scholarly journals Kinesiotherapy with Exergaming as a Potential Modulator of Epigenetic Marks and Clinical Functional Variables of Elderly Women: Protocol for a Mixed Methods Study (Preprint)

2021 ◽  
Author(s):  
Patrícia Paula Bazzanello Henrique ◽  
Fabrízzio Martin Pelle Perez ◽  
Osvaldo Henrique Cemin Becker ◽  
Ericles Andrei Bellei ◽  
Daiana Biduski ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Elderly Women ◽  
Intervention Group ◽  
The Elderly ◽  
Control Group ◽  
Timed Up And Go ◽  
Epigenetic Marks ◽  
Exercise Interventions ◽  
Clinical Trials Registry ◽  
The Impact

BACKGROUND Kinesiotherapy is an option to mitigate the neuropsychomotor worsening of human aging. Also, exergames are beneficial for the practice of physical therapy of the elderly. There is evidence that physical exercise interventions can alter the epigenome, but little is known about its association with exergames. OBJECTIVE We aim to evaluate the effects of kinesiotherapy with exergaming on elderly women's epigenetic marks and cognitive ability, alongside the effects on clinical functional variables. Our hypothesis states this kind of therapy can elicit equal or even better outcomes than the conventional one. METHODS We will develop a virtual clinic exergame with 8 types of kinesiotherapy exercises. Afterward, we will conduct a 1:1 randomized clinical trial to compare the practice of kinesiotherapy with exergames (intervention group) against conventional kinesiotherapy (control group). A total of 24 elderly women will be enrolled for 1-hour sessions performed twice a week, for 6 weeks, totaling 12 sessions. We will assess outcomes at various stages using epigenetic blood tests, Montreal Cognitive Assessment test, Timed Up and Go test, muscle strength grading in a hydraulic dynamometer, and Game Experience Questionnaire. RESULTS The project was funded at the end of 2019. Game development takes place during 2020. Patient recruitment and clinical trial are planned for 2021. CONCLUSIONS Research on this topic is likely to significantly expand the understanding of kinesiotherapy and the impact of exergames. To our knowledge, this may be one of the first studies exploring epigenetic outcomes of exergaming interventions. CLINICALTRIAL Brazilian Clinical Trials Registry RBR-9tdrmw

scholarly journals Kinesiotherapy With Exergaming as a Potential Modulator of Epigenetic Marks and Clinical Functional Variables of Older Women: Protocol for a Mixed Methods Study

10.2196/32729 ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. e32729
Author(s):  
Patrícia Paula Bazzanello Henrique ◽  
Fabrízzio Martin Pelle Perez ◽  
Osvaldo Henrique Cemin Becker ◽  
Ericles Andrei Bellei ◽  
Daiana Biduski ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Older Women ◽  
Intervention Group ◽  
Control Group ◽  
Timed Up And Go ◽  
Epigenetic Marks ◽  
Exercise Interventions ◽  
Group A ◽  
Clinical Trials Registry ◽  
The Impact

Background Kinesiotherapy is an option to mitigate worsening neuropsychomotor function due to human aging. Moreover, exergames are beneficial for the practice of physical therapy by older patients. Physical exercise interventions are known to alter the epigenome, but little is known about their association with exergames. Objective We aim to evaluate the effects of kinesiotherapy with exergaming on older women’s epigenetic marks and cognitive ability, as well as on their clinical functional variables. Our hypothesis states that this kind of therapy can elicit equal or even better outcomes than conventional therapy. Methods We will develop a virtual clinic exergame with 8 types of kinesiotherapy exercises. Afterward, we will conduct a 1:1 randomized clinical trial to compare the practice of kinesiotherapy with exergames (intervention group) against conventional kinesiotherapy (control group). A total of 24 older women will be enrolled for 1-hour sessions performed twice a week, for 6 weeks, totaling 12 sessions. We will assess outcomes using epigenetic blood tests, the Montreal Cognitive Assessment test, the Timed Up and Go test, muscle strength grading in a hydraulic dynamometer, and the Game Experience Questionnaire at various stages. Results The project was funded in October 2019. Game development took place in 2020. Patient recruitment and a clinical trial are planned for 2021. Conclusions Research on this topic is likely to significantly expand the understanding of kinesiotherapy and the impact of exergames. To the best of our knowledge, this may be one of the first studies exploring epigenetic outcomes of exergaming interventions. Trial Registration Brazilian Clinical Trials Registry/Registro Brasileiro de Ensaios Clínicos (ReBEC) RBR-9tdrmw; https://ensaiosclinicos.gov.br/rg/RBR-9tdrmw. International Registered Report Identifier (IRRID) DERR1-10.2196/32729

scholarly journals Clinical trial for the control of water intake of patients undergoing hemodialysis treatment

