Effects of Hormonal Contraceptives on Breast Milk Composition and Infant Growth

1988 ◽  
Vol 19 (6) ◽  
pp. 361 ◽  
Keyword(s):  
Breast Milk ◽  
Milk Composition ◽  
Infant Growth ◽  
Hormonal Contraceptives

Exercise and Lactation: Are They Compatible?

2001 ◽  
Vol 26 (1) ◽  
pp. 55-74 ◽  
Author(s):  
Gale B. Carey ◽  
Timothy J. Quinn
Keyword(s):  
Breast Milk ◽  
Maternal Health ◽  
Growth And Development ◽  
Well Being ◽  
Milk Composition ◽  
Infant Growth ◽  
Cardiovascular Fitness ◽  
Milk Volume ◽  
Exercising Women ◽  
Pregnancy And Lactation

Lactation is an energy-demanding physiological process for the maternal organism and life-giving for the offspring. Likewise, exercise is an energy-demanding process. This review addresses the Compatibility of exercise during lactation. Human studies suggest no detrimental effect of exercise during lactation on milk composition and volume, infant growth and development, or maternal health. Studies also demonstrate improved cardiovascular fitness in lactating, exercising women and suggest a quicker return to pre-pregnancy body weight and a more positive sense of well-being, compared to sedentary controls. Findings from rodent studies, although of questionable value for humans, have generally shown no detrimental influence of exercise during pregnancy and lactation on pup growth and development. To date, findings suggest that exercise and lactation are compatible activities. Key words: maternal health, infant growth, breast milk composition, breast milk volume, cardiovascular fitness

scholarly journals Microbiota and Metabolomic Patterns in the Breast Milk of Subjects with Celiac Disease on a Gluten-Free Diet

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2243
Author(s):  
Katherine L. Olshan ◽  
Ali R. Zomorrodi ◽  
Meritxell Pujolassos ◽  
Jacopo Troisi ◽  
Nayeim Khan ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Breast Milk ◽  
Milk Composition ◽  
Gluten Free Diet ◽  
Intestinal Microbiome ◽  
Healthy Controls ◽  
Gluten Free ◽  
Bacterial Strains ◽  
Shotgun Metagenomics ◽  
Functional Pathways

The intestinal microbiome may trigger celiac disease (CD) in individuals with a genetic disposition when exposed to dietary gluten. Research demonstrates that nutrition during infancy is crucial to the intestinal microbiome engraftment. Very few studies to date have focused on the breast milk composition of subjects with a history of CD on a gluten-free diet. Here, we utilize a multi-omics approach with shotgun metagenomics to analyze the breast milk microbiome integrated with metabolome profiling of 36 subjects, 20 with CD on a gluten-free diet and 16 healthy controls. These analyses identified significant differences in bacterial and viral species/strains and functional pathways but no difference in metabolite abundance. Specifically, three bacterial strains with increased abundance were identified in subjects with CD on a gluten-free diet of which one (Rothia mucilaginosa) has been previously linked to autoimmune conditions. We also identified five pathways with increased abundance in subjects with CD on a gluten-free diet. We additionally found four bacterial and two viral species/strains with increased abundance in healthy controls. Overall, the differences observed in bacterial and viral species/strains and in functional pathways observed in our analysis may influence microbiome engraftment in neonates, which may impact their future clinical outcomes.

scholarly journals Psychosocial stress and cortisol stress reactivity predict breast milk composition

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anna Ziomkiewicz ◽  
Magdalena Babiszewska ◽  
Anna Apanasewicz ◽  
Magdalena Piosek ◽  
Patrycja Wychowaniec ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Breast Milk ◽  
Psychosocial Stress ◽  
Stress Reactivity ◽  
Unsaturated Fatty Acids ◽  
Fatty Acid Content ◽  
Milk Composition ◽  
Stressful Events ◽  
Psychological Status ◽  
Long Chain

AbstractWe studied a sample of 146 Polish, exclusively breastfeeding mothers and their healthy born on time infants to explore the effect of perinatal psychosocial stress on breast milk composition. Maternal perinatal stress was assessed using Recent Life Changes Questionnaire summarizing stressful events from the previous six months. Stress reactivity was determined by administering the cold pressor test and measuring cortisol in saliva samples taken during the test. Breast milk sample was taken to measure energy, protein, fat, lactose, and fatty acid content. Analyses revealed that stress reactivity was positively associated with milk fat and long-chain unsaturated fatty acids and negatively associated with milk lactose. Perinatal psychosocial stress negatively affected energy density, fat as well as medium-chain and long-chain saturated fatty acids in milk. These results, together with previous studies, advocate monitoring maternal psychological status during the peripartum to promote breastfeeding and healthy infant nutrition.

