scholarly journals Application of stem cell based "Cell Sheet Engineering" for periodontal regeneration

Author(s):  
Takanori Iwata
Biomaterials ◽  
2010 ◽  
Vol 31 (12) ◽  
pp. 3212-3221 ◽  
Author(s):  
Wei Zhou ◽  
Chun Han ◽  
Yingliang Song ◽  
Xingrong Yan ◽  
Dehua Li ◽  
...  

2009 ◽  
Vol 51 (1) ◽  
pp. 220-238 ◽  
Author(s):  
Isao Ishikawa ◽  
Takanori Iwata ◽  
Kaoru Washio ◽  
Teruo Okano ◽  
Toshiyuki Nagasawa ◽  
...  

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 209 ◽  
Author(s):  
Hyunbum Kim ◽  
Yunhye Kim ◽  
Jihyun Park ◽  
Nathaniel Hwang ◽  
Yun Lee ◽  
...  

The substantial progress made in the field of stem cell-based therapy has shown its significant potential applications for the regeneration of defective tissues and organs. Although previous studies have yielded promising results, several limitations remain and should be overcome for translating stem cell-based therapies to clinics. As a possible solution to current bottlenecks, cell sheet engineering (CSE) is an efficient scaffold-free method for harvesting intact cell sheets without the use of proteolytic enzymes, and may be able to accelerate the adoption of stem cell-based treatments for damaged tissues and organs regeneration. CSE uses a temperature-responsive polymer-immobilized surface to form unique, scaffold-free cell sheets composed of one or more cell layers maintained with important intercellular junctions, cell-secreted extracellular matrices, and other important cell surface proteins, which can be achieved by changing the surrounding temperature. These three-dimensional cell sheet-based tissues can be designed for use in clinical applications to target-specific tissue regeneration. This review will highlight the principles, progress, and clinical relevance of current approaches in the cell sheet-based technology, focusing on stem cell-based therapies for bone, periodontal, skin, and vascularized muscles.


2013 ◽  
Vol 9 (4) ◽  
pp. 343-356 ◽  
Author(s):  
Takanori Iwata ◽  
Kaoru Washio ◽  
Toshiyuki Yoshida ◽  
Isao Ishikawa ◽  
Tomohiro Ando ◽  
...  

2006 ◽  
Vol 14 (7) ◽  
pp. 471-482 ◽  
Author(s):  
Joseph Yang ◽  
Masayuki Yamato ◽  
Kohji Nishida ◽  
Yasutaka Hayashida ◽  
Tatsuya Shimizu ◽  
...  

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