Treadmill Exercise Performance by the Aging Irradiated Rat

1967 ◽  
Vol 30 (4) ◽  
pp. 714 ◽  
Author(s):  
D. C. Jones ◽  
G. K. Osborn ◽  
D. J. Kimeldorf
2009 ◽  
Vol 34 (6) ◽  
pp. 1040-1047 ◽  
Author(s):  
Ying-Ju Chen ◽  
Hsuan-Ying Chen ◽  
Ming-Fu Wang ◽  
Mei-Hsiang Hsu ◽  
Woei-Ming Liang ◽  
...  

Repeated blood sampling in rodents is often necessary and difficult. Magnesium has been touted as an agent for enhancing physical activity. An auto-blood-sampling device coupled with a microdialysis analyzer was developed to determine blood glucose and lactate concentrations in rats subjected to treadmill exercise. The effects of magnesium on exercise performance and blood energy metabolism were also evaluated. Sprague–Dawley rats fed a magnesium-adequate diet were randomly assigned to 2 experimental groups. Exercise performance was evaluated at 3 treadmill speeds (10, 15, and 20 m·min–1) with or without magnesium administration (90 mg·kg–1, intraperitoneal) in the first experiment. In the other experiment, each rat was fitted with a catheter in the jugular vein for collection of blood samples during the treadmill exercise at a speed of 20 m·min–1. Exercise performance was significantly higher at the lower speed of 10 m·min–1 in the control group. In addition, exercise performance was significantly enhanced only at 20 m·min–1 in the magnesium-sulfate-treated group when compared with the control group. Blood samples were collected every 15 min. Glucose concentrations increased significantly and then declined immediately after completion of the exercise task at 20 m·min–1 in both groups. However, glucose concentrations increased immediately after administration of magnesium and increased further during exercise when compared with those of the control group. Findings from a repeated blood-sampling assay suggest that increased blood glucose contributes to enhanced exercise performance by rats injected intraperitoneally with magnesium.


2013 ◽  
Vol 304 (2) ◽  
pp. H206-H214 ◽  
Author(s):  
Steven W. Copp ◽  
Tadakatsu Inagaki ◽  
Michael J. White ◽  
Daniel M. Hirai ◽  
Scott K. Ferguson ◽  
...  

Consumption of the dietary flavanol (−)-epicatechin (EPI) is associated with enhanced endothelial function and augmented skeletal muscle capillarity and mitochondrial volume density. The potential for EPI to improve peripheral vascular function and muscle oxygenation during exercise is unknown. We tested the hypothesis that EPI administration in healthy rats would improve treadmill exercise performance secondary to elevated skeletal muscle blood flow and vascular conductance [VC, blood flow/mean arterial pressure (MAP)] and improved skeletal muscle microvascular oxygenation. Rats received water (control, n = 12) or 4 mg/kg EPI ( n = 12) via oral gavage daily for 24 days. Exercise endurance capacity and peak O2 uptake (V̇o2 peak) were measured via treadmill runs to exhaustion. MAP (arterial catheter) and blood flow (radiolabeled microspheres) were measured and VC was calculated during submaximal treadmill exercise (25 m/min, 5% grade). Spinotrapezius muscle microvascular O2 pressure (Po2mv) was measured (phosphorescence quenching) during electrically induced twitch (1 Hz) contractions. In conscious rats, EPI administration resulted in lower (↓∼5%) resting ( P = 0.03) and exercising ( P = 0.04) MAP. There were no differences in exercise endurance capacity, V̇o2 peak, total exercising hindlimb blood flow (control, 154 ± 13; and EPI, 159 ± 8 ml·min−1·100 g−1, P = 0.68), or VC (control, 1.13 ± 0.10; and EPI, 1.24 ± 0.08 ml·min−1·100 g−1·mmHg−1, P = 0.21) between groups. Following anesthesia, EPI resulted in lower MAP (↓∼16%) but did not impact resting Po2mv or any kinetics parameters ( P > 0.05 for all) during muscle contractions compared with control. EPI administration (4 mg·kg−1·day−1) improved modestly cardiovascular function (i.e., ↓MAP) with no impact on exercise performance, total exercising skeletal muscle blood flow and VC, or contracting muscle microvascular oxygenation in healthy rats.


2002 ◽  
Vol 92 (6) ◽  
pp. 2245-2255 ◽  
Author(s):  
Imanuel Lerman ◽  
Brooke C. Harrison ◽  
Kalev Freeman ◽  
Timothy E. Hewett ◽  
David L. Allen ◽  
...  

The goal of this study was to characterize the genetic contribution to both forced and voluntary exercise performance and to determine whether performance in these two paradigms is controlled by similar genetic influences. There were marked strain differences in treadmill exercise performance, with Swiss Webster (SW) and FVB/NJ mice showing elevated performance and C57BL/6J animals showing decreased performance compared with all other strains. There was no apparent relationship between treadmill performance and voluntary wheel performance, with the exception of SW mice, which demonstrated high performances on both the treadmill and the voluntary wheel. Numerous properties were measured to attempt to understand the basis for these differences in exercise performance. DBA/1J and SW mice exhibited significantly greater cardiac contractility than all other analyzed strains. Conversely, BALB/cByJ mice exhibited significantly reduced cardiac contractility compared with all other strains. Expression of molecular indicators of hypertrophy (atrial natriuretic factor and β-myosin heavy chain) was significantly elevated in DBA/2J myocardium compared with all other analyzed strains.


2021 ◽  
Vol 53 (8S) ◽  
pp. 4-4
Author(s):  
Avery D. Faigenbaum ◽  
Jie Kang ◽  
Nicholas A. Ratamess ◽  
Anne Farrell ◽  
Christian Mendez ◽  
...  

2020 ◽  
Vol 52 (7S) ◽  
pp. 59-59
Author(s):  
Avery D. Faigenbaum ◽  
Jie Kang ◽  
Nicholas A. Ratamess ◽  
Anne Farrell ◽  
Morgan Choma ◽  
...  

2014 ◽  
Vol 31 (1) ◽  
pp. 69-72 ◽  
Author(s):  
Mei-Lin Wang ◽  
Ying-Ju Chen ◽  
Fu-Chou Cheng

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