scholarly journals Cord Blood Theophylline Levels and Respiratory Morbidities In Preterm Infants

2019 ◽  
pp. 1
Author(s):  
Tolga Hasan Celik ◽  
Ayse Korkmaz ◽  
Sule Yigit ◽  
Murat Yurdakok
Keyword(s):  
Cord Blood ◽  
Premature Infants ◽  
Neonatal Period ◽  
Serum Levels ◽  
University Hospital ◽  
Blood Gas ◽  
Significant Difference ◽  
The Mean ◽  
Blood Gas Parameters ◽  
Pulmonary Morbidity

<p><strong>Objective:</strong> to investigate whether there is any relationship between cord blood theophylline levels and pulmonary morbidities in the early neonatal period in premature infants.</p><p><strong>Study Design:</strong> This prospective cohort study was conducted in Hacettepe University Hospital Neonatology Unit, between November 2010 and January 2012. Cord blood samples were collected at birth from premature infants, and theophylline levels were measured. Theophylline levels of cord blood were compared between infants with and without pulmonary morbidity.</p><p><strong>Results:</strong> A total of 90 infants (42 females, 48 males) were enrolled in the study. The mean gestational age was 31.1±3.1 weeks, and the mean birth weight was 1527±540 g. Early respiratory morbidities developed in 57 infants (63.3%), while no respiratory morbidities were observed in 33 infants (36.7%). There was no significant difference between the groups in blood gas parameters, oxygen saturation values and cord blood theophylline levels.</p><p><strong>Conclusions:</strong> Although the theophylline levels that were measured in the cord blood were much lower than therapeutic serum levels, we concluded that the cord theophylline level is not valuable as a prognostic factor for pulmonary morbidities in premature newborns. </p>

VARIATIONS IN PLASMA THYROXINE DURING LABOUR AND EARLY PUERPERIUM

1969 ◽  
Vol 60 (3) ◽  
pp. 423-432 ◽  
Author(s):  
K. Siersbæk-Nielsen ◽  
J. Mølholm Hansen
Keyword(s):  
Cord Blood ◽  
Premature Infants ◽  
Perinatal Period ◽  
Maternal Blood ◽  
Mean Value ◽  
Rapid Decrease ◽  
Term Infants ◽  
Mean Values ◽  
Significant Difference ◽  
The Mean

ABSTRACT Repeated determinations of plasma T4, PBI, dialysable T4 and free T4 were undertaken on 31 mothers of full-term infants and ten mothers of premature infants in the perinatal period. The blood samples were obtained 2–7 hours before delivery, at delivery, 3–6 hours after delivery, 6–12 hours after delivery and on the 2nd, 3rd–4th and 5th–6th day after birth. Similar investigations were also undertaken on cord blood. A significant increase in the mean value for plasma T4 of approximately 25 % was found from before delivery to the time of delivery. This was followed by a rapid decrease, so that a return to values observed before delivery occurred on the 2nd day after delivery. Dial. T4 did not alter during the rapid variations in the plasma T4. Plasma T4 was found to be significantly increased in maternal blood at delivery as compared with cord blood but there was no significant difference in the mean values for free T4 in the cord blood and the maternal blood at delivery, suggesting a free passive passage of T4 via the placenta. The variations found have not been described previously and they provide a possible explanation for the disagreements between the results of previous investigators. The reason for the variations and their significance in assessing possible equilibrium between free T4 in the maternal blood and cord blood are discussed.

scholarly journals Comparison of Serum Lead and Cadmium Levels in Parkinson's Patients and Healthy Controls

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Hadi Parsian ◽  
Pouya Alipour ◽  
Hemmat Gholinia ◽  
Payam Saadat
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Healthy Subjects ◽  
Lead Level ◽  
Serum Levels ◽  
Atomic Absorption Spectrophotometry ◽  
University Hospital ◽  
Lead And Cadmium ◽  
Significant Difference ◽  
The Mean

Background: Several studies have investigated the association of heavy metals such as lead and cadmium with neurodegenerative diseases such as Parkinson's disease. Objectives: In this study, we investigated the relationship between the serum levels of lead and cadmium in Parkinson's disease. Methods: In this case-control study, the serum levels of lead and cadmium in 100 patients with Parkinson's disease referred to our university hospital, and 30 healthy individuals were investigated. Basic information such as age and gender and other demographic and clinical data were registered in the checklist. The levels of lead and cadmium were measured using atomic absorption spectrophotometry (AAS). Data was analyzed by SPSS software version 23, and a P < 0.05 was considered as significant. Results: The mean cadmium level in patient and control groups was 14.91 ± 8.72 and 4.71 ± 2.72 ppb, respectively (P < 0.001). The mean lead level was 158.35 ± 157.64 and 35.35 ± 16.25 ppb in patients and controls, respectively (P < 0.001). At ages above 65 years, there was a significant difference between the level of cadmium (P < 0.001) and lead (P < 0.001) in patients and healthy subjects. In addition, there was a significant difference in the level of cadmium (P = 0.003) between patients and healthy subjects at ages below 65 years. This was true for both males (P < 0.05) and females (P < 0.05). There was no significant difference in the level of lead and cadmium in various severity rates of the disease, as well as in different symptoms of the patients. Conclusions: Based on the findings, the levels of serum lead and cadmium were higher in the patients, indicating a probable relationship between the Parkinson's disease and the levels of these metals.

