scholarly journals Nutritional Intake, White Matter Integrity, and Neurodevelopment in Extremely Preterm Born Infants

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3409
Author(s):  
Lisa M. Hortensius ◽  
Els Janson ◽  
Pauline E. van van Beek ◽  
Floris Groenendaal ◽  
Nathalie H. P. Claessens ◽  
...  
Keyword(s):  
White Matter ◽  
Preterm Infants ◽  
Motor Development ◽  
Protein Intake ◽  
Diffusion Tensor ◽  
Neurodevelopmental Outcome ◽  
White Matter Integrity ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Preterm Born

Background: Determining optimal nutritional regimens in extremely preterm infants remains challenging. This study aimed to evaluate the effect of a new nutritional regimen and individual macronutrient intake on white matter integrity and neurodevelopmental outcome. Methods: Two retrospective cohorts of extremely preterm infants (gestational age <28 weeks) were included. Cohort B (n = 79) received a new nutritional regimen, with more rapidly increased, higher protein intake compared to cohort A (n = 99). Individual protein, lipid, and caloric intakes were calculated for the first 28 postnatal days. Diffusion tensor imaging was performed at term-equivalent age, and cognitive and motor development were evaluated at 2 years corrected age (CA) (Bayley-III-NL) and 5.9 years chronological age (WPPSI-III-NL, MABC-2-NL). Results: Compared to cohort A, infants in cohort B had significantly higher protein intake (3.4 g/kg/day vs. 2.7 g/kg/day) and higher fractional anisotropy (FA) in several white matter tracts but lower motor scores at 2 years CA (mean (SD) 103 (12) vs. 109 (12)). Higher protein intake was associated with higher FA and lower motor scores at 2 years CA (B = −6.7, p = 0.001). However, motor scores at 2 years CA were still within the normal range and differences were not sustained at 5.9 years. There were no significant associations with lipid or caloric intake. Conclusion: In extremely preterm born infants, postnatal protein intake seems important for white matter development but does not necessarily improve long-term cognitive and motor development.

scholarly journals Perinatal Clinical Antecedents of White Matter Microstructural Abnormalities on Diffusion Tensor Imaging in Extremely Preterm Infants

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72974 ◽  
Author(s):  
Ulana Pogribna ◽  
Xintian Yu ◽  
Katrina Burson ◽  
Yuxiang Zhou ◽  
Robert E. Lasky ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Preterm Infants ◽  
Diffusion Tensor ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

scholarly journals Isoprostanes as Biomarker for White Matter Injury in Extremely Preterm Infants

2021 ◽  
Vol 8 ◽  
Author(s):  
Caterina Coviello ◽  
Serafina Perrone ◽  
Giuseppe Buonocore ◽  
Simona Negro ◽  
Mariangela Longini ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
White Matter ◽  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Area Under The Curve ◽  
White Matter Injury ◽  
Roc Curve Analysis ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Early Biomarker

Background and Aim: Preterm white matter is vulnerable to lipid peroxidation-mediated injury. F2-isoprostanes (IPs), are a useful biomarker for lipid peroxidation. Aim was to assess the association between early peri-postnatal IPs, white matter injury (WMI) at term equivalent age (TEA), and neurodevelopmental outcome in preterm infants.Methods: Infants with a gestational age (GA) below 28 weeks who had an MRI at TEA were included. IPs were measured in cord blood (cb) at birth and on plasma (pl) between 24 and 48 h after birth. WMI was assessed using Woodward MRI scoring system. Multiple regression analyses were performed to assess the association between IPs with WMI and then with BSITD-III scores at 24 months corrected age (CA). Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive value of pl-IPs for the development of WMI.Results: Forty-four patients were included. cb-IPs were not correlated with WMI score at TEA, whereas higher pl-IPs and lower GA predicted higher WMI score (p = 0.037 and 0.006, respectively) after controlling for GA, FiO2 at sampling and severity of IVH. The area under the curve was 0.72 (CI 95% = 0.51–0.92). The pl-IPs levels plotted curve indicated that 31.8 pg/ml had the best predictive threshold with a sensitivity of 86% and a specificity of 60%, to discriminate newborns with any WMI from newborns without WMI. IPs were not associated with outcome at 24 months.Conclusion: Early measurement of pl-IPs may help discriminate patients showing abnormal WMI score at TEA, thus representing an early biomarker to identify newborns at risk for brain injury.

White matter changes in extremely preterm infants, a population-based diffusion tensor imaging study

2010 ◽  
Vol 99 (6) ◽  
pp. 842-849 ◽  
Author(s):  
Béatrice Skiöld ◽  
Sandra Horsch ◽  
Boubou Hallberg ◽  
Mathias Engström ◽  
Zoltan Nagy ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Preterm Infants ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Population Based ◽  
White Matter Changes ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Diffusion Tensor Imaging Study

Neurodevelopmental outcome of extremely preterm infants born to rural and urban residents' mothers in Australia

2015 ◽  
Vol 91 (8) ◽  
pp. 437-443 ◽  
Author(s):  
Andrea N. Rodrigues ◽  
Barbara Bajuk ◽  
Julee Oei ◽  
Kei Lui ◽  
Mohamed E. Abdel-Latif
Keyword(s):  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Urban Residents ◽  
Rural And Urban ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

scholarly journals Diffusion Tensor Imaging Changes Do Not Affect Long-Term Neurodevelopment Following Early Erythropoietin Among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection Trial

2021 ◽  
Vol 11 (10) ◽  
pp. 1360
Author(s):  
Janessa B. Law ◽  
Bryan A. Comstock ◽  
Todd L. Richards ◽  
Christopher M. Traudt ◽  
Thomas R. Wood ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Linear Models ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Neurodevelopmental Outcomes ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Postmenstrual Age

We aimed to evaluate diffusion tensor imaging (DTI) in infants born extremely preterm, to determine the effect of erythropoietin (Epo) on DTI, and to correlate DTI with neurodevelopmental outcomes at 2 years of age for infants in the Preterm Erythropoietin Neuroprotection (PENUT) Trial. Infants who underwent MRI with DTI at 36 weeks postmenstrual age were included. Neurodevelopmental outcomes were evaluated by Bayley Scales of Infant and Toddler Development (BSID-III). Generalized linear models were used to assess the association between DTI parameters and treatment group, and then with neurodevelopmental outcomes. A total of 101 placebo- and 93 Epo-treated infants underwent MRI. DTI white matter mean diffusivity (MD) was lower in placebo- compared to Epo-treated infants in the cingulate and occipital regions, and occipital white matter fractional isotropy (FA) was lower in infants born at 24–25 weeks vs. 26–27 weeks. These values were not associated with lower BSID-III scores. Certain decreases in clustering coefficients tended to have lower BSID-III scores. Consistent with the PENUT Trial findings, there was no effect on long-term neurodevelopment in Epo-treated infants even in the presence of microstructural changes identified by DTI.

Erythropoietin improves neurodevelopmental outcome of extremely preterm infants

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Achim-Peter Neubauer ◽  
Wolfgang Voss ◽  
Michael Wachtendorf ◽  
Tanja Jungmann
Keyword(s):  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Extremely Preterm ◽  
Extremely Preterm Infants
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