scholarly journals Non-Linearity Effect of Low-Doses γ-Radiation on Essential Metals, Lipid Peroxidation and Metallothionein Levels in Rats

2011 ◽  
Vol 24 (1) ◽  
pp. 45-58
Keyword(s):  
Lipid Peroxidation ◽  
Low Doses ◽  
Essential Metals ◽  
Γ Radiation

scholarly journals Influence of very low dietary intake of marine oil on some fuctional aspects of immune cells in healthy elderly people

2003 ◽  
Vol 89 (4) ◽  
pp. 523-531 ◽  
Author(s):  
Shaliha Bechoua ◽  
Madeleine Dubois ◽  
Evelyne Véricel ◽  
Paul Chapuy ◽  
Michel Lagarde ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acids ◽  
Placebo Group ◽  
Elderly People ◽  
Cyclic Nucleotide ◽  
Elderly Subjects ◽  
Low Doses ◽  
Marine Oil ◽  
Healthy Elderly ◽  
Healthy Elderly People

Ageing is a multifactorial process involving decreased antioxidant defences and immune functions. n-3 Polyunsaturated fatty acids have been associated with human health benefits, especially against inflammatory and autoimmune diseases. However, their immunomodulatory effects were usually observed with high dosages (>2 g/d) known to increase lipid peroxidation. In contrast, very low doses, that may prevent lipid peroxidation, might affect the immune system differently. To study the latter hypothesis further, we investigated whether the supplementation of healthy elderly people with very low doses of marine oil (MO), a docosahexaenoate (DHA)- and eicosapentaenoate (EPA)-rich triacylglycerol, was able to affect lymphocyte proliferation and biochemical markers known to be altered with age. In a randomized, double-blind design, twenty healthy elderly subjects were assigned to a placebo group (600 mg sunflower oil/d) or to a group consuming 600 mg MO/d providing 150 mg DHA + 30 mg (EPA) for 6 weeks. At day 42, the proliferative responses of lymphocytes to several mitogens were significantly (P<0·01) decreased in the MO group compared with control values. This was accompanied by a slight lowering of their cytosolic cyclic nucleotide phosphodiesterase (PDE) activity, a marked and significant (P<0·05) increase of their particulate PDE activity (+56–57 %) and a slight but significant (P<0·05) increase in cyclic nucleotide intracellular levels. At the same time, the glutathione peroxidase activity was markedly and significantly (P<0·01) depressed in the MO group. None of these modifications could be seen in the placebo group. Collectively, these results demonstrate that even very low doses of n-3 fatty acids are sufficient to affect the immune responses of elderly subjects.

Low doses of α- and γ-radiation enhance DNA thermal stability

1999 ◽  
Vol 80 (2) ◽  
pp. 103-118 ◽  
Author(s):  
A.G Georgakilas ◽  
E.G Sideris ◽  
L Sakelliou ◽  
C.A Kalfas
Keyword(s):  
Thermal Stability ◽  
Low Doses ◽  
Γ Radiation

Low doses of γ-radiation induce consistent protein expression changes in human leukocytes

2011 ◽  
Vol 8 (5/6) ◽  
pp. 374 ◽  
Author(s):  
Sara Skiöld ◽  
Susanne Becker ◽  
Ulf Hellman ◽  
Gert Auer ◽  
Ingemar Näslund ◽  
...  
Keyword(s):  
Protein Expression ◽  
Low Doses ◽  
Γ Radiation ◽  
Human Leukocytes
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