scholarly journals Modulatory effects of delta sleep-inducing peptide in a lindane model of generalized seizures

2018 ◽  
Vol 70 (3) ◽  
pp. 559-566
Author(s):  
Dragan Hrncic ◽  
Zeljko Grubac ◽  
Nikola Sutulovic ◽  
Aleksandra Rasic-Markovic ◽  
Anida Ademovic ◽  
...  
Keyword(s):  
Latency Period ◽  
Brain Regions ◽  
Male Rats ◽  
Behavioral Characteristics ◽  
Implanted Electrodes ◽  
Generalized Seizures ◽  
Prolonged Seizure ◽  
Delta Sleep ◽  
Descriptive Scale ◽  
Delta Sleep Inducing Peptide

Delta sleep-inducing peptide (DSIP) is an endogenous peptide that is constantly present in several different brain regions. Lindane is used as a pesticide and scabicide, but it also induces seizures refractory to conventional antiepileptics. The aim of this paper was to determine whether DSIP modulates lindane-induced seizures in rats in a behavioral and electroencephalographic (EEG) study. DSIP (1 mg/kg, i.p.) or dimethyl-sulfoxide (DMSO, 0.5 ml/kg, intraperitoneally (i.p.)) were injected 30 min before lindane (8 mg/kg, i.p.) to adult male rats with previously implanted electrodes for EEG registration. During the following 30 min, the EEG was registered, and the following behavioral characteristics of seizures were observed: incidence, latency and intensity. A descriptive scale with grades from 0 to 4 provided an estimate of seizure intensity. In the EEG, the number and duration of ictal periods were analyzed using NeuroSciLaBG (Belgrade, Serbia) software. The lethality rate was also analyzed. DSIP-treated animals showed significantly modified characteristics of lindane-induced seizures when compared to the group without DSIP pretreatment (i.e. a reduced seizure intensity and a prolonged seizure latency period). However, no significant effects of DSIP on seizure incidence and lindane-induced lethality were observed. EEG analyses showed a significantly decreased number of lindane-induced EEG ictal periods in DSIP-treated animals, but with unaltered duration. These results show that DSIP favorably modulates lindane-induced seizures in rats, showing a potential to be an adjuvant component of antiepileptic treatment strategy for refractory seizures.

STUDY OF THE COMBINED INFLUENCE OF SODIUM THIOPENTAL AND DELTA SLEEP-INDUCING PEPTIDE ON ANTIOXIDANT DEFENSE SYSTEM IN RATS

2016 ◽  
pp. 49-52
Author(s):  
A. V. Shvetsov ◽  
E. G. Batotsyrenova ◽  
N. A. Dyuzhikova ◽  
V. A. Kashuro ◽  
N. V. Lapina ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Time Interval ◽  
Sodium Thiopental ◽  
Antioxidant Defense Enzymes ◽  
Delta Sleep ◽  
Thiopental Coma ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Delta Sleep Inducing Peptide

A biochemical investigation was performed into activity of rat antioxidant defense enzymes at different time interval after administration of sodium thiopental and delta-sleep-inducing peptide (DSIP). It was shown that thiopental coma was accompanied by a decreased level of superoxide dismutase ( 6 and 24 h after exposure) and increased level of caspase-3 ( 6 h after exposure) in the rat blood plasma. A pharmacological correction with DSIP induced a decrease of the level of superoxide dismutase ( 6 and 24 h after exposure), glutathione peroxidase and glucose 6-phosphate dehydrogenase (after 6h).

Characterization of Delta-Sleep-Inducing Peptide-Evoked Release of Met-Enkephalin from Brain Synaptosomes in Rats

1991 ◽  
Vol 57 (3) ◽  
pp. 1013-1018 ◽  
Author(s):  
Akihiro Nakamura ◽  
Kenji Sakai ◽  
Yukie Takahashi ◽  
Hirohito Shiomi
Keyword(s):  
Brain Synaptosomes ◽  
Delta Sleep ◽  
Delta Sleep Inducing Peptide

Delta sleep-inducing peptide and glucocorticoid-induced leucine zipper: potential links between circadian mechanisms and obesity?

2009 ◽  
Vol 10 ◽  
pp. 46-51 ◽  
Author(s):  
J. M. Gimble ◽  
A. A. Ptitsyn ◽  
B. C. Goh ◽  
T. Hebert ◽  
G. Yu ◽  
...  
Keyword(s):  
Leucine Zipper ◽  
Delta Sleep ◽  
Delta Sleep Inducing Peptide

P.3.064 Membrane-protective effect of delta-sleep inducing peptide

1997 ◽  
Vol 7 ◽  
pp. S245
Author(s):  
T.I. Bondarenko ◽  
I.A. Goronshinskaya ◽  
I.I. Mikhaleva
Keyword(s):  
Protective Effect ◽  
Delta Sleep ◽  
Delta Sleep Inducing Peptide

Cascade afteraction of delta sleep-inducing peptide in rats

1995 ◽  
Vol 119 (1) ◽  
pp. 1-4 ◽  
Author(s):  
K. V. Sudakov ◽  
J. P. Coghland ◽  
A. V. Kotov ◽  
R. M. Salieva ◽  
Yu. V. Polyntsev ◽  
...  
Keyword(s):  
Delta Sleep ◽  
Delta Sleep Inducing Peptide

Abstract P730: MCA Stroke Chronically Disrupts Hippocampal Activity and Cortico-Hippocampal Communication

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Zachary Ip ◽  
Gratianne Rabiller ◽  
Jiwei He ◽  
Shivalika Chavan ◽  
Yasuo Nishijima ◽  
...  
Keyword(s):  
Structural Integrity ◽  
Memory Function ◽  
Brain Regions ◽  
Male Rats ◽  
Brain State ◽  
Signal Power ◽  
Hippocampal Function ◽  
Electrode Arrays ◽  
Mca Occlusion ◽  
Hippocampal Activity

Introduction: Cognition and memory deficits are common sequelae following middle cerebral artery (MCA) stroke, one of the most common strokes in humans. However MCA stroke does not compromise the structural integrity of the hippocampus, which is highly involved in memory function, because the MCA does not supply blood flow to the hippocampus. We previously reported on the acute effect of MCA stroke, where we observed increased hippocampal activity and cortico-hippocampal communication. Here we investigate chronic changes to local oscillations and cortico-hippocampal communication following MCA occlusion in rats two weeks and one month following stroke. Hypothesis: Cortical stroke affects remote brain regions, disrupting hippocampal function and cortico-hippocampal communication. Methods: We subjected male rats (n=28) to distal MCA occlusion compared to controls (n=19). We recorded local field potentials simultaneously from cortex and hippocampus two weeks and one month following stroke using 16-site linear electrode arrays under urethane anesthesia. We analyzed signal power, brain state, CFC, and sharp wave SPW-Rs to assess hippocampal function and cortico-hippocampal communication. Results: Our results show disruptions to local oscillations; lowered delta (1-3 Hz) signal power in the cortex and hippocampus, increased signal power in gamma (30-60 Hz) and high gamma (60-200 Hz) in cortex and hippocampus. Theta/delta brain state is disrupted, and SPW-Rs increase in power at two weeks, before returning to baseline levels at one month. Communication is also disrupted; Theta-gamma coupling, a measure of information being communicated between regions, breaks down after stroke. Conclusions: These results suggest that chronic stroke causes significant changes to hippocampal function, which can be characterized by these electrophysiological biomarkers, establishing putative targets for targeted stimulation therapies.

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