Cross-Resistance to Other Anthelmintics in an Experimentally Produced Cambendazole-Resistant Strain of Haemonchus contortus in Lambs

1975 ◽  
Vol 61 (4) ◽  
pp. 778 ◽  
Author(s):  
M. L. Colglazier ◽  
K. C. Kates ◽  
F. D. Enzie
Keyword(s):  
Resistant Strain ◽  
Haemonchus Contortus ◽  
Cross Resistance

Efficacy of some anthelmintics on an ivermectin-resistant strain of Haemonchus contortus in sheep

1991 ◽  
Vol 39 (3-4) ◽  
pp. 279-284 ◽  
Author(s):  
F.A.M. Echevarria ◽  
J.L. Armour ◽  
J.L. Duncan
Keyword(s):  
Resistant Strain ◽  
Haemonchus Contortus

scholarly journals UDP-Glycosyltransferases and Albendazole Metabolism in the Juvenile Stages of Haemonchus contortus

2020 ◽  
Vol 11 ◽  
Author(s):  
Pavlína Kellerová ◽  
Martina Navrátilová ◽  
Linh Thuy Nguyen ◽  
Diana Dimunová ◽  
Lucie Raisová Stuchlíková ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Resistant Strain ◽  
Haemonchus Contortus ◽  
Resistance Mechanism ◽  
Constitutive Expression ◽  
Primary Metabolite ◽  
Resistance Development ◽  
Enhanced Solubility ◽  
Juvenile Stages ◽  
Resistant Strains

The nematode Haemonchus contortus, a gastrointestinal parasite of ruminants, can severely burden livestock production. Although anthelmintics are the mainstay in the treatment of haemonchosis, their efficacy diminishes due to drug-resistance development in H. contortus. An increased anthelmintics inactivation via biotransformation belongs to a significant drug-resistance mechanism in H. contortus. UDP-glycosyltransferases (UGTs) participate in the metabolic inactivation of anthelmintics and other xenobiotic substrates through their conjugation with activated sugar, which drives the elimination of the xenobiotics due to enhanced solubility. The UGTs family, in terms of the biotransformation of commonly used anthelmintics, has been well described in adults as a target stage. In contrast, the free-living juvenile stages of H. contortus have attracted less attention. The expression of UGTs considerably varies throughout the life cycle of the juvenile nematodes, suggesting their different roles. Furthermore, the constitutive expression in a susceptible strain with two resistant strains shows several resistance-related changes in UGTs expression, and the exposure of juvenile stages of H. contortus to albendazole (ABZ) and ABZ-sulfoxide (ABZSO; in sublethal concentrations) leads to the increased expression of several UGTs. The anthelmintic drug ABZ and its primary metabolite ABZSO biotransformation, tested in the juvenile stages, shows significant differences between susceptible and resistant strain. Moreover, higher amounts of glycosidated metabolites of ABZ are formed in the resistant strain. Our results show similarly, as in adults, the UGTs and glycosidations significant for resistance-related differences in ABZ biotransformation and warrant further investigation in their individual functions.

scholarly journals The cross-resistance patterns and biochemical characteristics of an imidacloprid-resistant strain of the cotton aphid

2015 ◽  
Vol 40 (2) ◽  
pp. 55-59 ◽  
Author(s):  
Xiaokun Chen ◽  
Xugen Shi ◽  
Hongyan Wang ◽  
Jie Wang ◽  
Kaiyun Wang ◽  
...  
Keyword(s):  
Resistant Strain ◽  
Cross Resistance ◽  
Cotton Aphid ◽  
Biochemical Characteristics ◽  
Resistance Patterns ◽  
The Cross
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