2018 ◽  
Vol 26 (0) ◽  
Author(s):  
Graziella Allana Serra Alves de Oliveira Oller ◽  
Marília Pilotto de Oliveira ◽  
Cláudia Bernardi Cesarino ◽  
Carla Regina de Souza Teixeira ◽  
José Abrão Cardeal da Costa ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Weight Loss ◽  
Water Intake ◽  
Intervention Group ◽  
Control Group ◽  
Motivational Intervention ◽  
Hemodialysis Treatment ◽  
Quasi Experimental ◽  
Clinical Trials Registry ◽  
The Impact

ABSTRACT Objective: to analyze the impact of an educational and motivational intervention for patients with a chronic kidney disease, undergoing hemodialysis treatment, on the control of fluid intake during interdialytic periods. Method: a quasi-experimental, non-randomized clinical trial with patients from a Nephrological Unit of the State of São Paulo. Participants were included in two groups: Control Group with 106 patients and Intervention Group with 86 patients, totaling 192 participants. The used intervention was an educational and motivational video to control liquid intake, based on the Bandura’s Theory. The measure of control of water intake was the percentage of lost weight, also considered the variable outcome of the research. For the data analysis, descriptive analyses and regression analysis of the Inflated Beta Model were used. Results: patients who participated in the intervention had a decrease in the pattern of weight gain in interdialytic periods, with a 3.54 times more chance of reaching the goal of 100% of weight loss when compared to participants from the control group. Conclusion: the educational and motivational intervention was effective in reducing the percentage of weight loss in patients undergoing hemodialysis. Brazilian Clinical Trials Registry (ReBEC) under the opinion RBR-4XYTP6.

scholarly journals GERIATRIC GYMNASTIC TO QUALITY OF SLEEP IN PTSW SENJARAWI BANDUNG

2018 ◽  
Vol 2 (2) ◽  
pp. 223
Author(s):  
Meilirianta Meilirianta ◽  
Maspupah Maspupah
Keyword(s):  
Sleep Quality ◽  
Intervention Group ◽  
The Elderly ◽  
Control Group ◽  
P Value ◽  
Quality Of Sleep ◽  
Control Group Design ◽  
Equivalent Control ◽  
The Impact

Introduction. Elderly has decreased in many body system including the impact on sleep disorder. The purpose of this study was to analize effect of geriatric gymnastic on sleep quality of the elderly. Methods. This research used quasy experiment methods with pre and post test only non equivalent control group design. The population in this study was the elderly as many as 82 people. Sample in this research was 30 participants that are defi ned with total sampling method who was appropriated with the criteria. Sampel was devided into two groups which are 15 people of intervention group and 15 people of control group. Data instrument in measuring the quality of sleep used PSQI (Pittsburgh Sleep Quality Index) by observation. Result. There was a signifi cant effect of geriatric gymnasticon sleep quality of the elderly at Tresna Werdha Senjarawi Social Home Bandung with t-test, p-value 0.000 or < 0.05. Discussion. The geriatric gymnastics can be designed more interest the elderly to follow this activities regulary so can overcome sleep disorders in the elderly.Keywords : Quality of Sleep, Geriatric Gymnastic, Elderly

scholarly journals Effects of aquatic physiotherapy versus conventional physical therapy on the risk of fall in the elderly: a randomized clinical trial

2020 ◽  
Vol 21 (3) ◽  
pp. 253
Author(s):  
Christye Ramos Da Silva ◽  
Leonardo Farias Rodrigues Magalhães ◽  
Fernanda Manaia Gonçalves Chaves ◽  
Erica Cardaretti do Nascimento Vieira ◽  
Ana Paula Radies Adames ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Physical Therapy ◽  
Randomized Clinical Trial ◽  
Gait Speed ◽  
The Elderly ◽  
Individual Treatment ◽  
Control Group ◽  
Timed Up And Go ◽  
Motor Abilities ◽  
Risk Of Fall