scholarly journals Can the blood gas analyser results be believed? A prospective multicentre study comparing haemoglobin, sodium and potassium measurements by blood gas analysers and laboratory auto-analysers

2019 ◽  
Vol 47 (2) ◽  
pp. 120-127 ◽  
Author(s):  
Katherine E Triplett ◽  
Bradley A Wibrow ◽  
Richard Norman ◽  
Dana A Hince ◽  
Liesel E Hardy ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Point Of Care ◽  
Mean Difference ◽  
Full Blood Count ◽  
Blood Gas ◽  
Prospective Multicentre Study ◽  
Significant Difference ◽  
The Mean ◽  
Sodium And Potassium

Blood gas analysers are point-of-care testing devices used in the management of critically ill patients. Controversy remains over the agreement between the results obtained from blood gas analysers and laboratory auto-analysers for haematological and biochemistry parameters. We conducted a prospective analytical observational study in five intensive care units in Western Australia, in patients who had a full blood count (FBC), urea, electrolytes and creatinine (UEC), and a blood gas performed within 1 h of each other during the first 24 h of their intensive care unit admission. The main outcome measure was to determine the agreement in haemoglobin, sodium, and potassium results between laboratory haematology and biochemistry auto-analysers and blood gas analysers. A total of 219 paired tests were available for haemoglobin and sodium, and 215 for potassium. There was no statistically significant difference between the results of the blood gas and laboratory auto-analysers for haemoglobin (mean difference –0.35 g/L, 95% confidence interval (CI) –1.20 to 0.51, P = 0.425). Although the mean differences between the two methods were statistically significant for sodium (mean difference 1.49 mmol/L, 95% CI 1.23–1.76, P < 0.0001) and potassium (mean difference 0.19 mmol/L, 95% CI 0.15–0.24, P < 0.0001), the mean biases on the Bland–Altman plots were small and independent of the magnitude of the measurements. The two methods of measurement for haemoglobin, sodium and potassium agreed with each other under most clinical situations when their values were within or close to normal range suggesting that routine concurrent blood gas and formal laboratory testing for haemoglobin, sodium and potassium concentrations in the intensive care unit is unwarranted.

scholarly journals Effects of eye cover among high risk neonates at night shift on their distress levels

2019 ◽  
Vol 9 (7) ◽  
pp. 9
Author(s):  
Eman Ali Moselhi Mater ◽  
Huda Shawky Mahamud ◽  
Mohamed Farouk Mohamed
Keyword(s):  
High Risk ◽  
Night Shift ◽  
Newborn Infants ◽  
Study Groups ◽  
University Hospital ◽  
Control Group ◽  
Stressful Environment ◽  
Distress Level ◽  
Significant Difference ◽  
The Mean

Background and aim: The Neonatal Intensive Care Unit (NICU) is a stressful environment for high risk neonates. Persistent bright light is one of the main environmental stressors that are distressed newborn infants in NICU. Cycled lighting may decrease distress level of newborn infants by enhancing calming status. This study aimed to investigate effects of eye cover among high risk neonates at night shift on their distress levels.Methods: Quasi experimental research design was carried out on a randomized sample of 60 newborn infants attending the NICU of El Manial University Hospital (Kasr Al Ainy), (30 control group and 30 study group). Neonatal assessment tool and COMFORTneoNRS scale were utilized for data collection.Results: There was a statistically significant difference between control and study groups regarding the distress levels (p < .00). The mean score of distress levels were 6.80 ± 1.80 and 0.80 ± 1.15 respectively and the mean score of comfort levels in the newborn infants in the control and study groups were 23.22 ± 5.50 and 6.60 ± 1.06 respectively. Eye coved enhanced quite sleep (66.7%), relaxed muscle (73.3%), decrease movement (66.7%) and no crying (85.7%).Conclusions: The use of eye cover among high risk neonates at night shift is effective to decrease their distress level and improve their comfort state in the morning shift by promoting quite sleep and relaxation. Recommendations: The educational program is needed to raise awareness among neonatal nurses about the effect of light reduction methods such as eye patches on the distress level and comfort state that enhances the growth and development of newborn infants.

scholarly journals Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1β, IL6, TNFα, and CRP)

