Joris van Speilbergen's Journal and a Site in the Huarmey Valley, Peru

1967 ◽  
Vol 32 (1) ◽  
pp. 113-116 ◽  
Author(s):  
Donald E. Thompson
Keyword(s):  
Archaeological Survey ◽  
Inca Empire ◽  
The One ◽  
A Site

AbstractAn illustration of the Huarmey Valley in Joris van Speilbergen's journal from the year 1615 shows a “ruined castle, occupied by our men.” In an archaeological survey conducted by the author, a site was located which is very likely to be the one occupied by van Speilbergen. The site appears to be Chimu or Inca in date on the basis of the plan, the construction of tapia adobe, and the high percentage of reduced-fired ceramics. Despite the small size and relative unimportance of the Huarmey Valley, the site, to judge by the illustration and the existing ruins, was a large and impressive structure of some importance to the Chimu and/or the Inca Empire.

scholarly journals The T788G Mutation in thecyp51CGene Confers Voriconazole Resistance in Aspergillus flavus Causing Aspergillosis

2012 ◽  
Vol 56 (5) ◽  
pp. 2598-2603 ◽  
Author(s):  
Wei Liu ◽  
Yi Sun ◽  
Wei Chen ◽  
Weixia Liu ◽  
Zhe Wan ◽  
...  
Keyword(s):  
Aspergillus Flavus ◽  
Resistant Strain ◽  
Antifungal Susceptibility ◽  
Gene Replacement ◽  
Content Type ◽  
Replacement Method ◽  
First Choice ◽  
The One ◽  
A Site ◽  
First Time

ABSTRACTWith voriconazole (VRC) being approved as the first choice in treating invasive aspergillosis (IA) and its increasing use in treatment, a VRC-resistant strain ofAspergillus flavus, the second leading cause of IA afterAspergillus fumigatus, has emerged. The VRC-resistant strain ofA. flavuswas isolated for the first time from the surgical lung specimen of an IA patient with no response to VRC therapy. In order to ascertain the mechanism of VRC resistance, the azole target enzyme genes in this strain ofA. flavuswere cloned and sequenced, and 4 mutations generating amino acid residue substitutions were found in thecyp51Cgene. To further determine the role of this mutated gene for VRC resistance inA. flavus, anAgrobacterium tumefaciens-mediated gene replacement approach was applied. Consequently, the mutatedcyp51Cgene from thisA. flavusstrain was proven to confer the VRC resistance. Finally, to discern the one out of the four mutations in thecyp51Cgene that is responsible for contributing to VRC resistance, a site-directed gene mutagenesis procedure combined with a gene replacement method was performed. As a result, the T788G missense mutation in thecyp51Cgene was identified as responsible for VRC resistance inA. flavus. These findings indicated that the detection of this mutation inA. flavuscould serve as an indicator for physicians to avoid the use of VRC during IA treatment. Further comprehensive surveillance for antifungal susceptibility, as well as intensive study on the mechanism of azole resistance inA. flavuscausing IA, would be required to fully understand this mechanism.

scholarly journals Re-Assembling Anti-Oppressive Practice (1): The Personal, the Political, the Professional

2021 ◽  
Vol 11 (10) ◽  
pp. 645
Author(s):  
Janet Batsleer
Keyword(s):  
Theory And Practice ◽  
Academic Disciplines ◽  
Memory Work ◽  
Work Spaces ◽  
Informal Educators ◽  
Paolo Freire ◽  
The One ◽  
The Uk ◽  
A Site ◽  
Uk Higher Education

This essay offers a broken narrative concerning the early history of anti-oppressive practice as an approach in the U.K. to youth and community work and the struggles over this in the context of UK higher education between the 1960′s and the early 2000’s. Educating informal educators as youth and community workers in the UK has been a site of contestation. Aspects of a genealogy of that struggle are presented in ways which link publicly available histories with personal memories and narratives, through the use of a personal archive developed through collective memory work. These are chosen to illuminate the links between theory and practice: on the one hand, the conceptual field which has framed the education of youth and community workers, whose sources lie in the academic disciplines of education and sociology, and, on the other hand, the social movements which have formed the practice of informal educators. Six have been chosen: (1) The long 1968: challenging approaches to authority; (2) the group as a source of learning; (3) The personal and political: experiential learning from discontent; (4) Paolo Freire and Critical Praxis; (5) A critical break in social education and the reality of youth work spaces as defensive spaces; (6) New managerialism: ethics vs. paper trails. The approach taken, of linking memory work with present struggles, is argued to be a generative form for current critical and enlivening practice.

