Efficacy of moxidectin, nemadectin and ivermectin against an ivermectin-resistant strain of Haemonchus contortus in sheep

1992 ◽  
Vol 130 (12) ◽  
pp. 241-242 ◽  
Author(s):  
J. Pankavich ◽  
H. Berger ◽  
K. Simkins
Keyword(s):  
Resistant Strain ◽  
Haemonchus Contortus

Efficacy of some anthelmintics on an ivermectin-resistant strain of Haemonchus contortus in sheep

1991 ◽  
Vol 39 (3-4) ◽  
pp. 279-284 ◽  
Author(s):  
F.A.M. Echevarria ◽  
J.L. Armour ◽  
J.L. Duncan
Keyword(s):  
Resistant Strain ◽  
Haemonchus Contortus

scholarly journals UDP-Glycosyltransferases and Albendazole Metabolism in the Juvenile Stages of Haemonchus contortus

2020 ◽  
Vol 11 ◽  
Author(s):  
Pavlína Kellerová ◽  
Martina Navrátilová ◽  
Linh Thuy Nguyen ◽  
Diana Dimunová ◽  
Lucie Raisová Stuchlíková ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Resistant Strain ◽  
Haemonchus Contortus ◽  
Resistance Mechanism ◽  
Constitutive Expression ◽  
Primary Metabolite ◽  
Resistance Development ◽  
Enhanced Solubility ◽  
Juvenile Stages ◽  
Resistant Strains

The nematode Haemonchus contortus, a gastrointestinal parasite of ruminants, can severely burden livestock production. Although anthelmintics are the mainstay in the treatment of haemonchosis, their efficacy diminishes due to drug-resistance development in H. contortus. An increased anthelmintics inactivation via biotransformation belongs to a significant drug-resistance mechanism in H. contortus. UDP-glycosyltransferases (UGTs) participate in the metabolic inactivation of anthelmintics and other xenobiotic substrates through their conjugation with activated sugar, which drives the elimination of the xenobiotics due to enhanced solubility. The UGTs family, in terms of the biotransformation of commonly used anthelmintics, has been well described in adults as a target stage. In contrast, the free-living juvenile stages of H. contortus have attracted less attention. The expression of UGTs considerably varies throughout the life cycle of the juvenile nematodes, suggesting their different roles. Furthermore, the constitutive expression in a susceptible strain with two resistant strains shows several resistance-related changes in UGTs expression, and the exposure of juvenile stages of H. contortus to albendazole (ABZ) and ABZ-sulfoxide (ABZSO; in sublethal concentrations) leads to the increased expression of several UGTs. The anthelmintic drug ABZ and its primary metabolite ABZSO biotransformation, tested in the juvenile stages, shows significant differences between susceptible and resistant strain. Moreover, higher amounts of glycosidated metabolites of ABZ are formed in the resistant strain. Our results show similarly, as in adults, the UGTs and glycosidations significant for resistance-related differences in ABZ biotransformation and warrant further investigation in their individual functions.

Synergic interaction of aromatic compounds thymol and carvacrol against nematode Haemonchus contortus resistant strain

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
L Katiki ◽  
A Evangelista ◽  
E Canova ◽  
A Piza ◽  
B Fornazari ◽  
...  
Keyword(s):  
Aromatic Compounds ◽  
Resistant Strain ◽  
Haemonchus Contortus

Characterisation of an avermectin resistant strain of Australian Haemonchus contortus

1995 ◽  
Vol 25 (6) ◽  
pp. 691-698 ◽  
Author(s):  
Leo F. Le Jambre ◽  
Jennifer H. Gill ◽  
Ian J. Lenane ◽  
Ernest Lacey
Keyword(s):  
Resistant Strain ◽  
Haemonchus Contortus

Changes in response of a benzimidazole resistant strain of Haemonchus contortus from sheep after passing through calves

1981 ◽  
Vol 30 (2) ◽  
pp. 143-146 ◽  
Author(s):  
C.A. Hall ◽  
J.D. Kelly ◽  
I.C.A. Martin ◽  
H.V. Whitlock ◽  
P.A. Mcdonell ◽  
...  
Keyword(s):  
Resistant Strain ◽  
Haemonchus Contortus
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