breeding Programs ◽  
Preventative Health ◽  
Genome Wide ◽  
A Genome

Genetic variants that are associated with susceptibility to type 2 diabetes (T2D) are important for identification of individuals at risk and can provide insights into the molecular basis of disease. Analysis of T2D in domestic animals provides both the opportunity to improve veterinary management and breeding programs as well as to identify novel T2D risk genes. Australian-bred Burmese (ABB) cats have a 4-fold increased incidence of type 2 diabetes (T2D) compared to Burmese cats bred in the United States. This is likely attributable to a genetic founder effect. We investigated this by performing a genome-wide association scan on ABB cats. Four SNPs were associated with the ABB T2D phenotype with p values <0.005. All exons and splice junctions of candidate genes near significant single-nucleotide polymorphisms (SNPs) were sequenced, including the genes DGKG, IFG2BP2, SLC8A1, E2F6, ETV5, TRA2B and LIPH. Six candidate polymorphisms were followed up in a larger cohort of ABB cats with or without T2D and also in Burmese cats bred in America, which exhibit low T2D incidence. The original SNPs were confirmed in this cohort as associated with the T2D phenotype, although no novel coding SNPs in any of the seven candidate genes showed association with T2D. The identification of genetic markers associated with T2D susceptibility in ABB cats will enable preventative health strategies and guide breeding programs to reduce the prevalence of T2D in these cats.

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