scholarly journals The Triad Mother-Breast Milk-Infant as Predictor of Future Health: A Narrative Review

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 486 ◽  
Author(s):  
Elvira Verduci ◽  
Maria Lorella Giannì ◽  
Giulia Vizzari ◽  
Sara Vizzuso ◽  
Jacopo Cerasani ◽  
...  
Keyword(s):  
Health Outcome ◽  
Breast Milk ◽  
Human Milk ◽  
Maternal Diet ◽  
Milk Composition ◽  
Narrative Review ◽  
Future Health ◽  
Interconnected System ◽  
Offspring Health ◽  
Diet And Lifestyle

The benefits of human milk for both mother and infant are widely acknowledged. Human milk could represent a link between maternal and offspring health. The triad mother-breast milk-infant is an interconnected system in which maternal diet and lifestyle might have effects on infant’s health outcome. This link could be in part explained by epigenetics, even if the underlining mechanisms have not been fully clarified yet. The aim of this paper is to update the association between maternal diet and human milk, pointing out how maternal diet and lifestyle could be associated with breast-milk composition, hence with offspring’s health outcome.

scholarly journals Human Milk Composition and Dietary Intakes of Breastfeeding Women of Different Ethnicity from the Manawatu-Wanganui Region of New Zealand

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1231 ◽  
Author(s):  
Christine Butts ◽  
Duncan Hedderley ◽  
Thanuja Herath ◽  
Gunaranjan Paturi ◽  
Sarah Glyn-Jones ◽  
...  
Keyword(s):  
Fatty Acids ◽  
New Zealand ◽  
Breast Milk ◽  
Human Milk ◽  
Milk Composition ◽  
Pacific Island ◽  
Dietary Intakes ◽  
Omega 3 ◽  
Food Diary ◽  
Milk Samples

Human milk is nutrient rich, complex in its composition, and is key to a baby’s health through its role in nutrition, gastrointestinal tract and immune development. Seventy-eight mothers (19–42 years of age) of Asian, Māori, Pacific Island, or of European ethnicity living in Manawatu-Wanganui, New Zealand (NZ) completed the study. The women provided three breast milk samples over a one-week period (6–8 weeks postpartum), completed a three-day food diary and provided information regarding their pregnancy and lactation experiences. The breast milk samples were analyzed for protein, fat, fatty acid profile, ash, selected minerals (calcium, magnesium, selenium, zinc), and carbohydrates. Breast milk nutrient profiles showed no significant differences between the mothers of different ethnicities in their macronutrient (protein, fat, carbohydrate, and moisture) content. The breast milk of Asian mothers contained significantly higher levels of polyunsaturated fatty acids (PUFAs), omega-3 (n-3) and omega-6 (n-6) fatty acids, docosahexaenoic acid (DHA), and linoleic acids. Arachidonic acid was significantly lower in the breast milk of Māori and Pacific Island women. Dietary intakes of protein, total energy, saturated and polyunsaturated fat, calcium, phosphorus, zinc, iodine, vitamin A equivalents, and folate differed between the ethnic groups, as well as the number of serves of dairy foods, chicken, and legumes. No strong correlations between dietary nutrients and breast milk components were found.

scholarly journals What Evidence Do We Have for Pharmaceutical Galactagogues in the Treatment of Lactation Insufficiency?—A Narrative Review

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 974 ◽  
Author(s):  
Luke E. Grzeskowiak ◽  
Mary E. Wlodek ◽  
Donna T. Geddes
Keyword(s):  
Clinical Practice ◽  
Breast Milk ◽  
Milk Composition ◽  
Narrative Review ◽  
Pharmacological Intervention ◽  
Future Research ◽  
Individual Treatment ◽  
Efficacy And Safety ◽  
Milk Supply ◽  
Insufficient Milk

Inadequate breast milk supply is a frequently reported reason for early discontinuation of breastfeeding and represents a critical opportunity for intervening to improve breastfeeding outcomes. For women who continue to experience insufficient milk supply despite the utilisation of non-pharmacological lactation support strategies, pharmacological intervention with medications used to augment lactation, commonly referred to as galactagogues, is common. Galactagogues exert their pharmacological effects through altering the complex hormonal milieu regulating lactation, particularly prolactin and oxytocin. This narrative review provides an appraisal of the existing evidence regarding the efficacy and safety of pharmaceutical treatments for lactation insufficiency to guide their use in clinical practice. The greatest body of evidence surrounds the use of domperidone, with studies demonstrating moderate short-term improvements in breast milk supply. Evidence regarding the efficacy and safety of metoclopramide is less robust, but given that it shares the same mechanism of action as domperidone it may represent a potential treatment alternative where domperidone is unsuitable. Data on remaining interventions such as oxytocin, prolactin and metformin is too limited to support their use in clinical practice. The review provides an overview of key evidence gaps and areas of future research, including the impacts of pharmaceutical galactagogues on breast milk composition and understanding factors contributing to individual treatment response to pharmaceutical galactagogues.

