scholarly journals Effects of olive leaf extract prepared in water on streptozotocin-induced oxidative stress and lipid peroxidation in rats

2020 ◽  
pp. 2406-2415
Author(s):  
Fatma GÜR ◽  
Ahmet Gökhan AĞGÜL ◽  
Mine GÜLABOĞLU
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Leaf Extract ◽  
Olive Leaf ◽  
Olive Leaf Extract

scholarly journals Liposomal Encapsulation of Oleuropein and an Olive Leaf Extract: Molecular Interactions, Antioxidant Effects and Applications in Model Food Systems

2020 ◽  
Author(s):  
Rodrigo González-Ortega ◽  
Luka Šturm ◽  
Mihaela Skrt ◽  
Carla Daniela Di Mattia ◽  
Paola Pittia ◽  
...  
Keyword(s):  
Phase Transition ◽  
Lipid Peroxidation ◽  
Transition Temperature ◽  
Liquid Phase ◽  
Phase Transition Temperature ◽  
Leaf Extract ◽  
Olive Leaf ◽  
Liquid Phase Transition ◽  
Olive Leaf Extract ◽  
Fluorescence Measurements

Abstract The influence of actively/passively encapsulated oleuropein on DPPC liposomes thermal and structural properties, and its antioxidant capacity against lipid peroxidation were investigated. Also, an oleuropein-rich olive leaf extract was encapsulated in soy phosphatidylcholine (PL-90 g) and incorporated in model and commercial drinks. Oleuropein induced a concentration-dependent broadening and splitting of the gel-to-liquid phase transition temperature. Fluorescence measurements revealed a fluidizing effect on liposomes below their gel-to-liquid phase transition temperature, and a higher lipid ordering above, especially to active encapsulation. Oleuropein also showed an antioxidant effect against lipid peroxidation in PL-90 g liposomes. PL-90 g Liposomes with olive leaf extract showed a mean diameter of 405 ± 4 nm and oleuropein encapsulation efficiency of 34% and delayed oleuropein degradation at pH 2.0 and 2.8 model drinks. In conclusion, greater effects were observed on the structure and fluidity of DPPC liposomes when oleuropein was actively encapsulated, while its incorporation into acidic foods in encapsulated form could enhance its stability.

Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats

2014 ◽  
Vol 14 (4) ◽  
pp. 996-1002 ◽  
Author(s):  
Jale Çoban ◽  
Serdar Öztezcan ◽  
Semra Doğru-Abbasoğlu ◽  
Ilknur Bingül ◽  
Kübra Yeşil-Mizrak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Leaf Extract ◽  
Aged Rats ◽  
Olive Leaf ◽  
Olive Leaf Extract

Effect of Tunisian Olive Leaf Extract on oxidative stress and lung fibrosis in rats

2020 ◽  
Author(s):  
Sana Bahri ◽  
Raed Abdennabi ◽  
Afef Nahdi ◽  
Ridha Ben Ali ◽  
Mona Mlika ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Fibrosis ◽  
Leaf Extract ◽  
Olive Leaf ◽  
Olive Leaf Extract

Antioxidant and anti-inflammatory effect of olive leaf extract treatment in diabetic rat brain

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mehmet Berköz ◽  
Tahir Kahraman ◽  
Zwain Nozad Shamsulddin ◽  
Mirosław Krośniak
Keyword(s):  
Oxidative Stress ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Proinflammatory Cytokines ◽  
Leaf Extract ◽  
Glycated Hemoglobin ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Olive Leaf ◽  
Olive Leaf Extract

Abstract Objectives Olive (Olea europaea L.) plays a promising role in pharmaceutical, nutraceutical, and cosmetic production. On the other hand, olive leaf is widely used in folk medicine due to its antihyperglycemic activity. For this aim, possible effects of olive leaf extract (OLE) in the brain tissue of streptozotocin-induced diabetic rats were investigated. Methods A total of 28 male rats were divided into four equal groups as control, diabetic (single dose of 45 mg/kg streptozotocin, i.p.), OLE (500 mg/kg/day), and diabetic + OLE groups. The study was terminated 21 days after the diabetes model was formed. At the end of the study, all the animals were sacrificed and blood and brain tissues were isolated. Relative brain weights, complete blood count, blood glycated hemoglobin, serum glucose, total protein, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, insulin, gonadal hormone levels, production and messenger ribonucleic acid (mRNA) levels of proinflammatory cytokines and mediators, total thiol, total oxidative stress, and total antioxidant status levels and fatty acid composition in brain tissue were measured in all study groups. Results In diabetic rats, relative brain weight and serum insulin level decreased, glycated hemoglobin, oxidative stress, production and mRNA level of proinflammatory cytokines and mediators increased, hyperglycemia, hypercholesterolemia and hypertriglyceridemia, degraded fatty acid composition, anemia, leukopenia, and thrombocytopenia occurred. After OLE treatment, a remarkable improvement in most of these parameters, except gonadal hormones, has been observed in diabetic rats. Conclusions This study suggests that olive leaf can be a precious neuroprotective agent in diabetes.

