scholarly journals The effects of chronic manganese administration on blood pressure in rats

2014 ◽  
Vol 66 (1) ◽  
pp. 157-160 ◽  
Author(s):  
Serban Lacramioara ◽  
Mihai Hogas ◽  
Alin Ciobica ◽  
Romeo Dobrin ◽  
Florin Petrariu
Keyword(s):  
Blood Pressure ◽  
Repeated Measures ◽  
Wistar Rats ◽  
Vascular System ◽  
Time Effect ◽  
Pressure Measurements ◽  
Disease Mechanisms ◽  
Male Wistar Rats ◽  
Font Color ◽  
Different Doses

Several trace elements, including manganese (Mn), affect the cardiovascular system and are implicated in some cardiovascular disease mechanisms. The effects of Mn on the vascular system, such as in the control of blood flow and blood pressure, are not completely understood. Thus, the main objective of the present study was to determine the effects of a 45-day exposure to two different doses of Mn on blood pressure values of male Wistar rats. Our results showed a significant time effect (p<0.001, ANOVA, repeated measures) on the values of blood pressure measurements during 45 days of Mn treatment of rats with two doses (3 mg/kg/day and 10 mg/kg/day). Additionally, we observed significant differences in the values of blood pressure measurements, especially on days 2 (p<0.001), 9 (p<0.05), 24 (p<0.05), 28 (p<0.01) and 43 (p<0.05). Further studies are necessary in order to establish the mechanism and relevance of Mn in this area of research. <br><br><font color="red"><b> This article has been retracted. Link to the retraction <u><a href="http://dx.doi.org/10.2298/ABS161021104E">10.2298/ABS161021104E</a><u></b></font>

Effect of different doses of 2,4-dichlorophenoxyacetic acid (2,4-d) on cardiac parameters in male Wistar rats

2020 ◽  
Vol 28 (3) ◽  
pp. 3078-3087
Author(s):  
Raíssa De Oliveira Mantovani ◽  
Dyovana Gomes Pinheiro ◽  
Geovana Letícia Fernandes De Oliveira ◽  
Stéfani Nobrega Perrud ◽  
Giovana Rampazzo Teixeira ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Dichlorophenoxyacetic Acid ◽  
Male Wistar Rats ◽  
2,4 Dichlorophenoxyacetic Acid ◽  
Different Doses

Dietary linoleic acid and salt-induced hypertension

1981 ◽  
Vol 59 (8) ◽  
pp. 872-875 ◽  
Author(s):  
Murray C. Macdonald ◽  
Robert L. Kline ◽  
Gordon J. Mogenson
Keyword(s):  
Blood Pressure ◽  
Linoleic Acid ◽  
Systolic Blood Pressure ◽  
Wistar Rats ◽  
Sodium Content ◽  
Significant Elevation ◽  
Dietary Linoleic Acid ◽  
Low Level ◽  
Induced Hypertension ◽  
Male Wistar Rats

Male Wistar rats chronically fed a low level (0.41%) of linoleic acid (LA) in the diet as supplied by 5% olive oil developed a significant elevation of systolic blood pressure as compared with rats fed either a medium (4.2%) or high (9.4%) level of dietary LA. Chronic excess intake of NaCl (3.75% in the diet) was associated with a significant elevation of blood pressure on all three diets but a low level of LA in the diet exaggerated the salt-induced hypertension. The results suggest that inadequate dietary LA may result in an increase in systolic blood pressure regardless of the sodium content of the diet.

scholarly journals Effects of Clofibrate on Salt Loading-Induced Hypertension in Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Antonio Cruz ◽  
Isabel Rodríguez-Gómez ◽  
Rocío Pérez-Abud ◽  
Miguel Ángel Vargas ◽  
Rosemary Wangensteen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Thyroid Hormone ◽  
Wistar Rats ◽  
Sodium Balance ◽  
Salt Loading ◽  
Blood Pressure Elevation ◽  
Hormone Levels ◽  
Induced Hypertension ◽  
Male Wistar Rats ◽  
Thyroid Hormone Levels

The effects of clofibrate on the hemodynamic and renal manifestations of increased saline intake were analyzed. Four groups of male Wistar rats were treated for five weeks: control, clofibrate (240 mg/kg/day), salt (2% via drinking water), andsalt+clofibrate. Body weight, systolic blood pressure (SBP), and heart rate (HR) were recorded weekly. Finally, SBP, HR, and morphologic, metabolic, plasma, and renal variables were measured. Salt increased SBP, HR, urinary isoprostanes, NOx, ET, vasopressin and proteinuria and reduced plasma freeT4(FT4) and tissueFT4andFT3versus control rats. Clofibrate prevented the increase in SBP produced by salt administration, reduced the sodium balance, and further reduced plasma and tissue thyroid hormone levels. However, clofibrate did not modify the relative cardiac mass, NOx, urinary ET, and vasopressin of saline-loaded rats. In conclusion, chronic clofibrate administration prevented the blood pressure elevation of salt-loaded rats by decreasing sodium balance and reducing thyroid hormone levels.

