Proline Methanologues: Design, Synthesis, Structural Properties, and Applications in Medicinal Chemistry

2015 ◽  
pp. 51-95
Author(s):  
Miguel Angel Vilchis-Reyes ◽  
Stephen Hanessian
Keyword(s):  
Structural Properties ◽  
Medicinal Chemistry ◽  
Design Synthesis

scholarly journals Difluoro-Substituted bicyclo[1.1.1]pentanes as Novel Motifs for Medicinal Chemistry: Design, Synthesis and Characterization

2019 ◽  
Author(s):  
Roman Bychek ◽  
Valeriia Hutskalova ◽  
Julia Bas ◽  
Olga A. Zaporozhets ◽  
Sergei Zozulya ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Benzene Ring ◽  
Medicinal Chemistry ◽  
Synthesis And Characterization ◽  
Synthetic Approach ◽  
Design Synthesis ◽  
New Generation

Herein we developed a practical synthetic approach to the previously unknown difluoro-substituted bicyclo[1.1.1]pentanes. The key step was an addition of difluorocarbene to electron-rich bicyclo[1.1.0]butanes by CF<sub>3</sub>TMS/NaI system. The obtained difluoro-bicyclo[1.1.1]pentanes are a new generation of saturated bioisosteres of the benzene ring for drug discovery projects.

scholarly journals Constitutional Isomers of Dendrimer-like Star Polymers:  Design, Synthesis, and Conformational and Structural Properties

2000 ◽  
Vol 33 (17) ◽  
pp. 6423-6438 ◽  
Author(s):  
Mikael Trollsås ◽  
Björn Atthof ◽  
Andreas Würsch ◽  
James L. Hedrick ◽  
John A. Pople ◽  
...  
Keyword(s):  
Structural Properties ◽  
Star Polymers ◽  
Design Synthesis

A new approach to artificial and modified proteins: theory-based design, synthesis in a cell-free system and fast testing of structural properties by radiolabels

1994 ◽  
Vol 7 (8) ◽  
pp. 1041-1052 ◽  
Author(s):  
Violetta V. Chemeris ◽  
Dmitry A. Dolgikh ◽  
Alexey N. Fedorov ◽  
Alexey V. Finkelstein ◽  
Michail P. Kirpichnikov ◽  
...  
Keyword(s):  
Structural Properties ◽  
Design Synthesis ◽  
Free System ◽  
New Approach ◽  
Cell Free System ◽  
A Cell ◽  
Modified Proteins

scholarly journals Corrigendum to

2022 ◽  
Vol 230 ◽  
pp. 114107
Author(s):  
Xin Deng ◽  
Qianqian Qiu ◽  
Baowei Yang ◽  
Xuekun Wang ◽  
Wenlong Huang ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Medicinal Chemistry ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Anti Cancer ◽  
Synthesis And Biological Evaluation

scholarly journals Difluoro-Substituted bicyclo[1.1.1]pentanes as Novel Motifs for Medicinal Chemistry: Design, Synthesis and Characterization

2019 ◽  
Author(s):  
Roman Bychek ◽  
Valeriia Hutskalova ◽  
Julia Bas ◽  
Olga A. Zaporozhets ◽  
Sergei Zozulya ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Benzene Ring ◽  
Medicinal Chemistry ◽  
Synthesis And Characterization ◽  
Synthetic Approach ◽  
Design Synthesis ◽  
New Generation

Herein we developed a practical synthetic approach to the previously unknown difluoro-substituted bicyclo[1.1.1]pentanes. The key step was an addition of difluorocarbene to electron-rich bicyclo[1.1.0]butanes by CF<sub>3</sub>TMS/NaI system. The obtained difluoro-bicyclo[1.1.1]pentanes are a new generation of saturated bioisosteres of the benzene ring for drug discovery projects.

Sign in / Sign up

Export Citation Format

Share Document