Irrigation and intraventricular fibrinolytic therapy for posthemorrhagic ventricular dilatation in preterm infants: does it improve neurodevelopmental outcome?

2010 ◽  
Vol 5 (4) ◽  
pp. 485-489
Author(s):  
Janyte C Holwerda ◽  
Arend F Bos
Keyword(s):  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Fibrinolytic Therapy ◽  
Ventricular Dilatation

Neurodevelopmental Outcome of Preterm Infants with Severe Intraventricular Hemorrhage and Therapy for Post-Hemorrhagic Ventricular Dilatation

2008 ◽  
Vol 152 (5) ◽  
pp. 648-654 ◽  
Author(s):  
Annemieke Brouwer ◽  
Floris Groenendaal ◽  
Inge-Lot van Haastert ◽  
Karin Rademaker ◽  
Patrick Hanlo ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
Neurodevelopmental Outcome ◽  
Ventricular Dilatation

scholarly journals Neurodevelopmental outcome of preterm infants with ventricular dilatation with and without associated haemorrhage

2006 ◽  
Vol 48 (5) ◽  
pp. 348-352 ◽  
Author(s):  
Brigitte Vollmer ◽  
Simon Roth ◽  
Katharine Riley ◽  
Mark W Sellwood ◽  
Jenny Baudin ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Ventricular Dilatation

scholarly journals Oral melatonin as a new tool for neuroprotection in preterm newborns: study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Francesca Garofoli ◽  
Stefania Longo ◽  
Camilla Pisoni ◽  
Patrizia Accorsi ◽  
Micol Angelini ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Lipid Peroxidation Product ◽  
Cerebral Magnetic Resonance Imaging ◽  
Neurodevelopmental Impairment ◽  
Anti Oxidant ◽  
Preterm Newborns

Abstract Background Prevention of neurodevelopmental impairment due to preterm birth is a major health challenge. Despite advanced obstetric and neonatal care, to date there are few neuroprotective molecules available. Melatonin has been shown to have anti-oxidant/anti-inflammatory effects and to reduce brain damage, mainly after hypoxic ischemic encephalopathy. The planned study will be the first aiming to evaluate the capacity of melatonin to mitigate brain impairment due to premature birth. Method In our planned prospective, multicenter, double-blind, randomized vs placebo study, we will recruit, within 96 h of birth, 60 preterm newborns with a gestational age ≤ 29 weeks + 6 days; these infants will be randomly allocated to oral melatonin, 3 mg/kg/day, or placebo for 15 days. After the administration period, we will measure plasma levels of malondialdehyde, a lipid peroxidation product considered an early biological marker of melatonin treatment efficacy (primary outcome). At term-equivalent age, we will evaluate neurological status (through cerebral ultrasound, cerebral magnetic resonance imaging, vision and hearing evaluations, clinical neurological assessment, and screening for retinopathy of prematurity) as well as the incidence of bronchodysplasia and sepsis. We will also monitor neurodevelopmental outcome during the first 24 months of corrected age (using the modified Fagan Test of Infant Intelligence at 4–6 months and standardized neurological and developmental assessments at 24 months). Discussion Preterm birth survivors often present long-term neurodevelopmental sequelae, such as motor, learning, social-behavioral, and communication problems. We aim to assess the role of melatonin as a neuroprotectant during the first weeks of extrauterine life, when preterm infants are unable to produce it spontaneously. This approach is based on the supposition that its anti-oxidant mechanism could be useful in preventing neurodevelopmental impairment. Considering the short- and long-term morbidities related to preterm birth, and the financial and social costs of the care of preterm infants, both at birth and over time, we suggest that melatonin administration could lead to considerable saving of resources. This would be the first study addressing the role of melatonin in very low birth weight preterm newborns, and it could provide a basis for further studies on melatonin as a neuroprotection strategy in this vulnerable population. Trial registration ClinicalTrials.gov NCT04235673. Prospectively registered on 22 January 2020.

scholarly journals Circulatory insulin-like growth factor-I and brain volumes in relation to neurodevelopmental outcome in very preterm infants

2013 ◽  
Vol 74 (5) ◽  
pp. 564-569 ◽  
Author(s):  
Ingrid Hansen-Pupp ◽  
Holger Hövel ◽  
Chatarina Löfqvist ◽  
Lena Hellström-Westas ◽  
Vineta Fellman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Insulin Like Growth Factor ◽  
Brain Volumes ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Factor I ◽  
Growth Factor I

scholarly journals Nutritional Intake, White Matter Integrity, and Neurodevelopment in Extremely Preterm Born Infants

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3409
Author(s):  
Lisa M. Hortensius ◽  
Els Janson ◽  
Pauline E. van van Beek ◽  
Floris Groenendaal ◽  
Nathalie H. P. Claessens ◽  
...  
Keyword(s):  
White Matter ◽  
Preterm Infants ◽  
Motor Development ◽  
Protein Intake ◽  
Diffusion Tensor ◽  
Neurodevelopmental Outcome ◽  
White Matter Integrity ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Preterm Born

Background: Determining optimal nutritional regimens in extremely preterm infants remains challenging. This study aimed to evaluate the effect of a new nutritional regimen and individual macronutrient intake on white matter integrity and neurodevelopmental outcome. Methods: Two retrospective cohorts of extremely preterm infants (gestational age <28 weeks) were included. Cohort B (n = 79) received a new nutritional regimen, with more rapidly increased, higher protein intake compared to cohort A (n = 99). Individual protein, lipid, and caloric intakes were calculated for the first 28 postnatal days. Diffusion tensor imaging was performed at term-equivalent age, and cognitive and motor development were evaluated at 2 years corrected age (CA) (Bayley-III-NL) and 5.9 years chronological age (WPPSI-III-NL, MABC-2-NL). Results: Compared to cohort A, infants in cohort B had significantly higher protein intake (3.4 g/kg/day vs. 2.7 g/kg/day) and higher fractional anisotropy (FA) in several white matter tracts but lower motor scores at 2 years CA (mean (SD) 103 (12) vs. 109 (12)). Higher protein intake was associated with higher FA and lower motor scores at 2 years CA (B = −6.7, p = 0.001). However, motor scores at 2 years CA were still within the normal range and differences were not sustained at 5.9 years. There were no significant associations with lipid or caloric intake. Conclusion: In extremely preterm born infants, postnatal protein intake seems important for white matter development but does not necessarily improve long-term cognitive and motor development.

scholarly journals Ultrasound appearance of the brain in very preterm infants and neurodevelopmental outcome at 18 months of age.

1983 ◽  
Vol 58 (8) ◽  
pp. 598-604 ◽  
Author(s):  
A L Stewart ◽  
R J Thorburn ◽  
P L Hope ◽  
M Goldsmith ◽  
A P Lipscomb ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
The Brain
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