Triggering Mechanism for DNA Electrical Conductivity: Reversible Electron Transfer between DNA and Iron Oxide Nanoparticles

2015 ◽  
Vol 25 (12) ◽  
pp. 1822-1831 ◽  
Author(s):  
Massimiliano Magro ◽  
Davide Baratella ◽  
Petr Jakubec ◽  
Giorgio Zoppellaro ◽  
Jiri Tucek ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Electron Transfer ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Triggering Mechanism ◽  
Reversible Electron Transfer

Enhanced electrical conductivity of collagen films through long-range aligned iron oxide nanoparticles

2017 ◽  
Vol 501 ◽  
pp. 185-191 ◽  
Author(s):  
Valentina Bonfrate ◽  
Daniela Manno ◽  
Antonio Serra ◽  
Luca Salvatore ◽  
Alessandro Sannino ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Iron Oxide ◽  
Long Range ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

The effect of shell modification in iron oxide nanoparticles on electrical conductivity in polythiophene-based nanocomposite

2021 ◽  
Author(s):  
Roma Wirecka ◽  
Mateusz M Marzec ◽  
Marianna Marciszko ◽  
Maria Lis ◽  
Marta Gajewska ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Iron Oxide ◽  
Energy Level ◽  
Iron Oxide Nanoparticles ◽  
Organic Electronics ◽  
Oxide Nanoparticles ◽  
Final Performance ◽  
Energy Level Alignment

In the field of organic electronics, the energy level alignment between components of the device is crucial for its final performance. Final properties' improvement can be achieved using hybrids made...

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cellular Uptake ◽  
Superparamagnetic Iron Oxide ◽  
Cyclin B1 ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mcf7 Cells ◽  
M Phase ◽  
The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

Ferrozine Assay for Simple and Cheap Iron Analysis of Silica-Coated Iron Oxide Nanoparticles

2018 ◽  
Author(s):  
Hattie Ring ◽  
Zhe Gao ◽  
Nathan D. Klein ◽  
Michael Garwood ◽  
John C. Bischof ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Hydrofluoric Acid ◽  
Inductively Coupled Plasma ◽  
Silica Shell ◽  
Oxide Nanoparticles ◽  
Inductively Coupled ◽  
Digestion Process ◽  
Plasma Methods ◽  
Iron Analysis

The Ferrozinen assay is applied as an accurate and rapid method to quantify the iron content of iron oxide nanoparticles (IONPs) and can be used in biological matrices. The addition of ascorbic aqcid accelerates the digestion process and can penetrate an IONP core within a mesoporous and solid silica shell. This new digestion protocol avoids the need for hydrofluoric acid to digest the surrounding silica shell and provides and accessible alternative to inductively coupled plasma methods. With the updated digestion protocol, the quantitative range of the Ferrozine assay is 1 - 14 ppm. <br>

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