Delta sleep-inducing peptide (DSIP) effect on brain structures of August and Wistar rats under dopaminergic system hyperfunction

2004 ◽  
Author(s):  
A. V. Sergutina ◽  
L. M. Gershtein
Keyword(s):  
Wistar Rats ◽  
Dopaminergic System ◽  
Brain Structures ◽  
August And Wistar Rats ◽  
Delta Sleep ◽  
Delta Sleep Inducing Peptide

STUDY OF THE COMBINED INFLUENCE OF SODIUM THIOPENTAL AND DELTA SLEEP-INDUCING PEPTIDE ON ANTIOXIDANT DEFENSE SYSTEM IN RATS

2016 ◽  
pp. 49-52
Author(s):  
A. V. Shvetsov ◽  
E. G. Batotsyrenova ◽  
N. A. Dyuzhikova ◽  
V. A. Kashuro ◽  
N. V. Lapina ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Time Interval ◽  
Sodium Thiopental ◽  
Antioxidant Defense Enzymes ◽  
Delta Sleep ◽  
Thiopental Coma ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Delta Sleep Inducing Peptide

A biochemical investigation was performed into activity of rat antioxidant defense enzymes at different time interval after administration of sodium thiopental and delta-sleep-inducing peptide (DSIP). It was shown that thiopental coma was accompanied by a decreased level of superoxide dismutase ( 6 and 24 h after exposure) and increased level of caspase-3 ( 6 h after exposure) in the rat blood plasma. A pharmacological correction with DSIP induced a decrease of the level of superoxide dismutase ( 6 and 24 h after exposure), glutathione peroxidase and glucose 6-phosphate dehydrogenase (after 6h).

Antitumoral and Anticholinesterasic Activities of the Seven Species from Rubiaceae

2019 ◽  
Vol 20 (4) ◽  
pp. 302-308 ◽  
Author(s):  
Carla R.F. Volobuff ◽  
Pedro C.O. Junior ◽  
Sidney M. dos Santos ◽  
Zefa V. Pereira ◽  
Diego C. Ferreira ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Biological Activities ◽  
Brain Structures ◽  
Acetylcholinesterase Inhibition ◽  
Mato Grosso ◽  
Male Wistar Rats ◽  
First Time ◽  
Mato Grosso Do Sul ◽  
Antiproliferative Activities ◽  
Mcf 7

Background: The genus Psychotria and Palicourea are reported as a source of alkaloids and iridoids, which exhibit biological activities. This study aimed to evaluate antiproliferative and anticholinesterase activities and quantification of the alkaloids of seven species among the genus found in Mato Grosso do Sul region in Brazil. Methods: Concentrations of alkaloids were measured spectrophotometrically. The extracts were submitted to antiproliferative activity against ten cell lines. The anticholinesterase activity of the extracts was developed using brain structures of male Wistar rats: cerebral cortex, hippocampus, hypothalamus and striatum by the Ellman method. Results: Alkaloids from Psychotria and Palicourea species were quantified which showed values of 47.6 to 21.9 µg/g. Regarding the antiproliferative potential, Palicourea crocea demonstrated selectivity against the 786-0 cell line (GI50: 22.87 µg/mL). Psychotria leiocarpa inhibited cell growth against OVCAR-3 (GI50: 3.28 µg/mL), K-562 (GI50: 5.26 µg/mL), HaCaT (GI50: 27.20 µg/mL), PC-3 (GI50: 34.92 µg/mL), MCF-7 (GI50: 35.80 µg/mL) and P. capillacea showed activity against OVCAR-3 (GI50: 2.33 µg/ml) and U251 (GI50: 16.66 µg/ml). The effect of acetylcholinesterase inhibition was more effective in the hippocampus, demonstrating inhibition for Paliourea crocea, Psychotria deflexa, P. brachybotrya and P. leiocarpa of 70%, 57%, 50% and 40%, respectively, followed by P. poeppigiana and P. capillacea, inhibiting 21%, compared to the control. Conclusion: Herein, the present work showed for the first time, anticholinesterasic and antiproliferative activities of extracts of Palicourea and Psychotria seem to be mainly associated with the levels of alkaloids in the leaves of these species.

Characterization of Delta-Sleep-Inducing Peptide-Evoked Release of Met-Enkephalin from Brain Synaptosomes in Rats

1991 ◽  
Vol 57 (3) ◽  
pp. 1013-1018 ◽  
Author(s):  
Akihiro Nakamura ◽  
Kenji Sakai ◽  
Yukie Takahashi ◽  
Hirohito Shiomi
Keyword(s):  
Brain Synaptosomes ◽  
Delta Sleep ◽  
Delta Sleep Inducing Peptide

Delta sleep-inducing peptide and glucocorticoid-induced leucine zipper: potential links between circadian mechanisms and obesity?

2009 ◽  
Vol 10 ◽  
pp. 46-51 ◽  
Author(s):  
J. M. Gimble ◽  
A. A. Ptitsyn ◽  
B. C. Goh ◽  
T. Hebert ◽  
G. Yu ◽  
...  
Keyword(s):  
Leucine Zipper ◽  
Delta Sleep ◽  
Delta Sleep Inducing Peptide

P.3.064 Membrane-protective effect of delta-sleep inducing peptide

1997 ◽  
Vol 7 ◽  
pp. S245
Author(s):  
T.I. Bondarenko ◽  
I.A. Goronshinskaya ◽  
I.I. Mikhaleva
Keyword(s):  
Protective Effect ◽  
Delta Sleep ◽  
Delta Sleep Inducing Peptide

Cascade afteraction of delta sleep-inducing peptide in rats

1995 ◽  
Vol 119 (1) ◽  
pp. 1-4 ◽  
Author(s):  
K. V. Sudakov ◽  
J. P. Coghland ◽  
A. V. Kotov ◽  
R. M. Salieva ◽  
Yu. V. Polyntsev ◽  
...  
Keyword(s):  
Delta Sleep ◽  
Delta Sleep Inducing Peptide
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