scholarly journals Constitutional Isomers of Dendrimer-like Star Polymers: Design, Synthesis and Conformational and Structural Properties

2001 ◽  
Author(s):  
John A Pople
Keyword(s):  
Structural Properties ◽  
Star Polymers ◽  
Design Synthesis

scholarly journals Constitutional Isomers of Dendrimer-like Star Polymers:  Design, Synthesis, and Conformational and Structural Properties

2000 ◽  
Vol 33 (17) ◽  
pp. 6423-6438 ◽  
Author(s):  
Mikael Trollsås ◽  
Björn Atthof ◽  
Andreas Würsch ◽  
James L. Hedrick ◽  
John A. Pople ◽  
...  
Keyword(s):  
Structural Properties ◽  
Star Polymers ◽  
Design Synthesis

A new approach to artificial and modified proteins: theory-based design, synthesis in a cell-free system and fast testing of structural properties by radiolabels

1994 ◽  
Vol 7 (8) ◽  
pp. 1041-1052 ◽  
Author(s):  
Violetta V. Chemeris ◽  
Dmitry A. Dolgikh ◽  
Alexey N. Fedorov ◽  
Alexey V. Finkelstein ◽  
Michail P. Kirpichnikov ◽  
...  
Keyword(s):  
Structural Properties ◽  
Design Synthesis ◽  
Free System ◽  
New Approach ◽  
Cell Free System ◽  
A Cell ◽  
Modified Proteins

scholarly journals Star Polymer-Drug Conjugates with pH-Controlled Drug Release and Carrier Degradation

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
H. Kostková ◽  
L. Schindler ◽  
L. Kotrchová ◽  
M. Kovář ◽  
M. Šírová ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Star Polymers ◽  
Controlled Drug Release ◽  
Blood Stream ◽  
In Vitro Cytotoxicity ◽  
Star Polymer ◽  
Molar Ratio ◽  
Design Synthesis ◽  
Dendritic Core

In this study, we describe the design, synthesis, and physicochemical and preliminary biological characteristics of new biodegradable, high-molecular-weight (HMW) drug delivery systems with star-like architectures bearing the cytotoxic drug doxorubicin (DOX) attached by a hydrazone bond-containing spacer. The star polymers were synthesized by grafting semitelechelic N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers on a 2,2-bis(hydroxymethyl)propionic acid- (bis-MPA-) based polyester dendritic core. The molecular weight of the star polymers ranged from 280 to 450 000 g/mol and could be adjusted by proper selection of the bis-MPA dendrimer generation and by considering the polymer to dendrimer molar ratio. The biodegradation of the polymer conjugates is based on the spontaneous slow hydrolysis of the dendritic core in neutral physiological conditions. Hydrazone spacers in the conjugates were fairly stable at neutral pH (7.4) mimicking blood stream conditions, and DOX was released from the conjugates under mild acidic conditions simulating the tumor cell microenvironment in endosomes and lysosomes (pH 5). Finally, we have shown the significant in vitro cytotoxicity of the star polymer-DOX conjugate on selected cancer cell lines with IC50 values almost comparable with that of the free drug and higher than that observed for a linear polymer-DOX conjugate with much lower molecular weight.

Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy

2019 ◽  
Vol 10 (45) ◽  
pp. 6116-6121 ◽  
Author(s):  
Tan Ji ◽  
Lei Xia ◽  
Wei Zheng ◽  
Guang-Qiang Yin ◽  
Tao Yue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Star Polymers ◽  
New Family ◽  
Potential Applications

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.

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