Carbapenemase-producing Gram-negative bacteria: current epidemics, antimicrobial susceptibility and treatment options

2015 ◽  
Vol 10 (3) ◽  
pp. 407-425 ◽  
Author(s):  
Shio-Shin Jean ◽  
Wen-Sen Lee ◽  
Carlos Lam ◽  
Chin-Wang Hsu ◽  
Ray-Jade Chen ◽  
...  
Keyword(s):  
Antimicrobial Susceptibility ◽  
Treatment Options ◽  
Gram Negative Bacteria ◽  
Gram Negative

Prevalence and Antibiogram of Extended-Spectrum Beta-Lactamase Producing Gram-negative Bacteria Isolated from Septicemic Neonates in a Tertiary Care Hospital

KYAMC Journal ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 171-175
Author(s):  
Tania Rahman ◽  
Momtaz Begum ◽  
Sharmeen Sultana ◽  
SM Shamsuzzaman
Keyword(s):  
Antimicrobial Susceptibility ◽  
Diffusion Method ◽  
Gram Negative Bacteria ◽  
Care Hospital ◽  
Beta Lactamase ◽  
Blood Samples ◽  
Gram Negative ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum ◽  
Esbl Producers

Background: In recent years, Extended-spectrum beta-lactamase (ESBL) producing microorganisms have complicated treatment of infections due to resistance of ESBL producing strains to a wide range of antimicrobials. Objective: Target of this study was to determine the prevalence of ESBL producing gramnegative bacteria in neonatal sepsis cases and to reveal the antimicrobial susceptibility pattern of those isolated ESBL producers. Materials and Methods: This cross sectional study was carried out in Dhaka Medical College Hospital (DMCH) over a period of 12 months from January to December in 2016. Following isolation and identification of gram-negative bacteria from blood samples of suspected septicemic neonates, antimicrobial susceptibility test was performed by Kirby Bauer disk-diffusion method and ESBL producers were detected by Double Disk Synergy (DDS) test. Results: Among 52 Gram-negative bacteria isolated from 106 blood samples, 34.61% ESBL producers were detected and Enterobacter spp. (45%) was predominant followed by Klebsiella pneumoniae (33.33%). None of the ESBL producers was resistant to colistin and tigecycline. All ESBL producing Acinetobacter baumannii, 77.78% and 66.67% of ESBL producing Enterobacter spp and Klebsiella spp. respectively showed resistance to meropenem. All ESBL producers were resistant to piperacillintazobactam. Conclusion: Appropriate measures should be taken to prevent the spread of ESBL producing strains by combining strategies for infection prevention, control and rational use of antibiotics. KYAMC Journal Vol. 11, No.-4, January 2021, Page 171-175

scholarly journals Case Commentary: the Need for Cefiderocol Is Clear, but Are the Supporting Clinical Data?

2020 ◽  
Vol 64 (4) ◽  
Author(s):  
Ryan K. Shields
Keyword(s):  
Clinical Trials ◽  
Clinical Practice ◽  
Salvage Therapy ◽  
Randomized Clinical Trials ◽  
Treatment Options ◽  
Multidrug Resistant ◽  
Gram Negative Bacteria ◽  
Potential Utility ◽  
Gram Negative

ABSTRACT Cefiderocol is a newly approved siderophore cephalosporin that demonstrates expanded in vitro activity against multidrug-resistant Gram-negative bacteria. In two challenging cases reported here, cefiderocol shows potential utility as salvage therapy against difficult-to-treat pathogens with limited or no treatment options; however, two multicenter, randomized clinical trials have yielded mixed results among cefiderocol-treated patients. Taken together, clinicians must balance a clear need for cefiderocol in clinical practice with the uncertainties that have stemmed from the available data.

scholarly journals Treatment Options for Carbapenem-resistant Gram-negative Bacterial Infections

2019 ◽  
Vol 69 (Supplement_7) ◽  
pp. S565-S575 ◽  
Author(s):  
Yohei Doi
Keyword(s):  
Bacterial Infections ◽  
Treatment Options ◽  
Clinical Development ◽  
Gram Negative Bacteria ◽  
First Line ◽  
Safe Alternative ◽  
New Agents ◽  
Gram Negative ◽  
Carbapenem Resistant

AbstractAntimicrobial resistance has become one of the greatest threats to public health, with rising resistance to carbapenems being a particular concern due to the lack of effective and safe alternative treatment options. Carbapenem-resistant gram-negative bacteria of clinical relevance include the Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter baumannii, and more recently, Stenotrophomonas maltophilia. Colistin and tigecycline have been used as first-line agents for the treatment of infections caused by these pathogens; however, there are uncertainties regarding their efficacy even when used in combination with other agents. More recently, several new agents with activity against certain carbapenem-resistant pathogens have been approved for clinical use or are reaching late-stage clinical development. They include ceftazidime-avibactam, ceftolozane-tazobactam, meropenem-vaborbactam, imipenem-cilastatin-relebactam, plazomicin, eravacycline, and cefiderocol. In addition, fosfomycin has been redeveloped in a new intravenous formulation. Data regarding the clinical efficacy of these new agents specific to infections caused by carbapenem-resistant pathogens are slowly emerging and appear to generally favor newer agents over previous best available therapy. As more treatment options become widely available for carbapenem-resistant gram-negative infections, the role of antimicrobial stewardship will become crucial in ensuring appropriate and rationale use of these new agents.

Antimicrobial Susceptibility of Nonfermentative Gram negative Bacteria Isolated from Blood Cultures

ANKEM Dergisi ◽  
2014 ◽  
Vol 28 (3) ◽  
pp. 79-85
Author(s):  
Esra Gultekin ◽  
M. Hamidullah Uyanik ◽  
Hayrunisa Hanci ◽  
Zeynep Erdil ◽  
Fatma Nesime Gelen ◽  
...  
Keyword(s):  
Antimicrobial Susceptibility ◽  
Blood Cultures ◽  
Gram Negative Bacteria ◽  
Gram Negative

A 13-Year Study of Antimicrobial Susceptibility of Common Gram-Negative Bacteria Isolated from the Bloodstream in a Teaching Hospital

Chemotherapy ◽  
2000 ◽  
Vol 47 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Thomas K.W. Ling ◽  
Thomas K.W. Ling ◽  
Esther Y.M. Liu ◽  
Esther Y.M. Liu ◽  
Augustine F.B. Cheng ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
Antimicrobial Susceptibility ◽  
Gram Negative Bacteria ◽  
Gram Negative

scholarly journals Prevalence and antimicrobial susceptibility of gram-negative bacteria isolated from bovine mastitis between 2003 and 2008 in Korea

2009 ◽  
Vol 92 (5) ◽  
pp. 2020-2026 ◽  
Author(s):  
H.M. Nam ◽  
S.K. Lim ◽  
H.M. Kang ◽  
J.M. Kim ◽  
J.S. Moon ◽  
...  
Keyword(s):  
Antimicrobial Susceptibility ◽  
Bovine Mastitis ◽  
Gram Negative Bacteria ◽  
Gram Negative
Sign in / Sign up

Export Citation Format

Share Document