scholarly journals Branding Stratford: Social Representation and the Re-making of Place

2013 ◽  
Author(s):  
Antonio Desiderio
Keyword(s):  
Critical Discourse Analysis ◽  
Urban Space ◽  
Urban Regeneration ◽  
Social Representation ◽  
London 2012 ◽  
Dialectical Process ◽  
The Media ◽  
The One ◽  
A Site ◽  
The Way

As part of the societal world, architecture and urban space do not have any ‘objective’ quality. They are representations. Their meaning is produced through the negotiation and interaction of individuals, groups and classes. Yet, such ‘subjective’ meanings do have a ‘material’ relevance, as they reflect a dialectical process between the functions, forms, ownership and practices of space. They reveal construal and construction: the way in which architectural spaces are represented on the one hand, and the way in which they are physically constructed and used on the other. Nowhere does this become more evident in our current society than in the arguments around urban renewal and regeneration. The Westfield Stratford City is a typical example. Part of the vast process of the urban regeneration of East London prompted by London 2012 Olympic Games, Westfield is a massive complex of luxury shops, restaurants, bars and five star hotels. It is seen by investors and local and national political authorities as capable of transforming Stratford into a site for shopping, tourism and leisure. It does this in numerous ways, one of which involves reconfiguring the image of the region through the press and media - through visual imagery and linguistic manipulations that promote a neoliberal agenda of gentrification that simultaneously devalue the existent societal structures and communities in the area. This paper offers a Critical Discourse Analysis of the manipulation of Stratford’s image by government, business and the media and suggests that the purely financially motivated misrepresentation it reveals, is typical of the urban regeneration ethos at work across the developed world today.

Design and Implementation of a Site for a One-Ångstrom TEM

1997 ◽  
Vol 3 (S2) ◽  
pp. 1177-1178
Author(s):  
John H. Turner ◽  
M.A. O'Keefe ◽  
M.A. O'Keefe
Keyword(s):  
Field Emission ◽  
Acoustic Noise ◽  
Mechanical Vibration ◽  
Region I ◽  
Critical Requirement ◽  
The One ◽  
A Site ◽  
Region Ii ◽  
Critical Direction ◽  
Suitable Environment

The National Center for Electron Microscopy has recently acquired a field-emission TEM to form thebasis of a project to achieve a resolution of one Ångstrom. To reach this resolution, both instrumental and environmental factors need to be considered. We have designed and constructed a new building to provide a suitable environment for this instrument, with emphasis on providing isolation from external influences detrimental to the achievement of ultra-high resolution. Such influences include mechanical vibration, temperature fluctuations, acoustic noise, and stray electromagnetic fields.The microscope chosen for the one-Ångstrom project is a Philips CM300 Ultra-Twin equipped with a field-emission gun. Pre-installation specifications provided by Philips for this 1.7Å-resolution TEM specify maximum-allowable values for vibration levels in three mutually-perpendicular directions. In the most critical direction (console left to right), vibration is required to remain below 0.8)μm/sec in the frequency range from 1Hz to 5Hz, although allowed to rise to 6μm/sec above 10Hz (Region I in fig. 1). Even when resolution is not a critical requirement, vibration must be minimized at 2.5Hz (Region II in fig.1).

Ecologies of Oil and Trauma of the Future in Curse of the Black Gold

2019 ◽  
Vol 7 (1) ◽  
pp. 69-91
Author(s):  
Cajetan Iheka
Keyword(s):  
Niger Delta ◽  
Ecological Footprint ◽  
Fossil Fuel ◽  
Trauma Studies ◽  
Ecological Degradation ◽  
The Past ◽  
The Future ◽  
To Come ◽  
The One ◽  
A Site

