Prognostic biomarkers in squamous cell carcinoma of the head and neck

2013 ◽  
pp. 116-131
Author(s):  
Vasu Divi ◽  
Carol Bradford
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Biomarkers

scholarly journals Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma

Head & Neck ◽  
2017 ◽  
Vol 39 (12) ◽  
pp. 2433-2443
Author(s):  
Hongzheng Zhang ◽  
Sungjin Kim ◽  
Zhengjia Chen ◽  
Sreenivas Nannapaneni ◽  
Amy Y. Chen ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Immunodeficiency Virus

scholarly journals Prognostic Biomarkers of Salvage Chemotherapy Following Nivolumab Treatment for Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2299 ◽  
Author(s):  
Takahiro Wakasaki ◽  
Ryuji Yasumatsu ◽  
Muneyuki Masuda ◽  
Toranoshin Takeuchi ◽  
Tomomi Manako ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Progression Free Survival ◽  
Salvage Chemotherapy ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Free Survival ◽  
Reactive Protein

Recent studies have suggested the benefit of salvage chemotherapy (SCT) after immune checkpoint inhibitor (ICI) treatment for recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC). We retrospectively examined the outcome of SCT and the usefulness of the serum C-reactive protein level (CRP) and neutrophil-to-lymphocyte ratio (NLR) as prognostic biomarkers. Thirty-nine patients with R/M HNSCC were enrolled in this study. Twenty-five patients (64.1%) received combination chemotherapy of weekly paclitaxel and cetuximab (PC) as SCT, and 14 patients (35.9%) received tegafur-gimestat-otastat potassium (S1), an oral fluoropyrimidine. In all patients, the response rate, disease control rate, median progression-free survival (PFS), and median overall survival (OS) were 45.2%, 85.7%, 6.5 months, and 13.5 months, respectively. No chemotherapy-related deaths were observed. These PC groups had low CRP (<1.2 mg/dL) or low NLR (<7.0) values at the time of SCT induction, which was significantly associated with an improved OS (p = 0.0440, p = 0.0354). A multivariate analysis also showed that a lower CRP value was significantly associated with a better OS (p = 0.0078). We clarified the usefulness of the PC and S1 regimens as SCT. In addition, SCT with the PC regimen showed a better prognosis with a lower CRP or NLR at induction than a higher CRP or NLR. This is the first report on biomarkers of SCT in R/M HNSCC.

Abstract 1812: LncRNAs as prognostic biomarkers in head and neck squamous cell carcinoma (HNSCC)

2019 ◽  
Author(s):  
Ritu Chaudhary ◽  
Xuefeng Wang ◽  
Biwei Cao ◽  
Nicholas T. Gimbrone ◽  
Robbert JC Slebos ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers

Cell surface markers for T and B lymphocytes activation and adhesion as putative prognostic biomarkers for head and neck squamous cell carcinoma

2013 ◽  
Vol 74 (12) ◽  
pp. 1563-1574 ◽  
Author(s):  
Mariléia Chaves Andrade ◽  
Shirlene Barbosa Pimentel Ferreira ◽  
Luciana C. Gonçalves ◽  
Alfredo Maurício Batista De-Paula ◽  
Elaine Speziali de Faria ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Surface ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
B Lymphocytes ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Surface Markers ◽  
Cell Surface Markers

Abstract 1812: LncRNAs as prognostic biomarkers in head and neck squamous cell carcinoma (HNSCC)

2019 ◽  
Author(s):  
Ritu Chaudhary ◽  
Xuefeng Wang ◽  
Biwei Cao ◽  
Nicholas T. Gimbrone ◽  
Robbert JC Slebos ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers

An 11‐lncRNA expression could be potential prognostic biomarkers in head and neck squamous cell carcinoma

2019 ◽  
Vol 120 (10) ◽  
pp. 18094-18103 ◽  
Author(s):  
Qingyong Xu ◽  
Hang Yin ◽  
Haijiao Ao ◽  
Xue Leng ◽  
Mingdong Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Lncrna Expression

Exosomal-miRNA profiles as diagnostic and prognostic biomarkers in head and neck squamous cell carcinoma (HNSCC).

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 5515-5515
Author(s):  
G. Rabinowits ◽  
C. G. Taylor ◽  
G. H. Kloecker ◽  
A. Patel ◽  
M. B. Hall ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Exosomal Mirna
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