scholarly journals Efficacy of oral amphotericin B for refractory atopic dermatitis with specific IgE to Candida albicans and food allergens in sera

1997 ◽  
Vol 46 (2) ◽  
pp. 125-133 ◽  
Author(s):  
Kazuko Kitamura ◽  
Chizuka Suga ◽  
Sumi Onuma ◽  
Toshiko Kawaguchi ◽  
Fusae Yamazaki ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Candida Albicans ◽  
Amphotericin B ◽  
Specific Ige ◽  
Food Allergens

scholarly journals House dust mite sensitisation and association with atopic dermatitis in Brunei

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Haziq Emran ◽  
Christina Siew Eng Chieng ◽  
Surita Taib ◽  
Anne Catherine Cunningham
Keyword(s):  
Atopic Dermatitis ◽  
House Dust ◽  
House Dust Mite ◽  
Retrospective Cohort ◽  
Specific Ige ◽  
Dermatophagoides Pteronyssinus ◽  
Food Allergens ◽  
Dust Mite ◽  
Storage Mite ◽  
Tropical Areas

AbstractIgE sensitisation in tropical areas is under-reported. A 2 year retrospective cohort study of allergy data specific to aero and food allergens in Brunei demonstrated that specific IgE levels to house dust mite (Dermatophagoides pteronyssinus, D.farinae, Blomia tropicalis) were highest in this population and correlated with atopic dermatitis (p < 0.001). Shrimp and peanut were the most common food allergens. A dominance of house/storage mite sensitization is seen in Brunei which is consistent with other tropical countries.

scholarly journals Sensitisation patterns and allergy outcomes in pregnant women living in the urban area

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Hanna Danielewicz ◽  
Anna Dębińska ◽  
Grzegorz Myszczyszyn ◽  
Anna Myszkal ◽  
Lidia Hirnle ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Pregnant Women ◽  
Allergic Disease ◽  
De Novo ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Food Allergens ◽  
Metabolic Complications ◽  
Total Ige ◽  
In Pregnancy

Abstract Background Worldwide, allergy affects more than one billion people, with particularly rising prevalence in industrialised areas. Specifically, young adults appear to be predominantly targeted for an allergy diagnosis. Allergic diseases in pregnancy are mainly pre-existing but could also occur de novo. The immunological changes while pregnant, with increased Th2 lymphocyte activity, can facilitate allergen sensitisation. Objective The aim of this study was to evaluate the pattern of specific IgE (sIgE) sensitisation to common inhalant and food allergens in pregnancy, and assess its relationship to self-reported allergic disease. Methods We assessed 200 pregnant women, aged 20–38 years (mean age = 29 years), participant of ELMA (Epigenetic Hallmark of Maternal Atopy and Diet) study, living in a metropolitan area, with no pregnancy associated metabolic complications, for total IgE and allergen specific IgE to 20 allergens. Results 48% of pregnant women were sensitised to at least one allergen, at a cut-off point of 0.35 kU/L and they were assigned as atopic. However 42% in atopic group were not reporting any allergic disease. The most common inhalant allergens were: pollen (24.5%) and animal dander (23.5%). The most common food allergens were: cow’s milk (5.5%) and apples (4.5%). 7.5% of women reported asthma, 21.5% allergic rhinitis, 11.5% atopic dermatitis and 18.5% food allergy. 8.5% of were taking medication for asthma or allergies. Atopic dermatitis had the highest tendency to become more severe during pregnancy. Total IgE values were significantly higher in atopic women. Conclusions Allergic sensitisation is a common phenomenon in pregnancy. Some sensitisations could be asymptomatic. Further studies should investigate if sensitisation in mothers confers risks for immune alterations in their children.

scholarly journals Sensibilization Spectrum in Preschool Children with Atopic Dermatitis

2021 ◽  
Vol 18 (4) ◽  
pp. 286-291
Author(s):  
Tat'yana S. Kashinskaya ◽  
Natal'ya V. Shahova ◽  
Yurij F. Lobanov ◽  
Natal'ya K. Bishevskaya
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Milk Proteins ◽  
Specific Ige ◽  
Cow’S Milk ◽  
Food Allergens ◽  
Positive Correlation ◽  
Weak Positive Correlation ◽  
Staphylococcus Aureus Enterotoxins ◽  
Airborne Allergens