Mineral extraction in Africa has exacerbated ecological degradation across the continent. This article focuses on the example of the Niger Delta scene of oil exploration depicted in Michael Watts and Ed Kashi’s multimedia project, Curse of the Black Gold: 50 Years of Oil in the Niger Delta. Analyzing the infringement on human and nonhuman bodies due to fossil fuel extraction, I read the Delta, inscribed in Watts and Kashi’s image-text, as an ecology of suffering and as a site of trauma. Although trauma studies tend to foreground the past and the present, I argue that Curse of the Black Gold invites serious consideration of trauma of the future, of-the-yet-to-come, in apprehending the problematic of suffering in the Delta. I conclude with a discussion of the ethics of representing postcolonial wounding, which on the one hand can create awareness of ecological degradation and generate affect, but which on the other hand, exploits the vulnerability of the depicted and leaves an ecological footprint.

Rethinking gaming: The ethical work of optimization in web search engines

2019 ◽  
Vol 49 (5) ◽  
pp. 707-731 ◽  
Author(s):  
Malte Ziewitz
Keyword(s):  
Search Engine ◽  
Search Engines ◽  
Web Search ◽  
The United Kingdom ◽  
Ethical Work ◽  
Web Search Engines ◽  
The One ◽  
A Site ◽  
Shifting Boundaries ◽  
Precarious Situation

When measures come to matter, those measured find themselves in a precarious situation. On the one hand, they have a strong incentive to respond to measurement so as to score a favourable rating. On the other hand, too much of an adjustment runs the risk of being flagged and penalized by system operators as an attempt to ‘game the system’. Measures, the story goes, are most useful when they depict those measured as they usually are and not how they intend to be. In this article, I explore the practices and politics of optimization in the case of web search engines. Drawing on materials from ethnographic fieldwork with search engine optimization (SEO) consultants in the United Kingdom, I show how maximizing a website’s visibility in search results involves navigating the shifting boundaries between ‘good’ and ‘bad’ optimization. Specifically, I am interested in the ethical work performed as SEO consultants artfully arrange themselves to cope with moral ambiguities provoked and delegated by the operators of the search engine. Building on studies of ethics as a practical accomplishment, I suggest that the ethicality of optimization has itself become a site of governance and contestation. Studying such practices of ‘being ethical’ not only offers opportunities for rethinking popular tropes like ‘gaming the system’, but also draws attention to often-overlooked struggles for authority at the margins of contemporary ranking schemes.

INTERPRETATIONS OF THE CARBON DIOXIDE DEPENDENCE OF THE HILL REACTION

1965 ◽  
Vol 43 (1) ◽  
pp. 119-127 ◽  
Author(s):  
Norman E. Good
Keyword(s):  
Carbon Dioxide ◽  
Quantum Theory ◽  
Hill Reaction ◽  
Oxygen Production ◽  
Quantum Mechanism ◽  
Photosynthetic Oxygen ◽  
The One ◽  
A Site ◽  
The Hill ◽  
Isolated Chloroplasts

Heretofore Warburg's one-quantum theory of photosynthesis has seemed inconsistent with the existence of the Hill reaction. The one-quantum theory states that massive oxygen uptake and CO2 release are preconditions of photosynthetic oxygen production, yet isolated chloroplasts produce oxygen at high rates apparently without consuming any oxygen or producing any CO2. Warburg has attempted to resolve the dilemma by pointing out a CO2 dependence of the Hill reaction. On the basis of this observation he proposed a reinterpretation of the Hill reaction which is consistent with the one-quantum theory. The effect of CO2 on isolated chloroplasts has been confirmed and some of the conditions which are necessary for the demonstration of the effect have been defined. It is not clear if CO2 is actually metabolized as Warburg claims. Contrary to Warburg's model, its participation seems to be at a site remote from the photochemical act. A number of other reasons for doubting the reality of the one-quantum mechanism are presented.

scholarly journals A fragment of antithrombin that binds both heparin and thrombin

1986 ◽  
Vol 237 (3) ◽  
pp. 639-646 ◽  
Author(s):  
L Rosenfeld ◽  
I Danishefsky
Keyword(s):  
Rate Constant ◽  
Inhibitory Activity ◽  
Order Rate Constant ◽  
Neutralizing Activity ◽  
Unique Fragment ◽  
High Concentrations ◽  
The One ◽  
A Site ◽  
Polypeptide Chains ◽  
Inhibition Of Thrombin

