scholarly journals Kinesiotherapy With Exergaming as a Potential Modulator of Epigenetic Marks and Clinical Functional Variables of Older Women: Protocol for a Mixed Methods Study

10.2196/32729 ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. e32729
Author(s):  
Patrícia Paula Bazzanello Henrique ◽  
Fabrízzio Martin Pelle Perez ◽  
Osvaldo Henrique Cemin Becker ◽  
Ericles Andrei Bellei ◽  
Daiana Biduski ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Older Women ◽  
Intervention Group ◽  
Control Group ◽  
Timed Up And Go ◽  
Epigenetic Marks ◽  
Exercise Interventions ◽  
Group A ◽  
Clinical Trials Registry ◽  
The Impact

Background Kinesiotherapy is an option to mitigate worsening neuropsychomotor function due to human aging. Moreover, exergames are beneficial for the practice of physical therapy by older patients. Physical exercise interventions are known to alter the epigenome, but little is known about their association with exergames. Objective We aim to evaluate the effects of kinesiotherapy with exergaming on older women’s epigenetic marks and cognitive ability, as well as on their clinical functional variables. Our hypothesis states that this kind of therapy can elicit equal or even better outcomes than conventional therapy. Methods We will develop a virtual clinic exergame with 8 types of kinesiotherapy exercises. Afterward, we will conduct a 1:1 randomized clinical trial to compare the practice of kinesiotherapy with exergames (intervention group) against conventional kinesiotherapy (control group). A total of 24 older women will be enrolled for 1-hour sessions performed twice a week, for 6 weeks, totaling 12 sessions. We will assess outcomes using epigenetic blood tests, the Montreal Cognitive Assessment test, the Timed Up and Go test, muscle strength grading in a hydraulic dynamometer, and the Game Experience Questionnaire at various stages. Results The project was funded in October 2019. Game development took place in 2020. Patient recruitment and a clinical trial are planned for 2021. Conclusions Research on this topic is likely to significantly expand the understanding of kinesiotherapy and the impact of exergames. To the best of our knowledge, this may be one of the first studies exploring epigenetic outcomes of exergaming interventions. Trial Registration Brazilian Clinical Trials Registry/Registro Brasileiro de Ensaios Clínicos (ReBEC) RBR-9tdrmw; https://ensaiosclinicos.gov.br/rg/RBR-9tdrmw. International Registered Report Identifier (IRRID) DERR1-10.2196/32729

scholarly journals Kinesiotherapy with Exergaming as a Potential Modulator of Epigenetic Marks and Clinical Functional Variables of Elderly Women: Protocol for a Mixed Methods Study (Preprint)

2021 ◽  
Author(s):  
Patrícia Paula Bazzanello Henrique ◽  
Fabrízzio Martin Pelle Perez ◽  
Osvaldo Henrique Cemin Becker ◽  
Ericles Andrei Bellei ◽  
Daiana Biduski ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Elderly Women ◽  
Intervention Group ◽  
The Elderly ◽  
Control Group ◽  
Timed Up And Go ◽  
Epigenetic Marks ◽  
Exercise Interventions ◽  
Clinical Trials Registry ◽  
The Impact

BACKGROUND Kinesiotherapy is an option to mitigate the neuropsychomotor worsening of human aging. Also, exergames are beneficial for the practice of physical therapy of the elderly. There is evidence that physical exercise interventions can alter the epigenome, but little is known about its association with exergames. OBJECTIVE We aim to evaluate the effects of kinesiotherapy with exergaming on elderly women's epigenetic marks and cognitive ability, alongside the effects on clinical functional variables. Our hypothesis states this kind of therapy can elicit equal or even better outcomes than the conventional one. METHODS We will develop a virtual clinic exergame with 8 types of kinesiotherapy exercises. Afterward, we will conduct a 1:1 randomized clinical trial to compare the practice of kinesiotherapy with exergames (intervention group) against conventional kinesiotherapy (control group). A total of 24 elderly women will be enrolled for 1-hour sessions performed twice a week, for 6 weeks, totaling 12 sessions. We will assess outcomes at various stages using epigenetic blood tests, Montreal Cognitive Assessment test, Timed Up and Go test, muscle strength grading in a hydraulic dynamometer, and Game Experience Questionnaire. RESULTS The project was funded at the end of 2019. Game development takes place during 2020. Patient recruitment and clinical trial are planned for 2021. CONCLUSIONS Research on this topic is likely to significantly expand the understanding of kinesiotherapy and the impact of exergames. To our knowledge, this may be one of the first studies exploring epigenetic outcomes of exergaming interventions. CLINICALTRIAL Brazilian Clinical Trials Registry RBR-9tdrmw

