Host genetic determinants of spontaneous hepatitis C clearance

2009 ◽  
Vol 10 (11) ◽  
pp. 1819-1837 ◽  
Author(s):  
Andri Rauch ◽  
Silvana Gaudieri ◽  
Chloe Thio ◽  
Pierre-Yves Bochud
Keyword(s):  
Hepatitis C ◽  
Genetic Determinants ◽  
Host Genetic

701 HOST GENETIC DETERMINANTS IN HCV-RELATED MIXED CRYOGLOBULINEMIA

2010 ◽  
Vol 52 ◽  
pp. S272-S273
Author(s):  
A. Piluso ◽  
L. Gragnani ◽  
P. Caini ◽  
E. Fognani ◽  
C. Giannini ◽  
...  
Keyword(s):  
Mixed Cryoglobulinemia ◽  
Genetic Determinants ◽  
Host Genetic

scholarly journals Genetic determinants in hepatitis C virus-associated mixed cryoglobulinemia: Role of polymorphic variants of BAFF promoter and Fcγ receptors

2011 ◽  
Vol 63 (5) ◽  
pp. 1446-1451 ◽  
Author(s):  
Laura Gragnani ◽  
Alessia Piluso ◽  
Carlo Giannini ◽  
Patrizio Caini ◽  
Elisa Fognani ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Mixed Cryoglobulinemia ◽  
Genetic Determinants ◽  
Fcγ Receptors ◽  
Polymorphic Variants

scholarly journals Liver Fibrosis, Host Genetic and Hepatitis C Virus Related Parameters as Predictive Factors of Response to Therapy against Hepatitis C Virus in HIV/HCV Coinfected Patients

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e101760 ◽  
Author(s):  
Sara Corchado ◽  
Luis F. López-Cortés ◽  
Antonio Rivero-Juárez ◽  
Almudena Torres-Cornejo ◽  
Antonio Rivero ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Predictive Factors ◽  
Response To Therapy ◽  
Host Genetic

Interrelation between the virus and host genetic factors in chronic hepatitis C

2015 ◽  
Vol 13 (3) ◽  
pp. 30-36
Author(s):  
S.D. Kuznetsov ◽  
◽  
V.V. Makashova ◽  
A.V. Tutel’yan ◽  
S.V. Shabalina ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Genetic Factors ◽  
Host Genetic ◽  
Host Genetic Factors

scholarly journals Host genetic factors influence disease progression in chronic hepatitis C

Hepatology ◽  
2000 ◽  
Vol 31 (4) ◽  
pp. 828-833 ◽  
Author(s):  
Elizabeth E. Powell ◽  
Catherine J. Edwards-Smith ◽  
John L. Hay ◽  
Andrew D. Clouston ◽  
Darrell H. Crawford ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Disease Progression ◽  
Chronic Hepatitis C ◽  
Genetic Factors ◽  
Host Genetic ◽  
Host Genetic Factors

scholarly journals ‘Favourable’ IL28B polymorphisms are associated with a marked increase in baseline viral load in hepatitis C virus subtype 3a infection and do not predict a sustained virological response after 24 weeks of therapy

2013 ◽  
Vol 94 (6) ◽  
pp. 1259-1265 ◽  
Author(s):  
Cristina Bucci ◽  
Annette von Delft ◽  
Annabel Christian ◽  
Vicki M. Flemming ◽  
Abby Harrison ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Response To Therapy ◽  
Baseline Viral Load ◽  
Median Viral Load ◽  
Host Genetic

IL28B host genetic make-up is known to play a critical role in the outcome of genotype 1 hepatitis C virus (HCV) infection in the context of both primary infection and therapy. However, the role of IL28B in subtype 3a infection remains unclear, and has not yet been assessed in the UK population where subtype 3a is dominant. In this study, we evaluated the role of the IL28B single-nucleotide polymorphism rs8099917 in 201 patients recruited from two well-defined cohorts (from Nottingham and Oxford), treated with the standard-of-care therapy of pegylated interferon and ribavirin for 24 weeks. We showed that the ‘favourable’ IL28B gene was associated with a rapid virological response to therapy at 4 weeks (P<0.0001), but not with a sustained virological response to therapy. The median viral load at baseline, before therapy, was markedly increased in people with the ‘favourable’ IL28B genotype [median viral load for the TT allele, 925 961 IU ml−1 (range 2200–21 116 965 IU ml−1), and for the GT or GG allele, 260 284 IU ml−1 (range 740–7 560 000 IU ml−1); P = 0.0010]. Our results suggest that the host genetic response plays an important role in early viral clearance of subtype 3a virus from the blood. However, significant reservoirs of infection must persist, as viral relapse is common, even in those with the favourable host genotype.

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