VARIATIONS IN PLASMA THYROXINE DURING LABOUR AND EARLY PUERPERIUM

1969 ◽  
Vol 60 (3) ◽  
pp. 423-432 ◽  
Author(s):  
K. Siersbæk-Nielsen ◽  
J. Mølholm Hansen
Keyword(s):  
Cord Blood ◽  
Premature Infants ◽  
Perinatal Period ◽  
Maternal Blood ◽  
Mean Value ◽  
Rapid Decrease ◽  
Term Infants ◽  
Mean Values ◽  
Significant Difference ◽  
The Mean

ABSTRACT Repeated determinations of plasma T4, PBI, dialysable T4 and free T4 were undertaken on 31 mothers of full-term infants and ten mothers of premature infants in the perinatal period. The blood samples were obtained 2–7 hours before delivery, at delivery, 3–6 hours after delivery, 6–12 hours after delivery and on the 2nd, 3rd–4th and 5th–6th day after birth. Similar investigations were also undertaken on cord blood. A significant increase in the mean value for plasma T4 of approximately 25 % was found from before delivery to the time of delivery. This was followed by a rapid decrease, so that a return to values observed before delivery occurred on the 2nd day after delivery. Dial. T4 did not alter during the rapid variations in the plasma T4. Plasma T4 was found to be significantly increased in maternal blood at delivery as compared with cord blood but there was no significant difference in the mean values for free T4 in the cord blood and the maternal blood at delivery, suggesting a free passive passage of T4 via the placenta. The variations found have not been described previously and they provide a possible explanation for the disagreements between the results of previous investigators. The reason for the variations and their significance in assessing possible equilibrium between free T4 in the maternal blood and cord blood are discussed.

A new simpler approach to measure the strength of toe plantar flexion requiring no mechanical restraint with a light-weight device

2021 ◽  
pp. 095441192110029
Author(s):  
Yuko Komuro ◽  
Yuji Ohta
Keyword(s):  
Plantar Flexion ◽  
Mean Value ◽  
Simple Approach ◽  
Light Weight ◽  
New Approach ◽  
Mean Values ◽  
Mechanical Restraint ◽  
Significant Difference ◽  
Ankle Joints ◽  
The Mean

Conventionally, the strength of toe plantar flexion (STPF) is measured in a seated position, in which not only the target toe joints but also the knee and particularly ankle joints, are usually restrained. We have developed an approach for the measurement of STPF which does not involve restraint and considers the interactions of adjacent joints of the lower extremities. This study aimed to evaluate this new approach and comparing with the seated approach. A thin, light-weight, rigid plate was attached to the sole of the foot in order to immobilize the toe area. Participants were 13 healthy young women (mean age: 24 ± 4 years). For measurement of STPF with the new approach, participants were instructed to stand, raise the device-wearing leg slightly, plantar flex the ankle, and push the sensor sheet with the toes to exert STPF. The sensor sheet of the F-scan II system was inserted between the foot sole and the plate. For measurement with the seated approach, participants were instructed to sit and push the sensor with the toes. They were required to maintain the hip, knee, and ankle joints at 90°. The mean values of maximum STPF of the 13 participants obtained with each approach were compared. There was no significant difference in mean value of maximum STPF when the two approaches were compared (new: 59 ± 23 N, seated: 47 ± 33 N). The coefficient of variation of maximum STPF was smaller for data obtained with the new approach (new: 39%, seated: 70%). Our simple approach enables measurement of STPF without the need for the restraints that are required for the conventional seated approach. These results suggest that the new approach is a valid method for measurement of STPF.

scholarly journals The Effect of Smoking on the Lipid Profile of Inhabitant Smokers of Hasilpur, District Bahawalpur, Pakistan

2020 ◽  
Vol 10 (2) ◽  
pp. 82-86
Author(s):  
Mushtaq Hussain Lashari ◽  
Sumbel Sumera ◽  
Umer Farooq ◽  
Zia Ur Rehman ◽  
Nuzhat Sial ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Serum Triglyceride ◽  
Mean Value ◽  
Heavy Smoker ◽  
Control Group ◽  
Mean Values ◽  
Significant Difference ◽  
The Mean ◽  
Control Light ◽  
Heavy Smokers

