scholarly journals Evaluation of the depth of infiltration of urothelial carcinoma in the vesical wall obtained by transurethral intravesical echotomography

2007 ◽  
Vol 64 (10) ◽  
pp. 677-683
Author(s):  
Radovan Milosevic ◽  
Novak Milovic ◽  
Borislav Stijelja ◽  
Milan Djokic ◽  
Zoran Campara ◽  
...  
Keyword(s):  
Ct Scan ◽  
Urothelial Carcinoma ◽  
Treatment Planning ◽  
Clinical Investigation ◽  
Tnm Classification ◽  
Transitional Cell ◽  
The Body ◽  
Significant Difference ◽  
The Difference ◽  
Depth Of Infiltration

Background/Aim. Transitional cell carcinoma (TCC) is the most frequent tumor of the bladder and represents 95?98% of blader neoplasams and 2?3% of all carcinomas in the body. In urogenital oncology more frequent is only prostatic cancer. Evaluation of the depth of infiltration of urothelial carcinoma in the vesical wall represents the clinical base in treatment planning and prognosis. Clinical investigation and convential radiological procedures have a low level of accuracy in estimating the local growth of the tumor. The aims of our investigation were to determine the depth of infiltration of urothelial carcinoma in the vesical wall in the investigated group of patients by transurethral intravesical echotomography (TIE) and computerised tomography (CT scan) and to compare results obtained by both methods with pathohistological (PH) results, and, based on the difference of the results determine which method was more accurate in the evaluation of the depth of infiltration of urothelial carcinoma in the vesical wall. Methods. Thirty patients with TCC of the bladder both genders, aged 51?81 years were involved in our investigation. In all of these patients, radical cystectomy (RC) was performed. This was neccessary to provide the defintive PH result. Transurethral intravesical echotomography was performed by ultrasound scanner type 1846 Bruel and Kjaer, sond type 1850, and the CT scan was perfomed by Pace plus, General Electric, U.S.A. The specimen for the definitive PH result obtained by RC includes all standards of the TNM classification. Results. Using CT scan, the most frequent was T1 stage (17 patients or 56.68%). Using TIE, the most frequent was T2 stage (22 patients or 73.33%). After RC the most frequent was T2 stage (21 patients or 70%). The Kolmogorov-Smirnov test, showed a high significant difference between the results obtained using CT and definitive PH results after RC. The same test showed no statistically significant difference between the results obtained using TIE and definitive PH results. The sensitivity and accurance of TIE compared to definitive PH results was 93.3%, but using CT it was only 33.3%. Conclusion. There was a significant difference between the results obtained using CT and TIE. The results obtained by TIE were in closer relation with the definitive PH results than the results obtained by CT scan. TIE provides more precise evaluation of the depth of infiltration of urothelial carcinoma in the vesical wall than CT scan. We conclude that the use of this procedure in local staging in TCC is justified and represents the clinical basis in the treatment planning and disease outcome prognosis.

Perbedaan Penggunaan Antikoagulan K2EDTA DAN K3EDTA Terhadap Hasil Pemeriksaan Indeks Eritrosit

2018 ◽  
Vol 1 (2) ◽  
pp. 114
Author(s):  
Wahdaniah Wahdaniah ◽  
Sri Tumpuk
Keyword(s):  
Screening Test ◽  
Venous Blood ◽  
The Body ◽  
Ethylene Diamine ◽  
P Value ◽  
Cross Sectional ◽  
Significant Difference ◽  
Ethylene Diamine Tetra Acetate ◽  
The Difference ◽  
Index Value

