A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in an Extended Arab Family

2013 ◽  
Vol 77 (6) ◽  
pp. 488-503 ◽  
Author(s):  
Habiba S. Al Safar ◽  
Heather J. Cordell ◽  
Osman Jafer ◽  
Denise Anderson ◽  
Sarra E. Jamieson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Susceptibility Genes ◽  
Diabetes Susceptibility ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Search

scholarly journals A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in West Africans: The Africa America Diabetes Mellitus (AADM) Study

Diabetes ◽  
2004 ◽  
Vol 53 (3) ◽  
pp. 838-841 ◽  
Author(s):  
C. N. Rotimi ◽  
G. Chen ◽  
A. A. Adeyemo ◽  
P. Furbert-Harris ◽  
D. Guass ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Susceptibility Genes ◽  
Diabetes Susceptibility ◽  
Genome Wide ◽  
A Genome ◽  
West Africans ◽  
Genome Wide Search

A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians

Diabetes ◽  
1999 ◽  
Vol 48 (5) ◽  
pp. 1175-1182 ◽  
Author(s):  
S. C. Elbein ◽  
M. D. Hoffman ◽  
K. Teng ◽  
M. F. Leppert ◽  
S. J. Hasstedt
Keyword(s):  
Type 2 Diabetes ◽  
Susceptibility Genes ◽  
Diabetes Susceptibility ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Search

scholarly journals A Genome-Wide Linkage Scan for Diabetic Retinopathy Susceptibility Genes in Mexican Americans With Type 2 Diabetes From Starr County, Texas

Diabetes ◽  
2007 ◽  
Vol 56 (4) ◽  
pp. 1167-1173 ◽  
Author(s):  
D. M. Hallman ◽  
E. Boerwinkle ◽  
V. H. Gonzalez ◽  
B. E. K. Klein ◽  
R. Klein ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Mexican Americans ◽  
Susceptibility Genes ◽  
Genome Wide ◽  
A Genome ◽  
Starr County

A genome-wide search for human type 1 diabetes susceptibility genes

Nature ◽  
1994 ◽  
Vol 371 (6493) ◽  
pp. 130-136 ◽  
Author(s):  
June L. Davies ◽  
Yoshihiko Kawaguchi ◽  
Simon T. Bennett ◽  
James B. Copeman ◽  
Heather J. Cordell ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Susceptibility Genes ◽  
Diabetes Susceptibility ◽  
Human Type ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Search ◽  
Human Type 1 Diabetes

A Genome-Wide Search for Genes Involved in Type 2 Diabetes in a Recently Genetically Isolated Population From the Netherlands

Diabetes ◽  
2003 ◽  
Vol 52 (12) ◽  
pp. 3001-3004 ◽  
Author(s):  
Y. S. Aulchenko ◽  
N. Vaessen ◽  
P. Heutink ◽  
J. Pullen ◽  
P. J.L.M. Snijders ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
The Netherlands ◽  
Isolated Population ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Search

scholarly journals Replication of Genome-Wide Association Studies of Type 2 Diabetes Susceptibility in Japan

2008 ◽  
Vol 93 (8) ◽  
pp. 3136-3141 ◽  
Author(s):  
Yukio Horikawa ◽  
Kazuaki Miyake ◽  
Kazuki Yasuda ◽  
Mayumi Enya ◽  
Yushi Hirota ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Studies ◽  
Susceptibility Genes ◽  
Large Sample Size ◽  
Genome Wide Association Studies ◽  
Nucleotide Polymorphisms ◽  
Diabetes Susceptibility ◽  
Genome Wide ◽  
Candidate Loci

Abstract Background: In Europeans and populations of European origin, several groups have recently identified novel type 2 diabetes susceptibility genes, including FTO, SLC30A8, HHEX, CDKAL1, CDKN2B, and IGF2BP2, none of which were in the list of functional candidates. Objective and Design: The aim of this study was to replicate in a Japanese population previously identified associations of single nucleotide polymorphisms (SNPs) within 10 candidate loci with type 2 diabetes using a relatively large sample size: 1921 subjects with type 2 diabetes and 1622 normal controls. Results: A total of 15 SNPs were genotyped. Eight SNPs in five loci were found to be associated with type 2 diabetes: rs3802177 [odds ratio (OR) = 1.16 (95% confidence interval (CI) 1.05–1.27); P = 4.5 × 10−3] in SLC30A8; rs1111875 [OR = 1.27 (95% CI 1.14–1.40); P = 1.4 × 10−5] and rs7923837 [OR = 1.27 (95% CI 1.13–1.43); P = 1.0 × 10−4] in HHEX; rs10811661 [OR = 1.27 (95% CI 1.15–1.40); P = 1.9 × 10−6] in CDKN2B; rs4402960 [OR = 1.23 (95% CI 1.11–1.36); P = 8.1 × 10−5] and rs1470579 [OR = 1.18 (95% CI 1.07–1.31); P = 8.3 × 10−4] in IGF2BP2; and rs7754840 [OR = 1.28 (95% CI 1.17–1.41); P = 4.5 × 10−7] and rs7756992 [OR = 1.27 (95% CI 1.15–1.40); P = 9.8 × 10−7] in CDKAL1. The first and second strongest associations were found at variants in CDKAL1 and CDKN2B, both of which are involved in the regenerative capacity of pancreatic β-cells. Conclusion: Some of these variants represent common type 2 diabetes-susceptibility genes in both Japanese and Europeans.

A Genome-Wide Search for Linkage to Renal Function Phenotypes in West Africans With Type 2 Diabetes

2007 ◽  
Vol 49 (3) ◽  
pp. 394-400 ◽  
Author(s):  
Guanjie Chen ◽  
Adebowale A. Adeyemo ◽  
Jie Zhou ◽  
Yuanxiu Chen ◽  
Ayo Doumatey ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Genome Wide ◽  
A Genome ◽  
West Africans ◽  
Genome Wide Search
Sign in / Sign up

Export Citation Format

Share Document