Background: Health problem are culturally associated with smoking in developing countries. Many hazardous chemicals are taken up by direct or passive smoking causing lipid peroxidation resulting in oxidative stress. Objectives: To estimate the occurrence of smoking and its effects on the lipid profile in populations of Hasilpur, Pakistan. Methodology: The current study was conducted from April - August 2014. Out of 247 apparently healthy subjects of both genders (male=220; female=27), 134 were smokers and 113 were non-smokers. In order to analyze lipid profile, blood samples were collected in early morning hours from the selected members who were asked to fast all night. By using Chem-100 chemistry analyzer, cholesterol, triglyceride, HDL, LDL and VLDL were analyzed. Results: The overall prevalence of smokers was 54.25%. The results showed 60.9% prevalence in males and 0% in females. The mean value of serum triglyceride in control, light smokers and heavy smokers was 147.4±11.7mg/dl, 190.8±41.4 and 205.3±29.7mg/dl, respectively. The results of cholesterol in control, light smokers and heavy smokers were 147.38±7.99mg/dl, 136.8 ±12. 8mg/dl and 173.44±8.63mg/dl, respectively. There was a considerable distinction in the mean level of serum triglyceride and cholesterol between the control group, light smokers and heavy smoker groups (P<00.5). The mean value of HDL of control, light smokers and heavy smokers was 30.93±1.30mg/dl, 31.10±2.45 and 34.58±1.55mg/dl, respectively. The mean values of LDL and VLDL of control, light smokers and heavy smokers were 110.46±3.63mg/dl, 106.00±4.52mg/dl, 117.19±3.48mg/dl and 33.54±3.11mg/dl, 49±9.02mg/dl, 41.06±5.34mg/dl, respectively. There was significant difference in the mean level of HDL, LDL and VLDL between the control group, light smokers and heavy smoker groups (P<0.05). Conclusion: This study concluded that smoking is the reasons of variation in the lipid profile. Elevated period of smoking and the number of smoked cigarettes/day reason the alteration in serum lipid levels and is probably related with increased danger for coronary artery disease.

CD59 Deficient Granulocytes in High Risk Groups of Myelodysplastic Syndromes (MDS).

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4717-4717
Author(s):  
Georgia Kaiafa ◽  
Vasiliki Tsavdaridou ◽  
Athanasios Papadopoulos ◽  
Christos Savopoulos ◽  
Apostolos Hatzitolios ◽  
...  
Keyword(s):  
Normal Subjects ◽  
Risk Groups ◽  
Mean Value ◽  
Control Group ◽  
Refractory Anaemia ◽  
Mean Values ◽  
Significant Difference ◽  
The Mean ◽  
Group B ◽  
Pnh Clone