Abstract: Routine blood examination is the earliest blood test or screening test to determine the diagnosis of an abnormality. Blood easily froze if it is outside the body and can be prevented by the addition of anticoagulants, one of which Ethylene Diamine Tetra Acetate (EDTA). Currently available vacuum tubes containing EDTA anticoagulants in the form of K2EDTA and K3EDTA. K3EDTA is usually a salt that has better stability than other EDTA salts because it shows a pH approaching a blood pH of about 6.4. The purpose of this research is to know the difference of erythrocyte index results include MCH, MCV and MCHC using K3EDTA anticoagulant with K2EDTA. This research is a cross sectional design. This study used venous blood samples mixed with K2EDTA anticoagulant and venous blood mixed with K3EDTA anticoagulants, each of 30 samples. Data were collected and analyzed using paired different test. Based on data analysis that has been done on MCH examination, p value <0,05 then there is a significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value. Then on the examination of MCV and MCHC obtained p value <0.05 then there is no significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value.Abstrak: Pemeriksaan darah rutin merupakan pemeriksaan darah yang paling awal atau screening test untuk mengetahui diagnosis suatu kelainan. Darah mudah membeku jika berada diluar tubuh dan bisa dicegah dengan penambahan antikoagulan, salah satunya Ethylene Diamine Tetra Acetate (EDTA). Dewasa ini telah tersedia tabung vakum yang sudah berisi antikoagulan EDTA dalam bentuk  K2EDTA dan  K3EDTA. K3EDTA  biasanya berupa garam yang mempunyai stabilitas yang lebih baik dari garam EDTA yang lain karena menunjukkan pH yang mendekati pH darah yaitu sekitar 6,4. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan hasil indeks eritrosit meliputi MCH, MCV dan MCHC menggunakan antikoagulan K3EDTA dengan K2EDTA. Penelitian ini merupakan penelitian dengan desain cross sectional. Penelitian ini menggunakan sampel darah vena yang dicampur dengan antikoagulan K2EDTA dan darah vena yang dicampur dengan antikoagulan K3EDTA, masing-masing sebanyak 30 sampel. Data dikumpulkan dan dianalisis menggunakan uji beda berpasangan. Berdasarkan analisis data yang telah dilakukan pada pemeriksaan MCH didapatkan nilai p < 0,05 maka ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit. Kemudian pada pemeriksaan MCV dan MCHC didapatkan nilai p < 0,05 maka tidak ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit.

scholarly journals Systematic Review of the Role of BCG in the Treatment of Urothelial Carcinoma of the Prostatic Urethra

2021 ◽  
pp. 1-8
Author(s):  
Oliver Patschan ◽  
Philippe E. Spiess ◽  
George N. Thalmann ◽  
Joan Palou Redorta ◽  
Georgios Gakis
Keyword(s):  
Side Effects ◽  
Urothelial Carcinoma ◽  
Evidence Synthesis ◽  
Tnm Classification ◽  
Transitional Cell ◽  
Prostatic Urethra ◽  
Local Response ◽  
Pubmed Database ◽  
Bcg Therapy ◽  
Tumor Stages

BACKGROUND: In patients with non-invasive urothelial carcinoma of the prostatic urethra (PUC), treatment with Bacillus Calmette-Guárin (BCG) could be beneficial. OBJECTIVE: To assess the response rates to BCG in the different tumor stages, to describe the clinical impact of transurethral resection of the prostate (TURP) before BCG treatment, and to review the side effects of BCG treatment for PUC. METHODS: A systematic search was conducted using the PubMed database to identify original studies between 1977 and 2019 reporting on PUC and BCG. RESULTS: Of a total of 865 studies, ten were considered for evidence synthesis. An indication for BCG treatment was found in non-stromal invasive stages (Tis pu, Tis pd) and in stromal infiltrating cases (T1) of primary and secondary PUC when transitional cell carcinoma was the histology of origin. Studies including patients treated with TURP before BCG showed a better local response in the prostatic urethra with a higher DFS (80–100% vs. 63–89%) and PFS (90–100% vs. 75–94%) than patients in studies in which no TURP was performed. However, this difference in recurrence and progression in the prostate neither affected the total PFS (57–75% vs. 58–93%), nor the disease specific survival (70–100% vs. 66–100%). CONCLUSIONS: The use of resection loop biopsies of the prostatic urethra in appropriate cases during the primary work-up for suspected PUC, as well as the use of the current TNM classification for PUC, need to be improved. BCG therapy for non-stromal invasive stages of PUC show a good local response. Local response is further improved by a TURP before BCG therapy, although the overall prognosis does not seem to be affected. Further evidence for BCG treatment in the rare cases of stromal invasive PUC is needed. Specific side effects of BCG treatment for PUC are not reported.