scholarly journals Clinical trial for the control of water intake of patients undergoing hemodialysis treatment

2018 ◽  
Vol 26 (0) ◽  
Author(s):  
Graziella Allana Serra Alves de Oliveira Oller ◽  
Marília Pilotto de Oliveira ◽  
Cláudia Bernardi Cesarino ◽  
Carla Regina de Souza Teixeira ◽  
José Abrão Cardeal da Costa ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Weight Loss ◽  
Water Intake ◽  
Intervention Group ◽  
Control Group ◽  
Motivational Intervention ◽  
Hemodialysis Treatment ◽  
Quasi Experimental ◽  
Clinical Trials Registry ◽  
The Impact

ABSTRACT Objective: to analyze the impact of an educational and motivational intervention for patients with a chronic kidney disease, undergoing hemodialysis treatment, on the control of fluid intake during interdialytic periods. Method: a quasi-experimental, non-randomized clinical trial with patients from a Nephrological Unit of the State of São Paulo. Participants were included in two groups: Control Group with 106 patients and Intervention Group with 86 patients, totaling 192 participants. The used intervention was an educational and motivational video to control liquid intake, based on the Bandura’s Theory. The measure of control of water intake was the percentage of lost weight, also considered the variable outcome of the research. For the data analysis, descriptive analyses and regression analysis of the Inflated Beta Model were used. Results: patients who participated in the intervention had a decrease in the pattern of weight gain in interdialytic periods, with a 3.54 times more chance of reaching the goal of 100% of weight loss when compared to participants from the control group. Conclusion: the educational and motivational intervention was effective in reducing the percentage of weight loss in patients undergoing hemodialysis. Brazilian Clinical Trials Registry (ReBEC) under the opinion RBR-4XYTP6.

scholarly journals Pupillometry pain index decreases intraoperative sufentanyl administration in cardiac surgery: a prospective randomized study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Vivien Berthoud ◽  
Maxime Nguyen ◽  
Anouck Appriou ◽  
Omar Ellouze ◽  
Mohamed Radhouani ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cardiac Surgery ◽  
Primary Outcome ◽  
Randomized Study ◽  
Intervention Group ◽  
Prospective Randomized Study ◽  
Control Group ◽  
Standard Group ◽  
Postoperative Course ◽  
The Impact

AbstractPupillometry has proven effective for the monitoring of intraoperative analgesia in non-cardiac surgery. We performed a prospective randomized study to evaluate the impact of an analgesia-guided pupillometry algorithm on the consumption of sufentanyl during cardiac surgery. Fifty patients were included prior to surgery. General anesthesia was standardized with propofol and target-controlled infusions of sufentanyl. The standard group consisted of sufentanyl target infusion left to the discretion of the anesthesiologist. The intervention group consisted of sufentanyl target infusion based on the pupillary pain index. The primary outcome was the total intraoperative sufentanyl dose. The total dose of sufentanyl was lower in the intervention group than in the control group and (55.8 µg [39.7–95.2] vs 83.9 µg [64.1–107.0], p = 0.04). During the postoperative course, the cumulative doses of morphine (mg) were not significantly different between groups (23 mg [15–53] vs 24 mg [17–46]; p = 0.95). We found no significant differences in chronic pain at 3 months between the 2 groups (0 (0%) vs 2 (9.5%) p = 0.49). Overall, the algorithm based on the pupillometry pain index decreased the dose of sufentanyl infused during cardiac surgery.Clinical trial number: NCT03864016.

scholarly journals Interleukin-31 Serum And Pruritus Dimension After Acupuncture Treatment In Hemodialysis Patients: A Randomized Clinical Trial