Abstract Background: Blood cells are deficient in membrane-bound glycosyl-phosphatidylinositol (GPI)-anchored proteins in paroxysmal nocturnal hemoglobinuria (PNH) because of an acquired disorder of the pluripotent stem cell. CD55 and CD59 antigens are the most common GPI-anchored proteins that are used for the diagnosis of the presence of PNH clone. The association of MDS with PNH is rather controversial. There are few published individual cases of PNH arrived from a previous MDS or MDS following PNH. Aim: Recent studies have demonstrated the existence of PNH clone in some MDS patients. These studies were performed mostly on erythrocytes and to the best of our knowledge they are only 4. Granulocytes appear to be more sensitive markers of PNH clone existence than erythrocytes and therefore we investigate the expression of PNH clone on granulocytes of patients with MDS. Material-Methods: A total number of 95 patients 25–80 yrs old with MDS {A:19 with refractory anaemia (RA), B:9 with refractory anaemia with ring sideroblasts (RARS), C:17 with refractory anaemia with excess blasts (RAEB), D: 12 with refractory anaemia with excess blasts in transformation (RAEB-t) and E: 19 with chronic myelomonocytic leukemia (CMLL)} and 19 healthy donors were included in our study. The presence of GPI-anchored proteins (CD55, CD59)-deficient granulocytes was examined by flow cytometry. For the detection of the PNH clone the commercial kit by Beckman Coulter (cellquant CD55/CD59) was used. Statistical analysis was made by ANOVA, while Robust test was performed because there was no homogeneity of variances by ANOVA. Results: Table 1 shows the percentages of CD55 and CD59 deficient granulocytes in the 5 groups of pts with MDS comparing with the control group. a) Although the mean values of CD55 deficient granulocytes in the groups RAEB, RAEB-t and CMLL were higher enough than those of the normal subjects, there were no statistically significant differences (p>0.10) in the comparison of the mean values of CD55 deficient granulocytes between each group of patients with the control group. b) On the contrary there was a very statistically significant difference in the comparison of the mean value of CD59 deficient granulocytes between the three last groups (C, D and E) of pts with the control group (p< 0.086, p< 0.001 and p<0.001 respectively). The percentages of CD55 and CD59 deficient granulocytes in the 5 groups of patients with MDS and in the control group CD55 CD55 CD59 CD59 Groups N Mean Value Std deviation Mean Value Std deviation A (RA) 19 2.89 2.79 2.91 2.85 B (RARS) 9 1.05 1.14 3.89 3.63 C (RAEB) 17 4.78 4.76 11.75 6.06 D (RAEB-t) 12 4.23 2.85 23.76 8.53 E (CMLL) 19 6.01 4.97 38.26 16.18 Control 19 3.67 2.89 3.67 2.89 Total 95 4.00 3.87 14.44 16.39 Conclusions: There are relatively large CD59 negative subpopulations (mean values 11.75–38.26%) of granulocytes in the last three groups (RAEB, RAEB-t, CMLL) of MDS patients. On the contrary the two low risk forms (RA, RARS) revealed no such populations. Non-expression of CD59 antigen on granulocytes is a more sensitive marker than that of CD55 antigen for the presence of a possible PNH clone in MDS patients.

scholarly journals Carbocysteine in the Management of Stable COPD: Are Its Antioxidant and Anti-Inflammatory Properties Clinically Relevant?

2017 ◽  
Vol 2017 ◽  
pp. 1 ◽  
Author(s):  
Jordan Minov ◽  
Jovanka Karadzinska-Bislimovska ◽  
Tatjana Petrova ◽  
Kristin Vasilevska ◽  
Saso Stoleski ◽  
...  
Keyword(s):  
Real Life ◽  
Mean Value ◽  
Control Group ◽  
Chronic Obstructive ◽  
Initial Visit ◽  
Mean Values ◽  
Regular Treatment ◽  
Positive Effects ◽  
Significant Difference ◽  
The Mean

BACKGROUND: The recent epidemiological and experimental evidence suggest possible antioxidant effect of carbocysteine in patients with chronic obstructive pulmonary disease (COPD).AIM: To assess efficacy and tolerability of carbocysteine in the management of stable COPD.METHODS: We performed an observational, non-randomized, open study (a real life study) including 87 patients with stable COPD (group B and D by combined COPD assessment) divided in two groups, examined group (EG) and control group (CG). All participants were treated with the regular treatment of the stable disease, but in the participants of the EG carbocysteine 1,500 mg daily was added to their regular treatment during the period of two months. The study protocol included completion of the COPD Assessment Test (CAT) and spirometric measurements at initial visit and at the end of the mentioned period.RESULTS: We found significantly lower mean value of the overall CAT score in the EG at the end of the study as compared to its mean value registered at initial visit (26.9 vs. 24.3; P = 0.007). In regard to certain CAT items, we found significantly lower values of the mean scores related to cough phlegm and sleep disturbances as compared to their mean scores at initial visit. In addition, the mean values of the overall CAT scores at initial visit and at the end of the study in controls were similar. In EG we found significantly higher mean value of the MEF 25-75 at the end of the study as compared to its mean value registered at initial visit (59.3% vs. 67.2%; P = 0.003). There was no significant difference in the mean values of other spirometric parameters at the end of the study as compared to their mean values at initial visit. In controls we registered similar values of all measured spirometric parameters at the end of the study as compared to their values registered at initial visit. Mild gastrointestinal manifestations were registered in 13.3% of the participants of the EG during the examined period.CONCLUSION: Our findings indicate positive effects of carbocysteine regarding the symptoms and lung function, as well as its good tolerability in the patients with stable COPD.

