scholarly journals Final Report: The Impact of Carbonate on Surface Protonation, Electron Transfer and Crystallization Reactions in Iron Oxide Nanoparticles and Colloids

2013 ◽  
Author(s):  
David Adams Dixon
Keyword(s):  
Electron Transfer ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Final Report ◽  
The Impact

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cellular Uptake ◽  
Superparamagnetic Iron Oxide ◽  
Cyclin B1 ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mcf7 Cells ◽  
M Phase ◽  
The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

scholarly journals The impact of species and cell type on the nanosafety profile of iron oxide nanoparticles in neural cells

2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Freya Joris ◽  
Daniel Valdepérez ◽  
Beatriz Pelaz ◽  
Stefaan J. Soenen ◽  
Bella B. Manshian ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Neural Cells ◽  
Cell Type ◽  
The Impact

Triggering Mechanism for DNA Electrical Conductivity: Reversible Electron Transfer between DNA and Iron Oxide Nanoparticles

2015 ◽  
Vol 25 (12) ◽  
pp. 1822-1831 ◽  
Author(s):  
Massimiliano Magro ◽  
Davide Baratella ◽  
Petr Jakubec ◽  
Giorgio Zoppellaro ◽  
Jiri Tucek ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Electron Transfer ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Triggering Mechanism ◽  
Reversible Electron Transfer

scholarly journals Effects of iron nanoparticles on Mentha piperita L. under salinity stress

Biologija ◽  
2017 ◽  
Vol 63 (1) ◽  
Author(s):  
Meheri Askary ◽  
Seyed Mehdi Talebi ◽  
Fariba Amini ◽  
Ali Dousti Balout Bangan
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Salinity Stress ◽  
Iron Nanoparticles ◽  
Antioxidant Activities ◽  
Nutrient Deficiency ◽  
Dry Weight ◽  
Mentha Piperita ◽  
Oxide Nanoparticles ◽  
The Impact

The progress of nanotechnology presents many nanoparticles that are important in medicine, agriculture and industry. Quickly and entirely absorbed by plants, nano-compounds and remedy their nutrient deficiency and satisfy this need. Iron oxide nanoparticles with suitable surface chemistry can be used as a rich source of iron for plants due to its gradual release of Fe in a wide pH range (pH 3 to 11). The present study investigated the impact of iron oxide nanoparticles (Fe2O3NPs in 0, 10, 20 and 30  µM concentrations) on physiological parameters of peppermint (Mentha piperita) under salt stress (0, 50, 100 and 150 mM concentrations of NaCl). Fe2O3NPs caused increases in leaf fresh weight and dry weight, phosphorus, potassium, iron, zinc, and calcium contents of the peppermint under salinity stress but did not have an effect on the sodium element. 30 µM concentration of Fe2O3NP was more impressive. Lipid peroxidation and proline contents of the peppermint under salinity decreased significantly by applying Fe2O3NPs. The maximum activities of total antioxidant enzymes (I %), catalase, superoxide dismutase, and guailcol peroxidase were observed in plants treated with 150 mM of NaCl, but application of Fe2O3NPs declined these antioxidant activities. The results suggest that the appropriate concentration of iron nanoparticles could be used for stress resistance of the peppermint.

scholarly journals A Novel Approach for Non-Invasive Lung Imaging and Targeting Lung Immune Cells

2020 ◽  
Vol 21 (5) ◽  
pp. 1613 ◽  
Author(s):  
Amlan Chakraborty ◽  
Simon Royce ◽  
Cordelia Selomulya ◽  
Magdalena Plebanski
Keyword(s):  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Immune Cells ◽  
Alveolar Macrophages ◽  
Lung Imaging ◽  
Oxide Nanoparticles ◽  
Super Paramagnetic Iron Oxide ◽  
Non Invasive ◽  
The Impact

Despite developments in pulmonary radiotherapy, radiation-induced lung toxicity remains a problem. More sensitive lung imaging able to increase the accuracy of diagnosis and radiotherapy may help reduce this problem. Super-paramagnetic iron oxide nanoparticles are used in imaging, but without further modification can cause unwanted toxicity and inflammation. Complex carbohydrate and polymer-based coatings have been used, but simpler compounds may provide additional benefits. Herein, we designed and generated super-paramagnetic iron oxide nanoparticles coated with the neutral natural dietary amino acid glycine (GSPIONs), to support non-invasive lung imaging and determined particle biodistribution, as well as understanding the impact of the interaction of these nanoparticles with lung immune cells. These GSPIONs were characterized to be crystalline, colloidally stable, with a size of 12 ± 5 nm and a hydrodynamic diameter of 84.19 ± 18 nm. Carbon, Hydrogen, Nitrogen (CHN) elemental analysis estimated approximately 20.2 × 103 glycine molecules present per nanoparticle. We demonstrated that it is possible to determine the biodistribution of the GSPIONs in the lung using three-dimensional (3D) ultra-short echo time magnetic resonance imaging. The GSPIONs were found to be taken up selectively by alveolar macrophages and neutrophils in the lung. In addition, the GSPIONs did not cause changes to airway resistance or induce inflammatory cytokines. Alveolar macrophages and neutrophils are critical regulators of pulmonary inflammatory diseases, including allergies, infections, asthma and chronic obstructive pulmonary disease (COPD). Therefore, pulmonary Magnetic Resonance (MR) imaging and preferential targeting of these lung resident cells by our nanoparticles offer precise imaging tools, which can be utilized to develop precision targeted radiotherapy as well as diagnostic tools for lung cancer, thereby having the potential to reduce the pulmonary complications of radiation.

scholarly journals Oxygen Evolution on Iron Oxide Nanoparticles: The Impact of Crystallinity and Size on the Overpotential

2021 ◽  
Vol 168 (3) ◽  
pp. 034518
Author(s):  
Zhongbin Zhuang ◽  
Stephen A. Giles ◽  
Glen R. Jenness ◽  
Reza Abbasi ◽  
Xi Chen ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Oxygen Evolution ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
The Impact
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