scholarly journals Seasonal changes in oxidative stress biomarkers of the snail Viviparus acerosus from the Velika Morava River, Serbia

2012 ◽  
Vol 64 (3) ◽  
pp. 953-962 ◽  
Author(s):  
Svetlana Despotovic ◽  
Branka Perendija ◽  
Jelena Gavric ◽  
Slavica Borkovic-Mitic ◽  
M.M. Paunovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Phase Ii ◽  
Seasonal Changes ◽  
Important Variable ◽  
Whole Body ◽  
Glutathione S Transferase ◽  
Total Glutathione ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Morava River

The river snail (Viviparus acerosus) from the Velika Morava River, Serbia was chosen in our study in order to determine seasonal changes in oxidative stress biomarkers between July (summer) and September (autumn). The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and the phase II biotransformation enzyme glutathione-S-transferase (GST), as well as the concentration of total glutathione (GSH), were examined in the whole body of the river snails. The obtained results show significantly higher activities of CAT, GSH-Px, GR and biotransformation phase II enzyme GST in September compared to July, while the GSH concentration was lower. There was no general trend in the seasonal changes in the activity of SOD. The presented data show that animals in their natural environment are exposed to constant fluctuations of environmental conditions that could cause antioxidants to exhibit seasonal variations. This fact should be considered as an important variable in the interpretation of results in biomonitoring studies.

scholarly journals High 15-F2t-Isoprostane Levels in Patients with a Previous History of Nonmelanoma Skin Cancer: The Effects of Supplementary Antioxidant Therapy

2015 ◽  
Vol 2015 ◽  
pp. 1-8
Author(s):  
Betânia de Jesus e Silva de Almendra Freitas ◽  
Gustavo Rafaini Lloret ◽  
Marília Berlofa Visacri ◽  
Bruna Taliani Tuan ◽  
Lais Sampaio Amaral ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skin Cancer ◽  
Phase I ◽  
Phase Ii ◽  
Healthy Subjects ◽  
Nonmelanoma Skin Cancer ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
History Of ◽  
Previously Treated

Background. Phase I of this study was aimed at comparing the profiles of oxidative stress biomarkers in patients with history of nonmelanoma skin cancer (NMSC), previously treated with surgery, to the healthy subjects. Phase II aimed to evaluate the effects of supplementary antioxidant therapy on the levels of biomarkers in the case group.Materials and Methods. In Phase I, oxidative stress biomarkers were measured in blood samples obtained from 24 healthy subjects and 60 patients with history of NMSC previously treated with surgery. In Phase II, the 60 patients with history of NMSC were randomized into two subgroups, one receiving placebo (n=34) and the other (n=26) receiving vitamin C, vitamin E, and zinc supplementation for 8 weeks, followed by reevaluation of biomarkers.Results. In Phase I, patients with history of NMSC showed increased plasma concentrations of all biomarkers, but only 15-F2t-isoprostane was significantly higher than in the healthy subjects. Risk of NMSC increased by 4% for each additional 1 pg/mL increase in 15-F2t-isoprostane. In Phase II, supplementation did not significantly reduce levels of oxidative stress biomarkers.Conclusion. Patients with history of NMSC had significantly high 15-F2t-isoprostane plasma levels; supplementation did not result in significant reduction of oxidative stress biomarkers. This trial was registered with ClinicalTrials.gov (IDNCT02248584).

scholarly journals Seasonal changes in serum oxidative stress biomarkers in dairy and beef cows in a daytime grazing system

2018 ◽  
Vol 80 (1) ◽  
pp. 20-27 ◽  
Author(s):  
Ahmad Nawid MIRZAD ◽  
Takashi TADA ◽  
Hitoshi ANO ◽  
Ikuo KOBAYASHI ◽  
Takenori YAMAUCHI ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Seasonal Changes ◽  
Beef Cows ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Grazing System

scholarly journals Activity of oxidative stress biomarkers in the white muscle of red mullet (Mullus barbatus L.) from the Adriatic sea