scholarly journals The difference in pediatric blood pressure between middle childhood and late childhood prior to dental treatment

2018 ◽  
Vol 25 (1) ◽  
Author(s):  
Fitri Anissa Syaimima Syaiful Azim ◽  
Arlette Suzy Puspa Pertiwi ◽  
Rosiliwati Wihardja
Keyword(s):  
Blood Pressure ◽  
Middle Childhood ◽  
Dental Treatment ◽  
Systolic Pressure ◽  
The Body ◽  
Late Childhood ◽  
Test Analysis ◽  
Mean Values ◽  
Significant Difference ◽  
The Difference

Every child will go through several stages in his or her life. They are different from each other as they are in the process of development of cognition, physics, emotion, and personality. For many children, a visit to the dentist can raise their anxiety. This anxiousness will lead to stress that influences the cardiovascular function in the body. The purpose of this research was to determine the difference in pediatric blood pressure between middle childhood and late childhood prior to dental treatment. This research was a clinical trial, pure experimental study. The sample consisted of 30 children within the range of 4-12 years old where they were divided into two groups of age; middle childhood (4-7 years old) and late childhood (8-12 years old). The blood pressures were measured before any dental treatment began and the values were recorded. The data were then analyzed using the One-Sample T-Test analysis. The results of blood pressure in middle childhood and late childhood were compared to the average mean values for each age group. It showed that there was a significant difference in the systolic pressure, which was found higher in the middle childhood group compared to the late childhood. From the result can be concluded that there was a difference in the pediatric blood pressure between middle childhood and late childhood prior to dental treatment.

Platelet Mechanosensing: Adhesion and Spreading On Immobilized Fibrinogen Depends On Substrate Stiffness

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 384-384
Author(s):  
Yongzhi Qiu ◽  
Ashley C Brown ◽  
Woo Jin Jung ◽  
Yumiko Sakurai ◽  
Robert Mannino ◽  
...  
Keyword(s):  
Physical Properties ◽  
Platelet Adhesion ◽  
The Body ◽  
Substrate Stiffness ◽  
Fibrinogen Concentration ◽  
Spreading Area ◽  
Significant Difference ◽  
The Difference ◽  
Underlying Substrate ◽  
Covalently Bound

