scholarly journals A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4 ) gene with severe diabetic retinopathy in type 2 diabetes

2018 ◽  
Vol 96 (7) ◽  
pp. e811-e819 ◽  
Author(s):  
Weihua Meng ◽  
Kaanan P. Shah ◽  
Samuela Pollack ◽  
Iiro Toppila ◽  
Harry L. Hebert ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Nadph Oxidase ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Nadph Oxidase 4 ◽  
Genome Wide ◽  
A Genome ◽  
New Evidence

scholarly journals A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

Science ◽  
2007 ◽  
Vol 316 (5829) ◽  
pp. 1341-1345 ◽  
Author(s):  
L. J. Scott ◽  
K. L. Mohlke ◽  
L. L. Bonnycastle ◽  
C. J. Willer ◽  
Y. Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (7) ◽  
pp. 1414-1427 ◽  
Author(s):  
Natalie R. van Zuydam ◽  
Emma Ahlqvist ◽  
Niina Sandholm ◽  
Harshal Deshmukh ◽  
N. William Rayner ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Disease ◽  
Association Study ◽  
Diabetic Kidney Disease ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Diabetic Kidney ◽  
Genome Wide ◽  
A Genome

scholarly journals A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e22353 ◽  
Author(s):  
Bin Cui ◽  
Xiaolin Zhu ◽  
Min Xu ◽  
Ting Guo ◽  
Dalong Zhu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Han Chinese ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals A Genome-Wide Association Study IdentifiesGRK5andRASGRP1as Type 2 Diabetes Loci in Chinese Hans

Diabetes ◽  
2012 ◽  
Vol 62 (1) ◽  
pp. 291-298 ◽  
Author(s):  
Huaixing Li ◽  
Wei Gan ◽  
Ling Lu ◽  
Xiao Dong ◽  
Xueyao Han ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-Wide Association Study of lipid traits in youth with type 2 diabetes

2021 ◽  
Author(s):  
Nicola Santoro ◽  
Ling Chen ◽  
Jennifer Todd ◽  
Jasmin Divers ◽  
Amy S Shah ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Risk Allele ◽  
Density Lipoprotein ◽  
Genome Wide Association ◽  
Relationship Matrix ◽  
Genome Wide ◽  
A Genome

Abstract Context Dyslipidemia is highly prevalent in youth with type 2 diabetes (T2D), yet the pathogenic components of dyslipidemia in youth with T2D are poorly understood. Objective To evaluate the genetic determinants of lipid traits in youth with T2D through a genome-wide association study (GWAS). Design, participants and main outcome measures We genotyped 206,928 variants and imputed 17,642,824 variants in 1,076 youth (mean age 15.0 ±2.48 years) with T2D from the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) and SEARCH for Diabetes in Youth (SEARCH) studies as part of the Progress in Diabetes Genetics in Youth (ProDiGY) consortium. We performed association testing for triglyceride, low-density lipoprotein (LDL-c) and high-density lipoprotein (HDL-c) concentrations adjusted for the genetic relationship matrix within each sub-study followed by meta-analyses for each trait. Results We identified a novel association between a deletion on chromosome 3 (3:67817380_AT/A_Deletion:RP11-81N13.1) and triglyceride levels at genome-wide level of significance (P=2.3×10 -8) with each risk allele increasing triglycerides by 20%. We also identified a genome-wide significant signal at rs247617 (P=5.1×10 -9) between HERFUD1 and CETP associated with HDL-c, with carriers of one copy of the risk allele having twice higher HDL-c. Conclusions Our genetic analyses of lipid traits in youth with T2D have identified one novel and one previously known locus. Additional studies are needed to further characterize the genetic architecture of dyslipidemia in youth with T2D.

scholarly journals Confirmation of Multiple Risk Loci and Genetic Impacts by a Genome-Wide Association Study of Type 2 Diabetes in the Japanese Population

Diabetes ◽  
2009 ◽  
Vol 58 (7) ◽  
pp. 1690-1699 ◽  
Author(s):  
F. Takeuchi ◽  
M. Serizawa ◽  
K. Yamamoto ◽  
T. Fujisawa ◽  
E. Nakashima ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Study ◽  
Japanese Population ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome ◽  
Multiple Risk
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