In order to identify the regions of antithrombin that interact with heparin and thrombin, it was degraded with CNBr and the activities of the isolated products were investigated. These fragments did not exhibit direct thrombin-neutralizing activity; however, one unique fragment was found to bind to heparin-Sepharose and also to interfere with the inhibition of thrombin by intact antithrombin. This fragment was identified as the one consisting of three disulphide-linked polypeptide chains containing residues 1-17, 104-251 and 424-432. At a concentration of 46 nM, this product decreased the heparin-enhanced thrombin-inhibitory activity of antithrombin by half, and completely abolished this inhibition when above 300 nM. In the absence of heparin, the action of antithrombin was not completely nullified by the fragment, even when present at relatively high concentrations. At a given fragment concentration, the extent of inhibition was independent of antithrombin concentration over the range tested. It was found that the fragment decreased the second-order rate constant for the antithrombin-thrombin reaction. Reduction and alkylation of the fragment showed that the above properties reside primarily in the peptide with residues 104-251. It is concluded that this peptide possesses portions of the antithrombin molecule that bind to heparin as well as to a site on thrombin.

scholarly journals Changes in forms of available nitrogen and respiration in soil of beech forest as a reaction to a deforestation resulting from wind storm

2013 ◽  
Vol 61 (1) ◽  
pp. 107-113 ◽  
Author(s):  
Aleš Kučera ◽  
Ladislav Holík ◽  
Karel Marosz ◽  
Antonín Martiník ◽  
Dušan Vavříček
Keyword(s):  
Beech Forest ◽  
Nitrate Content ◽  
Available Nitrogen ◽  
Respiration Activity ◽  
Ammonium N ◽  
Significant Difference ◽  
The One ◽  
Long Term Observation ◽  
A Site

The article deals with the reaction of soil environment to a violent deforestation resulting from a wind storm. As a material, permanent inventory plot located in Training Forest Enterprise Masaryk Forest Křtiny was selected. The plot represents beech high forest, where soil was sampled from four types of sample plots: (1) maternal forest representing situation before the storm; (2) zone of transition from the maternal forest to the open area; (3) reafforested clearing; (4) natural evolution. From each sample plot type, 6 mixed samples of Ah horizon were analysed to assess N-ammonium (N-NH4+) and N-nitrates (NO3−) content and respiration activity. The results show a significant difference between the respiration activities of the particular sample plots, as well as a significant difference in the content of N-ammonium and N-nitrate forms, the maternal forest representing a site of the lowest biological (and respiration) activity on the one hand, and, on the other hand, site of high N-ammonium and low N-nitrate content, respectively. From the results, intensive nitrification caused by the deforestation is evident. The results are to be used as a starting level for a long-term observation of reaction of the forest beech ecosystem to deforestation and selected types of forest management.

scholarly journals KUPU-KUPU DI ATAS BUNGA – ANGIN MENARI MELALUI PADANG: MENYIMAK FILSAFAT SENI MARTIN HEIDEGGER

2019 ◽  
Vol 10 (1) ◽  
pp. 45-82
Author(s):  
Yasintus T. Runesi
Keyword(s):  
Martin Heidegger ◽  
Common Sense ◽  
Small Dimension ◽  
The Other ◽  
Human Being ◽  
Work Of Art ◽  
Art And Politics ◽  
Contemporary Politics ◽  
The One ◽  
A Site

In his path of thinking, particularly from the 1930s onwards, Martin Heidegger firmly believed that Sein reveals itself, when human being, whom he termed as Dasein, awakened from his blindness of common sense and struggle for grasps his own authenticity. In this paper I examine Heidegger’s destruction of the work of art as a site of strife between art and politics in his text, Der Ursprung des Kunstwerkes. Heidegger’s position is complex: on the one hand, he acknowledges that Sein is a phenomenon beyond our horizon of understanding, Sein is all about not something particular; on the other hand, he insists that Sein’s presence through art inscribed in a certain particular identity, especially German volks. In response, I argue that the identification of Sein with a particular identity such as German volks, offers the truth that the politics itself is forged and instituted in and as work of art. Some conclusions will be drawn concerning the importance of the small dimension of Heidegger’s thought on art in contemporary politics.

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