scholarly journals Genetic determinants in hepatitis C virus-associated mixed cryoglobulinemia: Role of polymorphic variants of BAFF promoter and Fcγ receptors

2011 ◽  
Vol 63 (5) ◽  
pp. 1446-1451 ◽  
Author(s):  
Laura Gragnani ◽  
Alessia Piluso ◽  
Carlo Giannini ◽  
Patrizio Caini ◽  
Elisa Fognani ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Mixed Cryoglobulinemia ◽  
Genetic Determinants ◽  
Fcγ Receptors ◽  
Polymorphic Variants

Role of ribavirin in the treatment of hepatitis C virus-associated mixed cryoglobulinemia with interferon-free regimens

2018 ◽  
Vol 163 (4) ◽  
pp. 961-967 ◽  
Author(s):  
Lucio Boglione ◽  
Jessica Cusato ◽  
Simone Mornese Pinna ◽  
Amedeo De Nicolò ◽  
Giuseppe Cariti ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Mixed Cryoglobulinemia

OC-23 Role of microRNA profile modifications in hepatitis C virus-related mixed cryoglobulinemia

2013 ◽  
Vol 45 ◽  
pp. S8
Author(s):  
E. Fognani ◽  
C. Giannini ◽  
A. Piluso ◽  
L. Gragnani ◽  
M. Monti ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Mixed Cryoglobulinemia ◽  
Microrna Profile

scholarly journals Hepatitis C virus within a malignant lymphoma lesion in the course of type II mixed cryoglobulinemia

Blood ◽  
1995 ◽  
Vol 86 (5) ◽  
pp. 1887-1892 ◽  
Author(s):  
S De Vita ◽  
D Sansonno ◽  
R Dolcetti ◽  
G Ferraccioli ◽  
A Carbone ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cell ◽  
Human Herpesvirus ◽  
Mixed Cryoglobulinemia ◽  
Hcv Infection ◽  
Etiologic Factor ◽  
Type Ii ◽  
B Cell Malignancies

Hepatitis C virus (HCV) has been implicated as the major etiologic factor sustaining B-cell clonal expansion in type II mixed cryoglobulinemia (MC). A putative pathogenetic role of HCV in the development of MC-associated B-cell malignancies has also been speculated. We report for the first time the localization of HCV within a parotid non-Hodgkin's lymphoma (NHL) lesion in the course of HCV- related type II essential MC, an important step to implicate any infectious agent in the lymphomagenesis. Plus and minus strand HCV RNA was first demonstrated by polymerase chain reaction on the whole RNA from the lesion. Further immunohistochemical studies localized HCV c22 proteins in the residual ductal or acinar parotid structures, which also abnormally expressed HLA-DR antigens. Weak c22 signals were inconstantly detected in cells strictly confined around the residual epithelium, while all the remaining infiltrating cells in the parotid lesion stained c-22-negative. Staining for c33 and c100 HCV antigens was negative. In situ hybridization (ISH) studies again identified the residual parotid epithelial cells as the site of HCV infection and replication in the NHL lesion. Sialotropic viruses previously involved in lymphoproliferation, ie, Epstein-Barr virus and human herpesvirus-6, were absent in the same tissue lesion. According to the current models of B-cell lymphomagenesis, a role of HCV as an exogenous antigenic stimulus should be considered for NHL development in the present case, whereas malignant B cells do not appear permissive of active HCV replication. Further efforts would be worthwhile to clarify a role of HCV infection in the development of some B-cell malignancies.

scholarly journals Role of MicroRNA Profile Modifications in Hepatitis C Virus-Related Mixed Cryoglobulinemia

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62965 ◽  
Author(s):  
Elisa Fognani ◽  
Carlo Giannini ◽  
Alessia Piluso ◽  
Laura Gragnani ◽  
Monica Monti ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Mixed Cryoglobulinemia ◽  
Microrna Profile

scholarly journals Hepatitis C virus and non-Hodgkin’s lymphoma: biology, epidemiology and therapy

2011 ◽  
Author(s):  
Gabriele Pozzato ◽  
Francesca Zorat ◽  
Stefania Bonetto ◽  
Cesare Mazzaro
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cell ◽  
Regional Differences ◽  
Mixed Cryoglobulinemia ◽  
Point Of View ◽  
Therapeutic Approaches ◽  
Biological Mechanisms ◽  
Hodgkin's Lymphomas

Although the association between the hepatitis C virus and B-cell non-Hodgkin’s lymphomas is still controversial, there is increasing evidence of the role of this virus in several B-cell lymphoproliferative disorders, whose prototype is mixed cryoglobulinemia. The aim of the present paper was to provide an overview of the biological mechanisms involved in the development of B-cell disorders in the course of chronic hepatitis C virus infection. The link between this virus and non-Hodgkin’s lymphomas is also considered from an epidemiological point of view, and the great regional differences in the prevalence of hepatitis C-associated lymphomas are discussed. Finally, the role of antiviral therapy and suggestions about the most appropriate, currently available, therapeutic approaches are also discussed.

Role of IL28B genotyping in patients with hepatitis C virus-associated mixed cryoglobulinemia and response to PEG-IFN and ribavirin treatment

2015 ◽  
Vol 160 (8) ◽  
pp. 2009-2017 ◽  
Author(s):  
Lucio Boglione ◽  
Jessica Cusato ◽  
Sarah Allegra ◽  
Giuseppe Cariti ◽  
Giovanni Di Perri ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Mixed Cryoglobulinemia

scholarly journals Hepatitis C virus and non-Hodgkin’s lymphoma: biology, epidemiology and therapy

2011 ◽  
Vol 5 (4) ◽  
pp. 249 ◽  
Author(s):  
Gabriele Pozzato ◽  
Francesca Zorat ◽  
Stefania Bonetto ◽  
Cesare Mazzaro
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cell ◽  
Regional Differences ◽  
Mixed Cryoglobulinemia ◽  
Point Of View ◽  
Therapeutic Approaches ◽  
Biological Mechanisms ◽  
Hodgkin's Lymphomas

Although the association between the hepatitis C virus and B-cell non-Hodgkin’s lymphomas is still controversial, there is increasing evidence of the role of this virus in several B-cell lymphoproliferative disorders, whose prototype is mixed cryoglobulinemia. The aim of the present paper was to provide an overview of the biological mechanisms involved in the development of B-cell disorders in the course of chronic hepatitis C virus infection. The link between this virus and non-Hodgkin’s lymphomas is also considered from an epidemiological point of view, and the great regional differences in the prevalence of hepatitis C-associated lymphomas are discussed. Finally, the role of antiviral therapy and suggestions about the most appropriate, currently available, therapeutic approaches are also discussed.

Role of autophagy in hepatitis C virus replication

2019 ◽  
Author(s):  
WI Twu ◽  
K Tabata ◽  
D Paul ◽  
R Bartenschlager
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication
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