Abstract Abstract 384 Background: Whereas surface-immobilized fibrinogen readily causes platelet adhesion and spreading, soluble fibrinogen, on the other hand, does not lead to platelet activation without the presence of other hemostatic/thrombotic signals. This dramatically different response of platelets to fibrinogen may be due to biochemical difference in fibrinogen unfolding (Agnihotri, et al., Langmuir, 2004), but may also be due to the difference in how platelets directly react to the physical properties of the substrate underneath the fibrinogen. Similarly, recent studies have shown that many types of adherent eukaryotic cells respond differently to substrates of different physical properties. In particular, cells are able to mechanosense the stiffness of their underlying substrate, and to change their spreading, re-organize their cytoskeleton, and even alter gene expression responding to the sensed stiffness (Discher, et al., Science, 2005). More specific to platelets, our group has recently shown that the contraction of single platelets on fibrinogen surfaces increases with increasing substrate stiffness (Lam, et al., Nat Mater, 2011). Therefore, we hypothesize that substrate stiffness can also affect platelet adhesion and spreading on fibrinogen. In this study, we synthesized polyacrylamide (PAA) gels, which can be tuned to different stiffnesses and easily modified with covalently-bound fibrinogen on the surface. This assay enables independent control of substrate stiffness while maintaining constant biochemical composition and fibrinogen density, and we applied this system to quantitatively investigate the role of substrate stiffness in platelet adhesion and spreading on fibrinogen. Results and Discussions: 3 μg/ml fibrinogen was covalently bound to the surface of PAA gels of different stiffnesses (0.25, 0.5, 2.5, 5, 50 and 100 kilopascals (KPa)) (Figure 1A). This applied range of substrate stiffness mimics the stiffness of different tissues in the body (Engler, et al., Cell, 2006). Moreover, glass (with a stiffness of ∼65–70 × 103 KPa) adsorbed with 3 μg/ml fibrinogen was also used for comparison. During 2 hour incubations, washed human platelets differently adhered to and spread on the surface of PAA gels. By simply varying the stiffness of the fibrinogen-bound PAA gels, we observed dramatic differences in the number of adherent platelets and their morphology (Figure 1B). The number of adherent platelets increased with increasing stiffness, reaching a plateau at 2.5 KPa, with adherence similar to that of fibrinogen-adsorbed glass (Figure 1C). While platelets did not spread on 2.5 KPa and softer gels, approximately 30–40% adherent platelets spread on 5KPa and stiffer gels, resulting in a significantly higher average spreading area of adherent platelets (Figure 1D and E). However, compared to all the gels, mostly all platelets adhered on glass surface spread (area > 35 μm2) and showed a significantly higher spreading area (Figure 1D and E). Moreover, no significant difference in fibrinogen concentration was detected among fibrinogen-bound PAA gels of different stiffnesses and fibrinogen-adsorbed glass (Data not shown), which indicated that the difference we observed could be independently due to the substrate stiffness. Conclusions and Ongoing Efforts: Our data suggest that platelets sense the mechanical properties of the underlying substrate to fine-tune the degree of adhesion and spreading on fibrinogen. Thus, fibrinogen on soft substrates appears to activate platelets to a lesser degree than the same concentration of fibrinogen on stiffer substrates. We are currently investigating how substrate stiffness triggers mechanotransduction in platelets and affects their outside-in activation and signaling. Our study also provides potential insights for preventing clot formation on implanted biomaterials and medical devices. Disclosures: No relevant conflicts of interest to declare.

Exposure to priority organochlorine contaminants in the Italian general population. Part 2

2013 ◽  
Vol 33 (2) ◽  
pp. 170-184 ◽  
Author(s):  
EJ Mrema ◽  
FM Rubino ◽  
S Mandic-Rajcevic ◽  
E Sturchio ◽  
R Turci ◽  
...  
Keyword(s):  
Body Mass Index ◽  
General Population ◽  
Polychlorinated Biphenyl ◽  
The Body ◽  
Population Total ◽  
Pcb Congeners ◽  
Organochlorine Contaminants ◽  
Significant Difference ◽  
The Difference ◽  
Age Range

Concentrations of 36 polychlorinated biphenyl (PCB) congeners were measured in serum of 372 Italian residents of general population living in Novafeltria, Pavia, and Milan. Total PCB level differed significantly between these sites ( p < 0.0001) with median concentrations of 836.50, 1354.57, and 2062.08 pmol/g lipid, respectively. However, there is no evidence for the difference in distribution of total PCB levels by genders. Total dioxin-like PCBs differed significantly ( p < 0.0001) between the sites (median 109.78, 50.88, and 166.99 pmol/g lipid, respectively) and genders of Novafeltria and Pavia ( p = 0.011 and 0.009, respectively). PCB 138, 153, 170, and 180 differed significantly between the places of residence ( p < 0.0001) with higher values in Milan population. In the overall population, total PCB and PCB 138, 153, 156, 170, and 180 correlated positively with age (correlations range between 0.320 and 0.569, p < 0.0001). In Novafeltria, the correlations ranged between 0.545 and 0.670, and in Pavia, the correlations ranged between 0.516 and 0.666. In Milan, correlations with age range between 0.327 and 0.417 for total PCB and congeners 138, 153, and 180. With an exception of PCB 170, there was no evidence of significant difference in the distribution of most abundant PCB congeners and total PCB across the body mass index categories.

scholarly journals Evaluation of Pupils’ Knowledge about Kidney Health

2021 ◽  
Vol 18 (23) ◽  
pp. 12811
Author(s):  
Theodore Vassilikopoulos ◽  
Athena Kalokairinou ◽  
Georgia Kourlaba ◽  
Eirini Grapsa
Keyword(s):  
Renal Function ◽  
General Education ◽  
Knowledge Score ◽  
Cross Sectional Study ◽  
The Body ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Significant Difference ◽  
The Difference ◽  
Clinically Significant