Nephrotoxicity as a cause of death in male wistar rats exposed to toxic doses of paracetamol\methionine combination

2011 ◽  
Vol 1 (4) ◽  
pp. 182-187
Author(s):  
A. A. Iyanda ◽  
J. I. Anetor ◽  
F. A. Adeniyi ◽  
C. I. Iheakanwa
Keyword(s):  
Uric Acid ◽  
Cause Of Death ◽  
Wistar Rats ◽  
Hepatic Necrosis ◽  
Renal Abnormality ◽  
Renal Histology ◽  
Male Wistar Rats ◽  
Physiologic Saline ◽  
Different Doses

In an earlier study, we observed that male Wistar rats administered withtoxic doses of methionine containing paracetamol formulation(acetaminophen) did not manifest hepatic necrosis even at doses as high as3000 mg\kg and 5000 mg\kg body weight (BW) yet death occurred. Thisstudy sets out to investigate the cause of death by focusing on another sensitiveorgan to acetaminophen exposure and to highlight the role of some vitaminsin this. Thirty male Wistar rats were divided into six groups consisting 5rats in each, and further administered with different doses of paracetamol\methionine, ranging from 100 mg\kg – 5000 mg\kg. 5 rats, suppliedwith only physiologic saline were considered as control. Results show thatrats exposed to 100mg\kg, 350 mg\kg and 1000 mg\kg BW did not exhibitany form of renal abnormality. The nephrotoxic indices consisting of urea,creatinine and uric acid were not significantly increased in comparison tocontrol (p>0.05). Renal histology was also not identified as abnormal; moreover0% mortality was recorded for these groups. However, the creatininewas significantly increased in 3000 mg\kg group (p

Abstract 16884: Involvement of Hydrogen Sulfide (H2S) in Dexamethasone (DEX) Induced Hypertension in Rat

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Erminia Donnarumma ◽  
Emma Mitidieri ◽  
Teresa Tramontano ◽  
Vincenzo Brancaleone ◽  
Mariarosaria Bucci ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Shear Stress ◽  
Carotid Artery ◽  
Wistar Rats ◽  
Colorimetric Assay ◽  
Induced Hypertension ◽  
Effect Curve ◽  
Male Wistar Rats ◽  
H2s Production

Introduction: Glucocorticoid (GC) excess is related to hypertension. The deletion of endothelial GC-receptors abrogates the blood pressure increase, suggesting GC-induced hypertension is endothelium-dependent. In response to shear stress endothelium releases nitric oxide, endothelial derived hyperpolarizing factor (EDHF) and prostacyclin. Recently H2S has been proposed as a candidate for EDHF. H2S is mainly produced by the enzymes cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) from L-cysteine. The aim of this study was to investigate the EDHF/H2S signaling in GC-hypertension. Methods: Male Wistar rats were treated with DEX (1.5 mg/kg/sc) or vehicle (VEH) for 8 days. Systolic blood pressure (SBP) was monitored every 2 days. EDHF was evaluated in mesenteric plexus and carotid artery performing a concentration-effect curve of acetylcholine in presence of indomethacin (INDO) and nitro-L-arginine methyl ester (L-NAME). Apamin (APA) plus charibdotoxin (CTX), SKCa and BKCa inhibitors, or propargylglycine (PAG), CSE inhibitor, were used. CBS and CSE levels were analyzed by immunoblot. H2S levels were measured by a colorimetric assay. Results: DEX treatment significantly increased SBP compared to VEH (*p<0.05, **p<0.01, ***p<0.001 at days 2-4, 6, 8 respectively). EDHF-mediated relaxation of mesenteric bed or carotid artery was markedly reduced in DEX group compared to VEH (***p<0.001). APA and CTX as well as PAG abolished EDHF-mediated relaxation in DEX or VEH group (***,°°°p<0.001 respectively). CBS and CSE levels were significantly reduced in mesenteric plexus and carotid artery in DEX group (*p<0.05). The H2S production was markedly reduced in mesenteric plexus and carotid artery (*p<0.05, **p<0.01 respectively) as well as plasmatic H2S levels (*p<0.05) in DEX rats compared to VEH. Conclusions: Our data demonstrate that GC-excess induces an impairment of H2S/EDHF signaling indicating an additional cause of GC-mediated hypertension.

scholarly journals To compare the blood pressure and heart rate during course of various types of anesthesia in wistar rat: A novel experiences

2018 ◽  
Vol 9 (6) ◽  
pp. 37-39
Author(s):  
Jagdish Narayan ◽  
Pradeep Kumar ◽  
Ankit Gupta ◽  
Sunita Tiwari
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Body Weight ◽  
Wistar Rats ◽  
Wistar Rat ◽  
Medical Sciences ◽  
The Awakening ◽  
Group I ◽  
Male Wistar Rats ◽  
Thiopental Sodium

