Behavioral treatments for speech in Parkinson's disease: meta-analyses and review of the literature

2015 ◽  
Vol 5 (3) ◽  
pp. 233-248 ◽  
Author(s):  
Cyril Atkinson-Clement ◽  
Jasmin Sadat ◽  
Serge Pinto
Author(s):  
Lars-Gunnar Gunnarsson ◽  
Lennart Bodin

Objectives: To carry out an integrated and stratified meta-analysis on occupational exposure to electromagnetic fields (EMFs), metals and pesticides and its effects on amyotrophic lateral sclerosis (ALS) and Parkinson’s and Alzheimer’s disease, and investigate the possibility of publication bias. Methods: In the current study, we updated our recently published meta-analyses on occupational exposures in relation to ALS, Alzheimer’s and Parkinson’s disease. Based on 66 original publications of good scientific epidemiological standard, according to the Meta-analysis of Observational Studies in Epidemiology (MOOSE) and the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) guidelines, we analysed subgroups by carrying out stratified meta-analyses on publication year, statistical precision of the relative risk (RR) estimates, inspection of the funnel plots and test of bias. Results: Based on 19 studies the weighted RR for occupational exposure to EMFs was 1.26 (95% confidence interval (CI) 1.07–1.50) for ALS, 1.33 (95% CI 1.07–1.64) for Alzheimer’s disease and 1.02 (95% CI 0.83–1.26) for Parkinson’s disease. Thirty-one studies concerned occupational exposure to pesticides and the weighted RR was 1.35 (95% CI 1.02–1.79) for ALS, 1.50 (95% CI 0.98–2.29) for Alzheimer’s disease and 1.66 (95% CI 1.42–1.94) for Parkinson’s disease. Finally, 14 studies concerned occupational exposure to metals and only exposure to lead (five studies) involved an elevated risk for ALS or Parkinson’s disease and the weighted RR was 1.57 (95% CI 1.11–2.20). The weighted RR for all the non-lead exposures was 0.97 (95% CI 0.88–1.06). Conclusions: Exposure to pesticides increased the risk of getting the mentioned neurodegenerative diseases by at least 50%. Exposure to lead was only studied for ALS and Parkinson’s disease and involved 50% increased risk. Occupational exposure to EMFs seemed to involve some 10% increase in risk for ALS and Alzheimer’s disease only.


2020 ◽  
Vol 10 ◽  
Author(s):  
Sara Olivola ◽  
Serena Xodo ◽  
Enrica Olivola ◽  
Fabiana Cecchini ◽  
Ambrogio Pietro Londero ◽  
...  

Medicina ◽  
2019 ◽  
Vol 56 (1) ◽  
pp. 5
Author(s):  
Irina Odajiu ◽  
Eugenia Irene Davidescu ◽  
Cristina Mitu ◽  
Bogdan Ovidiu Popescu

Neurodegenerative diseases such as Parkinson’s disease (PD)have increasing incidence, due to lifespan expansion. The association between PD and Myasthenia Gravis (MG) is uncommon, and so far, since 1987, 26 cases have been reported. We report here a series of three new cases, two men and one woman with this peculiar combination of conditions, identified in the Neurology Department of Colentina Clinical Hospital. In this article, the pathogenesis of MG in patients with PD is discussed, along with a literature review regarding the co-occurrence of these two neurological diseases.


2000 ◽  
Vol 14 (2) ◽  
pp. 233-246 ◽  
Author(s):  
Craig J. Whittington ◽  
John Podd ◽  
Melanie M. Kan

2015 ◽  
Vol 23 (2) ◽  
pp. 247-261 ◽  
Author(s):  
S. A. Schneider ◽  
M. Boettner ◽  
A. Alexoudi ◽  
D. Zorenkov ◽  
G. Deuschl ◽  
...  

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