Human milk composition and infant growth

2018 ◽  
Vol 21 (3) ◽  
pp. 200-206 ◽  
Author(s):  
Kamilla G. Eriksen ◽  
Sophie H. Christensen ◽  
Mads V. Lind ◽  
Kim F. Michaelsen
Keyword(s):  
Human Milk ◽  
Milk Composition ◽  
Infant Growth

scholarly journals Breast Milk Macronutrient Components in Prolonged Lactation

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1893 ◽  
Author(s):  
Matylda Czosnykowska-Łukacka ◽  
Barbara Królak-Olejnik ◽  
Magdalena Orczyk-Pawiłowicz
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Energy Demand ◽  
Infant Nutrition ◽  
Early Stage ◽  
Dietary Exposure ◽  
Milk Composition ◽  
Limited Data ◽  
Older Children ◽  
Healthy Development

Human milk (HM) is the first dietary exposure in infancy and the best nutritional option for growth and healthy development of the newborn and infant. The concentrations of macronutrients, namely proteins, carbohydrates and lipids, change during lactation stages. HM has been studied extensively in the first 6 months of lactation, but there are limited data regarding milk composition beyond 1 or 2 years postpartum. The aim of our study was to describe longitudinal changes in HM macronutrient concentrations during the prolonged lactation of healthy mothers from the 1st to the 48th month. For the macronutrient content of milk of mothers breastfeeding for longer than 18 months, fat and protein increased and carbohydrates decreased significantly, compared with milk expressed by women breastfeeding up to 12 months. Moreover, the concentration of fat, protein and carbohydrates in HM over 2 years of lactation from the 24th to the 48th month remained at a stable level. However, analyzed macronutrients were positively (carbohydrate, r = 0.51) or negatively (fat, r = −0.36 and protein, r = −0.58) correlated with the amount of feeding. Our results create a greater potential for understanding the nutritional contribution of HM over 2 years of lactation and showed that the source of calories in breast milk for older children is mainly fat, while carbohydrates play a greater role in infant nutrition in the early stage. The observed changes of macronutrient concentrations from the 1st to the 48th month of lactation are probably related to the adaptation of milk composition to the increased energy demand of the intensively growing child.

scholarly journals New strategies for profiling and characterization of human milk oligosaccharides

Glycobiology ◽  
2020 ◽  
Vol 30 (10) ◽  
pp. 774-786 ◽  
Author(s):  
Sara Porfirio ◽  
Stephanie Archer-Hartmann ◽  
G Brett Moreau ◽  
Girija Ramakrishnan ◽  
Rashidul Haque ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Milk Composition ◽  
Human Breast Milk ◽  
Human Milk Oligosaccharides ◽  
Bacterial Strains ◽  
Milk Oligosaccharides ◽  
Vast Number ◽  
The Impact

Abstract Human breast milk is an incredibly rich and complex biofluid composed of proteins, lipids and complex carbohydrates, including a diverse repertoire of free human milk oligosaccharides (HMOs). Strikingly, HMOs are not digested by the infant but function as prebiotics for bacterial strains associated with numerous benefits. Considering the broad variety of beneficial effects of HMOs, and the vast number of factors that affect breast milk composition, the analysis of HMO diversity and complexity is of utmost relevance. Using human milk samples from a cohort of Bangladeshi mothers participating in a study on malnutrition and stunting in children, we have characterized breast milk oligosaccharide composition by means of permethylation followed by liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-MS/MS) analysis. This approach identified over 100 different glycoforms and showed a wide diversity of milk composition, with a predominance of fucosylated and sialylated HMOs over nonmodified HMOs. We observed that these samples contain on average 80 HMOs, with the highest permethylated masses detected being >5000 mass units. Here we report an easily implemented method developed for the separation, characterization and relative quantitation of large arrays of HMOs, including higher molecular weight sialylated HMOs. Our ultimate goal is to create a simple, high-throughput method, which can be used for full characterization of sialylated and/or fucosylated HMOs. These results demonstrate how current analytical techniques can be applied to characterize human milk composition, providing new tools to help the scientific community shed new light on the impact of HMOs during infant development.

Sign in / Sign up

Export Citation Format

Share Document