scholarly journals Cord Blood Theophylline Levels and Respiratory Morbidities In Preterm Infants

2019 ◽  
pp. 1
Author(s):  
Tolga Hasan Celik ◽  
Ayse Korkmaz ◽  
Sule Yigit ◽  
Murat Yurdakok
Keyword(s):  
Cord Blood ◽  
Premature Infants ◽  
Neonatal Period ◽  
Serum Levels ◽  
University Hospital ◽  
Blood Gas ◽  
Significant Difference ◽  
The Mean ◽  
Blood Gas Parameters ◽  
Pulmonary Morbidity

<p><strong>Objective:</strong> to investigate whether there is any relationship between cord blood theophylline levels and pulmonary morbidities in the early neonatal period in premature infants.</p><p><strong>Study Design:</strong> This prospective cohort study was conducted in Hacettepe University Hospital Neonatology Unit, between November 2010 and January 2012. Cord blood samples were collected at birth from premature infants, and theophylline levels were measured. Theophylline levels of cord blood were compared between infants with and without pulmonary morbidity.</p><p><strong>Results:</strong> A total of 90 infants (42 females, 48 males) were enrolled in the study. The mean gestational age was 31.1±3.1 weeks, and the mean birth weight was 1527±540 g. Early respiratory morbidities developed in 57 infants (63.3%), while no respiratory morbidities were observed in 33 infants (36.7%). There was no significant difference between the groups in blood gas parameters, oxygen saturation values and cord blood theophylline levels.</p><p><strong>Conclusions:</strong> Although the theophylline levels that were measured in the cord blood were much lower than therapeutic serum levels, we concluded that the cord theophylline level is not valuable as a prognostic factor for pulmonary morbidities in premature newborns. </p>

scholarly journals The somatic growth pattern of preterm infants until term age

2009 ◽  
Vol 49 (1) ◽  
pp. 39
Author(s):  
Ida Bagus Andhita ◽  
Soetjianingsih Soetjianingsih ◽  
I. Wayan Retayasa
Keyword(s):  
Preterm Infants ◽  
Premature Infants ◽  
Growth Pattern ◽  
Somatic Growth ◽  
Mortality Rates ◽  
Term Infants ◽  
Important Indicator ◽  
Breastfed Infants ◽  
Significant Difference ◽  
The Mean

Background  Pre term infants contribute substantially to neonatalmorbidity  and  mortality rates. Somatic growth  is  consideredto be  an  important indicator  of  an  infant's health status.  Themeasurement parameters include body weight (BW), body length(BL), head circumference (HC), and ponderal index (PI). Specificdata  on  the somatic growth pattern  of  preterm infants in Indonesiaare unavailable.Objectives  To  identify the somatic  pattern  of  preterm infantsuntil term age  and  the influence  of  gender, nutrition, and nursingmethod  on  BW,  BL,  HC,  and  PI growth during the first week  oflife.Methods  We  recruited premature infants born in Sanglah Hopsital,Denpasar, Bali,  and  collected data  on  BW,  BL,  HC,  and  PI>All  data  were presented  as  mean (SD)  and  plotted in curves.The  relationships among several factors and the somatic growthparameters were analyzed with  ANOV  A.  The  level  of  significancewas set  at  P  <  0.05.Results  Among  100  infants, significant differences were detectedin  the  mean  ofBW,  BL,  HC, and PI, particularly in early preterminfants. Breastfed infants had the highest values with BW  2199grams (SD  198),  HC  31.4  em  (SD  1.71),  and PI  2.48  grams/cm 3(SD  0.36).  Infants nursed with the kangaroo method had thehighest values  of  BW  [2450  grams (SD  259)]  and  BL  [48  em(SD  2.34)].Conclusion  A significant difference was  detected  in somaticgrowth according to some parameters, particularly in the earlypreterm infants group. Thus, breast feeding and the kangaroomethod contribute to better somatic growth, and specifically BW.