2009 ◽  
Vol 61 (4) ◽  
pp. 693-701 ◽  
Author(s):  
S.Z. Pavlovic ◽  
Slavica Borkovic-Mitic ◽  
Tijana Radovanovic ◽  
Branka Perendija ◽  
Svetlana Despotovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
White Muscle ◽  
Adriatic Sea ◽  
Glutathione S Transferase ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Red Mullet ◽  
Mullus Barbatus ◽  
Total Superoxide Dismutase

The aim of this study was to investigate the activity of oxidative stress biomarkers (total superoxide dismutase - Tot SOD; and copper and zinc-containing superoxide dismutase - CuZn SOD; manganese-containing superoxide dismutase - Mn SOD; catalase - CAT; glutathione peroxidase - GSH-Px; and glutathione reductase - GR), as well as the biotransformation phase II enzyme glutathione-S-transferase (GST), in the white muscle of red mullet (Mullus barbatus L.) at Platamuni (PL) and Valdanos (VAL) in the Adriatic Sea during the winter and spring seasons. The obtained results show both site and seasonal influences on the investigated parameters, with lower enzyme activities at VAL than at PL and in spring than in winter.

scholarly journals Assessment of Plasma Oxidative Stress Biomarkers and Metabolic Parameters of Dairy Heifers: Relationship with Success at First Service

2021 ◽  
Vol 78 (2) ◽  
pp. 11
Author(s):  
Sofiane BOUDJELLABA ◽  
Habiba SAADI ◽  
Mohamed ZAOUANI ◽  
Lynda AINOUZ ◽  
Amira Fatma HANI ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dairy Herds ◽  
Glutathione S Transferase ◽  
Oxidative Stress Biomarkers ◽  
Dairy Heifers ◽  
Stress Biomarkers ◽  
Significant Difference ◽  
The Difference ◽  
The Relationship

First insemination success is considered as good indicator of heifer fertility to ensure renewal of dairy herds. The objective of this study was to determine the relationship between first insemination success and biomarkers of oxidative stress (OS). A total of 25 heifers were divided into two groups according to their success at first insemination: group FS+ (heifers that were pregnant at first service, n = 14) and group FS- (heifers that were not pregnant at first service, n = 11). The serum of these two groups were analyzed for malondialdehyde (MDA), glutathione S-transferase (GST), reduced glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), myeloperoxidase (MPO), nitric Oxide (NO) and superoxide dismutase (SOD) as oxidative stress biomarkers and biochemical parameters. Heifers in the group FS+ showed no significant difference in all OS parameters compared to heifers in the group FS-. The OS parameters showed almost similar values in both groups except for GST and CAT where the difference was at the limit of significance. The plasma concentration of OS biomarkers assessed in our study were not related to first service success in heifers. Further studies are needed to clarify the role of oxidative status in the reproductive performance of heifers.

scholarly journals Induction of oxidative stress biomarkers following whole-body irradiation in mice

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0240108
Author(s):  
Tsutomu Shimura ◽  
Chinami Nakashiro ◽  
Momoka Narao ◽  
Akira Ushiyama
Keyword(s):  
Oxidative Stress ◽  
Whole Body ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers

scholarly journals Influence of trout farm effluents on selected oxidative stress biomarkers in larvae of Ecdyonurus venosus (Ephemeroptera, Heptageniidae)

2019 ◽  
Vol 71 (2) ◽  
pp. 225-233
Author(s):  
Andjelina Radojevic ◽  
Dejan Mircic ◽  
Miroslav Zivic ◽  
Vesna Peric-Mataruga ◽  
Milenka Bozanic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fish Farm ◽  
Chemical Parameters ◽  
Ammonium Ions ◽  
Total Glutathione ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Trout Farms ◽  
Physical And Chemical ◽  
Biomarkers Of Oxidative Stress

