The Value of an Assessment of Erythema and Increase in Thickness of the Skin Reaction for a Full Appreciation of the Nature of Delayed Hypersensitivity in the Guinea Pig

1977 ◽  
Vol 54 (1) ◽  
pp. 58-66 ◽  
Author(s):  
R.J. Scheper ◽  
Bernice Noble ◽  
Darien Parker ◽  
J.L. Turk
Keyword(s):  
Guinea Pig ◽  
Skin Reaction ◽  
Delayed Hypersensitivity

A delayed hypersensitivity reaction to dentine primer in the guinea-pig

1995 ◽  
Vol 23 (5) ◽  
pp. 295-299 ◽  
Author(s):  
K. Katsuno ◽  
A. Manabe ◽  
K. Itoh ◽  
H. Hisamitsu ◽  
S. Wakumoto ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Hypersensitivity Reaction ◽  
Delayed Hypersensitivity ◽  
Delayed Hypersensitivity Reaction

Delayed Hypersensitivity in Guinea Pig Gingiva

1975 ◽  
Vol 46 (2) ◽  
pp. 90-101 ◽  
Author(s):  
Efrain Peretzman ◽  
Patrick D. Toto ◽  
Anthony W. Gargiulo
Keyword(s):  
Guinea Pig ◽  
Delayed Hypersensitivity

scholarly journals THE SPECIFICITY OF ALLERGIC REACTIONS

1963 ◽  
Vol 117 (3) ◽  
pp. 401-423 ◽  
Author(s):  
John E. Coe ◽  
S. B. Salvin
Keyword(s):  
Immune Response ◽  
Guinea Pig ◽  
The State ◽  
Delayed Hypersensitivity ◽  
Protein Carrier ◽  
Specific Contact ◽  
Tolerant Animal ◽  
Gastric Feeding

"Gastric feeding" of adult guinea pigs with dinitrochlorobenzene (DCB) resulted in a specific unresponsiveness to sensitization with the specific contact hapten. The more DCB gastric-fed to a guinea pig, the more complete the unresponsiveness to the hapten. When mycobacteria were incorporated into the sensitizing emulsion, the state of unresponsiveness to the dinitrophenyl (DNP) group was less apparent. When animals gastric-fed with DCB were later sensitized with an in vitro conjugate of the hapten combined with a heterologous protein such as dinitrophenyl-hen egg albumin (DNP·HEA), an immune response similar to that in the controls occurred both to the hapten and to the protein carrier. However, when the tolerant animals were sensitized with a conjugate containing a homologous protein carrier such as dinitrophenyl guinea pig serum (DNP·GPS), they showed diminished immune responses in comparison with those in the non-tolerant controls. The presence of circulating anti-DNP antibodies from sensitization with DNP-HEA did not affect the unresponsiveness to the specific contact hapten, regardless of whether these antibodies are present before or after induction of tolerance. Sensitization with picryl chloride (PiCl) (a cross-reacting hapten), either before or after gastric feeding of DCB, did not affect the state of unresponsiveness to DNP. Similarly when the DNP-tolerant animal was sensitized with PiCl, the subsequent immune response was similar to that in the controls; cross-reactions with the DNP group both in the contact and circulating antibody phase occurred at a rate similar to that in the controls. The foregoing relationships can be explained by presuming that, upon the gastric feeding of DCB, an in vivo conjugate is formed with a somatic protein, which determines the basic specificity of the tolerance. Acquired tolerance seems to manifest an immunologic specificity similar to that of delayed hypersensitivity, a relationship not unexpected if delayed hypersensitivity is an early phase of the immune response.

IMMUNOPATHOLOGICAL CHARACTERIZATION OF THE DELAYED HYPERSENSITIVITY SKIN REACTION TO CARRIER PROTEIN

1983 ◽  
Vol 33 (4) ◽  
pp. 739-749
Author(s):  
Tetsuro Yamamoto ◽  
Junji Tsueuta ◽  
Tatsuomi Yasaka ◽  
Takeshi Kambara
Keyword(s):  
Skin Reaction ◽  
Delayed Hypersensitivity ◽  
Carrier Protein ◽  
Hypersensitivity Skin

A Skin Reaction in Guinea Pig Homograft Donors with a Cell-free Substance from Recipient Lymph Nodes

Nature ◽  
1962 ◽  
Vol 193 (4821) ◽  
pp. 1198-1199 ◽  
Author(s):  
A. E. POWELL ◽  
OTIS RAY ◽  
D. WHITENACK ◽  
C. A. HUBAY ◽  
W. D. HOLDEN
Keyword(s):  
Guinea Pig ◽  
Lymph Nodes ◽  
Skin Reaction ◽  
A Cell

scholarly journals MACROPHAGE-DIGESTED ANTIGEN AS INDUCER OF DELAYED HYPERSENSITIVITY

1971 ◽  
Vol 133 (3) ◽  
pp. 494-505 ◽  
Author(s):  
Margot N. Pearson ◽  
Sidney Raffel
Keyword(s):  
Immune Responses ◽  
Guinea Pig ◽  
Peritoneal Macrophages ◽  
Delayed Hypersensitivity ◽  
Sheep Erythrocytes

Sheep erythrocytes ingested by guinea pig peritoneal macrophages in vitro, and permitted to undergo digestion for various periods, were found after some hours to lose the capacity to induce antibodies while gaining the ability to invoke delayed hypersensitivity. These observations may be related to the known predilection of small molecular immunogens to act as good inducers of delayed reactivity and poor stimulators of antibody. They may be related also to the activity of mycobacterial adjuvant as a vehicle for the induction of delayed hypersensitivity on the basis that this melange activates macrophages to phagocytose and enzymatically degrade macromolecular antigens rapidly. The thesis that small fragments of antigenic molecules may preferentially invoke hypersensitivity can be interpreted on the basis of current concepts of multicellular involvements in immune responses.

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