2021 ◽  
Vol 9 (B) ◽  
pp. 196-201
Author(s):  
Dedi Ardinata ◽  
Rozaimah Zain-Hamid ◽  
Irma. D. Roesyanto-Mahadi ◽  
Hasan Mihardja
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Intervention Group ◽  
Serum Levels ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Placebo Control ◽  
Limited Information ◽  
Before And After ◽  
The Impact

BACKGROUND: Interleukin (IL)-31 serum levels were significantly higher in hemodialysis patients with pruritus, whereas acupuncture in LI11 was shown to improve symptoms of pruritus. However, there is limited information that IL-31 serum levels that correlate with decreased dimensions of the pruritus after acupuncture in LI11 in a hemodialysis patient. AIM: The aim of the study was to demonstrate the impact of acupuncture in LI11 and IL-31 serum level and its correlation with dimensions of the pruritus in hemodialysis patients. METHODS: A randomized clinical trial has been carried out from August 2019 to December 2019 at H. Adam Malik General Hospital, Medan, Indonesia. Sixty patients underwent hemodialysis who were randomly allocated to two groups, one group got acupuncture in Quchi LI11 (intervention group), and the other group got a placebo (control group). IL-31 serum levels and pruritus were measured before and after 6 weeks of acupuncture in both groups. RESULTS: Acupuncture did not significantly reduce IL-31 (p = 0.931) and decreased dimensions: Degree, duration, disability, and distribution of the pruritus between the intervention group and the control group after 6 weeks of acupuncture in LI11. It can be shown that there is no significant correlation between IL-31 serum levels and dimensions of the pruritus. CONCLUSION: This study demonstrates the effect of acupuncture on reducing dimensions of the pruritus not related to IL-31 serum levels. Identifying the action mechanism of acupuncture to minimize pruritus considerably enhances knowledge of the impacts of acupuncture on reducing pruritus in hemodialysis patients.

scholarly journals Investigating the impact of physical-mental exercises on depression after prederm delivery: a clinical trial

2020 ◽  
pp. 128-138
Keyword(s):  
Clinical Trial ◽  
Intervention Group ◽  
Psychological Trauma ◽  
The Body ◽  
Public Hospitals ◽  
Control Group ◽  
Control Groups ◽  
The Mean ◽  
The Impact ◽  
Stretching Exercises

Background and Aim: Prederm delivery, and the consequences are include premature newborn, hospitalization in the NICU ward, psychological damage to mother and heart family performing low-cost, practical interventions can play an important role in promoting maternal health by to reduce psychological trauma. Therefore, the present study was performed to determine the impact of physical-mental exercises on depression after prederm delivery. Materials and Methods: In this clinical trial, 100 women with prederm delivery 28-36 weeks, it was performed in public hospitals in Mashhad in 2019. Sampling was performed by random blocking method and the subjects were selected by available method and were divided into two control groups (n=50) and intervention (n=50). The intervention group performed stretching exercises as well as meditation by the researcher on the third day after delivery with a frequency of two sessions per week for up to 8 sessions, and the control group received the usual care. Beck's depression questionnaire was completed for both groups in the first 24 hours after delivery and at the end of the study. Statistical analysis of the data was performed by independent t-test, Mann-Whitney and Wilkaxon. Results: The mean score of depression in the intervention and control groups at the end of the study was statistically significant (p≤0.001). The mean score of depression in the intervention group was significant at the beginning and the end of the study (P<0.001). Conclusion: Stretching exercises with a focus on the body after delivery can reduce the rate of depression in mothers with prederm delivery. Key Words: Meditation; Postpartum Depression; prederm delivery; Stretching Exercise

scholarly journals Supervisi Klinik Berbasis 4S (Structure, Skills, Support, and Sustainable) terhadap Penerapan Keselamatan Pasien

2020 ◽  
Vol 20 (2) ◽  
pp. 556
Author(s):  
Tri Asih Oktariani ◽  
Yulastri Arif ◽  
Dewi Murni
Keyword(s):  
Patient Safety ◽  
Clinical Supervision ◽  
Intervention Group ◽  
Routine Activity ◽  
Control Group ◽  
Safety Incident ◽  
Patient Safety Incident ◽  
Group A ◽  
Vital Matter ◽  
The Impact

