scholarly journals Identification of Therapeutic and Prognostic Biomarkers of Lamin C (LAMC) Family Members in Head and Neck Squamous Cell Carcinoma

2020 ◽  
Vol 26 ◽  
Author(s):  
Pan Jiang ◽  
Shengteng He ◽  
Yanli Li ◽  
Zheng Xu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Family Members ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers

scholarly journals Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma

Head & Neck ◽  
2017 ◽  
Vol 39 (12) ◽  
pp. 2433-2443
Author(s):  
Hongzheng Zhang ◽  
Sungjin Kim ◽  
Zhengjia Chen ◽  
Sreenivas Nannapaneni ◽  
Amy Y. Chen ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Immunodeficiency Virus

scholarly journals The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma

2018 ◽  
Vol 97 (6) ◽  
pp. 645-653 ◽  
Author(s):  
T. Fukusumi ◽  
J.A. Califano
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Family Members ◽  
Notch Pathway ◽  
Suppressor Gene ◽  
Neck Squamous Cell Carcinoma ◽  
Notch1 Mutations

Comprehensive genomic analyses have been performed for head and neck squamous cell carcinoma (HNSCC), revealing a significant rate of NOTCH1 mutations and identifying NOTCH1 as the second most frequently mutated gene after TP53. Most NOTCH1 mutations are considered inactivating, indicating that NOTCH1 is a tumor suppressor gene. On the other hand, cohorts from Asian populations with HNSCC have shown activating NOTCH1 mutations. HNSCC with NOTCH1 mutations have a worse prognosis than the NOTCH1 wild-type tumors. Additional data on other NOTCH family members have shown that NOTCH promotes HNSCC progression. NOTCH family members, including NOTCH pathway genes, are upregulated in HNSCC compared with normal tissues, and inhibition of the NOTCH pathway decreases cell proliferation and invasion. NOTCH activity in HNSCC is therefore contextual, and NOTCH in HNSCC is considered to have a bimodal role as a tumor suppressor and an oncogene. In this review, recent understandings of NOTCH pathway genes, including NOTCH genes, in HNSCC are described. In addition, the implications of NOTCH pathway alteration for HNSCC-specific NOTCH-targeted cancer therapy are explored.

scholarly journals Down-regulation of the microRNA-99 family members in head and neck squamous cell carcinoma

Oral Oncology ◽  
2012 ◽  
Vol 48 (8) ◽  
pp. 686-691 ◽  
Author(s):  
Zujian Chen ◽  
Yi Jin ◽  
Dongsheng Yu ◽  
Anxun Wang ◽  
Ishrat Mahjabeen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Family Members ◽  
Neck Squamous Cell Carcinoma ◽  
Down Regulation

scholarly journals Identification and Confirmation of the miR-30 Family as a Potential Central Player in Tobacco-Related Head and Neck Squamous Cell Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Tingting Zhang ◽  
Xueqin Zhu ◽  
Qiang Sun ◽  
Xing Qin ◽  
Zhen Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Expression Profiles ◽  
Family Members ◽  
Neck Squamous Cell Carcinoma ◽  
Migration And Invasion ◽  
Control Group

