Skin Reaction Specificity of Guinea Pig Immediate Hypersensitivity to Bites of Four Mosquito Species

1971 ◽  
Vol 57 (2) ◽  
pp. 396 ◽  
Author(s):  
Frank E. French ◽  
A. S. West
Keyword(s):  
Guinea Pig ◽  
Skin Reaction ◽  
Mosquito Species ◽  
Immediate Hypersensitivity ◽  
Reaction Specificity

Immediate Hypersensitivity in the Guinea Pig Conjunctiva

1981 ◽  
Vol 65 (1) ◽  
pp. 102-106 ◽  
Author(s):  
R.St.C. Dwyer ◽  
S. Darougar ◽  
B.R. Jones ◽  
J.L. Turk
Keyword(s):  
Guinea Pig ◽  
Immediate Hypersensitivity

A Skin Reaction in Guinea Pig Homograft Donors with a Cell-free Substance from Recipient Lymph Nodes

Nature ◽  
1962 ◽  
Vol 193 (4821) ◽  
pp. 1198-1199 ◽  
Author(s):  
A. E. POWELL ◽  
OTIS RAY ◽  
D. WHITENACK ◽  
C. A. HUBAY ◽  
W. D. HOLDEN
Keyword(s):  
Guinea Pig ◽  
Lymph Nodes ◽  
Skin Reaction ◽  
A Cell

Pharmacologic Inhibition of Immediate Hypersensitivity in the Guinea Pig Conjunctiva

1985 ◽  
Vol 1 (2) ◽  
pp. 183-187 ◽  
Author(s):  
E. LEE STOCK ◽  
RAY ST. C. DWYER ◽  
BARRIE R. JONES ◽  
JOHN A. WATERS
Keyword(s):  
Guinea Pig ◽  
Immediate Hypersensitivity ◽  
Pharmacologic Inhibition

Antigen depolarizes guinea pig bronchial parasympathetic ganglion neurons by activation of histamine H1 receptors

1995 ◽  
Vol 268 (6) ◽  
pp. L879-L884 ◽  
Author(s):  
A. C. Myers ◽  
B. J. Undem
Keyword(s):  
Guinea Pig ◽  
Guinea Pigs ◽  
High Titer ◽  
Membrane Resistance ◽  
Dependent Manner ◽  
Immediate Hypersensitivity ◽  
Concentration Dependent Manner ◽  
Parasympathetic Ganglion ◽  
Histamine H1 Receptors ◽  
Ganglion Neurons

Studies were carried out to evaluate the mechanism by which neurotransmission through airway parasympathetic ganglia may be modulated during immediate hypersensitivity reactions. Guinea pigs were passively sensitized by injection of guinea pig serum containing high-titer anti-ovalbumin antibodies. Intracellular recordings were obtained from intrinsic parasympathetic ganglion neurons from the right mainstem bronchus in vitro. Ovalbumin (10 micrograms/ml) elicited a membrane potential depolarization and changes in membrane resistance in bronchial ganglion neurons from passively sensitized guinea pigs. Histamine mimicked the depolarizing effect of ovalbumin in a concentration-dependent manner (0.1–10 microM) and caused a transient increase and decrease in membrane resistance. Pyrilamine, a histamine H1-receptor antagonist, inhibited the histamine-induced membrane depolarization and decrease in resistance. By contrast, blocking histamine H2 and H3 receptors did not inhibit histamine-induced depolarization. Pyrilamine also reduced the antigen-induced depolarization of ganglion neurons, demonstrating a role for histamine H1 receptors in this response. The data provide evidence that the antigen-induced depolarization of airway ganglion neurons is secondary to an antigen-antibody interaction on intrinsic mast cells and the consequential effect of histamine on H1 receptors. These studies demonstrate that histamine released during an immediate hypersensitivity reaction has direct effects on airway parasympathetic nerves.

Immediate hypersensitivity reactions in the guinea-pig conjunctiva: studies with a second-generation leukotriene D4 receptor antagonist, MK-571

1989 ◽  
Vol 67 (8) ◽  
pp. 845-850 ◽  
Author(s):  
Chi-Chung Chan ◽  
Francois Dagenais ◽  
Patricia Firby ◽  
Aidan Foster ◽  
Anthony W. Ford-Hutchinson
Keyword(s):  
Guinea Pig ◽  
Receptor Antagonist ◽  
Second Generation ◽  
Antigen Challenge ◽  
Hypersensitivity Reactions ◽  
Immediate Hypersensitivity ◽  
Leukotriene D4 ◽  
Permeability Changes ◽  
Therapeutic Value ◽  
D4 Receptor

The role of leukotriene D4 (LTD4) as a mediator of immediate hypersensitivity reactions in the guinea-pig conjunctiva was examined using a potent, second-generation LTD4 receptor antagonist, MK-571 (also known as L-660,711). The microvascular permeability changes in the guinea-pig conjunctiva following challenge with either LTD4 or antigen were measured through accumulation of intravenously administered 99mtechnetium-labeled albumin. Topical application of MK-571 (up to 2 h pretreatment) significantly inhibited the conjunctival responses to LTD4 (ED50 of 18–60 ng/eye) but not to histamine. The responses to a single topical antigen challenge in ovalbumin-sensitized guinea pigs were significantly inhibited (44%) by topical treatment with MK-571, in contrast to the lack of effect previously observed with prototypic antagonists. The inhibitory effects of MK-571 did not involve an action on conversion of [3H]LTC4 to LTD4 and LTE4. Following a second antigen challenge (24 h after the first), MK-571 inhibited the resultant permeability changes by 78%. Specific histamine H1 and H2 antagonists similarly inhibited the responses to the first and second challenges (63 and 74%, respectively). The present study suggests that LTD4 is involved in conjunctival hypersensitivity reactions and that potent LTD4 receptor antagonists may be of therapeutic value in the treatment of allergic conjunctivitis.Key words: allergic conjunctivitis, leukotriene D4, leukotriene D4 antagonists, MK-571, vascular permeability changes.

Immediate Hypersensitivity in the Guinea Pig Conjunctiva

1974 ◽  
Vol 46 (6) ◽  
pp. 910-924 ◽  
Author(s):  
R.St.C. Dwyer ◽  
J.L. Turk ◽  
S. Darougar
Keyword(s):  
Guinea Pig ◽  
Immediate Hypersensitivity
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