scholarly journals Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma

Head & Neck ◽  
2017 ◽  
Vol 39 (12) ◽  
pp. 2433-2443
Author(s):  
Hongzheng Zhang ◽  
Sungjin Kim ◽  
Zhengjia Chen ◽  
Sreenivas Nannapaneni ◽  
Amy Y. Chen ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Immunodeficiency Virus

scholarly journals Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma

Cancer ◽  
2017 ◽  
Vol 124 (1) ◽  
pp. 84-94 ◽  
Author(s):  
Frederico O. Gleber-Netto ◽  
Mei Zhao ◽  
Sanchit Trivedi ◽  
Jiping Wang ◽  
Samar Jasser ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Distinct Pattern ◽  
Neck Squamous Cell Carcinoma ◽  
Tp53 Mutations ◽  
Immunodeficiency Virus

Human immunodeficiency disease in new diagnoses of head and neck squamous cell cancer: are we testing?

2019 ◽  
Vol 133 (12) ◽  
pp. 1038-1040 ◽  
Author(s):  
K J McNamara ◽  
C Fernandez ◽  
T F C Saunders ◽  
F Ahsan
Keyword(s):  
Human Immunodeficiency Virus ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Human Immunodeficiency Virus Testing ◽  
Neck Squamous Cell Carcinoma ◽  
Multidisciplinary Teams ◽  
Immunodeficiency Virus ◽  
Virus Testing

AbstractBackgroundHuman immunodeficiency virus infected patients have a three-fold increased risk of head and neck squamous cell carcinoma. The British HIV Association recommends human immunodeficiency virus testing in all new diagnoses of head and neck squamous cell carcinoma.ObjectivesThis observational study aimed to examine the current routine practice of human immunodeficiency virus testing in patients with newly diagnosed head and neck squamous cell carcinoma, and to address the importance of this test in promoting the early diagnosis and treatment of human immunodeficiency virus.MethodsAll head and neck cancer multidisciplinary teams in England were questioned on their protocol for human immunodeficiency virus testing in new diagnoses of head and neck squamous cell carcinoma.ResultsOnly 1 out of 30 hospitals leading head and neck multidisciplinary teams (3.3 per cent) routinely offered human immunodeficiency virus testing in this high-risk patient group.ConclusionThis observational study highlights that head and neck specialists are not aware of, and are consequently not complying with, routine human immunodeficiency virus testing as recommended by the British HIV Association guidelines.

scholarly journals Prognostic Biomarkers of Salvage Chemotherapy Following Nivolumab Treatment for Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2299 ◽  
Author(s):  
Takahiro Wakasaki ◽  
Ryuji Yasumatsu ◽  
Muneyuki Masuda ◽  
Toranoshin Takeuchi ◽  
Tomomi Manako ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Progression Free Survival ◽  
Salvage Chemotherapy ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Free Survival ◽  
Reactive Protein

Recent studies have suggested the benefit of salvage chemotherapy (SCT) after immune checkpoint inhibitor (ICI) treatment for recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC). We retrospectively examined the outcome of SCT and the usefulness of the serum C-reactive protein level (CRP) and neutrophil-to-lymphocyte ratio (NLR) as prognostic biomarkers. Thirty-nine patients with R/M HNSCC were enrolled in this study. Twenty-five patients (64.1%) received combination chemotherapy of weekly paclitaxel and cetuximab (PC) as SCT, and 14 patients (35.9%) received tegafur-gimestat-otastat potassium (S1), an oral fluoropyrimidine. In all patients, the response rate, disease control rate, median progression-free survival (PFS), and median overall survival (OS) were 45.2%, 85.7%, 6.5 months, and 13.5 months, respectively. No chemotherapy-related deaths were observed. These PC groups had low CRP (<1.2 mg/dL) or low NLR (<7.0) values at the time of SCT induction, which was significantly associated with an improved OS (p = 0.0440, p = 0.0354). A multivariate analysis also showed that a lower CRP value was significantly associated with a better OS (p = 0.0078). We clarified the usefulness of the PC and S1 regimens as SCT. In addition, SCT with the PC regimen showed a better prognosis with a lower CRP or NLR at induction than a higher CRP or NLR. This is the first report on biomarkers of SCT in R/M HNSCC.

Abstract 1812: LncRNAs as prognostic biomarkers in head and neck squamous cell carcinoma (HNSCC)

2019 ◽  
Author(s):  
Ritu Chaudhary ◽  
Xuefeng Wang ◽  
Biwei Cao ◽  
Nicholas T. Gimbrone ◽  
Robbert JC Slebos ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers

Cell surface markers for T and B lymphocytes activation and adhesion as putative prognostic biomarkers for head and neck squamous cell carcinoma

2013 ◽  
Vol 74 (12) ◽  
pp. 1563-1574 ◽  
Author(s):  
Mariléia Chaves Andrade ◽  
Shirlene Barbosa Pimentel Ferreira ◽  
Luciana C. Gonçalves ◽  
Alfredo Maurício Batista De-Paula ◽  
Elaine Speziali de Faria ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Surface ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
B Lymphocytes ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Surface Markers ◽  
Cell Surface Markers

Abstract 1812: LncRNAs as prognostic biomarkers in head and neck squamous cell carcinoma (HNSCC)

2019 ◽  
Author(s):  
Ritu Chaudhary ◽  
Xuefeng Wang ◽  
Biwei Cao ◽  
Nicholas T. Gimbrone ◽  
Robbert JC Slebos ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers

An 11‐lncRNA expression could be potential prognostic biomarkers in head and neck squamous cell carcinoma

2019 ◽  
Vol 120 (10) ◽  
pp. 18094-18103 ◽  
Author(s):  
Qingyong Xu ◽  
Hang Yin ◽  
Haijiao Ao ◽  
Xue Leng ◽  
Mingdong Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Lncrna Expression

Exosomal-miRNA profiles as diagnostic and prognostic biomarkers in head and neck squamous cell carcinoma (HNSCC).

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 5515-5515
Author(s):  
G. Rabinowits ◽  
C. G. Taylor ◽  
G. H. Kloecker ◽  
A. Patel ◽  
M. B. Hall ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Biomarkers ◽  
Exosomal Mirna
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