Objective: To identify whether physiotherapy treatment in water is more effective than the treatment in land environment, aiming at improving the process of physical limitation or functional inability (gait speed, balance, motor abilities) caused by lack of balance in elderly with risk of fall. Methods: Randomized clinical trial, experimental study. The sample was composed of 35 senior individuals of both sexes, with average age of 65. Nineteen people composed the control Group /Conventional Physiotherapy, while the rest composed the experimental Group/Aquatic Physical therapy. Both groups were submitted to twenty sessions of physical therapy, twice a week, for 50 minutes in individual treatment. Aerobic activities were conducted for both groups separately. Exercises using water specific therapy, such as Halliwick rotation control and Bad Ragaz ring method, were used in the aquatic group and in the conventional group, physiotherapeutic techniques were applied, approaching the concepts of proprioceptive neuromuscular facilitation (PNF) and decubitus change training. The following tests were used to measure the risk of fall/balance: Timed Up and Go Test, Sit-to-Stand in 30 seconds and Functional Reach. Results: Both physiotherapeutic interventions, aquatic and conventional, showed to be greatly efficient however aquatic physiotherapy showed certain advantages compared to conventional physical therapy, promoting more beneficial effects in the gait speed, balance, motor abilities and, mainly, in the reduction of the risk of fall.Keywords: elderly, Halliwick, Bad Ragaz, Physical therapy, aquatic, risk of fall.

scholarly journals Effects of Rio de Janeiro Ar Livre program on the autonomy of octogenarian elderly women

Motricidade ◽  
2018 ◽  
Vol 14 (4) ◽  
pp. 57-65
Author(s):  
Larissa Aguirres ◽  
Helio Furtado ◽  
Gabriela Rezende de Oliveira Venturini ◽  
Flavia Porto ◽  
José Manuel Vilaça Maio-Alves ◽  
...  
Keyword(s):  
Rio De Janeiro ◽  
Elderly Women ◽  
The Elderly ◽  
Step Test ◽  
Control Group ◽  
Upper Limbs ◽  
Health Promotion Programs ◽  
Functional Autonomy ◽  
Physical Program ◽  
The Impact

With the increase in life expectancy, it is important to acknowledge the impact of health promotion programs on the elderly. The aimed of this study was to evaluate the influence of the Rio de Janeiro Ar Livre physical program on the functional autonomy of octogenarian elderly women´s. To this end, elderly women´s from 19 Rio de Janeiro Ar Livre program gyms were selected for the experimental group (EG) (n=23; 82.57±3.78 years), and for the Control Group (CG) (n=17; 82.88±2.23 years) from the attending cohabitation houses of the City of Rio de Janeiro. To access the functional autonomy was used Rikli and Jones (1999) protocol in two times separated by (28 weeks). It was observed in the EG a significant (p=0.010) increase in Upper limbs' strength test (13.00±3.41 to 15.09±3.60 times, pre and post innervation, respectively) and a significant (p=0.002) increase in 2 minutes Step test in the CG (36.59±15.00 to 47.24±10.96 times, pre and post, respectively). However, any significant differences between groups were observed in all variables analysed. Based in the present data we can conclude that the training program was only effective in the promotions of the functional strength of the upper limbs and to maintain the functional autonomy of octogenarian elderly women.

scholarly journals Pupillometry pain index decreases intraoperative sufentanyl administration in cardiac surgery: a prospective randomized study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Vivien Berthoud ◽  
Maxime Nguyen ◽  
Anouck Appriou ◽  
Omar Ellouze ◽  
Mohamed Radhouani ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cardiac Surgery ◽  
Primary Outcome ◽  
Randomized Study ◽  
Intervention Group ◽  
Prospective Randomized Study ◽  
Control Group ◽  
Standard Group ◽  
Postoperative Course ◽  
The Impact