Background. Atopic dermatitis (AD) is an allergodermathosis that is widespread in children and adult populations. Sensibilization to food allergens prevails in children of early age, and to airborne allergens in older age. Impairments of skin barrier lead to increase in Staphylococcus aureus colonization and finally aggravate the course of AD and the sensibilization level.Objective. The aim of the study is to estimate the sensibilization spectrum in 3-6 years old children with AD and its correlation with severity.Methods. It was cross sectional study with two independent cohorts of 3-6 years old children with and without (healthy) AD. Estimation of sensibilization spectrum and revealing of correlation with disease severity were performed.Results. The study includes 106 children aged 4.4 ± 1.2 year (58.5% boys and 41.5% girls). Polysensibilization was revealed in 28.3% of children. According to our data: 3-6 years old children with AD most often had sensibilization to the cat epithelium (34.9%), cow's milk proteins (22.6%), Dermatophagoides pteronyssinus mite (16.0%). Sensibilization to enterotoxins of Staphylococcus aureus was revealed in 7.5% children. We have recorded weak positive correlation between the AD severity and the level of specific IgE to airborne and food allergens. There was no statistically significant correlation between the AD severity and the level of specific IgE to Staphylococcus aureus enterotoxins A and B. Conclusion. The most common sensibilization type among 3-6 years old children with AD was one to airborne allergens. Sensibilization to the cat epithelium prevails among airborne allergens, to the cow's milk proteins — among food allergens. The weak positive correlation between the AD severity and the level of specific IgE to airborne and food allergens was revealed. The weak negative correlation with the level of specific IgE to Staphylococcus aureus enterotoxins A and B was revealed, thus the data was statistically insignificant.

scholarly journals Features of sensitization to widespread allergens in residents of St. Petersburg and the Leningrad region with common allergic deseases

2013 ◽  
Vol 10 (4) ◽  
pp. 74-80
Author(s):  
O V Aak ◽  
A V Sobolev
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Leningrad Region ◽  
Food Allergens ◽  
Significant Similarity ◽  
High Degree

Background. To identify differences in sensitization to widespread allergens in patients with common allergic diseases: allergic rhinitis, bronchial asthma, angioedema, allergic urticaria and atopic dermatitis. Materials and methods. Determination of sIgE in serum using commercial and domestic reagent kits («AllergoI-FA-specific IgE» and biotinylated allergens of «Alcor Bio», St. Petersburg) was conducted in patients with allergic rhinitis, bronchial asthma, angioedema, allergic urticaria and atopic dermatitis. Results. There was a significant similarity between the spectrum of sensitization in patients with allergic rhinitis and asthma In atopic dermatitis patients the increasing of frequency of food and especially mold sensitization was estimated. The high degree of correlation between the moulds, plants and food allergens in atopic dermatitis was observed. Conclusion. The results obtained in the study can be interesting for physicians in allergological examination and for the researchers to identify new cross-reactive allergens.

scholarly journals Increased Frequency of CTLA-4 and PD-1 Expressing Regulatory T Cells and Basophils With an Activating Profile in Infants With Moderate-to-Severe Atopic Dermatitis Hypersensitized to Food Allergens

2021 ◽  
Vol 9 ◽  
Author(s):  
Agurtzane Bilbao ◽  
Raquel Pérez-Garay ◽  
Idoia Rius ◽  
Alex Irurzun ◽  
Iñigo Terrén ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Specific Ige ◽  
Treg Cells ◽  
Severe Atopic Dermatitis ◽  
Healthy Controls ◽  
Food Allergens ◽  
Phenotypic Analysis ◽  
Healthy Donors ◽  
Food Antigens ◽  
Complementary Diet

Background: Infants with severe atopic dermatitis (AD) may be sensitized to foods that have not been introduced into their diet, posing a risk for developing an immediate hypersensitivity reaction on the first exposure to the food to which they are sensitized. The aim of this work was to perform an analysis of the sensitization profile in infants with moderate-to-severe AD and to identify cellular and molecular markers for food allergy (FA).Methods: Blood samples from healthy donors and children with moderate-to-severe AD were studied. Specific IgE to several allergens were determined using ImmunoCAP FEIA system and ISAC technology. Furthermore, using flow cytometry-based studies, basophils and regulatory T (Treg) cells were phenotypically characterized.Results: 90% of children with AD were sensitized to food antigens before introducing them into the diet, and 100% developed FA. Phenotypic analysis showed a significantly higher percentage of CTLA-4 and PD-1 expressing Treg cells in AD patients than in healthy controls. Basophils from patients exhibited a marked reduction in the expression of CD300a, higher expression of FcεRI and CXCR4, and to some extent higher expression of CD63 and CD300c.Conclusions: Infants with moderate-to-severe AD are at high risk of being sensitized to food allergens. Therefore, to avoid allergic reactions, broad-spectrum sensitization studies are necessary before introducing complementary diet. Increased expression of CTLA-4 and PD-1 suggests greater suppressive potential of Treg cells in infants with AD than healthy controls. Furthermore, our results suggest a role for CD300 molecules on circulating basophils as possible biomarkers for FA susceptibility.

Sensitization to inhalant and food allergens in Brazilian atopic children by <i>in vitro</i> total and specific IgE assay. Allergy Project - PROAL

10.2223/1184 ◽  
2004 ◽  
Vol 80 (3) ◽  
pp. 203-210 ◽  
Author(s):  
Charles K. Naspitz ◽  
Dirceu Solé ◽  
Cristina A. Jacob ◽  
Emanuel Sarinho ◽  
Francisco J. P. Soares ◽  
...  
Keyword(s):  
Specific Ige ◽  
Food Allergens
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