Patient safety is a vital matter of a hospital. Reports related to Patient Safety Incident (IKP) continue to increase from 2018 to 2019 in two hospitals namely Abdul Manap Hospital and Raden Mattaher Hospital Jambi. The research aims to analyse the impact of the 4S-based clinical supervision clinic on patient safety implementation of nurse’s practiceat the Jambi Municipal public hospital in 2019. This type of research is quasy experiment with a pre-post approach test design with control group. A sample of implementing nurses amounted to 66 people. Sampling with proportional random sampling. There is a significant influence on the clinical 4S-based clinica lsupervision on the implementation of patient safety by the implementing nurses in the intervention group in the hospital of Raden Mattaher Jambi (0.012) and there is no influence on the application of safety of patients conducted by the implementing nurses in hospital Abdul Manap Jambi City (0.083). Hopefully, the hospital can make the 4S-based clinical supervision to be a routine activity that by making careful planning about the supervision activities performed so that supervision can work to objectives that have been determined.

scholarly journals The Impact of Involvement of Father's with Preterm Newborns on their Paternal-Infant Bonding and Self-Efficacy: non-randomized clinical trial

2020 ◽  
Author(s):  
Jila Mirlashari ◽  
Liisa Holsti ◽  
Hadi Ranjbar ◽  
Mahnaz Sanjari ◽  
Fatemeh Morovati ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Self Efficacy ◽  
Repeated Measures ◽  
Intervention Group ◽  
T Test ◽  
Control Group ◽  
Developmental Care ◽  
Premature Newborns ◽  
The Impact

Abstract Background: Premature birth and postpartum hospitalization can hurt the father-newborn bonding and fathers’ self-efficacy in the care of the newborn. This study was conducted to investigate the effect of the involvement of fathers with premature newborns on paternal-infant bonding and self-efficacy based on developmental care principles.Methods: This was a non-randomized clinical trial. Eighty fathers of hospitalized newborns in the neonatal intensive care unit were selected by convenience sampling method and divided into two groups ( 1 ). The intervention comprised training developmental care to fathers through simulations and then at the bedside of the newborn and the active involvement of fathers in the care of premature newborns admitted to the NICU. Pre-and post-intervention outcomes (after four weeks) were collected using Mother to Infant Bonding Scale and Perceived Maternal Parenting Self-Efficacy tool. Differences between groups were analyzed using independent t-test, paired t-test, repeated measures ANOVA.Results: The mean bonding score reduced by 2.3 ± 2.17 in the control group and 5.27 ± 2. 57 in the intervention group. A lower score represents a better bonding (f (1.78) = 9.19, p = 0.003). The self-efficacy score increased in both groups however, it was significantly higher in intervention group. In the intervention group increased by 8.85 ± 5.046, and in the control group, it increased by 1.27± 3.31, (f (1.78) = 21.88, p <0.001).Conclusions: Developmental care by fathers training and involvement in care can improve the father -infant bonding and increase the paternal self-efficacy for the care of the high risk newborn.Trial registration: Iranian Registry of Clinical Trials: IRCT20171010036690N1, 2018-01-31.

scholarly journals Effect of virtual reality exercises on balance and fall in elderly people with fall risk: a randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Noorolla Zahedian-Nasab ◽  
Azita Jaberi ◽  
Fatemeh Shirazi ◽  
Somayyeh Kavousipor
Keyword(s):  
Virtual Reality ◽  
Nursing Homes ◽  
Elderly People ◽  
Fear Of Falling ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Timed Up And Go ◽  
Xbox Kinect ◽  
The Impact