AbstractPupillometry has proven effective for the monitoring of intraoperative analgesia in non-cardiac surgery. We performed a prospective randomized study to evaluate the impact of an analgesia-guided pupillometry algorithm on the consumption of sufentanyl during cardiac surgery. Fifty patients were included prior to surgery. General anesthesia was standardized with propofol and target-controlled infusions of sufentanyl. The standard group consisted of sufentanyl target infusion left to the discretion of the anesthesiologist. The intervention group consisted of sufentanyl target infusion based on the pupillary pain index. The primary outcome was the total intraoperative sufentanyl dose. The total dose of sufentanyl was lower in the intervention group than in the control group and (55.8 µg [39.7–95.2] vs 83.9 µg [64.1–107.0], p = 0.04). During the postoperative course, the cumulative doses of morphine (mg) were not significantly different between groups (23 mg [15–53] vs 24 mg [17–46]; p = 0.95). We found no significant differences in chronic pain at 3 months between the 2 groups (0 (0%) vs 2 (9.5%) p = 0.49). Overall, the algorithm based on the pupillometry pain index decreased the dose of sufentanyl infused during cardiac surgery.Clinical trial number: NCT03864016.

scholarly journals Multisensory and closed kinetic chain exercises on the functional capacity and balance in elderly women: blinded randomized clinical trial

2017 ◽  
Vol 30 (suppl 1) ◽  
pp. 259-266
Author(s):  
Luiz Gustavo Padovini Ferreira ◽  
Caio Vitor dos Santos Genebra ◽  
Nicoly Machado Maciel ◽  
Eduardo Aguilar Arca ◽  
Alexandre Fiorelli ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Functional Capacity ◽  
Elderly Women ◽  
Functional Performance ◽  
The Elderly ◽  
Berg Balance Scale ◽  
Kinetic Chain ◽  
Timed Up And Go ◽  
Closed Kinetic Chain

Abstract Introduction: The aging process causes losses that lead to decreased balance, gait speed and functional capacity and, therefore, there is a need of specific protocols to work preventively these variables, which will contribute to the decrease in the frequency of falls in this population. Objective: Verify the effect of a program of multisensory and closed kinetic chain exercises on the functional capacity and balance in elderly women. Methods: Randomized clinical trial masked (blind). Subjects were 32 elderly women from the Centro de Convivência of the Bauru Department of Social Welfare (Secretaria de Bem-Estar Social de Bauru) distributed in two groups: control (CG = 15) and experimental (EG = 17). Interventions: The program of multisensory and closed kinetic chain exercises was applied during an hour, once a week, for 12 weeks. Main measures: Functional capacity was measured by Timed Up and Go (TUG) and the 10-meter walking test (TC10) and their balance by the Berg Balance Scale (BBS). Results: Regarding the comparison between the moments M1 and M2 of the EG after the intervention, there was a statistically significant increase in the functional capability (p = 0.00006), walking speed (p = 0.0008) and balance (p = 0.0006). Conclusion: The multisensory and closed kinetic chain-training program indicated a beneficial effect in the improvement of the elderly women balance and functional performance.

scholarly journals Interleukin-31 Serum And Pruritus Dimension After Acupuncture Treatment In Hemodialysis Patients: A Randomized Clinical Trial

2021 ◽  
Vol 9 (B) ◽  
pp. 196-201
Author(s):  
Dedi Ardinata ◽  
Rozaimah Zain-Hamid ◽  
Irma. D. Roesyanto-Mahadi ◽  
Hasan Mihardja
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Intervention Group ◽  
Serum Levels ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Placebo Control ◽  
Limited Information ◽  
Before And After ◽  
The Impact

BACKGROUND: Interleukin (IL)-31 serum levels were significantly higher in hemodialysis patients with pruritus, whereas acupuncture in LI11 was shown to improve symptoms of pruritus. However, there is limited information that IL-31 serum levels that correlate with decreased dimensions of the pruritus after acupuncture in LI11 in a hemodialysis patient. AIM: The aim of the study was to demonstrate the impact of acupuncture in LI11 and IL-31 serum level and its correlation with dimensions of the pruritus in hemodialysis patients. METHODS: A randomized clinical trial has been carried out from August 2019 to December 2019 at H. Adam Malik General Hospital, Medan, Indonesia. Sixty patients underwent hemodialysis who were randomly allocated to two groups, one group got acupuncture in Quchi LI11 (intervention group), and the other group got a placebo (control group). IL-31 serum levels and pruritus were measured before and after 6 weeks of acupuncture in both groups. RESULTS: Acupuncture did not significantly reduce IL-31 (p = 0.931) and decreased dimensions: Degree, duration, disability, and distribution of the pruritus between the intervention group and the control group after 6 weeks of acupuncture in LI11. It can be shown that there is no significant correlation between IL-31 serum levels and dimensions of the pruritus. CONCLUSION: This study demonstrates the effect of acupuncture on reducing dimensions of the pruritus not related to IL-31 serum levels. Identifying the action mechanism of acupuncture to minimize pruritus considerably enhances knowledge of the impacts of acupuncture on reducing pruritus in hemodialysis patients.