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Baris Alper ◽  
Baris Erdogan ◽  
Mehmet Özgür Erdogan ◽  
Korkut Bozan ◽  
Murat Can
Keyword(s):  
Mean Platelet Volume ◽  
Injury Severity ◽  
Serum Levels ◽  
Study Group ◽  
Platelet Volume ◽  
Trauma Severity ◽  
Severity Scores ◽  
Severity Of Injury ◽  
Significant Difference ◽  
The Mean

We investigated the associations of injury severity scores (ISSs) with the mean platelet volume, the serum levels of two interleukins (IL1βand IL6), and the serum levels of tumour necrosis factor-α(TNFα) and C-reactive protein (CRP). We sought to identify biochemical parameters that could be used as components of a new biochemical parameter-based ISS system. The levels of CRP, TNFα, IL1β, and IL6 differed significantly (allpvalues < 0.05) between severely injured patients and controls. The mean platelet volume (MPV) did not correlate with the ISSs (p> 0.05). The TNFαand IL6 levels were useful for determining the severity of injury, and the CRP level was elevated in all trauma patients but did not correlate with the ISS. The IL1βlevel was higher in the study group but did not increase as the ISS increased. IL6 and TNFαlevels were higher in the study group and increased as the ISS increased. We found no significant difference between the trauma group and healthy individuals in terms of MPV values. IL6 and TNFαlevels can be used to assess trauma severity. However, neither the MPV nor the CRP or IL1βlevel is useful for this purpose.

The Treatment of Salicylate Poisoning Using Mannitol and Forced Alkaline Diuresis

1970 ◽  
Vol 38 (3) ◽  
pp. 327-337 ◽  
Author(s):  
K. Prowse ◽  
M. Pain ◽  
A. D. Marston ◽  
G. Cumming
Keyword(s):  
Serum Potassium ◽  
Serum Levels ◽  
Urine Flow ◽  
Serum Electrolyte ◽  
Acid Base ◽  
Sodium Potassium ◽  
Salicylate Poisoning ◽  
Significant Difference ◽  
Rapid Removal ◽  
The Mean

1. A comparison has been made between alkaline mannitol diuresis and alkaline glucose diuresis in the treatment of salicylate poisoning during an 8 hr period. 2. Mannitol gave a higher rate of urine flow, but there was no significant difference in the rate of salicylate excretion. 3. Serum levels of sodium, potassium and calcium fell in both groups, mainly during the first 2 hr. The mean fall in serum sodium was greater (21·4 mEq/l compared with 10·0 mEq/l) and that in serum potassium less (0·6 mEq/l compared with 1·5 mEq/l) in patients who received mannitol than in those who did not. 4. All serum electrolyte values had returned to normal within 24 hr of the end of the treatment period. 5. Acid—base changes occurring during treatment are described. 6. No adverse clinical features were seen in either treatment group. 7. Syrup of ipecacuanha was used to induce emesis. The mean recovery of salicylate in the vomitus was 38% of the apparent total ingested. The variability in recovery (0–81%) was not related to the delay between ingestion and vomiting. 8. It is concluded that mannitol does not increase the excretion of salicylate. It maintains good urinary excretion, thereby increasing the safety of the procedure. It is associated with a smaller fall in serum potassium and permits rapid removal of salicylate for a smaller rise in serum pH than does forced alkaline diuresis alone.

Leptin and neuropeptide Y levels in newborns

2016 ◽  
Vol 29 (1) ◽  
Author(s):  
Avni Kaya ◽  
Zerrin Orbak ◽  
İsmail Polat ◽  
Harun Polat ◽  
Musa Gümüşdere
Keyword(s):  
Body Weight ◽  
Prospective Study ◽  
Neuropeptide Y ◽  
Neonatal Period ◽  
Medical Faculty ◽  
Faculty Research ◽  
Research Hospital ◽  
Significant Difference ◽  
The Mean ◽  
Plasma Leptin

AbstractSeveral studies have investigated leptin and neuropeptide Y (NPY) levels in children, but the information for newborns in the literature is limited. The purpose of this study was to determine leptin and NPY levels in 14- to 28-day-old newborns.This prospective study was performed in Atatürk University Medical Faculty Research Hospital Neonatal Clinic, Erzurum, Turkey between July and December, 2014. Sixty-two 14- to 28-day-old neonates, 26 female and 36 male, were included. Age, height, and body weight of the patients were recorded. Feeding status was also recorded. The newborns were divided into two groups – those receiving breastfeeding only and those receiving breastfeeding and formula. Plasma leptin levels were measured using enzyme amplified sensitivity immunoassay (EASIA).The mean leptin level in 14- to 28-day-old female neonates was 4.25±3.08 ng/mL, and the mean NPY level was 24.79±9.87 ng/mL. The mean leptin level in 14- to 28-day male neonates was 3.49±2.52 ng/mL, and the mean NPY level was 25.80±9.58 ng/mL. No significant difference was determined between leptin (p=0.228) or NPY (p=0.144) in terms of feeding status. No significant difference was also observed between the sex in terms of leptin or NPY levels (leptin p=0.775 and NPY p=0.687).There were no differences in terms of feeding status and sex in leptin and NPY levels in the neonatal period.