Abstract Background Deficient balance and fear of falling in elderly people can lead to disturbed daily activities, falling, and finally reduced quality of life. Therefore, evaluation of low-risk methods that might partially improve balance in this group of people is of utmost importance. The present study aimed to investigate the impact of Virtual Reality (VR) exercises based on Xbox Kinect on balance and fear of falling among elderly people. Methods This clinical trial was performed on 60 elderly individuals living in nursing homes divided into two groups of control and Xbox. The participants in the intervention group received VR exercises based on Xbox Kinect in form of two 30–45-min sessions held on a weekly basis for 6 weeks. The individuals in the control group, on the other hand, received routine exercises of the nursing homes. The research tools used in this study included a demographic questionnaire, the Berg Balance Scale (BBS), the Timed Up and Go (TUG) test, and the Falling Efficacy Scale (FES). Results The findings of the current study demonstrated that the scores of BBS and TUG test as the indices of balance among elderly people improved significantly in the Xbox group after the intervention (p < 0.001 for both BBS and TUG test). Moreover, the score of fear of falling diminished significantly in the intervention group compared to the control group (p < 0.001). Conclusion According to the results of the present investigation, 6 weeks of VR balance exercises could enhance balance and fear of falling among elderly people living in nursing homes. Trial registration Code:IRCT20190727044347N1, Date: 17-8-2019.

scholarly journals Effect of Square Dance Exercise on Older Women With Mild Mental Disorders

2021 ◽  
Vol 12 ◽  
Author(s):  
Jindong Chang ◽  
Yuping Chen ◽  
Chunzhen Liu ◽  
Liming Yong ◽  
Ming Yang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mental Disorders ◽  
Older Women ◽  
Intervention Group ◽  
Adjunctive Treatment ◽  
Control Group ◽  
Exercise Interventions ◽  
Therapeutic Benefits ◽  
Clinical Experiments

Many epidemiological studies have demonstrated the therapeutic benefits of exercise (EX) that can be used for adjunctive treatment in mental disorders. Despite several clinical experiments using exercise interventions, controlled studies are sparse in most disorder groups. Square dance is a popular aerobic exercise for older women in China. This study aimed to explore the effect of Chinese square dance exercise on mild mental disorders in older women. Participants included 109 older women with mild cognitive impairment from four large nursing homes. Participants were assigned either to the intervention group (n = 62) or the control group (n = 47), according to their residential nursing home. The intervention group underwent an 18-week square dance exercise, while the control group maintained their usual lifestyle. The outcomes were tested at baseline and weeks 9 and 18. The results showed that square dance exercise positively affected the results of all evaluations, especially on the participants' depressive symptoms and quality-of-life-related mental health. This study demonstrates that square dance exercise is a safe and effective approach for older women with mild cognitive impairment that benefits their long-term health.

scholarly journals The Impact of Educational Intervention of HighRisk Pregnancy and HighRisk Childbirth on Knowledge, Attitude, and Behavior in Recognizing Danger Signs in Pregnancy: A Single Blind Clinical Trial

2017 ◽  
pp. 69
Author(s):  
JM Seno Adjie ◽  
Devi M Malik
Keyword(s):  
Clinical Trial ◽  
High Risk ◽  
Educational Intervention ◽  
Intervention Group ◽  
Educational Interventions ◽  
Bivariate Analysis ◽  
Control Group ◽  
Risk Pregnancy ◽  
The Impact ◽  
Single Blind

Objective: To assess the impact of additional educational interventions given to pregnant women in identifying high-risk pregnancy and high-risk childbirth by measuring changes in knowledge, attitudes and behaviors in the pregnancy and after childbirth. Methods: This study was a single blind clinical trial conducted at obstetrics out-patient clinic of Dr. Cipto Mangunkusumo Hospital, Jakarta. Total sample were 52 responders, for the 26 responders to the control group and 26 responders to the intervention group. The research instrument was a questionnaire form, which include knowledge, attitude and behaviour of a number of 48 questions. Analysis was performed using SPSS 20 with bivariate analysis. Results: We did not found significant differences in a range of age (30.65  29.38 with 1.20  0.75), education (both groups showed a high level of education) and employment for both groups. We found significant differences on knowledge, behaviour (p = 0.001 and = 0.042, respectively) on the first antenatal care compared with after childbirth. Conclusion: The educational intervention gives significant impact in attitude and behaviour. [Indones J Obstet Gynecol 2017; 5-2: 69-72] Keywords: attitude, behaviour, educational intervention, knowledge

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