Can we use peripheral tissue biopsies to diagnose Parkinson's disease? A review of the literature

2015 ◽  
Vol 23 (2) ◽  
pp. 247-261 ◽  
Author(s):  
S. A. Schneider ◽  
M. Boettner ◽  
A. Alexoudi ◽  
D. Zorenkov ◽  
G. Deuschl ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Peripheral Tissue ◽  
Review Of The Literature

scholarly journals Parkinson's Disease in Pregnancy: A Case Report and Review of the Literature

2020 ◽  
Vol 10 ◽  
Author(s):  
Sara Olivola ◽  
Serena Xodo ◽  
Enrica Olivola ◽  
Fabiana Cecchini ◽  
Ambrogio Pietro Londero ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Report ◽  
Review Of The Literature ◽  
In Pregnancy

scholarly journals Patients with Parkinson’s Disease and Myasthenia Gravis—A Report of Three New Cases and Review of the Literature

Medicina ◽  
2019 ◽  
Vol 56 (1) ◽  
pp. 5
Author(s):  
Irina Odajiu ◽  
Eugenia Irene Davidescu ◽  
Cristina Mitu ◽  
Bogdan Ovidiu Popescu
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Literature Review ◽  
Myasthenia Gravis ◽  
Neurodegenerative Diseases ◽  
Neurological Diseases ◽  
Review Of The Literature ◽  
Clinical Hospital

Neurodegenerative diseases such as Parkinson’s disease (PD)have increasing incidence, due to lifespan expansion. The association between PD and Myasthenia Gravis (MG) is uncommon, and so far, since 1987, 26 cases have been reported. We report here a series of three new cases, two men and one woman with this peculiar combination of conditions, identified in the Neurology Department of Colentina Clinical Hospital. In this article, the pathogenesis of MG in patients with PD is discussed, along with a literature review regarding the co-occurrence of these two neurological diseases.

Multiple Factors Are Involved in the Dysarthria Associated With Parkinson's Disease: A Review With Implications for Clinical Practice and Research

2014 ◽  
Vol 57 (4) ◽  
pp. 1330-1343 ◽  
Author(s):  
Shimon Sapir
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Practice ◽  
Alternative View ◽  
Muscle Rigidity ◽  
Movement Amplitude ◽  
Review Of The Literature ◽  
Motor Speech ◽  
Multiple Factors

Purpose Motor speech abnormalities are highly common and debilitating in individuals with idiopathic Parkinson's disease (IPD). These abnormalities, collectively termed hypokinetic dysarthria (HKD), have been traditionally attributed to hypokinesia and bradykinesia secondary to muscle rigidity and dopamine deficits. However, the role of rigidity and dopamine in the development of HKD is far from clear. The purpose of the present study was to offer an alternative view of the factors underlying HKD. Method The authors conducted an extensive, but not exhaustive, review of the literature to examine the evidence for the traditional view versus the alternative view. Results The review suggests that HKD is a highly complex and variable phenomenon including multiple factors, such as scaling and maintaining movement amplitude and effort; preplanning and initiation of movements; internal cueing; sensory and temporal processing; automaticity; emotive vocalization; and attention to action (vocal vigilance). Although not part of the dysarthria, nonmotor factors, such as depression, aging, and cognitive-linguistic abnormalities, are likely to contribute to the overall speech symptomatology associated with IPD. Conclusion These findings have important implications for clinical practice and research.

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