scholarly journals Investigating the impact of physical-mental exercises on depression after prederm delivery: a clinical trial

2020 ◽  
pp. 128-138
Keyword(s):  
Clinical Trial ◽  
Intervention Group ◽  
Psychological Trauma ◽  
The Body ◽  
Public Hospitals ◽  
Control Group ◽  
Control Groups ◽  
The Mean ◽  
The Impact ◽  
Stretching Exercises

Background and Aim: Prederm delivery, and the consequences are include premature newborn, hospitalization in the NICU ward, psychological damage to mother and heart family performing low-cost, practical interventions can play an important role in promoting maternal health by to reduce psychological trauma. Therefore, the present study was performed to determine the impact of physical-mental exercises on depression after prederm delivery. Materials and Methods: In this clinical trial, 100 women with prederm delivery 28-36 weeks, it was performed in public hospitals in Mashhad in 2019. Sampling was performed by random blocking method and the subjects were selected by available method and were divided into two control groups (n=50) and intervention (n=50). The intervention group performed stretching exercises as well as meditation by the researcher on the third day after delivery with a frequency of two sessions per week for up to 8 sessions, and the control group received the usual care. Beck's depression questionnaire was completed for both groups in the first 24 hours after delivery and at the end of the study. Statistical analysis of the data was performed by independent t-test, Mann-Whitney and Wilkaxon. Results: The mean score of depression in the intervention and control groups at the end of the study was statistically significant (p≤0.001). The mean score of depression in the intervention group was significant at the beginning and the end of the study (P<0.001). Conclusion: Stretching exercises with a focus on the body after delivery can reduce the rate of depression in mothers with prederm delivery. Key Words: Meditation; Postpartum Depression; prederm delivery; Stretching Exercise

scholarly journals A Randomized Clinical Trial of the Effect of Zinc Supplement on Depression and Anxiety in the Elderly

2021 ◽  
Vol 14 (1) ◽  
pp. 537-544
Author(s):  
Abolfazl Afzali ◽  
Zarichehr Vakili ◽  
Shahrbanoo Goli ◽  
Hossein Bagheri ◽  
Seyedmohammad Mirhosseini ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Zinc Supplementation ◽  
Statistical Tests ◽  
Intervention Group ◽  
Depression Scale ◽  
The Elderly ◽  
Control Group ◽  
Depression And Anxiety ◽  
Zinc Supplements

Background: Anxiety and depression in the elderly are considered important mental disorders. Objective: This study was designed to determine the effect of zinc Supplementation on depression and anxiety in the elderly. Methods: This study was a parallel randomized clinical trial. A total of 150 elderly aged 60 years and older were allocated into intervention and control groups by using the quadruple blocking method. The elderly in the intervention group received a daily dose of 30 mg zinc supplementation pill for 70 days and the elderly in the control group did not receive this supplement. Depression and anxiety in the elderly were measured using the Geriatric Depression Scale and the Beck Anxiety Inventory, respectively. A significance level of 0.05 was considered for all statistical tests. Results: After the intervention, the mean scores of depression and anxiety in the elderly were significantly decreased in the intervention group, as compared with the control group. Moreover, after the intervention, the serum zinc level in the elderly was significantly increased in the intervention group, as compared with the control group (P<0.05). Conclusion: The use of zinc supplements improved depression and anxiety in the elderly. Therefore, it is recommended to use zinc supplements as a new therapeutic strategy for the prevention and treatment of depression and anxiety in the elderly. Registration No: This research was registered in the Iranian clinical trial system with code IRCT2017071635110N1.

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