The purpose of this study was to investigate the level of renal function knowledge of primary school pupils in Greece. We conducted a cross-sectional study with a convenience sample of 220 pupils, coming from the 5th and 6th grades of general education schools. A questionnaire consisting of 11 questions was developed from scratch. However, based on an analysis of Cronbach’s alpha values obtained when individual questions were deleted, two questions were removed from the analysis, and only nine remained for analysis and participated in the calculation of the knowledge score. Moreover, the gender and daily habits of pupils regarding water consumption and frequency of urination were recorded. Pupils had a high percentage of correct knowledge about the number of kidneys (95.2%), whether a child may have problems with the kidneys (85.5%) and whether a person can survive with one kidney (68.5%). Low levels of knowledge were observed in the function and role of the kidneys (36.4%), as well as the part of the body where the kidneys are located (30.9%). The median (interquartile range (IQR)) total knowledge score was 6 (5–7), with no difference detected between genders (p = 0.135). A statistically significant difference between pupils of 5th and 6th grades was found but the difference did not seem to be clinically significant (p = 0.035). The present research demonstrates that pupils’ knowledge of renal function and the protection of their kidneys needs improvement.

scholarly journals The Knowledge and The Hydration Status of Junior Martial Art Athletes

2021 ◽  
Vol 13 (2) ◽  
pp. 164
Author(s):  
Ajeng Sindi Tirtasari ◽  
Kunjung Ashadi
Keyword(s):  
Female Athletes ◽  
The Body ◽  
Hydration Status ◽  
Multiple Choice Questions ◽  
Male Athletes ◽  
Youth Athletes ◽  
Martial Art ◽  
Significant Difference ◽  
Before And After ◽  
The Difference

The purpose of this study was to determine the adequacy of fluids in the body during training for youth athletes of martial arts. The research method uses descriptive quantitative. Data collection techniques were obtained from urine tests, interviews, and multiple choice questions on 10 athletes consisting of five male athletes and five female athletes of martial art with a maximum age criteria of 18 years. Data analysis techniques used mean, standard deviation, percentage, graph, normality, and different test Paired Sample T Test to find out the difference in the mean. Athletes' knowledge of hydration was in the moderate category and there was a significant difference (Sig. <0.05) in the average hydration before and after training by the Madiun Regency martial art athletes.  

Water Content and Water Activity in the Cuticle of Terrestrial Isopods

1972 ◽  
Vol 56 (1) ◽  
pp. 49-55
Author(s):  
OSSI V. LINDQVIST ◽  
INGA SALMINEN ◽  
PAUL W. WINSTON
Keyword(s):  
Body Weight ◽  
Water Content ◽  
Water Activity ◽  
Equilibrium Points ◽  
The Body ◽  
Porcellio Scaber ◽  
Terrestrial Isopods ◽  
Osmotic Equilibrium ◽  
Significant Difference ◽  
The Difference

1. The water content of the cuticle of both desiccated and non-desiccated terrestrial isopods Porcellio scaber and Armadillidium vulgare was measured. The animals were desiccated for various times (up to 3 h) over silica gel and the mean water content of the cuticle was 54.0±0.78% for P. scaber and 52.7±1.11% for A. vulgare. There was no trend as regards the desiccation time, nor did the body weight affect the water content. 2. The water content of the cuticle remained virtually unchanged as long as the animal was alive in the desiccator. It dropped significantly after the animal had died after having lost some 30% of its body weight. 3. The cuticular water content of non-desiccated P. scaber tended to be slightly higher than that of desiccated ones. In A. vulgare no significant difference was observed between non-desiccated and desiccated specimens. 4. The water activity of the excised cuticle of the above two species and of Oniscus asellus and Cylisticus convexus was above that of the haemolymph and therefore not in osmotic equilibrium with it. The osmotic equilibrium points were below the osmotic pressures of the blood; the difference amounted from 1.5 to 2.8 atm. in different species. 5. The difference in water activity between blood and cuticle, the maintenance of water content with desiccation, and the drop in water level at death, all indicate the presence of an active mechanism regulating the cuticular water in terrestrial isopods.

