scholarly journals Host genetic factors influence disease progression in chronic hepatitis C

Hepatology ◽  
2000 ◽  
Vol 31 (4) ◽  
pp. 828-833 ◽  
Author(s):  
Elizabeth E. Powell ◽  
Catherine J. Edwards-Smith ◽  
John L. Hay ◽  
Andrew D. Clouston ◽  
Darrell H. Crawford ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Disease Progression ◽  
Chronic Hepatitis C ◽  
Genetic Factors ◽  
Host Genetic ◽  
Host Genetic Factors

Interrelation between the virus and host genetic factors in chronic hepatitis C

2015 ◽  
Vol 13 (3) ◽  
pp. 30-36
Author(s):  
S.D. Kuznetsov ◽  
◽  
V.V. Makashova ◽  
A.V. Tutel’yan ◽  
S.V. Shabalina ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Genetic Factors ◽  
Host Genetic ◽  
Host Genetic Factors

scholarly journals Coffee intake is associated with lower rates of liver disease progression in chronic hepatitis C

Hepatology ◽  
2009 ◽  
Vol 50 (5) ◽  
pp. 1360-1369 ◽  
Author(s):  
Neal D. Freedman ◽  
James E. Everhart ◽  
Karen L. Lindsay ◽  
Marc G. Ghany ◽  
Teresa M. Curto ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis C ◽  
Disease Progression ◽  
Chronic Hepatitis C ◽  
Coffee Intake ◽  
Liver Disease Progression

scholarly journals Long-Term Follow-Up of Chronic Hepatitis C Patients Treated with Interferon-Alpha: Risk of Cirrhosis and Hepatocellular Carcinoma in a Single Center over 10 Years

Intervirology ◽  
2015 ◽  
Vol 58 (1) ◽  
pp. 14-21
Author(s):  
Hyun Jung Lee ◽  
Jong Eun Yeon ◽  
Eileen L. Yoon ◽  
Sang Jun Suh ◽  
Keunhee Kang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Antiviral Therapy ◽  
Disease Progression ◽  
Chronic Hepatitis C ◽  
Cumulative Incidence ◽  
Proportional Hazards ◽  
Antiviral Treatment ◽  
Cox Proportional Hazards

Objectives: Interferon (IFN)-based therapy for chronic hepatitis C (CHC) is cost-effective and is associated with reduced risk of disease progression. We aimed to assess the incidence of cirrhosis and hepatocellular carcinoma (HCC) and to identify risk factors associated with disease progression. Methods: We retrospectively reviewed 280 CHC patients who were registered at our hospital between 2001 and 2010. Results: About 80% of patients received antiviral treatment. The 10-year cumulative incidence of cirrhosis was significantly lower among patients who received antiviral therapy than among those who did not (8.3 vs. 44.0%; p = 0.001). Among them, patients with sustained virological response (SVR) had a significantly lower incidence of cirrhosis than those without SVR (0.6 vs. 33.9%; p < 0.001). Cox proportional hazards regression showed that SVR was the significant independent factor for reducing the risk of cirrhosis (hazard ratio, HR = 0.03; p = 0.034). The 10-year cumulative incidence of HCC was higher among patients who did not receive antiviral therapy than among those who did (43.9 vs. 6.1%; p < 0.001). Multivariate analysis showed that underlying cirrhosis was the only independent risk factor associated with HCC development (HR = 7.70; p = 0.010). Conclusions: SVR secondary to IFN-based therapy could reduce cirrhosis development in CHC patients. Underlying cirrhosis was the strongest predictor of HCC development.

Sign in / Sign up

Export Citation Format

Share Document