APPLICATION OF PIXE TO DETERMINATION OF ELEMENTS IN THE PLACENTA, MATERNAL BLOOD AND CORD BLOOD

1997 ◽  
Vol 07 (03n04) ◽  
pp. 211-217 ◽  
Author(s):  
Yoshito Watanabe ◽  
Yoshie Takubo ◽  
Masae Yukawa ◽  
Yoshikazu Nishimura ◽  
Hitoshi Imaseki ◽  
...  
Keyword(s):  
Cord Blood ◽  
Maternal Blood ◽  
Pixe Analysis ◽  
Blood Samples ◽  
Mean Values ◽  
The Mean ◽  
Standard Deviations ◽  
Homogenize Sample ◽  
Cu And Zn

PIXE technique was applied to the measurement of elements in the placenta, maternal blood and cord blood of human. The elements determined in these samples include Cl , K , Ca , Fe , Cu and Zn . The values obtained by PIXE were compared with those by ICP-AES to test the accuracy of the method. In placental samples, the mean values of K , Fe , Cu and Zn concentrations obtained by the two methods agree, while Ca concentration is lower in PIXE analysis. The values from PIXE, however, show larger variations resulting from inhomogeneity of the placental samples composed of various tissues different in histological functions. In the analysis of blood samples, the results of the two methods agree for Cl , K , Ca , Fe , Cu and Zn , although the standard deviations tend to be larger in PIXE. These results indicate that PIXE is a useful method for the determination of elements in placental and blood samples, although the preparation to homogenize sample is necessary to obtain accurate results.

scholarly journals Evaluation of Respiratory Muscular Strength Compared to Predicted Values in Patients with Stroke

2020 ◽  
Vol 17 (3) ◽  
pp. 1091 ◽  
Author(s):  
Sarah Maria Ramos ◽  
Daniela Maciel da Silva ◽  
Daniela Vieira Buchaim ◽  
Rogério Leone Buchaim ◽  
Mauro Audi
Keyword(s):  
Statistical Analysis ◽  
Muscle Strength ◽  
Respiratory Muscles ◽  
Mean Value ◽  
P Value ◽  
Men And Women ◽  
Mean Values ◽  
Significant Difference ◽  
The Mean ◽  
Predicted Values

The purpose of this study was to evaluate the inspiratory and expiratory muscle strength of individuals affected by stroke and to compare it with the predicted values in the literature considering their corresponding age. Respiratory muscle strength was evaluated in 22 elderly people who had sequels of stroke, four with right hemiparesis, 16 with left hemiparesis and two with bilateral, of ages ranging from 34 to 82 years. The collected data were submitted to statistical analysis using a Mann–Whitney test to evaluate if there was a significant difference in the average data collected when compared with a mean of the predicted data in the literature. Fourteen men and eight women were evaluated, who obtained mean values of 71.85 cmH2O and 57.75 cmH2O, respectively, for a maximal inspiratory pressure (MIP), and when compared to the predicted values for men and women, 105.41 cmH2O (p-value 0.0019) and 80.57 cmH2O (p-value 0.00464) were significantly lower. For a maximal expiratory pressure (MEP), the mean value obtained for men was 62.28 cmH2O and 49.5 cmH2O for women, whereas the predicted values in the literature were 114.79 cmH2O (p-value < 0.0001) and 78, 46 cmH2O (p-value 0.0059), respectively. In the statistical analysis, it was possible to notice that the studied population did not reach the predicted age indexes and that there was a significant difference between the median columns. In conclusion, there is a weakness in the respiratory muscles of hemiparetic men and women due to stroke.