Should registrars be reporting after-hours CT scans? A calculation of error rate and the influencing factors in South Africa

2012 ◽  
Vol 53 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Owen D Terreblanche ◽  
Savvas Andronikou ◽  
Linda T Hlabangana ◽  
Taryn Brown ◽  
Pieter E Boshoff
Keyword(s):  
South Africa ◽  
Influencing Factors ◽  
Error Rate ◽  
The Body ◽  
Ct Scans ◽  
Body Region ◽  
Body Regions ◽  
Significant Difference ◽  
After Hours ◽  
The Difference

Background There is a heavy reliance on registrars for after-hours CT reporting with a resultant unavoidable error rate. Purpose To determine the after-hours CT reporting error rate by radiology registrars and influencing factors on this error rate. Material and Methods A 2-month prospective study was undertaken at two tertiary, level 1 trauma centers in Johannesburg, South Africa. Provisional CT reports issued by the registrar on call were reviewed by a qualified radiologist the following morning and information relating to the number, time and type of reporting errors made as well as the body region scanned, indication for the scan, year of training of the registrar, and workload during the call were recorded and analyzed. Results A total of 1477 CT scans were performed with an overall error rate of 17.1% and a major error rate of 7.7%. The error rate for 2nd, 3rd, and 4th year registrars was 19.4%, 15.1%, and 14.5%, respectively. A significant difference was found between the error rate in reporting trauma scans (15.8%) compared to non-trauma scans (19.2%) although the difference between emergency scans (16.9%) and elective scans (22.6%) was found to be not significant, a finding likely due to the low number of elective scans performed. Abdominopelvic scans elicited the highest number of errors (33.9%) compared to the other body regions such as head (16.5%) and cervical, thoracic, or lumbar spine (11.7%). Increasing workload resulted in a significant increase in error rate when analyzed with a generalized linear model. There was also a significant difference noted in the time of scan groups which we attributed to a workload effect. Missed findings were the most frequent errors seen (57.3%). Conclusion We found an increasing error rate associated with increasing workload and marked increase in errors with the reporting of abdominopelvic scans. There was a decrease in the error rate when looking an increasing year of training although this there was only found to be significant difference between the 2nd and 3rd year registrars.

scholarly journals Estimation of phenotypic variability of body measurements in Lipizzan mares

2019 ◽  
Vol 35 (4) ◽  
pp. 399-408
Author(s):  
Biljana Rogic ◽  
Bozo Vazic ◽  
Ivica Ravic
Keyword(s):  
Body Shape ◽  
Average Length ◽  
Phenotypic Variability ◽  
Correlation Coefficients ◽  
The Body ◽  
Body Measurements ◽  
Simple Analysis ◽  
Horse Breed ◽  
Significant Difference ◽  
The Difference

The aim of this work was a phenotypic description of the mare families of a Lipizzan horse breed from stud Vucijak. A total of 31 mares were measured, for every animal 28 measures were recorded. The mares are distributed by mare families in the following: Sana (3), Lipa (3), Bregava (3), Cremica (3), Ukrina (3), Visla (2), Neretva (3), Pliva (1), Drina (2), Sutjeska (2), Sitnica (1), Janja (2) and Sava. Simple analysis of variance was done to determine the difference in the morphological measures between mare families. Also, correlation between 28 measures was done. This study revealed phenotypic uniformity between mare families. Of the 28 measures recorded, a statistically significant difference was identified only for the length of cannon (front leg). The longest average length of the cannon (front leg) had at Sana (24.67 cm), and the shortest at Bregava (19.00 cm). The correlation ranged from slightly negative to highly positive with correlation coefficients from -0.465 to 0.779. Significant and highly significant correlation with height, length and depth was found in mare measures. The body shape of the mare families has a rectangular, which is in accordance with the Lipizzan horses from other stud in Europe. Also, the study revealed that mares from Vucijak are smaller than mares from other stud, which is in accordance with the breeding goals.

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