scholarly journals Influence of nanotopography on periodontal ligament stem cell functions and cell sheet based periodontal regeneration

2015 ◽  
pp. 4009 ◽  
Author(s):  
Lingzhou Zhao ◽  
Hui Gao ◽  
Bei Li ◽  
Yan Jin
Keyword(s):  
Stem Cell ◽  
Periodontal Ligament ◽  
Cell Sheet ◽  
Periodontal Regeneration ◽  
Cell Functions ◽  
Periodontal Ligament Stem Cell

Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration

2019 ◽  
Vol 89 ◽  
pp. 252-264 ◽  
Author(s):  
Jacob Ren Jie Chew ◽  
Shang Jiunn Chuah ◽  
Kristeen Ye Wen Teo ◽  
Shipin Zhang ◽  
Ruenn Chai Lai ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Periodontal Ligament ◽  
Periodontal Regeneration ◽  
Periodontal Ligament Cell ◽  
Cell Functions

scholarly journals Periodontal Regeneration Using Periodontal Ligament Stem Cell-Transferred Amnion

2013 ◽  
pp. 131209065021003 ◽  
Author(s):  
Kengo Iwasaki ◽  
Motohiro Komaki ◽  
Naoki Yokoyama ◽  
Yuichi Tanaka ◽  
Atsuko Taki ◽  
...  
Keyword(s):  
Stem Cell ◽  
Periodontal Ligament ◽  
Periodontal Regeneration ◽  
Periodontal Ligament Stem Cell

scholarly journals Macrophage polarization in periodontal ligament stem cells enhanced periodontal regeneration

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Jiaying Liu ◽  
Bin Chen ◽  
Jun Bao ◽  
Yangheng Zhang ◽  
Lang Lei ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Periodontal Ligament ◽  
Early Stage ◽  
Macrophage Polarization ◽  
Periodontal Regeneration ◽  
Treated Group ◽  
M2 Macrophages ◽  
M2 Polarization ◽  
Tnf Α

Abstract Background The inflammation and regeneration process may be accompanied by the shift in the M1/M2 polarization of macrophages to adapt to extracellular signals. How the macrophages responded to the altered immunological environment in the periodontal niche after stem cell transplantation has never been explored. The purpose of present study is to investigate whether M1/M2 polarization of macrophages participated in the tissue homeostasis and wound healing during periodontal ligament stem cell (PDLSC)-based periodontal regeneration. Methods A rat periodontal defect model was utilized to observe the regeneration process in the PDLSC transplantation-enhanced periodontal repair. Dynamic changes in the markers of M1/M2 macrophages were observed on days 3, 7, and 21 post surgery. In addition, the outcome of regeneration was analyzed on day 21 after surgery. To further investigate the effect of PDLSCs on macrophage polarization, the conditioned medium of PDLSCs was utilized to treat M0, M1, and M2 macrophages for 24 h; markers of M1/M2 polarization were evaluated in macrophages. Results Elevated bone volume and average thickness of bone trabecular was observed in the PDLSC-treated group by micro-computed tomography on day 21. In addition, enhanced periodontal regeneration was observed in the PDLSC-treated group with cementum-like structure regeneration and collagen fiber formation, which inserted into the newly formed cementum. On day 3, PDLSC transplantation increased IL-10 level in the periodontal tissue, while decreased TNF-α in the early stage of periodontal regeneration. On day 7, enhanced CD163+ cell infiltration and heightened expression of markers of M2 macrophages were observed. Furthermore, conditioned medium from PDLSC culture induced macrophage polarization towards the anti-inflammatory phenotype by downregulating TNF-α and upregulating IL-10, Arg-1, and CD163 in vitro. Conclusions PDLSCs could induce macrophage polarization towards the M2 phenotype, and the shift in the polarization towards M2 macrophages in the early stage of tissue repair contributed to the enhanced periodontal regeneration after stem cell transplantation. Therefore, signals from the transplanted PDLSCs might alter the immune microenvironment to enhance periodontal regeneration.

A compound of concentrated growth factor and periodontal ligament stem cell-derived conditioned medium

2020 ◽  
Vol 65 ◽  
pp. 101373
Author(s):  
Z. Aghamohamadi ◽  
M. Kadkhodazadeh ◽  
M. Torshabi ◽  
F. Tabatabaei
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Conditioned Medium ◽  
Periodontal Ligament ◽  
Periodontal Ligament Stem Cell

scholarly journals Nrf2 Inhibits Periodontal Ligament Stem Cell Apoptosis under Excessive Oxidative Stress

2017 ◽  
Vol 18 (5) ◽  
pp. 1076 ◽  
Author(s):  
Yanli Liu ◽  
Hongxu Yang ◽  
Yi Wen ◽  
Bingyi Li ◽  
Yinhua Zhao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cell ◽  
Cell Apoptosis ◽  
Periodontal Ligament ◽  
Periodontal Ligament Stem Cell

Bioprinting 3D cell-laden hydrogel microarray for screening human periodontal ligament stem cell response to extracellular matrix

2015 ◽  
Vol 7 (4) ◽  
pp. 044105 ◽  
Author(s):  
Yufei Ma ◽  
Yuan Ji ◽  
Guoyou Huang ◽  
Kai Ling ◽  
Xiaohui Zhang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Cell Response ◽  
Periodontal Ligament ◽  
Periodontal Ligament Stem Cell
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