scholarly journals Knowledge of Personal Hygiene among Undergraduates

2020 ◽  
Vol 5 (2) ◽  
pp. 66-71
Author(s):  
Akorede Seun Nurudeen Nurudeen ◽  
Atanda Toyin
Keyword(s):  
Well Being ◽  
Mean Value ◽  
Personal Hygiene ◽  
Sampling Techniques ◽  
Mean Values ◽  
Knowledge Based ◽  
Multi Stage ◽  
Significant Difference ◽  
The Mean ◽  
Level Of Significance

Background: Personal hygiene is the act of taking care of oneself, it is also referring to as an act of maintaining the cleanliness of one's body and clothing to improve overall health and well-being. The purpose of the study was to examine if undergraduates know about personal hygiene, investigate if undergraduates of University of Ilorin differ in personal hygiene knowledge based on age, and assess if there is a difference in knowledge of personal hygiene among undergraduates of University of Ilorin based on gender. Methods: A descriptive research design of using surveys was employed for this study. Multi-stage sampling techniques of simple random, proportionate, and convenient sampling techniques were used to select 398 respondents for the study. The researcher developed a questionnaire validated by three experts from the Department of Health Promotion and Environmental Health Education, University of Ilorin was used for the study. ANOVA and Independent t-test was used to test the hypotheses. All hypotheses were tested at 0.05 level of significance. Results: The findings from this study revealed that undergraduates of University of Ilorin know about personal hygiene. The mean values of Yes (330/ 82.9%) is greater than the mean value of No (68/17.8%). There is a significant difference in knowledge of personal hygiene among undergraduates of University of Ilorin based on age (p= 0.023). There is a significant difference in knowledge of personal hygiene among undergraduates of University of Ilorin based on gender (p= 0.018). Conclusion: The study concluded that undergraduates of University of Ilorin know about personal hygiene. 

scholarly journals Genetic and Environmental Dispositions for Cardiovascular Variability: A Pilot Study

2018 ◽  
Vol 7 (9) ◽  
pp. 232 ◽  
Author(s):  
Radmila Karan ◽  
Suzana Cvjeticanin ◽  
Natasa Kovacevic-Kostic ◽  
Dejan Nikolic ◽  
Milos Velinovic ◽  
...  
Keyword(s):  
Control Sample ◽  
Mean Value ◽  
Blood Type ◽  
Control Group ◽  
Mean Values ◽  
Individual Variations ◽  
Significant Difference ◽  
Abo Blood Type ◽  
The Mean ◽  
Artery Disease

Background: The aim of our study was to evaluate the degree of genetic homozygosity in the group of patients with coronary artery disease (CAD), as well as to evaluate morphogenetic variability in CAD patients regarding the presence of investigated risk factors (RF) compared to a control sample of individuals. Additionally, we aimed to evaluate the distribution of ABO blood type frequencies between tested samples of individuals. Methods: This study analyzed individual phenotype and morphogenetic variability of 17 homozygously-recessive characteristics (HRC), by using HRC test in a sample of 148 individuals in CAD patients group and 156 individuals in the control group. The following RF were analyzed: hypertension, diabetes mellitus, hyperlipidemia, and smoking. Results: The mean value of HRC in CAD patients is significantly higher, while variability decreases compared to the control sample (CAD patients: 4.24 ± 1.59, control sample: 3.75 ± 1.69; VCAD-patients = 37.50%, VC = 45.07%). There is a significant difference in individual variations of 17 HRC between control sample and CAD patients (χ2 = 169.144; p < 0.01), which points out to different variability for tested genes. Mean values of HRC significantly differed in CAD patients in regard to the number of RF present. A blood type (OR = 1.75) is significant predictor for CAD, while O blood type (OR = 0.43) was significantly associated with controls. Conclusion: There is a higher degree of recessive homozygosity in CAD patients versus individuals in the control sample, and the presence of significant variations in the degree of recessive homozygosity as the number of tested RF increases.

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