The aim of the present study was to establish the extent to which the outlet waters of trout farms affect the ecosystems of the Crnica and Skrapez rivers in Serbia. We monitored selected biomarkers of oxidative stress: superoxide dismutase (SOD), glutathione peroxidase (GPx) and total glutathione (GSH) in larvae of the species Ecdyonurus venosus, and simultaneously analyzed the changes in the physical and chemical parameters. The investigations were carried out in spring at four localities along the Skrapez and Crnica rivers: one upstream (the control localities), and three downstream from the fish farm outlets. On the Skrapez River, the fish farm was clearly visible and was markedly changed by the chemical parameters of the water, manifested as a decreased concentration of dissolved oxygen, increased concentrations of nitrates, nitrites, ammonium ions, total phosphorus and total organic carbon, and increased SOD and GPx activities and decreased GSH concentration in larvae from the first downstream locality as compared to the control locality. On the Crnica River, due to the high values of water flow (around 3 m3/s), effluents from the fish farm had no effect on the chemical parameters of the water or on the tested biomarkers.

scholarly journals Dichloroacetate Decreases Cell Health and Activates Oxidative Stress Defense Pathways in Rat Alveolar Type II Pneumocytes

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Alexis Valauri-Orton ◽  
Frizzi Bschorer ◽  
Karen K. Bernd
Keyword(s):  
Oxidative Stress ◽  
Alveolar Type ◽  
Type Ii ◽  
Total Glutathione ◽  
Oxidative Stress Biomarkers ◽  
Redox Ratio ◽  
Stress Biomarkers ◽  
Oxidative Stress Defense ◽  
Type Ii Pneumocytes ◽  
Stress Defense

Dichloroacetate (DCA) is a water purification byproduct that is known to be hepatotoxic and hepatocarcinogenic and to induce peripheral neuropathy and damage macrophages. This study characterizes the effects of the haloacetate on lung cells by exposing rat alveolar type II (L2) cells to 0–24 mM DCA for 6–24 hours. Increasing DCA concentration and the combination of increasing DCA concentration plus longer exposures decrease measures of cellular health. Length of exposure has no effect on oxidative stress biomarkers, glutathione, SOD, or CAT. Increasing DCA concentration alone does not affect total glutathione or its redox ratio but does increase activity in the SOD/CAT oxidative stress defense pathway. These data suggest that alveolar type II cells rely on SOD and CAT more than glutathione to combat DCA-induced stress.

scholarly journals Oxidative Stress Biomarkers in Erythrocytes of Captive Pre-Juvenile Loggerhead Turtles Following Acute Exposure to Methylmercury

2020 ◽  
Vol 10 (10) ◽  
pp. 3602 ◽  
Author(s):  
Javier Hernández-Fernández ◽  
Ellie Anne López-Barrera ◽  
Leonardo Mariño-Ramírez ◽  
Pilar Rodríguez-Becerra ◽  
Andrés Pinzón-Velasco
Keyword(s):  
Oxidative Stress ◽  
Cell Viability ◽  
Loggerhead Turtle ◽  
In Vitro Models ◽  
Glutathione S Transferase ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Loggerhead Turtles ◽  
And Oxidative Stress

This study describes the use of erythrocytes (RBCs) of loggerhead turtles as in vitro models for evaluating their toxicity to methylmercury. Blood samples of loggerhead turtles that were born in the Colombian Caribbean were used. The LC50 of RBCs to methylmercury was determined at 96 h using methylmercury concentrations of 0.5–100 mg L−1. Next, the viability of the RBCs and the activity of the enzymes superoxide dismutase (SOD), glutathione S-transferase (GST), and lipid peroxidation by malondialdehyde (MDA) at 6 and 12 h of exposure to acute concentrations of 0, 1, and 5 mg L−1 were evaluated. The LC50 for loggerhead turtle RBCs was 8.32 mg L−1. The cell viability bioassay of RBCs exposed for 12 h only showed 100% cell viability. Increasing in vitro MeHg concentrations caused a corresponding increase in MDA concentration as well as decreases in the activities of SOD and GST. The RBCs represent an excellent model for ecotoxicological studies and SOD, GST, and MDA are biomarkers of environmental pollution and oxidative stress in loggerhead turtles. This was the first study conducted on loggerhead turtle where the response of RBCs to MeHg-induced oxidative stress is evaluated.

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