Clinical Significance of Cryofibrinogenemia: Possible Pathophysiological Link with Raynaud’s Phenomenon

2011 ◽  
Vol 39 (1) ◽  
pp. 119-124 ◽  
Author(s):  
MUHAMMAD S. SOYFOO ◽  
AHMED GOUBELLA ◽  
ELIE COGAN ◽  
JEAN-CLAUDE WAUTRECHT ◽  
ANNICK OCMANT ◽  
...  
Keyword(s):  
Raynaud’S Phenomenon ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Raynaud's Phenomenon ◽  
Clinical Findings ◽  
University Hospital ◽  
Significant Difference ◽  
Primary Raynaud’S Phenomenon ◽  
The Mean ◽  
Mean Concentration

Objective.To describe the clinical findings and prevalence of patients with cryofibrinogenemia (CF) and to determine whether CF is associated with primary Raynaud’s phenomenon.Methods.Between June 2006 and December 2009, 227 patients were tested for CF in a single university hospital. Forty-five patients with primary Raynaud’s phenomenon were tested for CF.Results.A total of 117 patients with CF without cryoglobulinemia were included. The main clinical manifestations included skin manifestations (50%) and arthralgia (35%). There were 67 patients with primary CF and 50 patients with secondary CF. There was no significant difference in the mean concentration of the cryoprecipitate in primary CF as compared to the secondary form (172 ± 18.6 vs 192 ± 20.9 mg/dl, respectively; p = 0.41). Highest concentrations of cryoprecipitate were observed in those containing fibrinogen only as compared to cryoprecipitates containing fibrinogen and fibronectin (301 ± 43.5 vs 125 ± 10.6 mg/dl; p < 0.001). Patients having skin necrosis (n = 3) had significantly higher values of cryofibrinogen compared to those without necrosis (638 ± 105 vs 160 ± 10.2 mg/dl; p = 0.0046). Among the 45 patients with primary Raynaud’s phenomenon, 36 had associated CF. There was no significant difference in the mean concentration of the cryoprecipitate in these patients compared to those with primary CF.Conclusion.There seems to be a significant correlation between cryofibrinogen concentration and the severity of the clinical signs, particularly when cryoprecipitate is composed of fibrinogen alone. CF might have a possible pathophysiological role in primary Raynaud’s phenomenon.

scholarly journals Human milk for neonatal pain relief during ophthalmoscopy

2013 ◽  
Vol 47 (5) ◽  
pp. 1039-1045 ◽  
Author(s):  
Laiane Medeiros Ribeiro ◽  
Thaila Correa Castral ◽  
Liciane Langona Montanholi ◽  
Mariana Firmino Dare ◽  
Aline Carolina de Araujo Silva ◽  
...  
Keyword(s):  
Pain Relief ◽  
Early Diagnosis ◽  
Human Milk ◽  
Premature Infants ◽  
Neonatal Intensive Care ◽  
Small Sample Size ◽  
Small Sample ◽  
University Hospital ◽  
Experimental Investigations ◽  
Significant Difference

Ophthalmoscopy performed for the early diagnosis of retinopathy of prematurity (ROP) is painful for preterm infants, thus necessitating interventions for minimizing pain. The present study aimed to establish the effectiveness of human milk, compared with sucrose, for pain relief in premature infants subjected to ophthalmoscopy for the early diagnosis of ROP. This investigation was a pilot, quasi-experimental study conducted with 14 premature infants admitted to the neonatal intensive care unit (NICU) of a university hospital. Comparison between the groups did not yield a statistically significant difference relative to the crying time, salivary cortisol, or heart rate (HR). Human milk appears to be as effective as sucrose in relieving acute pain associated with ophthalmoscopy. The study’s limitations included its small sample size and lack of randomization. Experimental investigations with greater sample power should be performed to reinforce the evidence found in the present study.

705: Predicting fetal acidemia using venous cord blood gas parameters

2014 ◽  
Vol 210 (1) ◽  
pp. S346-S347
Author(s):  
Jessica Cantu ◽  
Jeffery Szychowski ◽  
Joseph Biggio ◽  
Rodney Edwards ◽  
Alan Tita
Keyword(s):  
Cord Blood ◽  
Blood Gas ◽  
Blood Gas Parameters
Sign in / Sign up

Export Citation Format

Share Document