Background: Rats are commonly used animals in development of newer drugs, rectification of toxicity and to record the various alterations in physiological parameters following pharmacological and non pharmacological interventions.Aim and Objectives: The purpose of this study was to identify the best physiological window during anesthesia. Therefore, we compared the effect of anesthesia using combination of ketamine and xylazine (KX) and thiopental sodium (intraperitoneally) on blood pressure and heart rate in adult male Wistar rats. Material and Methods: Twelve, male Wistar rats with a mean body weight of 260 ± 15 g were acquired. Thiopental sodium and cocktail of ketamine and xylazine (KX) were administered (ip) in group- I and group-II respectively. The systolic blood pressure and heart rate was recorded in both the groups till the awakening phase.Results: We found that there was a constant SBP and HR in Ketamine/Xylezine groups that are from 30 to 90 minutes after injection of anesthesia while this window was not observed in thiopental group.Conclusion: Our study concludes that the best time to observe the effect of newer drug during period between 30- 90 minutes after anesthesia.Asian Journal of Medical Sciences Vol.9(6) 2018 37-39

Weekend versus working day: differences in telemetric blood pressure in male Wistar rats

2007 ◽  
Vol 41 (1) ◽  
pp. 86-91 ◽  
Author(s):  
M F Schreuder ◽  
M Fodor ◽  
J A E van Wijk ◽  
H A Delemarre-van de Waal
Keyword(s):  
Blood Pressure ◽  
Wistar Rats ◽  
Male Wistar Rats ◽  
Working Day

Gastroprotective activity of essential oils from turmeric and ginger

2015 ◽  
Vol 26 (1) ◽  
Author(s):  
Vijayasteltar B. Liju ◽  
Kottarapat Jeena ◽  
Ramadasan Kuttan
Keyword(s):  
Gastric Ulcer ◽  
Antioxidant Enzymes ◽  
Essential Oils ◽  
Wistar Rats ◽  
Histopathological Examination ◽  
Antiulcer Activity ◽  
Ulcer Index ◽  
Degree Of Protection ◽  
Male Wistar Rats ◽  
Different Doses

AbstractTurmeric (Turmeric and ginger were evaluated for their antiulcer activity against ethanol-induced ulcers in male Wistar rats at different doses: 100, 500 and 1000 mg/kg body weight. Ethanol was used to induce gastric ulcer in Wistar rats. Parameters such as ulcer index, histopathology and levels of antioxidant enzymes such as glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase and glutathione (GSH) levels were measured to assess the degree of protection produced by the essential oils.TEO and GEO inhibited ulcer by 84.7% and 85.1%, respectively, as seen from the ulcer index. Reduced antioxidant enzymes such as GPx, SOD, catalase and GSH produced by alcohol administration were significantly (p<0.001) increased by simultaneous administration of TEO and GEO. Histopathological examination showed that ethanol-induced lesions such as necrosis, erosion and hemorrhage of the stomach wall were significantly reduced after oral administration of essential oils.Results suggest that TEO and GEO could reduce the gastric ulcer in rat stomach as seen from the ulcer index and histopathology of the stomach. Moreover, oxidative stress produced by ethanol was found to be significantly reduced by TEO and GEO.

Reduction of blood flow in the adenohypophysis of rats by bromocriptine

1985 ◽  
Vol 63 (1) ◽  
pp. 120-124 ◽  
Author(s):  
Andras A. Kemeny ◽  
Jan A. Jakubowski ◽  
Emil Pasztor ◽  
Anthony A. Jefferson ◽  
Richard Wojcikiewicz
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Wistar Rats ◽  
Content Type ◽  
Selective Effect ◽  
Arterial Blood ◽  
Male Wistar Rats ◽  
The Mean ◽  
Hydrogen Clearance ◽  
Fine Print

✓ The possibility that bromocriptine has a selective effect on blood flow in the adenohypophysis was examined in rats. Twenty-four anesthetized male Wistar rats underwent measurement of blood flow using the hydrogen clearance method. Intravenous injection of 50 µg/kg bromocriptine reduced the blood flow in both the medial and lateral parts of the adenohypophysis to about 70% of the baseline value. Simultaneously measured cerebral cortical and white matter flows were unchanged. Similar results were obtained following administration of a higher dose (500 µg/kg) of bromocriptine. This phenomenon cannot be attributed to the decrease in blood pressure. The course of change in blood flow in the medial and lateral adenohypophysis did not follow that of the mean arterial blood pressure, and the alteration of blood pressure remained within the limits of autoregulation in the adenohypophysis. The results indicate that bromocriptine is capable of reducing blood flow selectively in the pituitary region. This mechanism may contribute to the clinical usefulness of this drug.

Sign in / Sign up

Export Citation Format

Share Document