Constituents of tobacco that can cause DNA adduct formation and oxidative stress are implicated in the development of head and neck squamous cell carcinoma (HNSCC). However, there are few studies on the mechanism(s) that underlie tobacco-associated HNSCC. Here, we used a model in which tumors were induced in rats using 4-nitroquinoline 1-oxide (4NQO), which mimicked tobacco-related HNSCC, and analyzed the expression profiles of microRNAs and mRNAs. Our results indicated that 57 miRNAs and 474 mRNA/EST transcripts exhibited differential expression profiles between tumor and normal tongue tissues. In tumor tissue, the expression levels of rno-miR-30 family members (rno-miR-30a, rno-miR-30a-3p, rno-miR-30b-5p, rno-miR-30c, rno-miR-30d, rno-miR-30e and rno-miR-30e-3p) were only 8% to 37% of those in the control group. The GO terms enrichment analysis of the differentially expressed miRNAs indicated that oxidation reduction was the most enriched process. Low expression of miR-30 family members in human HNSCC cell lines and tissues was validated by qPCR. The results revealed that the expression of miR-30b-5p and miR-30e-5p was significantly decreased in the TCGA HNSCC dataset and validation datasets, and this decrease in expression further distinguishes HNSCC associated with tobacco use from other subtypes of HNSCC. CCK8, colony formation, transwell migration and HNSCC xenograft tumor assays indicated that miR-30b-5p or miR-30e-5p inhibited proliferation, migration and invasion in vitro, and miR-30b-5p suppressed tumor growth in vivo. Moreover, we uncovered that KRAS might be the potential target gene of miR-30e-5p or miR-30b-5p. Thus, our data clearly showed that decreased expression of miR-30e-5p or miR-30b-5p may play a crucial role in cancer development, especially that of tobacco-induced HNSCC, and may be a novel candidate biomarker and target for this HNSCC subtype.

scholarly journals Prognostic Biomarkers of Salvage Chemotherapy Following Nivolumab Treatment for Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2299 ◽  
Author(s):  
Takahiro Wakasaki ◽  
Ryuji Yasumatsu ◽  
Muneyuki Masuda ◽  
Toranoshin Takeuchi ◽  
Tomomi Manako ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Progression Free Survival ◽  
Salvage Chemotherapy ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Free Survival ◽  
Reactive Protein

Recent studies have suggested the benefit of salvage chemotherapy (SCT) after immune checkpoint inhibitor (ICI) treatment for recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC). We retrospectively examined the outcome of SCT and the usefulness of the serum C-reactive protein level (CRP) and neutrophil-to-lymphocyte ratio (NLR) as prognostic biomarkers. Thirty-nine patients with R/M HNSCC were enrolled in this study. Twenty-five patients (64.1%) received combination chemotherapy of weekly paclitaxel and cetuximab (PC) as SCT, and 14 patients (35.9%) received tegafur-gimestat-otastat potassium (S1), an oral fluoropyrimidine. In all patients, the response rate, disease control rate, median progression-free survival (PFS), and median overall survival (OS) were 45.2%, 85.7%, 6.5 months, and 13.5 months, respectively. No chemotherapy-related deaths were observed. These PC groups had low CRP (<1.2 mg/dL) or low NLR (<7.0) values at the time of SCT induction, which was significantly associated with an improved OS (p = 0.0440, p = 0.0354). A multivariate analysis also showed that a lower CRP value was significantly associated with a better OS (p = 0.0078). We clarified the usefulness of the PC and S1 regimens as SCT. In addition, SCT with the PC regimen showed a better prognosis with a lower CRP or NLR at induction than a higher CRP or NLR. This is the first report on biomarkers of SCT in R/M HNSCC.

Abstract 1812: LncRNAs as prognostic biomarkers in head and neck squamous cell carcinoma (HNSCC)

2019 ◽  
Author(s):  
Ritu Chaudhary ◽  
Xuefeng Wang ◽  
Biwei Cao ◽  
Nicholas T. Gimbrone ◽  
Robbert JC Slebos ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers

Cell surface markers for T and B lymphocytes activation and adhesion as putative prognostic biomarkers for head and neck squamous cell carcinoma

2013 ◽  
Vol 74 (12) ◽  
pp. 1563-1574 ◽  
Author(s):  
Mariléia Chaves Andrade ◽  
Shirlene Barbosa Pimentel Ferreira ◽  
Luciana C. Gonçalves ◽  
Alfredo Maurício Batista De-Paula ◽  
Elaine Speziali de Faria ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Surface ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
B Lymphocytes ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Surface Markers ◽  
Cell Surface Markers
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