Conformational Control in Metallofoldamers: Design, Synthesis and Structural Properties

2009 ◽  
Vol 2009 (33) ◽  
pp. 5699-5710 ◽  
Author(s):  
Galia Maayan
Keyword(s):  
Structural Properties ◽  
Conformational Control ◽  
Design Synthesis

scholarly journals Harnessing Chalcogen-bonding Interactions To Establish Conformational Control in Dirhodium(II) Paddlewheel Complexes

2020 ◽  
Author(s):  
Takuya Murai ◽  
Wenjie Lu ◽  
Toshifumi Kuribayashi ◽  
Kazuhiro Morisaki ◽  
Yoshihiro Ueda ◽  
...  
Keyword(s):  
Amino Acid ◽  
Structural Properties ◽  
Amino Acid Derivatives ◽  
Conformational Control ◽  
Total Syntheses ◽  
Paddlewheel Complexes ◽  
Naturally Occurring ◽  
Axially Chiral ◽  
Catalytically Active ◽  
Alpha Beta

Novel well-defined <i>D</i><sub>2</sub>-symmetric dirhodium(II) carboxylate complexes that bear axially chiral binaphthothiophene delta-amino acid derivatives have been developed. Conformational control was achieved through chalcogen-bonding interactions between sulfur and oxygen atoms in each ligand, providing well-defined and uniform asymmetric environments around the catalytically active Rh(II) centers. These structural properties render such complexes excellent catalysts for the inside-type asymmetric intramolecular C–H insertion into alpha-aryl-alpha-diazoacetates to yield a variety of <i>cis</i>- alpha, beta-diaryl gamma-lactones, as well as the corresponding <i>trans</i>-isomers through epimerization, in high diastereo- and enantioselectivities. Short total syntheses of the naturally occurring gamma-lactones cinnamomumolide, cinncassin A<sub>7</sub>, and cinnamomulactone were also accomplished using this conformationally controlled catalyst.<br><br>

scholarly journals Constitutional Isomers of Dendrimer-like Star Polymers:  Design, Synthesis, and Conformational and Structural Properties

2000 ◽  
Vol 33 (17) ◽  
pp. 6423-6438 ◽  
Author(s):  
Mikael Trollsås ◽  
Björn Atthof ◽  
Andreas Würsch ◽  
James L. Hedrick ◽  
John A. Pople ◽  
...  
Keyword(s):  
Structural Properties ◽  
Star Polymers ◽  
Design Synthesis

A new approach to artificial and modified proteins: theory-based design, synthesis in a cell-free system and fast testing of structural properties by radiolabels

1994 ◽  
Vol 7 (8) ◽  
pp. 1041-1052 ◽  
Author(s):  
Violetta V. Chemeris ◽  
Dmitry A. Dolgikh ◽  
Alexey N. Fedorov ◽  
Alexey V. Finkelstein ◽  
Michail P. Kirpichnikov ◽  
...  
Keyword(s):  
Structural Properties ◽  
Design Synthesis ◽  
Free System ◽  
New Approach ◽  
Cell Free System ◽  
A Cell ◽  
Modified Proteins

scholarly journals Harnessing Chalcogen-bonding Interactions To Establish Conformational Control in Dirhodium(II) Paddlewheel Complexes

2020 ◽  
Author(s):  
Takuya Murai ◽  
Wenjie Lu ◽  
Toshifumi Kuribayashi ◽  
Kazuhiro Morisaki ◽  
Yoshihiro Ueda ◽  
...  
Keyword(s):  
Amino Acid ◽  
Structural Properties ◽  
Amino Acid Derivatives ◽  
Conformational Control ◽  
Total Syntheses ◽  
Paddlewheel Complexes ◽  
Naturally Occurring ◽  
Axially Chiral ◽  
Catalytically Active ◽  
Alpha Beta

Novel well-defined <i>D</i><sub>2</sub>-symmetric dirhodium(II) carboxylate complexes that bear axially chiral binaphthothiophene delta-amino acid derivatives have been developed. Conformational control was achieved through chalcogen-bonding interactions between sulfur and oxygen atoms in each ligand, providing well-defined and uniform asymmetric environments around the catalytically active Rh(II) centers. These structural properties render such complexes excellent catalysts for the inside-type asymmetric intramolecular C–H insertion into alpha-aryl-alpha-diazoacetates to yield a variety of <i>cis</i>- alpha, beta-diaryl gamma-lactones, as well as the corresponding <i>trans</i>-isomers through epimerization, in high diastereo- and enantioselectivities. Short total syntheses of the naturally occurring gamma-lactones cinnamomumolide, cinncassin A<sub>7</sub>, and cinnamomulactone were also accomplished using this conformationally controlled catalyst.<br><br>

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