scholarly journals Effect of Olea europea L. leaf extract on haemodynamic status and lipid peroxidation in spontaneously hypertensive rats

2013 ◽  
Vol 67 (5-6) ◽  
pp. 303-315
Author(s):  
Zoran Miloradovic ◽  
Maja Gvozdenov ◽  
Djurdjica Jovovic ◽  
Nevena Mihailovic-Stanojevic ◽  
Milan Ivanov ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lipid Peroxidation ◽  
Cardiac Output ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Leaf Extract ◽  
Peripheral Resistance ◽  
Olive Tree ◽  
Olive Leaf ◽  
Olive Leaf Extract

Hypertension is one of the main causes of cardiovascular disorders and since ancient times olive tree leaves have been used in its therapy. However the mechanisms of their atihypertensive effect have not been sufficiently explained yet. The main objective of our study was to investigate acute effect of olive tree leaves extract on haemodynamics and lipid peroxidation in rats with congenital hypertension under normal and blocked synthesis of nitric oxide. For the purpose of our research, there were used olive tree leaf extract EFLA? 943 as well as inhibitor of nitric oxide synthase enzyme L-NAME. Nitric oxide synthesis inhibition led to statistically significant increase of mean arterial pressure, reducing heart rate and cardiac output, increase of total vascular resistance and lipid peroxidation in plasma. Treatment by olive leaf extract led to decrease of mean arterial pressure, reducing the frequency and cardiac output, without change in lipid peroxidation. Olive leaf extract under blockade of nitric oxide led to decrease of mean arterial pressure, total peripheral resistance remained high, cardiac output low, and lipid peroxidation significantly increased. General conclusion is that olive leaf extract has a strong antihypertensive effect, decreases cardiac pre and after load and does not influence lipid peroxidation. Under blockade of nitric oxide synthesis, this extract keeps antihypertensive properties, but due to strong endothelial dysfunction, it is unable to regulate increased total peripheral resistance and marked lipid peroxidation.

scholarly journals Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Toshio Mikami ◽  
Jimmy Kim ◽  
Jonghyuk Park ◽  
Hyowon Lee ◽  
Pongson Yaicharoen ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Exercise Capacity ◽  
Endurance Exercise ◽  
Leaf Extract ◽  
Metabolic Diseases ◽  
Olive Leaf ◽  
Olive Leaf Extract ◽  
Hypoxic Conditions ◽  
G Protein Coupled ◽  
Antioxidant Effects

AbstractObesity is a risk factor for development of metabolic diseases and cognitive decline; therefore, obesity prevention is of paramount importance. Neuronal mitochondrial dysfunction induced by oxidative stress is an important mechanism underlying cognitive decline. Olive leaf extract contains large amounts of oleanolic acid, a transmembrane G protein-coupled receptor 5 (TGR5) agonist, and oleuropein, an antioxidant. Activation of TGR5 results in enhanced mitochondrial biogenesis, which suggests that olive leaf extract may help prevent cognitive decline through its mitochondrial and antioxidant effects. Therefore, we investigated olive leaf extract’s effects on obesity, cognitive decline, depression, and endurance exercise capacity in a mouse model. In physically inactive mice fed a high-fat diet, olive leaf extract administration suppressed increases in fat mass and body weight and prevented cognitive declines, specifically decreased working memory and depressive behaviors. Additionally, olive leaf extract increased endurance exercise capacity under atmospheric and hypoxic conditions. Our study suggests that these promising effects may be related to oleanolic acid’s improvement of mitochondrial function and oleuropein’s increase of antioxidant capacity.

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