Mycobacterial antibody levels and immune restoration disease in HIV patients treated in South East Asia

2011 ◽  
Vol 5 (6) ◽  
pp. 847-853 ◽  
Author(s):  
Hermi R Sumatoh ◽  
Benjamin G Oliver ◽  
Manoj Kumar ◽  
Julian H Elliott ◽  
Saphonn Vonthanak ◽  
...  
Keyword(s):  
East Asia ◽  
South East Asia ◽  
Immune Restoration ◽  
Hiv Patients ◽  
Immune Restoration Disease ◽  
Antibody Levels

scholarly journals The Search for a Genetic Factor Associating with Immune Restoration Disease in HIV Patients Co-Infected withMycobacterium tuberculosis

2013 ◽  
Vol 34 (6) ◽  
pp. 445-449 ◽  
Author(s):  
Jacquita S. Affandi ◽  
Manoj Kumar ◽  
Upasna Agarwal ◽  
Sarman Singh ◽  
Patricia Price
Keyword(s):  
Genetic Factor ◽  
Nucleotide Polymorphisms ◽  
Mycobacterial Disease ◽  
Immune Restoration ◽  
Hiv Patients ◽  
Single Nucleotide ◽  
Immune Restoration Disease ◽  
Genes Encoding ◽  
Per Se ◽  
Immune Related Genes

BACKGROUND: Up to 43% of HIV-infected patients co-infected withMycobacterium tuberculosisexperience exacerbations of tuberculosis (TB) after commencing antiretroviral therapy (ART). These are termed immune restoration disease (IRD). It is unclear why individual susceptibility varies.OBJECTIVE: We investigate if single nucleotide polymorphisms (SNP) in genes encoding cytokines, chemokines and their receptors associate with development of an IRD event in patients of two different ethnicities.METHODS: DNA samples were available from small well-characterised groups of HIV patients treated in Cambodia (TB-IRD,n= 17; HIV+TB+controls, n = 55) and India (TB-IRD,n= 19; HIV+TB+controls,n= 43). HIV patients with a TB diagnosis but no evidence of IRD were included to control for susceptibility to TB per se. Sixteen SNP implicated in inflammation or mycobacterial disease were genotyped.RESULTS: Susceptibility to TB-IRD associated with carriage of TNFA-1031*T (rs1799964;P=0.05) and SLC11A1 D543N*G (rs17235409;P=0.04) in Cambodian patients and carriage of IL18-607*G (rs1946518;P=0.02) and VDR FokI (F/f)*T (rs10735810;P=0.05) in Indian patients.CONCLUSIONS: Associations between polymorphisms in immune-related genes and TB-IRD were found, but none were common across two ethnicities.

Interferon-γ and IL-5 Production Correlate Directly in HIV Patients Co-Infected with Mycobacterium tuberculosis with or without Immune Restoration Disease

2010 ◽  
Vol 26 (12) ◽  
pp. 1287-1289 ◽  
Author(s):  
Benjamin G. Oliver ◽  
Julian H. Elliott ◽  
Vonthanak Saphonn ◽  
Mean Chhi Vun ◽  
Martyn A. French ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Interferon Γ ◽  
Immune Restoration ◽  
Hiv Patients ◽  
Immune Restoration Disease

CIScoSI Study [Children Immunization Status and cases of Systemic Illness]

2018 ◽  
Vol 3 (3) ◽  
Keyword(s):  
Infectious Diseases ◽  
East Asia ◽  
Pediatric Patients ◽  
Severe Disease ◽  
Tertiary Care ◽  
Immunization Coverage ◽  
South East Asia ◽  
Immunization Status ◽  
Tertiary Care Hospitals ◽  
Total Coverage

To determine the immunization status of pediatric patients under age of 5 years visiting pediatric department of tertiary care hospitals in South East Asia. The aim of this study was to appreciate the awareness and implementation of vaccination in pediatric patients who came into pediatric outpatient Department with presenting complain other than routine vaccination. we can also know the count of patients who do not complete their vaccination after birth. we can differentiate between vaccinated and unvaccinated patients and incidence of severe disease in both groups. Immunization is a protective process which makes a person resistant to the harmful diseases prevailing in the community, typically by vaccine administration either orally or intravenously. It is proven for controlling and eliminating many threatening diseases from the community. WHO report that licensed vaccines are available for the prevention of many infectious diseases. After the implementation of effective immunization the rate of many infectious diseases have declined in many countries of the world. South-East Asia is far behind in the immunization coverage. An estimated total coverage is 56%-88% for a fully immunized child, which is variable between countries. Also the coverage is highest for BCG and lowest for Polio.

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